GNF-Pf-1408
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1408

>  <JC_XSMILES>
NC1=NC(N)=C2C=C(C=CC2=N1)S(=O)(=O)N3CCSCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1165

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.07

>  <Powder data?>
No

>  <IFI value>
0.177419355

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-163
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
  8 19  4  0  0  0  0
 13 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-163

>  <JC_XSMILES>
CN(C)CCCNC1=CC(C)=NC2=CC=C(C)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.41

>  <W2 Pf proliferation inhibition EC50 uM>
0.824

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>3.62

>  <Powder data?>
No

>  <IFI value>
0.023255814

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2152
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7751   -6.3432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9681   -6.5147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7132   -7.2993    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 13 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2152

>  <JC_XSMILES>
OC(COC1=CC=C(Cl)C=C1)CN2C(=N)N(CCN3CCCCC3)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.521

>  <W2 Pf proliferation inhibition EC50 uM>
0.2787

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.27

>  <Powder data?>
Yes

>  <IFI value>
0.094339623

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2343
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.0367    1.1759    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0284   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0578   -2.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6959   -3.2372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2479   -2.6241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8354   -1.9096    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
  8 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2343

>  <JC_XSMILES>
FC1=CC=CC=C1C(N2CCN(CC2)CC=C)C3=NN=NN3CC4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.912

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>77.05

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2629
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
  3 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2629

>  <JC_XSMILES>
COC1=CC(NCCCC(C)N)=C2N=CC=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.215

>  <W2 Pf proliferation inhibition EC50 uM>
0.418

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.37

>  <Powder data?>
Yes

>  <IFI value>
0.102040816

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2976
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2976

>  <JC_XSMILES>
CC(CC1=CC=CC=C1SC2=CC=CC=C2O)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.039

>  <W2 Pf proliferation inhibition EC50 uM>
0.722

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3383
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
  7 23  4  0  0  0  0
  3 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3383

>  <JC_XSMILES>
COC1=CC=CC(NC2=NC(NCCO)=C3C=CC=CC3=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1146

>  <W2 Pf proliferation inhibition EC50 uM>
0.3118

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.07

>  <Powder data?>
Yes

>  <IFI value>
0.014705882

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3397
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3397

>  <JC_XSMILES>
CCOC1=CC=C2N=C(C)C=C(NC3=CC=CC(O)=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2008

>  <W2 Pf proliferation inhibition EC50 uM>
0.2894

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.83

>  <Powder data?>
Yes

>  <IFI value>
0.010638298

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3695
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 10 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3695

>  <JC_XSMILES>
COC1=CC=CC=C1NC2=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3119

>  <W2 Pf proliferation inhibition EC50 uM>
0.2125

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.6

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3718
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    4.5888    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0638    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763    0.6336    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013    0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5388    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7763    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0638   -0.0809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -0.0809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013   -0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -1.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013   -2.2243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -2.9388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5388   -2.9388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513   -2.2243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5388   -1.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -2.2243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0638   -2.9388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -2.9388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263   -2.2243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -1.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0638   -1.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3718

>  <JC_XSMILES>
CCCCCN(CCCCC)C(O)C1=CC2=C(CCCC2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0582

>  <W2 Pf proliferation inhibition EC50 uM>
0.377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.45

>  <Powder data?>
Yes

>  <IFI value>
0.018181818

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-415
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
  6 25  4  0  0  0  0
 25 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-415

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2526

>  <W2 Pf proliferation inhibition EC50 uM>
0.421

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.974

>  <Powder data?>
Yes

>  <IFI value>
0.12

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-429
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
   -0.8458    3.2794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4558    4.0064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3688    4.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8034    3.3309    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4134    2.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4112    2.5782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6280    3.3567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0626    2.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8872    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3218    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1072    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6726    1.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 14 26  1  0  0  0  0
 22 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-429

>  <JC_XSMILES>
C1CCN(CC1)CC2=CC=C(C=C2)C3=CC4=CC=CC=C4C5=NCCN35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2783

>  <W2 Pf proliferation inhibition EC50 uM>
0.579

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.14

>  <Powder data?>
Yes

>  <IFI value>
0.029850746

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4301
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
  9 26  4  0  0  0  0
  7 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4301

>  <JC_XSMILES>
CC1=CC=C(C)C(NC2=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2459

>  <W2 Pf proliferation inhibition EC50 uM>
0.0902

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.47

>  <Powder data?>
Yes

>  <IFI value>
0.081081081

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-433
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
   -4.2868   -4.9500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537    2.1394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    2.7525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    3.4670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1481    4.2516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5961    4.8647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2109    4.6932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4658    3.9086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    3.2955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
 25 30  4  0  0  0  0
 18 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  4  0  0  0  0
 16 37  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1  24
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-433

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)N2CCN(CC2)C3=NC(NCCC4=CNC5=CC=CC=C45)=C6C=CC=CC6=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1706

>  <W2 Pf proliferation inhibition EC50 uM>
1.985

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.29

>  <Powder data?>
Yes

>  <IFI value>
0.061728395

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4331
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4331

>  <JC_XSMILES>
ClC1=CC=C(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1126

>  <W2 Pf proliferation inhibition EC50 uM>
0.0924

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.62

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4467
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8163   -1.7466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0416   -1.7466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  0  0  0  0
  9 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4467

>  <JC_XSMILES>
COC1=CC=CC(=C1)N2C(N)=NC(N)=NC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0555

>  <W2 Pf proliferation inhibition EC50 uM>
0.498

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4483
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4483

>  <JC_XSMILES>
CCC1=CC2=C(NCCN3CCCCC3)N=CN=C2S1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.32

>  <W2 Pf proliferation inhibition EC50 uM>
0.466

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>96.06

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4528
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
 15 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4528

>  <JC_XSMILES>
OC(CN1C(=N)N(CC2=CC=CC=C2)C3=CC=CC=C13)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2571

>  <W2 Pf proliferation inhibition EC50 uM>
0.0506

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.14

>  <Powder data?>
Yes

>  <IFI value>
0.04

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4924
  Mrv1591402191617072D          

 23 27  0  0  0  0            999 V2000
    1.7785   -4.7194    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.3187   -4.0958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0487   -3.3163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5889   -2.6927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3990   -2.8486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0570   -2.3510    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7336   -2.8230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5132   -2.5530    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4938   -3.6124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1728   -4.3724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6705   -5.0303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4891   -4.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8101   -4.1684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3125   -3.5104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7845   -2.8337    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5739   -3.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2803   -2.6474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0025   -3.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0184   -3.8709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3120   -4.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5897   -3.8984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6690   -3.6282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1288   -4.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
  9 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 16 21  4  0  0  0  0
  9 22  1  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4924

>  <JC_XSMILES>
BrC1=CC=C2NC(=O)C3(NCCC4=C3NC5=CC=CC=C45)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1976

>  <W2 Pf proliferation inhibition EC50 uM>
0.1111

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.25

>  <Powder data?>
Yes

>  <IFI value>
0.010869565

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4927
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    4.0168    4.0796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0970    3.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3670    2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1771    2.2086    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7172    2.8323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5274    2.6764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0675    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8776    3.1441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4472    1.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2573    1.2732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7974    1.8968    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5274    0.4936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3375    0.3377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6075   -0.4418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0675   -1.0655    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2573   -0.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7172   -1.5332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9071   -1.3773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3670   -2.0010    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -0.5978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1771    0.0259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9873   -0.1300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4177   -0.5978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9578    0.0259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7679   -0.1300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0379   -0.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8481   -1.0655    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.4979   -1.5332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6877   -1.3773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 17 23  4  0  0  0  0
 15 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4927

>  <JC_XSMILES>
CCCCN(CCCC)CC(O)C1=CC(=NC2=CC(Cl)=CC=C12)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1889

>  <W2 Pf proliferation inhibition EC50 uM>
0.0326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.42

>  <Powder data?>
No

>  <IFI value>
0.032786885

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4978
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4978

>  <JC_XSMILES>
CC1=CC(NCCC2=CC=CC=C2)=NC3=CC(O)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.377

>  <W2 Pf proliferation inhibition EC50 uM>
0.0695

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.47

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5264
  Mrv1591402191617072D          

 31 36  0  0  1  0            999 V2000
    4.4327   -2.4538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2042   -2.7460    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.3370   -3.5603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1085   -3.8524    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7473   -3.3303    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.5188   -3.6225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6516   -4.4368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1576   -3.1004    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.0249   -2.2862    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.7583   -1.9083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3443   -2.4890    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   10.1679   -2.4421    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   10.5391   -1.7054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3628   -1.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8153   -2.3483    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   12.6389   -2.3014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0914   -2.9913    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   13.9150   -2.9444    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.7202   -3.7280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8965   -3.7749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4440   -3.0851    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   11.0728   -3.8218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6204   -3.1320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2492   -3.8688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4255   -3.9157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9731   -3.2258    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    8.5269   -3.9197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2534   -1.9940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6146   -2.5161    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.4818   -1.7018    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8430   -2.2239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  1  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  6  1  0  0  0  0
  8  9  1  1  0  0  0
  9 10  1  6  0  0  0
 11 10  1  1  0  0  0
 11 12  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 15 14  1  1  0  0  0
 15 16  1  0  0  0  0
 17 16  1  0  0  0  0
 17 18  1  1  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 21 20  1  0  0  0  0
 21 15  1  0  0  0  0
 21 22  1  1  0  0  0
 21 23  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 26 25  1  0  0  0  0
  8 26  1  0  0  0  0
 26 11  1  0  0  0  0
 26 27  1  1  0  0  0
  9 28  1  0  0  0  0
 29 28  1  0  0  0  0
  5 29  1  0  0  0  0
 29 30  1  1  0  0  0
 29 31  1  0  0  0  0
  2 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5264

>  <JC_XSMILES>
C[C@H]1CN[C@@H]2C(C)[C@H]3[C@@H](C[C@H]4[C@@H]5CC[C@H]6C[C@@H](N)CC[C@]6(C)C5CC[C@]34C)O[C@@]2(O)C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.863

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01267

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.052631579

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5403
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5403

>  <JC_XSMILES>
OC1=CC=C(CN2CCCCC2)N=C1C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2407

>  <W2 Pf proliferation inhibition EC50 uM>
0.0866

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
Hydrochloride

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5565
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.6184    4.9204    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0309    4.2059    0.0000 Si  0  0  0  0  0  0  0  0  0  0  0  0
    4.3164    3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.7309    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164    1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    0.0809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875    1.3184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454    4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454    5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4599    5.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1743    5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1743    4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4599    4.2059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4434    3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2684    3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6809    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2684    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0309    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  2 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5565

>  <JC_XSMILES>
O[Si](CCCN1CCCCC1)(C2CCCCC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02361

>  <W2 Pf proliferation inhibition EC50 uM>
0.01212

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.04

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5650
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
  6 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 17 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5650

>  <JC_XSMILES>
CCOC1=CC2=C(C=C1OCC)C(NCC2)C3=CC=C(O)C(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1569

>  <W2 Pf proliferation inhibition EC50 uM>
0.01251

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>97.88

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-66
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-66

>  <JC_XSMILES>
NC1=NC(N)=C2C=C(C=CC2=N1)S(=O)(=O)N3CCOCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0626

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.05

>  <Powder data?>
Yes

>  <IFI value>
0.09375

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-69
  Mrv1591402191617072D          

 38 42  0  0  1  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3848   -3.0308    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8545   -2.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6670   -1.9690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3242   -1.4803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 17 16  1  0  0  0  0
 17 18  1  1  0  0  0
 17 19  1  0  0  0  0
 20 19  1  0  0  0  0
 20 14  1  0  0  0  0
 20 21  1  6  0  0  0
 22 21  1  1  0  0  0
 22 23  1  0  0  0  0
 24 23  1  0  0  0  0
 24 25  1  1  0  0  0
 26 24  1  0  0  0  0
 26 27  1  6  0  0  0
 26 28  1  0  0  0  0
 28 29  1  6  0  0  0
 28 30  1  0  0  0  0
 22 30  1  0  0  0  0
 17 31  1  6  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
 15 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 11 36  4  0  0  0  0
 36 37  1  0  0  0  0
  7 37  1  0  0  0  0
 37 38  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-69

>  <JC_XSMILES>
COC1=CC=CC2=C1C(=O)C3=C(O)C4=C(C[C@@](O)(C[C@@H]4O[C@H]5C[C@@H](N)[C@H](O)[C@H](C)O5)C(C)=O)C(O)=C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3079

>  <W2 Pf proliferation inhibition EC50 uM>
0.2133

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.1294

>  <Powder data?>
No

>  <IFI value>
0.196721311

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-809
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    1.2448   -0.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1842   -0.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-809

>  <JC_XSMILES>
CC1(C)N=C(N)N=C(N)N1C2=CC=C(I)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00723

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.059701493

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-89
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-89

>  <JC_XSMILES>
CCOC1=CC=C(NC2=NC(N)=C3C=CC=CC3=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.862

>  <W2 Pf proliferation inhibition EC50 uM>
1.576

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.371

>  <Powder data?>
Yes

>  <IFI value>
0.205882353

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1422
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -2.9279   -0.9694    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.5154   -0.2549    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.9279    0.4595    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1487   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9737   -0.2549    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1487   -1.0799    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1487    0.5701    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
 10 17  4  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1422

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C2=CN3N=C(SC3=N2)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.053

>  <W2 Pf proliferation inhibition EC50 uM>
0.818

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028169014

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3657
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
   -1.3099   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971    1.3977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5942    2.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4012    2.6239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6561    1.8393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1041    1.2262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3590    0.4416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  5  9  4  0  0  0  0
  2  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
M  CHG  1   9   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3657

>  <JC_XSMILES>
CC1=C[N+]2=C(SC=C2)N1CC3=CC=CC=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.284

>  <W2 Pf proliferation inhibition EC50 uM>
0.1126

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4739
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  6 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4739

>  <JC_XSMILES>
CC1=CC=NC(NC2=NC(=CS2)C3=CC=CC=N3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1128

>  <W2 Pf proliferation inhibition EC50 uM>
0.0463

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.92

>  <Powder data?>
Yes

>  <IFI value>
0.246153846

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-841
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    1.1041   -2.5611    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971   -2.7326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5474   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9599   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5474    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422   -3.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5942   -4.1303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3392   -4.9149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4677   -5.0865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0198   -4.4734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648   -3.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  4  0  0  0  0
  4 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-841

>  <JC_XSMILES>
O=C(CN1C2=[N+](C=CS2)C=C1C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.517

>  <W2 Pf proliferation inhibition EC50 uM>
1.216

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031746032

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-187
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    2.7365    1.7181    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1028    0.9789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9277    0.9881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4493    0.3489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2349    0.6008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8459    0.0465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6713   -0.7598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8857   -1.0118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2747   -0.4575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5354   -0.8237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5447   -1.6487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2637   -2.0531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2729   -2.8781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5631   -3.2985    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8441   -2.8941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8349   -2.0691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7882   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5956    0.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7732    0.3929    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4574   -0.3693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0847   -0.9051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-187

>  <JC_XSMILES>
O=C1CC2=CC=CC=C2C(=C3CCNCC3)C4=C1SC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.532

>  <W2 Pf proliferation inhibition EC50 uM>
2.039

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Fumarate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2095
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    0.1333    3.4887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9458    3.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6603    4.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3747    3.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3747    2.8070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0892    2.3945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0892    1.5695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037    1.1570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037    0.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162   -1.4753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912   -1.4753    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0625    0.8531    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.4556    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6603    2.3945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9458    2.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6636    4.4072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1489    4.5505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4310    5.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0993    5.9577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1829    6.7330    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.9117    5.8145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1939    5.0392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4420    6.4464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9723    7.0784    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.0740    5.9161    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8101    6.9767    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  1  0  0  0  0
 18 24  4  0  0  0  0
  5 25  1  0  0  0  0
 25 26  1  0  0  0  0
  2 26  1  0  0  0  0
  2 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2095

>  <JC_XSMILES>
OC1(CCN(CCOC2C3=CC=CC=C3CSC4=CC=C(Cl)C=C24)CC1)C5=CC=C(Cl)C(=C5)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.012

>  <W2 Pf proliferation inhibition EC50 uM>
0.888

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.21

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
Maleate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5316
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  7 28  4  0  0  0  0
  3 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5316

>  <JC_XSMILES>
COC1=CC=CC(CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.34

>  <W2 Pf proliferation inhibition EC50 uM>
0.0504

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.16

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
Oxalate

>  <Equiv of salt>
3

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3125
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3125

>  <JC_XSMILES>
OC1=CC=CC=C1CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.744

>  <W2 Pf proliferation inhibition EC50 uM>
0.166

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.92

>  <Powder data?>
Yes

>  <IFI value>
0.018181818

>  <Salt>
Oxalate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3590
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3909   -6.0731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6459   -6.8577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4528   -7.0293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0049   -6.4162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7499   -5.6315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429   -5.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 12 17  4  0  0  0  0
  3 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3590

>  <JC_XSMILES>
C1CN(CCC1NCC2=CNC3=CC=CC=C23)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2079

>  <W2 Pf proliferation inhibition EC50 uM>
0.1203

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
Oxalate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1224
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    6.4302   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  5 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1224

>  <JC_XSMILES>
O=C(COC(C1=CC=CC=C1)C2=CC=CN=C2)NCCNC(=O)OCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.967

>  <W2 Pf proliferation inhibition EC50 uM>
0.941

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009090909

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-140
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 14 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-140

>  <JC_XSMILES>
NC(=O)C1CCCN(C1)C(=O)COC(C2=CC=CC=C2)C3=CC=CN=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
4.81

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.64

>  <Powder data?>
Yes

>  <IFI value>
0.019417476

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1602
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    4.1801    3.1152    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    3.1152    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.8777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -1.4544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.6697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2827   -2.1218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6183   -2.8755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1333   -3.5429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3129   -3.4567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9773   -2.7030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4622   -2.0356    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
  9 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1602

>  <JC_XSMILES>
ClC1=CN=CC(Cl)=C1C(OCC(=O)N2CCC(C2)C3=CC=CC=N3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.96

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009708738

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1942
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1942

>  <JC_XSMILES>
ClC1=CN=CC(Cl)=C1C(OCC(=O)N2CCNCC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.592

>  <W2 Pf proliferation inhibition EC50 uM>
2.571

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.21

>  <Powder data?>
Yes

>  <IFI value>
0.03960396

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
3

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2183
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
  9 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2183

>  <JC_XSMILES>
COC1=CC=C(C=N1)C(OCC(=O)N2CCN(CC2)CC3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.604

>  <W2 Pf proliferation inhibition EC50 uM>
0.434

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3587
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8761   -0.4477    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8365    0.0820    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3464   -1.4873    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3587

>  <JC_XSMILES>
CC1=CC=C(CNC(=O)C2CNCC2C3=CC=C(C=C3)C(F)(F)F)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2427

>  <W2 Pf proliferation inhibition EC50 uM>
0.1209

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028169014

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3912
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.1665   -3.1175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -3.3724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -4.1570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -4.1570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -3.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  7 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3912

>  <JC_XSMILES>
CN1N=CC=C1C(OCC(=O)N2CCOCC2)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.134

>  <W2 Pf proliferation inhibition EC50 uM>
0.0892

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019607843

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4336
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
   14.1827   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682   -0.5973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    1.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8972    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8972    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8972    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6117    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.3261    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.3261    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6117    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.8972    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -1.4223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8489   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5939   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7689   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5140   -1.9072    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  5 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 34 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4336

>  <JC_XSMILES>
COC1=CC(=CC=C1OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NCC5=CC=CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.118

>  <W2 Pf proliferation inhibition EC50 uM>
0.0587

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014492754

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4959
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  9 17  4  0  0  0  0
  2 17  4  0  0  0  0
  5 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4959

>  <JC_XSMILES>
NC1=NOC2=CC=CC(OC3CCNCC3)=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
1.028

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0245

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.041666667

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5120
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5120

>  <JC_XSMILES>
CN(CC(O)C1=CC=CC=C1)CC2=CC(=CC=C2O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.438

>  <W2 Pf proliferation inhibition EC50 uM>
0.0181

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.01

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5332
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    6.9074    1.7441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    1.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6744    0.9434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8675    1.1150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5349    2.2710    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
  5 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5332

>  <JC_XSMILES>
CC1=CC=C(CN2CCC3=C(C2)SC(=N3)N4CCCCC4)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01413

>  <W2 Pf proliferation inhibition EC50 uM>
0.01051

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.069444444

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1852
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
   -4.3305   -0.0263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5542   -0.3056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4080   -1.1176    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6652   -1.4765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7770   -2.2939    0.0000 O   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5889   -2.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0235   -3.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8481   -3.1156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2381   -2.3886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0627   -2.3628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4527   -1.6358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0181   -0.9346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1935   -0.9604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8035   -1.6874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9789   -1.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9382   -1.0865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2369   -1.5211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5099   -1.1311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1913   -1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9551   -1.2539    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1517   -0.4527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9439   -0.2223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4877   -1.8839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3123   -1.9097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7469   -1.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5715   -1.2342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9615   -1.9612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5269   -2.6624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7023   -2.6367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2677   -3.3379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4431   -3.3122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0531   -2.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2519   -2.3885    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  3 15  4  0  0  0  0
  6 15  4  0  0  0  0
  4 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 23 32  4  0  0  0  0
 32 33  1  0  0  0  0
 19 33  1  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1852

>  <JC_XSMILES>
CCN1C(\OC2=CC=C3C=CC=CC3=C12)=C\C=C\C4=[N+](CC)C5=C6C=CC=CC6=CC=C5O4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.578

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.197080292

>  <Salt>
p-Toluenesulfonate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3889
  Mrv1591402191617072D          

 23 23  0  0  0  0            999 V2000
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.7322   -8.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.8539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -6.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3822   -6.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.0750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3889

>  <JC_XSMILES>
CCCCCCC[N+](CC)(CC)CCCCC1=CC=C(Cl)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.431

>  <W2 Pf proliferation inhibition EC50 uM>
0.0909

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.045112782

>  <Salt>
p-Toluenesulfonate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5303
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    4.1763   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6513   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138    0.9059    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1263    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3638   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9513   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1263   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3638   -1.9520    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   11.1888   -1.9520    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    9.9513   -2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5303

>  <JC_XSMILES>
CCN(CC)CCNC1=CC=NC2=CC=C(C=C12)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0898

>  <W2 Pf proliferation inhibition EC50 uM>
0.1152

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Phosphate

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3549
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  1  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3549

>  <JC_XSMILES>
CCN(CC)CCCNCC(=O)N1C2=CC=CC=C2SC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.254

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Formate

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4183
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  7 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  6 20  4  0  0  0  0
 13 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4183

>  <JC_XSMILES>
CCOC(=O)C1=C(CNC)N(C)C2=CC(Br)=C(O)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.458

>  <W2 Pf proliferation inhibition EC50 uM>
0.691

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Formate

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2039
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
  4 16  4  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2039

>  <JC_XSMILES>
CN(C)C1=CC=[N+](CC2=CC=CC=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.415

>  <W2 Pf proliferation inhibition EC50 uM>
>4.87

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015384615

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2433
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2433

>  <JC_XSMILES>
CN1C=C(\C=C\C2=CC=[N+](C)C=C2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0928

>  <W2 Pf proliferation inhibition EC50 uM>
0.3145

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.99

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3906
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
  7 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3906

>  <JC_XSMILES>
CN(C)C1=CC=[N+](CC(=O)NC2=CC=C(Cl)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.549

>  <W2 Pf proliferation inhibition EC50 uM>
0.897

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.064220183

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4364
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  6 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  CHG  1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4364

>  <JC_XSMILES>
COC1=CC=C2C(=C1)C(C)=CC=[N+]2CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0862

>  <W2 Pf proliferation inhibition EC50 uM>
0.1178

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.73

>  <Powder data?>
Yes

>  <IFI value>
0.062992126

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4659
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  3  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  1  0  0  0  0
  6 11  4  0  0  0  0
  4 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
M  CHG  1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4659

>  <JC_XSMILES>
CC[N+]1=C(SC2=CC=CC=C12)C=C3C=C(C)OC(C)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1471

>  <W2 Pf proliferation inhibition EC50 uM>
0.1193

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>31.99

>  <Powder data?>
Yes

>  <IFI value>
0.127272727

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4778
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
M  CHG  1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4778

>  <JC_XSMILES>
CN(C)C1=CC=C2N=C3C=C(C)C(N)=CC3=[N+](C4=CC=CC=C4)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1557

>  <W2 Pf proliferation inhibition EC50 uM>
0.0312

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.095238095

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-560
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.6900   -0.1403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1272   -0.8399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7399   -1.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0846   -1.5971    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.5218   -0.8975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1345   -0.1691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0846   -2.4221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6299   -2.8346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3444   -2.4221    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0588   -2.8346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7733   -2.4221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7733   -1.5971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4878   -1.1846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2022   -1.5971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2022   -2.4221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4878   -2.8346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7685   -2.0585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5100   -1.6968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1940   -2.1582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9355   -1.7965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9931   -0.9735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3091   -0.5122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5676   -0.8738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  4 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-560

>  <JC_XSMILES>
C1CC[N+](CC1)(CCOCC2=CC=CC=C2)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.16

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.007692308

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2104
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1  16   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2104

>  <JC_XSMILES>
BrC1=CC=C(C=C1)C2=CN3CCCSC3=[N+]2CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.413

>  <W2 Pf proliferation inhibition EC50 uM>
2.454

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.3

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2657
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
  9 23  4  0  0  0  0
 23 24  4  0  0  0  0
  6 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2657

>  <JC_XSMILES>
CCC(C)(C)C1=CC=C(OCCCC[N+]2=CC=CC(C)=C2C)C(=C1)C(C)(C)CC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.495

>  <W2 Pf proliferation inhibition EC50 uM>
0.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.18

>  <Powder data?>
Yes

>  <IFI value>
0.086956522

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3208
  Mrv1591402191617072D          

 23 27  0  0  0  0            999 V2000
    2.2041   -3.5635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2041   -2.7385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9887   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4736   -3.1510    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.9887   -3.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9586   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432   -2.7385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4576   -2.3260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1721   -2.7385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8866   -2.3260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6011   -2.7385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6011   -3.5635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8866   -3.9760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1721   -3.5635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4576   -3.9760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4576   -4.8010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1721   -5.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1721   -6.0385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4576   -6.4510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432   -6.0385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432   -5.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432   -3.5635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9586   -3.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  1  0  0  0  0
  4 23  1  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3208

>  <JC_XSMILES>
C1CC[N+]2(C1)CC3=CC4=CC=CC=C4C(C5=CC=CC=C5)=C3C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.335

>  <W2 Pf proliferation inhibition EC50 uM>
1.731

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3745
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633   -4.5039    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
  3 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  4  0  0  0  0
  2 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3745

>  <JC_XSMILES>
CC1=C(C2=CC=C(Cl)C=C2)[N+]3=C(SCCC3)N1C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.152

>  <W2 Pf proliferation inhibition EC50 uM>
1.041

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4078
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165   -1.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615   -2.0399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546   -2.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025   -1.5983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
  9 14  4  0  0  0  0
  6 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4078

>  <JC_XSMILES>
C[N+]1=C2SCC(=NN2C3=CC=CC=C13)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.454

>  <W2 Pf proliferation inhibition EC50 uM>
0.347

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.07

>  <Powder data?>
Yes

>  <IFI value>
0.037037037

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4206
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    1.8414   -2.5855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0164   -4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  3  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  2 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4206

>  <JC_XSMILES>
C[N+](C)(CC#CC1=CC=CC=C1)CC#CC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.931

>  <W2 Pf proliferation inhibition EC50 uM>
0.679

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036363636

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4424
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    2.8370    3.9911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
  3 25  4  0  0  0  0
M  CHG  1  14   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4424

>  <JC_XSMILES>
COC1=CC=C(C[N+]2=C3C=CC=CN3C(=C2)C4=CC=C(Cl)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.413

>  <W2 Pf proliferation inhibition EC50 uM>
0.524

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022222222

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4800
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
   -2.5154   -0.2549    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
  8 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4800

>  <JC_XSMILES>
BrC1=CC=C(C=C1)C2=CN3CCSC3=[N+]2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.335

>  <W2 Pf proliferation inhibition EC50 uM>
0.3026

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.007407407

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2872
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    7.5706   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2850   -2.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9995   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7140   -2.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4284   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1429   -2.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8574   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5719   -2.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2863   -1.7343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0008   -2.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7153   -1.7343    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   14.8015   -0.9138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1884   -0.3618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.6085   -0.7423    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.9440    0.0114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.7645    0.0976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.0210   -1.4567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.8279   -1.6283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0829   -2.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8899   -2.5844    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   16.5309   -3.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.7858   -3.8106    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   15.7239   -2.8545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4689   -2.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 11 24  4  0  0  0  0
 17 24  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2872

>  <JC_XSMILES>
CCCCCCCCCC[N+]1=C(C)N(CC)C2=CC(Cl)=C(Cl)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.613

>  <W2 Pf proliferation inhibition EC50 uM>
0.49

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.99

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3200
  Mrv1591402191617072D          

 15 17  0  0  0  0            999 V2000
    3.6829   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
  6 15  4  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3200

>  <JC_XSMILES>
C[N+]1=CC=CC2=CC=C3C=CC=NC3=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0664

>  <W2 Pf proliferation inhibition EC50 uM>
0.14

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.03

>  <Powder data?>
No

>  <IFI value>
0.013888889

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3931
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    6.2116   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9260   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6405   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0694   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7839   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4984   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2128   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9273   -1.2927    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   12.0136   -0.4722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4005    0.0798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8205   -0.3007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.1561    0.4530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2330   -1.0152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0400   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2949   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1019   -2.1428    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.7429   -2.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9978   -3.3690    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   12.9359   -2.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6810   -1.6283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 14 21  4  0  0  0  0
M  CHG  1   9   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3931

>  <JC_XSMILES>
CCCCCCCC[N+]1=C(C)N(C)C2=CC(Cl)=C(Cl)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.527

>  <W2 Pf proliferation inhibition EC50 uM>
0.356

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
40.51

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4460
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    6.2116   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9260   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6405   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0694   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7839   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4984   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2128   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9273   -1.2927    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   12.0136   -0.4722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4005    0.0798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8205   -0.3007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.1561    0.4530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9766    0.5392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.2330   -1.0152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0400   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2949   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7429   -2.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9359   -2.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6810   -1.6283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1019   -2.1428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.3568   -2.9275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.6539   -1.5298    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   16.4609   -1.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.0129   -1.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  9 20  4  0  0  0  0
 15 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  CHG  1   9   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4460

>  <JC_XSMILES>
CCCCCCCCN1C(C)=[N+](CC)C2=CC(=CC=C12)C(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.686

>  <W2 Pf proliferation inhibition EC50 uM>
0.504

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4464
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 12 11  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4464

>  <JC_XSMILES>
CC(C)CC[N+]1=CC=CC=C1C=CC2=CC=C(C=C2)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0829

>  <W2 Pf proliferation inhibition EC50 uM>
0.1504

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>30

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4936
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    3.2704   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  3 16  4  0  0  0  0
  7 16  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4936

>  <JC_XSMILES>
CC[N+]1=CC=CC2=CC=C3C=CC=NC3=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.553

>  <W2 Pf proliferation inhibition EC50 uM>
0.2574

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4946
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    3.8908    1.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783    0.5423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533    0.5423    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.2408   -0.1721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158   -0.1721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033    0.5423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158    1.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033    1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158    2.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033    3.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2408    2.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533    1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2408    1.2568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -0.2192    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -1.5540    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083   -2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2603   -2.9518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0054   -3.7364    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  3 13  4  0  0  0  0
  7 13  4  0  0  0  0
 14  4  1  4  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 15 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4946

>  <JC_XSMILES>
CC[N+]1=C(C=CC2=CC(C)=CC=C12)C=C3SC4=CC=CC=C4N3CCO

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1003

>  <W2 Pf proliferation inhibition EC50 uM>
0.1419

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
56.28

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2637
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  1  0  0  0  0
 13 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
 10 23  4  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2637

>  <JC_XSMILES>
C[N+]1=C2C=CC=CC2=NC3=CC=C(NC4CCCCC4N)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2565

>  <W2 Pf proliferation inhibition EC50 uM>
0.1216

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.21

>  <Powder data?>
Yes

>  <IFI value>
0.230769231

>  <Salt>
Perchlorate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2395
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  8 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2395

>  <JC_XSMILES>
CCCC[N+]1=C(C=C(C=C1C2=CC=CC=C2)C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.824

>  <W2 Pf proliferation inhibition EC50 uM>
0.467

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.94

>  <Powder data?>
Yes

>  <IFI value>
0.174603175

>  <Salt>
Tetrafluoroborate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1019
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6669   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -1.4924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6119   -2.2771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  9 20  4  0  0  0  0
 20 21  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  2  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  13
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1019

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C(C)=C3NC(C)=C(C)C3=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.306

>  <W2 Pf proliferation inhibition EC50 uM>
1.069

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-102
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    3.4990   -3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.6021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714    2.3479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  1  0  0  0  0
 18 17  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
  6 28  4  0  0  0  0
 28 29  4  0  0  0  0
  3 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-102

>  <JC_XSMILES>
COC1=CC=C(NC2=NC3=NON=C3N=C2NN=CC4=CC(Cl)=CC=C4O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.778

>  <W2 Pf proliferation inhibition EC50 uM>
1.618

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>3.17

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1024
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -0.4894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.1025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -1.8170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -1.6455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1024

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)C3=CC=CO3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.723

>  <W2 Pf proliferation inhibition EC50 uM>
1.398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.1

>  <Powder data?>
No

>  <IFI value>
0.009433962

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1032
  Mrv1591402191617072D          

 42 45  0  0  0  0            999 V2000
    7.0583    1.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3439    0.9195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3439    0.0945    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6294   -0.3180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9149    0.0945    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6294   -1.1430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2968   -1.6279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0815   -1.3730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0419   -2.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5268   -3.0800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1913   -3.8337    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3473   -2.9938    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6829   -2.2401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5033   -2.1539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2169   -2.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7320   -3.0800    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9115   -2.9938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5759   -2.2401    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4266   -3.6612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6061   -3.5750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1212   -4.2424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3761   -5.0270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7087   -5.5120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0412   -5.0270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2566   -5.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3565   -4.7299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1411   -4.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3126   -5.7918    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7542   -4.4328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5612   -4.6044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9737   -3.8899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4216   -3.2768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6680   -3.6124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2962   -4.2424    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8113   -3.5750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0092   -3.6612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4942   -2.9938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1586   -2.2401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6435   -1.5727    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.6619   -2.1539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1468   -2.8213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -1.6279    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 29 33  4  0  0  0  0
 24 34  4  0  0  0  0
 21 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  1  0  0  0  0
 38 40  4  0  0  0  0
 40 41  4  0  0  0  0
 35 41  4  0  0  0  0
 15 42  4  0  0  0  0
  6 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1032

>  <JC_XSMILES>
CCOC(=O)C1=C(C)C(C(=O)OCC)=C(NC(=O)CSC2=NN=C(CNC(=O)C3=CC=CO3)N2C4=CC=C(F)C=C4)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.254

>  <W2 Pf proliferation inhibition EC50 uM>
>1.062

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1033
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  5  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  3  0  0  0  0
 12 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 15 29  4  0  0  0  0
  9 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1033

>  <JC_XSMILES>
CC1=CC=C(C(C)=C1)C2=CC=C(C#N)C(OCC(=O)NCCC3=CC=CC=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.062

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1039
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0392    3.3769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5912    3.9900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787    4.7045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6282    4.5330    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  3  7  4  0  0  0  0
  1  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   5
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1039

>  <JC_XSMILES>
C(CC1=CNC=N1)NC2=C3C=CC=CC3=NC4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
1.727

>  <W2 Pf proliferation inhibition EC50 uM>
2.464

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.33

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1040
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    1.4780   -9.0188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -8.2342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -7.6211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -6.8365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -6.2234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -5.4388    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -6.9540    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.6787   -7.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4237   -7.9101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -8.7435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -9.5685    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2422   -8.7435    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -7.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -6.2865    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1937   -5.6734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0007   -5.8450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2556   -6.6296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0626   -6.8011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3175   -7.5857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -4.1039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -3.3193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.9464    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -5.5964    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -5.5964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 15 22  4  0  0  0  0
 22 23  4  0  0  0  0
 11 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  7 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 38 39  4  0  0  0  0
  6 39  1  0  0  0  0
 32 39  4  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1040

>  <JC_XSMILES>
CCCCCN1C(=C/C=C/C2=[N+](CC)C3=CC(Cl)=C(Cl)C=C3N2CCCCC)\N(CC)C4=CC(Cl)=C(Cl)C=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.301

>  <W2 Pf proliferation inhibition EC50 uM>
>1.056

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1048
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    1.5834    4.7849    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0180    4.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8426    4.1095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2772    3.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8872    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3218    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4134   -1.6293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6864   -1.2393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0148   -1.6739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7418   -1.2839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.4593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0664   -0.0247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6607   -0.4147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5452    0.1607    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0626    2.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6280    3.3567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 18 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
  8 28  4  0  0  0  0
 16 28  4  0  0  0  0
  5 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1048

>  <JC_XSMILES>
ClC1=CC=C(CSC2=NC3=CC=CC=C3C4=NC(CC5=CC=CC=C5)C(=O)N24)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.051

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-105
  Mrv1591402191617072D          

 34 39  0  0  1  0            999 V2000
    5.6974    3.6196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0083    2.8554    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.8256    2.7425    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.3319    3.3939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1492    3.2810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6555    3.9323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4601    2.5168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2773    2.4040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5882    1.6398    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9537    1.8655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2646    1.1013    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1365    1.9784    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5020    2.2041    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.7313    1.4116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0484    0.9486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3971    1.4549    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.5850    1.3097    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.3047    0.5338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4926    0.3886    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.6805    0.2434    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9608    1.0193    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1486    0.8741    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.8683    0.0982    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6168    1.5048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8971    2.2807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7092    2.4259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9895    3.2018    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2411    1.7952    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5214    2.5711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0532    1.9404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3335    2.7164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1456    2.8616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6774    2.2309    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.0373    2.9732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
  3 12  1  1  0  0  0
  2 13  1  0  0  0  0
 13 14  1  1  0  0  0
 14 15  1  0  0  0  0
 16 15  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  6  0  0  0
 19 18  1  0  0  0  0
 19 20  1  1  0  0  0
 21 20  1  1  0  0  0
 21 19  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  1  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 28 26  1  0  0  0  0
 21 28  1  0  0  0  0
 28 29  1  1  0  0  0
 28 30  1  0  0  0  0
 17 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 33 32  1  0  0  0  0
 13 33  1  0  0  0  0
 33 16  1  0  0  0  0
 33 34  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-105

>  <JC_XSMILES>
C[C@H]([C@H]1CC(C)=C(CO)C(=O)O1)[C@H]2CC[C@H]3[C@@H]4C[C@H]5O[C@]56[C@@H](O)C=CC(=O)[C@]6(C)C4CC[C@]23C

>  <PF proliferation inhibition 3D7 EC50 uM>
4.97

>  <W2 Pf proliferation inhibition EC50 uM>
1.684

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.63

>  <Powder data?>
Yes

>  <IFI value>
0.321428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1050
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1050

>  <JC_XSMILES>
COC1=CC=CC=C1CN2C(=O)C3=CC(Br)=CC=C3N=C2SCC4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.161

>  <W2 Pf proliferation inhibition EC50 uM>
>1.05

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1053
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 18 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1053

>  <JC_XSMILES>
CCCCCC1=CC=C(C=C1)C2=CC=C(C=C2)\C(=C/N(C)C)C=[N+](C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.606

>  <W2 Pf proliferation inhibition EC50 uM>
1.049

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1058
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  9 18  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  7 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1058

>  <JC_XSMILES>
BrC1=CC=C2N=C(C=C(C(=O)NC3=NC=CS3)C2=C1)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.081

>  <W2 Pf proliferation inhibition EC50 uM>
>10.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1060
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  4  0  0  0  0
  1 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1060

>  <JC_XSMILES>
C(NC1=CC=C2C=NNC2=C1)C3=CC=C(C=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.042

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1067
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    3.3320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408    3.9995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
  9 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 29 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1067

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2C(C(=O)NC3=NOC(C)=C3)C4=CC=CC=C4C(=O)N2C5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.895

>  <W2 Pf proliferation inhibition EC50 uM>
>1.034

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1076
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
 10 34  4  0  0  0  0
 34 35  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1076

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N2N=C(C(=O)NCCCN(C)CC3=CC=CC=C3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
10.27

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.026315789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1080
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 25 35  4  0  0  0  0
 16 35  4  0  0  0  0
 35 36  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1080

>  <JC_XSMILES>
CCN1CCN(CC1)C2CCN(CC2)CC3=CC4=CC=C(F)C=C4N(CCSC5=CC=CC=C5)C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.715

>  <W2 Pf proliferation inhibition EC50 uM>
0.56

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.48

>  <Powder data?>
Yes

>  <IFI value>
0.03

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1081
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  6 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1081

>  <JC_XSMILES>
CCC(O)CN(C1=CC=CC=C1)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.021

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018348624

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1082
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -4.7087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5817   -3.9683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0107   -3.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 24 25  1  0  0  0  0
 16 25  1  0  0  0  0
 25 26  2  0  0  0  0
  8 27  4  0  0  0  0
 27 28  4  0  0  0  0
  5 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1082

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(OC2=CC=C(C=C2)N3C(=O)C4CC=CCC4C3=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.02

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1083
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 11 20  4  0  0  0  0
  6 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1083

>  <JC_XSMILES>
CCCCNC1=CC(C)=NC(NCC2=CC=CC=C2)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.944

>  <W2 Pf proliferation inhibition EC50 uM>
1.02

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1093
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
   -0.0607   -4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243   -3.7430    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -6.0604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -7.2979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -7.7104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6097   -8.5174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7892   -8.6037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4537   -7.8500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -7.2979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1617   -9.1305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9822   -9.0443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3178   -9.7979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7047  -10.3500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9902   -9.9375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243   -5.0779    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 13 17  4  0  0  0  0
 14 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  1  0  0  0  0
  1 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1093

>  <JC_XSMILES>
C1OC2=CC=C(CNC3=CC=NC4=C(C=NN34)C5=COC=C5)C=C2O1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.017

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1114
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -1.9702    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633    3.1080    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1114

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=CSC3=C2C(=O)N(N)C=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.006

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1122
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.2093    7.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9237    6.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6382    7.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6382    7.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3527    8.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0671    7.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7816    8.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7816    9.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0671    9.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4961    9.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4961   10.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2106    9.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0671    7.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3527    6.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3527    5.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6382    5.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6382    4.5875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9237    4.1750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2093    4.5875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2093    5.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9237    5.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5052    4.1750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2197    4.5875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5052    3.3500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0782    2.7667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5052    2.1833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0886    2.7667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  6 13  4  0  0  0  0
 13 14  4  0  0  0  0
  3 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 24 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1122

>  <JC_XSMILES>
COC1=CC=C(CN(C)C(C)C)C=C1OC2CCN(CC2)C(=O)C3CCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1126
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    0.9845   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2546   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0647   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6048   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4149   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7651    0.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1152   -0.5814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9339   -0.4793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0898    0.3308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3675    0.7295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2654    1.5481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9233    2.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8213    2.8645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4792    3.3622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2392    3.0413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8972    3.5390    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.3413    2.2226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6834    1.7249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6850   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1449   -1.7052    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4951   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7651   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5753   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8453   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3052   -3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4951   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550   -4.0439    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2251   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4149   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0957   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6358   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4459   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7159   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1758   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3657   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
  6 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  1  0  0  0  0
  2 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1126

>  <JC_XSMILES>
CN(CCCN(CC1=CC=CN1CC2=CC=C(Cl)C=C2)C(=S)NC3=CC=CC(Cl)=C3C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.3

>  <W2 Pf proliferation inhibition EC50 uM>
>10

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.064516129

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1139
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.2228   -1.9441    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843    0.2692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3821   -2.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9868   -3.4115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8032   -4.2158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0149   -4.4590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4101   -3.8978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5937   -3.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843   -2.5075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829   -3.2754    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7001   -2.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2145   -3.0295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0303   -2.9065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5447   -3.5516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2433   -4.3195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4275   -4.4425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9131   -3.7975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1139

>  <JC_XSMILES>
ClC1=CC=C2NC(=O)CN(C(C3=CC=CC=C3)C2=C1)C(=O)CC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
7.61

>  <W2 Pf proliferation inhibition EC50 uM>
4.57

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.27

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1170
  Mrv1591402191617072D          

 27 32  0  0  0  0            999 V2000
    3.4232   -2.0090    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5531   -1.1943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9125   -0.6744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0424    0.1403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8129    0.4351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9428    1.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7133    1.5447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8433    2.3594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2605    2.9434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6358    3.6781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3410    4.4486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8609    5.0892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6756    4.9593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9704    4.1887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4505    3.5481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5787    2.7332    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3539    1.0248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1689    1.1530    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5427    0.4176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3394    0.2032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5520   -0.5939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9681   -1.1767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1714   -0.9623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9587   -0.1652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2240    0.2101    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4535   -0.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3236   -0.8994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
 25 26  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1170

>  <JC_XSMILES>
OC1=CC=C2C=C(C3=NC4=CC=CC=C4N3)C5=NC6=CC=CC=C6N5C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.05

>  <W2 Pf proliferation inhibition EC50 uM>
0.97

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1180
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8986    0.6320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592    0.6320    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  6 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  1  0  0  0  0
 20 25  4  0  0  0  0
  5 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1180

>  <JC_XSMILES>
CCNC1=C(N(CC(=O)C2=CC=C(Br)C=C2)S(=O)(=O)C3=CC=CC=C13)C(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.966

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1181
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    1.5077    0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0477   -0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3980   -0.6236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2081   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7482   -1.0914    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5583   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8284   -0.1559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2883    0.4677    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086    0.7796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4366    1.4562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9343    2.1142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7139    1.8441    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6980    1.0193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3559    0.5216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1159    0.8425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7739    0.3448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6718   -0.4739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3297   -0.9716    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.9118   -0.7948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8097   -1.6135    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.2538   -0.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6946    2.9036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4549    3.6930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4840    3.1433    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9052    2.6638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4782   -1.8709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0182   -2.4946    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680   -2.0268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3980   -2.8064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5878   -2.9623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0477   -2.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2229   -2.3227    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9832   -1.5333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6598   -1.0614    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3178   -1.5591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1279   -1.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 16 23  4  0  0  0  0
 13 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
  6 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  4  0  0  0  0
 37 38  4  0  0  0  0
 30 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1181

>  <JC_XSMILES>
CCCCCN(CC(=O)NC1=CC(=NN1C2=CC=C(Cl)C(Cl)=C2)C(C)(C)C)C(=O)C3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.035

>  <W2 Pf proliferation inhibition EC50 uM>
0.966

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1182
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
    2.6562    4.7238    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3517    4.2800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1195    4.5818    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6438    3.9448    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1999    3.2494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5359    2.4958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3600    2.5332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8045    1.8382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4248    1.1058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6007    1.0684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1562    1.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3468    1.6036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7172    2.1367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6314    1.3162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8779    0.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2102    1.4649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2960    2.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0496    2.6213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7415    2.9614    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4014    3.4565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  2  0  0  0  0
  2 20  1  0  0  0  0
  5 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1182

>  <JC_XSMILES>
O=C1NN=C2C3=CC=CC=C3CC4(CCCCC4)N=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.325

>  <W2 Pf proliferation inhibition EC50 uM>
0.376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.9

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1189
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -3.4656   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    1.1759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -5.0116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0837   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3387   -6.2812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1637   -6.2812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4186   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  1 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 23 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1189

>  <JC_XSMILES>
C(CNC1=CC(=NC(=N1)C2=CC=NC=C2)C3=CC=CN=C3)CN4C=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.087

>  <W2 Pf proliferation inhibition EC50 uM>
0.956

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1199
  Mrv1591402191617072D          

 10 10  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1199

>  <JC_XSMILES>
NC(=O)CC1=CC=CC=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
9.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.020408163

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1204
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 13 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1204

>  <JC_XSMILES>
OC1=CC=CC=C1C(=O)NC2=CC(=CC=C2OCC3=CC=CC=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.949

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1217
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
  8 28  4  0  0  0  0
  4 28  4  0  0  0  0
  2 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 30 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1217

>  <JC_XSMILES>
CN(CC1=CC=CC(OC2CCN(CC2)C(=O)C3=CC=C(NC(C)=O)C=C3)=C1)CC4=CC=CC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.945

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1246
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -1.4289    1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405    1.9856    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925    1.3725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800    0.6580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731    0.8295    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  6 17  4  0  0  0  0
  2 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1246

>  <JC_XSMILES>
ClC1=CC=CC(OCC(=O)NC2=NC=CS2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>9.29

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.05952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1249
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -0.5383    2.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1761    2.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5886    1.7231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2364    3.1520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8906    2.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6051    2.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1926    1.7231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0176    3.1520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3195    2.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0340    2.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7485    2.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7485    1.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4630    0.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4630   -0.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1774   -0.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1774   -1.2750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8919   -0.0375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8919    0.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6064    1.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6926    2.0205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0795    2.5726    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4996    2.1921    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9121    1.4776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7190    1.3061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9740    0.5214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4220   -0.0917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6150    0.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3600    0.8645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0340    0.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3195    1.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0340   -0.0375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.3195   -0.4500    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.7485   -0.4500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 18 17  1  4  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  1  0  0  0  0
 23 28  4  0  0  0  0
 12 29  4  0  0  0  0
 29 30  4  0  0  0  0
  9 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
M  CHG  2  31   1  32  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1249

>  <JC_XSMILES>
CC(C)(C)CC(C)(C)C1=CC=C(OCC(=O)NN=C2C(=O)NC3=CC=CC=C23)C(=C1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.001

>  <W2 Pf proliferation inhibition EC50 uM>
0.927

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02189781

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1283
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    1.4358   -6.8365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -6.2234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -5.4388    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -6.9540    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6787   -7.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -8.7435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -7.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -6.2865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4236   -6.0234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7322   -5.4665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -4.1039    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838   -3.3193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.9216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.3085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -1.4800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -2.2646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -5.5964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
  4 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 20 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1283

>  <JC_XSMILES>
CC[N+]1=C(\C=C\C=C2/N(C)C3=CC=CC=C3C2(C)C)N(CC4=CC=CC=C4)C5=CC=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
0.355

>  <W2 Pf proliferation inhibition EC50 uM>
0.2194

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.415

>  <Powder data?>
Yes

>  <IFI value>
0.326086957

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1284
  Mrv1591402191617072D          

 30 32  0  0  1  0            999 V2000
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 13 12  1  0  0  0  0
 13  8  1  0  0  0  0
 13 14  1  6  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 21 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1284

>  <JC_XSMILES>
CCCCNCCN1CCN(C[C@@H]1CC2=CC=CC=C2)C3=CC(OC)=CC(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.938

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.33

>  <Powder data?>
No

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1290
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4941   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2787   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8918   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7203   -4.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9357   -4.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3226   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0525   -1.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4394   -1.3460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6110   -0.5390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3956   -0.2841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0087   -0.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8372   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  2 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1290

>  <JC_XSMILES>
O=C(CN1CCCC1C(C2=CC=CC=C2)C3=CC=CC=C3)N4CCSCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.081

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.02

>  <Powder data?>
No

>  <IFI value>
0.009615385

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1306
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -14.4375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105  -14.4375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395  -14.4375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -15.2625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -15.6750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -16.9125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -15.6750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
  6 27  4  0  0  0  0
 27 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1306

>  <JC_XSMILES>
COC1=CC=C(\C=C\C(=O)NC2=CC=C(C=C2)S(=O)(=O)N3CCOCC3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.619

>  <W2 Pf proliferation inhibition EC50 uM>
0.891

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1318
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.8500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -14.0250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 26 35  4  0  0  0  0
 35 36  4  0  0  0  0
 23 36  4  0  0  0  0
  6 37  4  0  0  0  0
 37 38  4  0  0  0  0
  3 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1318

>  <JC_XSMILES>
COC1=CC=C(CNC2CCN(CCN3CCCCC3)C(C2)C4=CC=C(OCC5=CC=CC=C5)C=C4)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.662

>  <W2 Pf proliferation inhibition EC50 uM>
0.447

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.06

>  <Powder data?>
No

>  <IFI value>
0.111111111

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-136
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    1.3222   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -1.7116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
  6 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-136

>  <JC_XSMILES>
COC1=CN=C(N=C1N2CCCC2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.489

>  <W2 Pf proliferation inhibition EC50 uM>
0.648

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.297

>  <Powder data?>
Yes

>  <IFI value>
0.084337349

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1366
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -4.7651   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2251   -2.0171    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4149   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -1.0816    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560    1.1012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.2571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758    2.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.6603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    3.4398    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    2.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    1.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845   -2.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -4.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -3.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3347   -3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1449   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1366

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(Cl)C=C2)C(=O)C(C)C)=C3N=CC=CC3=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.682

>  <W2 Pf proliferation inhibition EC50 uM>
1.122

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.17

>  <Powder data?>
Yes

>  <IFI value>
0.056074766

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1374
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1374

>  <JC_XSMILES>
CC1=CC=C(NC2=NC(N)=C3C=CC=CC3=N2)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.527

>  <W2 Pf proliferation inhibition EC50 uM>
0.755

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.92

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1382
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 11 18  4  0  0  0  0
  8 19  4  0  0  0  0
  4 19  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1382

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(CNC2=CC=C(F)C(Cl)=C2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
8.05

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>95.64

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1410
  Mrv1591402191617072D          

 49 57  0  0  0  0            999 V2000
    0.5350   -6.9471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6212   -6.1266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0462   -5.6417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0400   -4.8212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7937   -4.4856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4612   -4.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3749   -5.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8799   -3.6651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2669   -3.1131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6024   -2.3594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4229   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5944   -3.2526    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0700   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8904   -2.3594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2260   -3.1131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6129   -3.6651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8984   -3.2526    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6991   -4.4856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4528   -4.8212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5391   -5.6417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8716   -6.1266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9579   -6.9471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1179   -5.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0317   -4.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3029   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8904   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3029   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1279   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5404   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1279   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1899   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6351   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0476   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6351   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1899   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6024   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 24 25  4  0  0  0  0
 13 25  4  0  0  0  0
 21 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
 27 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 38 43  4  0  0  0  0
 10 44  1  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 44 49  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  30
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1410

>  <JC_XSMILES>
OC1=CC=C(C=C1)C2=NC(=C(N2)C3=CC=C4OC5=CC=C(C=C5C4=C3)C6=C(N=C(N6)C7=CC=C(O)C=C7)C8=CC=CC=C8)C9=CC=CC=C9

>  <PF proliferation inhibition 3D7 EC50 uM>
3.3

>  <W2 Pf proliferation inhibition EC50 uM>
8.28

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1413
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0727    2.3174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5577    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0727    0.9826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  4  0  0  0  0
 22 27  4  0  0  0  0
  7 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1413

>  <JC_XSMILES>
CCC1=CC=CC(NC(=O)CCCN2C(=O)C3=CC=CN3C4=CC=CC=C24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.562

>  <W2 Pf proliferation inhibition EC50 uM>
0.826

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1417
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -11.5500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 22 29  4  0  0  0  0
  7 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1417

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=C(F)C(Cl)=C3)C(=O)COCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.607

>  <W2 Pf proliferation inhibition EC50 uM>
0.821

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1420
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.8500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -13.6125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.8500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -17.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -17.7375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -17.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -16.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 17 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  1  0  0  0  0
  5 35  4  0  0  0  0
 35 36  4  0  0  0  0
  2 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1420

>  <JC_XSMILES>
CC1=CC=C(NC(=O)N2CCN(CC2)CCN(CC3=CC=C(F)C=C3)C(=O)C4=CC=CC=C4C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.738

>  <W2 Pf proliferation inhibition EC50 uM>
0.818

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1423
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    0.7132   -7.2993    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9681   -6.5147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -5.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7751   -6.3432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470    2.8379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3020    3.6226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7499    4.2357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 15 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 13 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1423

>  <JC_XSMILES>
FC1=CC=C(C=C1)C(=O)NCCN2C=C(SCC(=O)NC3=CC=CC=C3F)C4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>8.09

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>98.9

>  <Powder data?>
Yes

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-143
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -5.7158    1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-143

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNS(=O)(=O)\C=C\C3=CC=CC=C3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.405

>  <W2 Pf proliferation inhibition EC50 uM>
0.397

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.478

>  <Powder data?>
No

>  <IFI value>
0.064102564

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1440
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -0.3327   -6.5651    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.4189   -5.7447    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.2485   -5.2597    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1726   -5.4091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8400   -5.8940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5937   -5.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6799   -4.7380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4336   -4.4024    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.0125   -4.2531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2588   -4.5886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -3.4326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -3.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -2.2131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -2.8806    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 16 14  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1  27
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1440

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(Cl)C(=C1)C2=CC=C(O2)C=NNC3=NC4=CC=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.946

>  <W2 Pf proliferation inhibition EC50 uM>
0.801

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024793388

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1450
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544    1.5402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2163    2.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0233    2.6679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2782    3.4525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7262    4.0656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9192    3.8940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6643    3.1094    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
  9 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1450

>  <JC_XSMILES>
CN1C2=CC=CC=C2C3=NN=C(NN=CC4=CC=CC=N4)N=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.866

>  <W2 Pf proliferation inhibition EC50 uM>
0.793

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1452
  Mrv1591402191617072D          

 49 56  0  0  0  0            999 V2000
    6.4415   -3.5686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6211   -3.6549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2856   -4.4086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1361   -2.9875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3156   -3.0738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8307   -2.4064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1662   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9866   -1.5664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4716   -2.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6812   -0.9853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8562   -0.9854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3713   -1.6528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7069   -2.4065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2221   -3.0740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4016   -2.9878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0659   -2.2341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5508   -1.5667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6012   -0.2008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2686    0.2842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2685    1.1092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5540    1.5217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5540    2.3467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2684    2.7592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9829    2.3468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9830    1.5218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2683    3.5842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5538    3.9967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9828    3.9968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9361   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1909    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4458    1.3686    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0159    0.5841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5679    1.1972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3749    1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6299    0.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0779   -0.3720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2709   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6035   -0.6855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2710   -1.1704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9338   -0.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2664   -1.1707    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2663   -0.2009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4593   -0.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0927    0.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1621    1.0253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9691    1.1968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5212    0.5838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3462    0.5839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0912    1.3685    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 19 29  1  0  0  0  0
 10 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  1  0  0  0  0
 29 38  1  0  0  0  0
 38 39  2  0  0  0  0
 18 40  1  0  0  0  0
 40 41  2  0  0  0  0
 40 42  1  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 42 47  4  0  0  0  0
 47 48  1  0  0  0  0
 18 48  1  0  0  0  0
 48 49  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1452

>  <JC_XSMILES>
CC(C)C1=CC=C(C=C1)C2N(C3=CC=CC=C3)C7(C(C4=CC=C(C=C4)C(C)C)C25C(=O)C6=CC=CC=C6C5=O)C(=O)C8=CC=CC=C8C7=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.802

>  <W2 Pf proliferation inhibition EC50 uM>
0.792

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1461
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 15 20  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1461

>  <JC_XSMILES>
CCOC1=CC=C(NCC2=CC=C(O)C3=NC=CC=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.61

>  <W2 Pf proliferation inhibition EC50 uM>
>4.37

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>55.62

>  <Powder data?>
Yes

>  <IFI value>
0.130434783

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1467
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    4.4919   -5.7576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8964   -5.1867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0930   -4.3855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4975   -3.8145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6941   -3.0133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0986   -2.4424    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2952   -1.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0874   -1.4109    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6996   -1.0703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963   -0.2691    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.0428    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995    0.8656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983    1.0622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.3610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837    1.8150    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083    1.7892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8429    2.4905    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4863   -2.7830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0819   -3.3539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8741   -3.1236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4696   -3.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8852   -4.1551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4808   -4.7260    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2730   -4.4957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  2  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
  3 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1467

>  <JC_XSMILES>
COC1=CC(NC(=O)CN2N=CC3=C2C4=CC=CC=C4OC3=O)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
7.83

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1478
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 19 23  4  0  0  0  0
 15 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 17 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1478

>  <JC_XSMILES>
CCCC(=O)N1CCN(CC1C)C(=O)C2=NC(=NC(CCC)=C2C(=O)OCC)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.201

>  <W2 Pf proliferation inhibition EC50 uM>
0.774

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046296296

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1479
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 16 23  4  0  0  0  0
 11 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1479

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCC(C)C)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.95

>  <W2 Pf proliferation inhibition EC50 uM>
0.773

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025862069

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1484
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    2.9253   -5.2616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0205   -4.4422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4136   -3.8834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5922   -3.9606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1146   -3.2878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4585   -2.5379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2799   -2.4607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7574   -3.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5769   -3.2287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1960   -2.6835    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9778   -2.9471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5969   -2.4018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3787   -2.6654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9978   -2.1202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6170   -1.5749    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5413   -3.4742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9222   -4.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1404   -3.7559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5213   -4.3011    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7395   -4.0376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3231   -3.7378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1048   -4.0014    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
 13 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 11 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  1  0  0  0  0
  9 20  4  0  0  0  0
 16 21  1  0  0  0  0
 21 22  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1484

>  <JC_XSMILES>
O=C1C2=CC=CC=C2C3=NC4=CC(C#N)=C(C=C4N=C13)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
6.97

>  <W2 Pf proliferation inhibition EC50 uM>
2.56

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.22

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1492
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -5.4349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8974   -6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7179   -6.8007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0535   -6.0471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5685   -5.3796    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8739   -5.9608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2864   -5.2464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0934   -5.4179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1796   -6.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4260   -6.5739    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8941   -6.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8941   -7.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6086   -7.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3231   -7.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3231   -6.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6086   -6.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2028   -7.4682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8673   -8.2219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3522   -8.8893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1727   -8.8031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5082   -8.0494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0233   -7.3820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6576   -9.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3220  -10.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8070  -10.8916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6274  -10.8054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9630  -10.0517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4781   -9.3843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5619   -7.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0468   -8.3081    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2586   -7.7269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5942   -8.4806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1595   -8.8161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3478   -8.1450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9297   -9.2342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  8 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
  7 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 37 40  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1492

>  <JC_XSMILES>
CC1=CC=C(O1)C(N(C(=O)C2=CC=C(N2)C3=CC=CC=C3)C4=CC=C(C=C4)C5CCCCC5)C(=O)NC(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.337

>  <W2 Pf proliferation inhibition EC50 uM>
0.765

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031578947

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1517
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152    0.0045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221   -0.1670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346    0.5475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826    1.1606    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1311    2.6459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.2292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2978    2.6459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  3 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 12 15  1  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  2  0  0  0  0
 25 27  4  0  0  0  0
 16 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1517

>  <JC_XSMILES>
CC(N(CC1=CC=CO1)C(=O)C2CCC2)C3=NC4=CC(Cl)=CC=C4C(=O)N3C5=CC=C(C)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.684

>  <W2 Pf proliferation inhibition EC50 uM>
0.2075

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.76

>  <Powder data?>
No

>  <IFI value>
0.030927835

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-152
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    2.2531    0.5706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4246   -0.2363    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8115   -0.7884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9830   -1.5953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3699   -2.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5853   -1.8924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4138   -1.0854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0269   -0.5334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0278   -2.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8124   -2.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1437   -3.2514    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8974   -3.5870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8112   -4.4075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0042   -4.5790    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4083   -3.8645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288   -3.7783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7137   -4.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5342   -4.3595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8697   -3.6058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3848   -2.9384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5643   -3.0246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6902   -3.5196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5107   -3.4333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6040   -2.6991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7764   -4.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -2.3495    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -3.5870    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7553   -3.5870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698   -2.3495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1842   -3.5870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 12 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-152

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)N2C(CSC2C3=CC=C(C=C3)C(C)(C)C)C(=O)NCCC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.797

>  <W2 Pf proliferation inhibition EC50 uM>
1.12

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.48

>  <Powder data?>
No

>  <IFI value>
0.02173913

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1526
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -4.9956    1.4232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5107    2.0906    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6902    2.0044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2053    2.6718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3848    2.5856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0492    1.8319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288    1.7457    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5342    1.1645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1986    0.4108    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6835   -0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3546    1.2507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 15 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 13 24  4  0  0  0  0
 24 25  2  0  0  0  0
  6 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
  3 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1526

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(=CS2)C3=CC4=CC(OC)=CC=C4OC3=O)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>7.47

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1532
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 14 15  1  4  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 11 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1532

>  <JC_XSMILES>
CCN(CC)C1=CC=C2C=C(C(C)=NNC(N)=S)C(=O)OC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.31

>  <W2 Pf proliferation inhibition EC50 uM>
7.46

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1533
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
M  CHG  1  14   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1533

>  <JC_XSMILES>
CCN(CC)C1=CC=C2C(C)=CC(NC3=CC=CC=C3)=[O+]C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2386

>  <W2 Pf proliferation inhibition EC50 uM>
0.746

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1538
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.2405   -3.2091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7004   -2.5855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8903   -2.7414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3502   -2.1177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5401   -2.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8101   -1.8059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0802   -2.5855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3502   -1.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1604   -1.3382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7004   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5106   -0.8704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0507   -0.2468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7806    0.5327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9705    0.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7004    1.4682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2405    2.0918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9705    2.8714    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0507    1.9359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3207    1.1564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7806   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5908   -1.8059    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2405   -2.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4304   -2.1177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8903   -2.7414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1604   -3.5209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9705   -3.6768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5106   -3.0532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3207   -3.2091    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2700   -3.0532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5401   -3.2091    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8101   -3.9887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2700   -4.6123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5401   -4.4564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8101   -3.6768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6203   -3.5209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
  5 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  4  0  0  0  0
  3 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1538

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(F)C=C2)C(=O)C3=CC=CC=C3F)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.692

>  <W2 Pf proliferation inhibition EC50 uM>
0.649

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.74

>  <Powder data?>
No

>  <IFI value>
0.021505376

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1542
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1060    3.7988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0499    0.4838    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    3.3001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5722   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5722   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7143   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4291   -2.4749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4291   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  8 12  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 16 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  2  0  0  0  0
 34 36  4  0  0  0  0
 26 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1542

>  <JC_XSMILES>
CC(C)C1=CC=CC(C(C)C)=C1NC(=O)N(CC2=CC=CC=C2)C(C)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.309

>  <W2 Pf proliferation inhibition EC50 uM>
0.738

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1565
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9049   -4.1974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
  9 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1565

>  <JC_XSMILES>
CC1=CC=CC(C)=C1N(CC(=O)NCC2=CC=CO2)S(C)(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.851

>  <W2 Pf proliferation inhibition EC50 uM>
0.725

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1571
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -6.1875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -6.1875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1571

>  <JC_XSMILES>
CCOC(=O)N1CCN(CC1)C2=CC=C(C=N2)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
7.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1584
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
  7 26  4  0  0  0  0
 26 27  4  0  0  0  0
  4 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1584

>  <JC_XSMILES>
CN(C)C1=CC=C(NC2=NC(NCC3CCCO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.852

>  <W2 Pf proliferation inhibition EC50 uM>
0.805

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.35

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1601
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0032   -5.3493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8237   -5.4355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1593   -6.1892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6744   -6.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1461   -6.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6310   -7.4378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4817   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4827   -0.6829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9925   -2.2521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5222   -1.2125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9199   -1.5096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8761   -0.4477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4784   -0.1506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 10 16  4  0  0  0  0
  5 17  4  0  0  0  0
  2 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
  4 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1601

>  <JC_XSMILES>
CN1N=C(C(COC(=O)C2=CC=CC(C)=C2)=C1S(=O)(=O)C3=CC=C(C)C=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
8.4

>  <W2 Pf proliferation inhibition EC50 uM>
6.97

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.038961039

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1605
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -2.5154   -1.6839    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9279   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5154   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1654   -1.6839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9904   -1.6839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4029   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1654   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2279   -0.9694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2279   -0.1444    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2279   -1.7944    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0529   -0.9694    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4108   -1.7127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2151   -1.8963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8602   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8602   -0.5569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2151   -0.0425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4108   -0.2261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
 10 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 27 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1605

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=CN3C=CSC3=N2)C4=CC=C(C=C4)S(=O)(=O)N5CCCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.634

>  <W2 Pf proliferation inhibition EC50 uM>
1.227

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.64

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1616
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    0.4323   -6.1377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323   -5.3127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2822   -4.9002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2822   -4.0752    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.5428   -4.0752    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1072   -4.0752    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2822   -3.2502    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9966   -2.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9966   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2822   -1.6002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8125   -0.9683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6249   -1.1115    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323   -2.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2481   -0.9683    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0340   -0.1930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8465   -0.0498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1287    0.7255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5984    1.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2141    1.2142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4963    0.4390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3087    0.2957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1212    0.1525    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.1655   -0.5168    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4520    1.1082    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  2  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
  7 14  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1616

>  <JC_XSMILES>
CCCS(=O)(=O)N1CCC(CO)(CC1)CC2=CC=CC=C2C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.254

>  <W2 Pf proliferation inhibition EC50 uM>
0.692

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1634
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
    1.3363   -4.7113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3073   -3.8868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5788   -3.4996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5498   -2.6751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2494   -2.2378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2204   -1.4133    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4919   -1.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2076   -1.4635    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4629   -0.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1725    0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0841    1.2649    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6349    1.1456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4025    1.4739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8583    0.7254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0550    0.3597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8811    0.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4594   -0.1263    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9973    1.2836    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7337    1.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4239    1.2035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1604    1.5753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8506    1.1234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8044    0.2997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0679   -0.0721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3777    0.3798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2637    1.6800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1776    2.5005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8451    2.9853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4239    2.8361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3378    3.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4158    3.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5019    4.8128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1656    5.2976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9193    4.9619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0054    4.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9779   -2.6249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0069   -3.4494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 10 14  1  0  0  0  0
 12 15  1  0  0  0  0
  9 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 18 26  1  0  0  0  0
 12 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 30 35  1  0  0  0  0
  5 36  4  0  0  0  0
 36 37  4  0  0  0  0
  2 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1634

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2C3OC4(C=C3)C2C(=O)N(CC5=CC=CN=C5)C4C(=O)NC6CCCCC6)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.637

>  <W2 Pf proliferation inhibition EC50 uM>
0.682

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1638
  Mrv1591402191617072D          

 16 16  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1638

>  <JC_XSMILES>
COC(=O)C(C)NC(=O)C1=CC=C(F)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.681

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1644
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
 13 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1644

>  <JC_XSMILES>
CC(=O)N(CC1=CC=C(F)C=C1)C2=C(NCC3=CC=CC=C3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.68

>  <W2 Pf proliferation inhibition EC50 uM>
0.679

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-165
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946   -1.8980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7747   -2.2373    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5485   -1.1332    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 17 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-165

>  <JC_XSMILES>
COC1=CC=CC=C1C2SCCN2C(=O)NC3=CC=C(Cl)C(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.017

>  <W2 Pf proliferation inhibition EC50 uM>
2.255

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1650
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    3.3523    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    5.6479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4944   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2201   -1.7771    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2201   -2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4944   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 24 25  4  0  0  0  0
  8 25  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1650

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NC3=CC=C(OC)C=C3)=C4NC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.667

>  <W2 Pf proliferation inhibition EC50 uM>
0.678

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1665
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    1.8526    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1094    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4673    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2900    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7947    3.8195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5713    3.5412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5467    2.7166    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7548    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3968    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0427   -1.6489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7641   -0.8714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7025    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
  6 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 16 23  1  0  0  0  0
 23 24  2  0  0  0  0
 17 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  5 31  1  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1665

>  <JC_XSMILES>
CCC(=O)N1C(C2=CC=C3OCOC3=C2)C4=C(CC(C)(C)CC4=O)NC5=CC=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
3.53

>  <W2 Pf proliferation inhibition EC50 uM>
6.72

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1670
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 16 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  1  0  0  0  0
 11 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1670

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)N=C(N=C1C(=O)N2CCN(C(C)C2)C(=O)NC3=CC=CC(C)=C3C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.509

>  <W2 Pf proliferation inhibition EC50 uM>
0.384

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>5.76

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1679
  Mrv1591402191617072D          

 13 13  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  5 12  4  0  0  0  0
 12 13  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1679

>  <JC_XSMILES>
CC(=O)NC1=C(C)C=C(Cl)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
1.449

>  <W2 Pf proliferation inhibition EC50 uM>
0.661

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.032258065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1698
  Mrv1591402191617072D          

 37 39  0  0  0  0            999 V2000
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.8276   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1776   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.7322   -3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
  8 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1698

>  <JC_XSMILES>
COCCNC(=O)C1=CC=C(NCCC2=CC=C(Cl)C=C2)C(=C1)S(=O)(=O)NC3=CC=CC(=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
7.34

>  <W2 Pf proliferation inhibition EC50 uM>
6.52

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1700
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.9909   -3.0425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9909   -3.8675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6583   -4.3524    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4034   -5.1370    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5784   -5.1370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0935   -5.8045    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3235   -4.3524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4612   -4.0975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0743   -4.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9880   -5.4700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7417   -5.8055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2937   -5.1924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8812   -4.4780    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1142   -5.2787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4498   -6.0324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2703   -6.1186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7552   -5.4512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4196   -4.6975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5991   -4.6112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5757   -5.5374    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.9112   -6.2911    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -6.0606   -4.8700    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  4  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1700

>  <JC_XSMILES>
CC1=NOC(=O)C1=CC2=CC=C(O2)C3=CC=C(C=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1705
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -1.8267    3.3100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0198    3.1385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648    2.3539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971    1.3977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168    1.7408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971   -2.7326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422   -3.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648   -3.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619   -2.2910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
M  CHG  1   9   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1705

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C=C(C3=CC=CC=C3)[N+]4=C2SCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.527

>  <W2 Pf proliferation inhibition EC50 uM>
0.647

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1718
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -3.9165   -1.0351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4316   -1.7025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6111   -1.6163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -2.2837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -1.4830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -1.6545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -2.8106    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
  8 22  4  0  0  0  0
  5 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1718

>  <JC_XSMILES>
CCOCC1=NN=C(NC(=O)COC2=CC=C(Cl)C=C2Cl)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.42

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1729
  Mrv1591402191617072D          

 32 36  0  0  1  0            999 V2000
   -1.4335    0.6727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7472   -0.0904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5648   -0.2003    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8784   -0.9634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6961   -1.0733    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3744   -1.6165    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.5498   -1.5927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2722   -2.3696    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.9254   -2.8736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6066   -2.4082    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3835   -2.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5316   -3.4973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9028   -4.0314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0509   -4.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8279   -5.1205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4567   -4.5864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2336   -4.8639    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3817   -5.6755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3085   -3.7748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9373   -3.2407    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7892   -2.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4806   -2.6017    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  6  4  1  6  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
  8 22  1  1  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 26 32  1  0  0  0  0
 25 26  1  0  0  0  0
 24 25  1  0  0  0  0
 23 31  1  0  0  0  0
 28 29  1  0  0  0  0
 31 32  1  0  0  0  0
 28 30  1  0  0  0  0
 27 28  1  0  0  0  0
 30 31  1  0  0  0  0
 24 29  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1729

>  <JC_XSMILES>
CCNC(=O)[C@@H]1C[C@H](CN1CC2=CC=CC(OC)=C2OC)NC3C4CC5CC(C4)CC3C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.6

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
72.16

>  <Powder data?>
Yes

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1735
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    0.6078   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.1848    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.6402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -1.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -0.5973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -2.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -3.0723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -3.8973    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -2.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.4223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -2.6598    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -3.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -3.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -3.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -3.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
 18 29  4  0  0  0  0
 29 30  4  0  0  0  0
 15 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1735

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)C3=CC=C(NC(=O)C4=CC=CC(F)=C4)C=C3C(=O)N5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009174312

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1765
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    1.6312    9.1853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9134    8.4101    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7259    8.2668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2562    8.8988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0686    8.7555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3508    7.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8205    7.3483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1027    6.5731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0421    6.5731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296    6.4298    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.7036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5955    3.2361    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    2.1965    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760    2.9812    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2460    1.5291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5009    0.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8335    0.2595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1661    0.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0080    7.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  1  0  0  0  0
 15 28  1  0  0  0  0
  9 28  1  0  0  0  0
  7 29  4  0  0  0  0
  3 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1765

>  <JC_XSMILES>
COC1=CC=CC(CC2(CO)CCCN(CC3=C(Cl)N=C(S3)N4CCCC4)C2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>6.21

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1766
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 16 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  2  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 11 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1766

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)N=C(N=C1C(=O)N2CCN(C(C)C2)C(=O)\C=C\C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.621

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-177
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -4.4104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
  9 26  4  0  0  0  0
  2 26  4  0  0  0  0
  5 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-177

>  <JC_XSMILES>
NC1=NOC2=CC=CC(OC3CCN(CC3)CC4=CC=CC=C4C#N)=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.662

>  <W2 Pf proliferation inhibition EC50 uM>
0.1894

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.891

>  <Powder data?>
No

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1770
  Mrv1591402191617072D          

 49 53  0  0  0  0            999 V2000
   -3.1709   -1.8525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7584   -1.1381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9334   -1.1381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5209   -1.8525    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5209   -0.4236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6959   -0.4236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2834    0.2909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5416    0.2909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6959    1.0053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5209    1.0053    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9334    1.7198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4183    1.0524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2029    1.3073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2029    2.1323    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0234    2.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4183    2.3872    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3745    2.9393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1281    3.2748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0419    4.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2349    4.2668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4813    4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8224    3.5524    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4022    5.0748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1541    5.4142    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0635    6.2343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2557    6.4015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8469    5.6849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0269    5.5943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6736    6.7895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4596    6.5388    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0698    7.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5107    6.3967    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8331    7.4071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4858    6.9026    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8940    7.9001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5041    8.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1080    8.1508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4979    7.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7119    7.8464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5209    2.4343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6959    2.4343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2834    3.1488    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2834    1.7198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5416    1.7198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2834   -1.1381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6959   -1.8525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5416   -1.1381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9541   -0.4236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9541   -1.8525    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  1  0  0  0  0
 27 28  1  0  0  0  0
 25 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 31 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 29 38  1  0  0  0  0
 38 39  1  0  0  0  0
 11 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 41 43  1  0  0  0  0
  9 43  1  0  0  0  0
 43 44  1  0  0  0  0
  6 45  1  0  0  0  0
 45 46  1  0  0  0  0
 45 47  1  0  0  0  0
 47 48  1  0  0  0  0
 47 49  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1770

>  <JC_XSMILES>
CCC(=O)OC(C(C)C1OC2(CCC(C)(O2)C3CCC(C)(O3)C4OC(CC4C)C5OC(O)(CO)C(C)CC5C)CC(O)C1C)C(C)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.379

>  <W2 Pf proliferation inhibition EC50 uM>
0.387

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.25

>  <Powder data?>
No

>  <IFI value>
0.086206897

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1786
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    7.1253   -1.7257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3184   -1.5541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7663   -2.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044   -1.2111    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2564   -0.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0634   -0.7695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454   -1.6527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1786

>  <JC_XSMILES>
CN1CCN(CC1)C(=O)C2=C(C)OC3=C2C(=O)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.829

>  <W2 Pf proliferation inhibition EC50 uM>
0.335

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.46

>  <Powder data?>
Yes

>  <IFI value>
0.108108108

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1803
  Mrv1591402191617072D          

 32 37  0  0  0  0            999 V2000
    2.2242   -6.8377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4705   -6.5021    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7560   -6.9146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1429   -6.3626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4785   -5.6089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3420   -5.5227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5135   -4.7157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2010   -4.3032    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8141   -4.8552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2872   -3.4827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3802   -2.9978    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0409   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2124   -2.3402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6604   -1.7271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.2539    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3684   -3.0076    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7553   -3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2990   -5.6951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 21 30  4  0  0  0  0
 30 31  4  0  0  0  0
 18 31  4  0  0  0  0
  5 32  1  0  0  0  0
  2 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1803

>  <JC_XSMILES>
CN1CCC2(CCN(C2)C(=O)C3=C(C)N(N=C3)C4=NC=C5CSC6=CC=CC=C6C5=N4)C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.556

>  <W2 Pf proliferation inhibition EC50 uM>
0.603

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.03

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1804
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    8.3536    6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    5.2354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    5.2354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6543    3.0624    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793    1.6335    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
 24 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  23
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1804

>  <JC_XSMILES>
CC1CCN(CC1)C(=O)C2CCCN(C2)S(=O)(=O)C3=CC=C4NC(=NC4=C3)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.03

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1807
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    4.9475    2.1959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1467    1.9978    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9179    1.2051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4899    0.6107    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2611   -0.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0814   -0.2697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3172   -1.0051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4602   -0.3801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8882    0.2143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6594   -0.5783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8585   -0.7765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6297   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2018   -2.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9729   -2.9562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1721   -3.1544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9433   -3.9470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6001   -2.5599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8289   -1.7672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2865   -0.1820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4857   -0.3801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0864    0.2143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8872    0.0162    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1424    1.0070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4296    1.6015    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9433    1.2051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5153    0.6107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3162    0.8088    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1170    1.0070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
 26 27  1  0  0  0  0
  9 27  1  0  0  0  0
  9 28  1  0  0  0  0
  3 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1807

>  <JC_XSMILES>
CSC1=NC(C)(C)CC2(CC(C3=CC=C(C)C=C3)C4=CC(Cl)=C(O)C=C4O2)N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.993

>  <W2 Pf proliferation inhibition EC50 uM>
0.602

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.104166667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1836
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    3.4491   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0366   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296   -3.7080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971   -2.5519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1715    3.2820    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9920    3.3682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3276    2.6145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
  9 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  7 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1836

>  <JC_XSMILES>
C1CCC(C1)NC2=NC(NC3=CC=C4OCOC4=C3)=NC5=CC=CC=C25

>  <PF proliferation inhibition 3D7 EC50 uM>
0.525

>  <W2 Pf proliferation inhibition EC50 uM>
0.753

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.8

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1847
  Mrv1591402191617072D          

 42 47  0  0  0  0            999 V2000
   -3.4539    2.9263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7222    3.3073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0264    2.8640    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2946    3.2450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5988    2.8017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6347    1.9775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3665    1.5965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0623    2.0398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0611    1.5342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0251    0.7100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7209    0.2668    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5028    0.5281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7196    1.3241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5174    1.5343    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    1.9099    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3555    2.7059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7746    3.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9914    4.0877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7892    4.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3701    3.7121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1533    2.9161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0915   -0.1481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7578   -0.8673    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2354   -0.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2914    0.2936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5142    0.5650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4546   -1.3132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6645   -0.8324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8159   -0.5645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1793   -1.0893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5362   -2.1341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8660   -2.6153    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2879   -2.4739    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3695   -3.2949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1213   -3.6347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2029   -4.4557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5327   -4.9368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7810   -4.5970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6994   -3.7760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6143   -5.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3661   -6.0976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9442   -6.2389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 22 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 22 28  1  0  0  0  0
 28 29  1  0  0  0  0
 11 29  1  0  0  0  0
 29 30  2  0  0  0  0
 27 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 37 40  1  0  0  0  0
 40 41  1  0  0  0  0
 40 42  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1847

>  <JC_XSMILES>
CCN1CCN(CC1)CCN2C(C(=O)NC3CCCCC3)C45OC(C=C4)C(C5C2=O)C(=O)NC6=CC=C(C=C6)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.82

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1850
  Mrv1591402191617072D          

 11 12  0  0  0  0            999 V2000
    1.2564   -0.1802    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2564   -1.0052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9239   -1.4901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6689   -2.2748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8439   -2.2748    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5890   -1.4901    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1538   -2.9422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9788   -2.9422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2338   -3.7268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5663   -4.2117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8989   -3.7268    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1850

>  <JC_XSMILES>
NC1=CC(=NN1)C2=CC=CS2

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>5.81

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1857
  Mrv1591402191617072D          

 41 47  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    4.8105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    6.4605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    7.2855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0203    7.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8273    7.5989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3793    8.2120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1244    8.9966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3174    9.1682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7654    8.5551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9404    8.5551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3884    9.1682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5814    8.9966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0293    9.6097    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.3264    8.2120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8785    7.5989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6854    7.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  4  0  0  0  0
 21 27  4  0  0  0  0
  2 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 29 41  4  0  0  0  0
 36 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1857

>  <JC_XSMILES>
OC(CN1CCN(CC1)CC(O)CN2C3=CC=CC=C3C4=CC(Br)=CC=C24)CN5C6=CC=CC=C6C7=CC=CC=C57

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.259

>  <W2 Pf proliferation inhibition EC50 uM>
0.576

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1868
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.3763    4.1168    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7888    3.4023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6138    3.4023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0263    2.6878    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6138    1.9734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0263    1.2589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6138    0.5444    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8513    2.6878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2638    1.9734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8513    1.2589    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0888    1.9734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5013    1.2589    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3218    1.1727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9349    1.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7195    1.4697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8910    0.6628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6757    0.4078    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.2780    0.1107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4933    0.3657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7789   -0.0468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6073   -0.8538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8227   -1.1087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6512   -1.9157    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.2096   -0.5567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3811    0.2503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1658    0.5052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1868

>  <JC_XSMILES>
OCCN(CCO)CC(O)CN1C2=CC=C(Br)C=C2C3=CC(Br)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
2.331

>  <W2 Pf proliferation inhibition EC50 uM>
1.549

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
27.27

>  <Powder data?>
Yes

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1874
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 17 22  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
  1 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1874

>  <JC_XSMILES>
C(COC1=CC=C(NC2=C3C=CC=CC3=NC4=CC=CC=C24)C=C1)OC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.505

>  <W2 Pf proliferation inhibition EC50 uM>
0.347

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.12

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1876
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -4.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7859   -3.9674    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2708   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7859   -2.6326    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  8  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
 13 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 10 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1876

>  <JC_XSMILES>
CCCN(CC1CC1)CC2=CC3=C(OCO3)C(OC)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.722

>  <W2 Pf proliferation inhibition EC50 uM>
0.566

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1885
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -2.1238    1.9123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168    1.7408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971    1.3977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8242    0.7846    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8242   -2.1195    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8792   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1167    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5292   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1167   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5292   -2.0964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8792   -2.0964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1885

>  <JC_XSMILES>
CCOC(=O)C1=NNC2C1C(=O)N(C2=O)C3=CC=CC(C)=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.563

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1893
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    3.8120   -5.0430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6047   -4.8143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1991   -5.3863    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0009   -6.1871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2084   -6.4158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9917   -5.1574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5861   -5.7295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3787   -5.5007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9731   -6.0727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7657   -5.8439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9639   -5.0430    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.3601   -6.4158    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1619   -7.2167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3694   -7.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1712   -8.2462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3787   -8.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7842   -7.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9824   -7.1023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7749   -6.8734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1527   -6.1871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7471   -6.7590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5397   -6.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1341   -7.1023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9267   -6.8734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5211   -7.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3138   -7.2167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3230   -8.2462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9174   -8.8183    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   12.5304   -8.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9359   -7.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1434   -8.1318    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.5489   -7.5599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7564   -7.7886    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 21 32  4  0  0  0  0
 32 33  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  31
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1893

>  <JC_XSMILES>
CCN(CC)CCCNC(=S)N(CC1=CC=CC=C1)CC2=CC3=CC(C)=C(Cl)C=C3NC2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.935

>  <W2 Pf proliferation inhibition EC50 uM>
1.165

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.86

>  <Powder data?>
Yes

>  <IFI value>
0.163934426

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1899
  Mrv1591402191617072D          

 38 41  0  0  1  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -10.7250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -9.5980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020  -11.0270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  1  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 15 21  1  0  0  0  0
  8 22  1  0  0  0  0
  4 22  1  0  0  0  0
  7 23  1  1  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
 35 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1899

>  <JC_XSMILES>
CC(C)N1CC[C@H]([C@@H](CCC(=O)N(C)C2CCN(C)CC2)C1)N3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.04

>  <W2 Pf proliferation inhibition EC50 uM>
0.285

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.13

>  <Powder data?>
No

>  <IFI value>
0.09

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1908
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.1439   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -3.8913    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9186   -3.8913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9186   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5564   -6.7491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3814   -6.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5564   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1561   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -2.5093    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3861   -1.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9381   -1.1116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -2.3518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -1.5268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -3.8442    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  3 14  4  0  0  0  0
  7 14  4  0  0  0  0
  4 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  1  0  0  0  0
 16 28  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1908

>  <JC_XSMILES>
CCN1C(\C=CC2=CC(OC)=CC=C12)=C\C3=[N+](CC)C4=CC(OC)=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.527

>  <W2 Pf proliferation inhibition EC50 uM>
0.552

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-191
  Mrv1591402191617072D          

 31 32  0  0  1  0            999 V2000
    2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
 10  8  1  0  0  0  0
 10 11  1  6  0  0  0
 11 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  0  0  0  0
 16 17  1  6  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 20 19  1  0  0  0  0
  3 20  1  0  0  0  0
 20 21  1  1  0  0  0
 22 21  1  6  0  0  0
 22 23  1  0  0  0  0
 24 23  1  0  0  0  0
 24 25  1  1  0  0  0
 26 24  1  0  0  0  0
 26 27  1  1  0  0  0
 26 28  1  0  0  0  0
 28 29  1  1  0  0  0
 28 30  1  0  0  0  0
 30 22  1  0  0  0  0
 30 31  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-191

>  <JC_XSMILES>
CC[C@@H]1CCCNC(=O)[C@H](CC)CCC[C@H](C)CC[C@H]1O[C@@H]2O[C@@H](C)[C@@H](O)[C@@H](N)[C@H]2O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.585

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.25

>  <Powder data?>
No

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1910
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    1.3556   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    5.6479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 14 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1910

>  <JC_XSMILES>
CCOC1=CC=CC=C1N2C(=O)C3=C(NN=C3)N=C2SCC(=O)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.02

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
73.05

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1916
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    2.9980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    4.4270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  3 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  2  0  0  0  0
 33 35  4  0  0  0  0
 25 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 39 41  4  0  0  0  0
 41 42  4  0  0  0  0
 36 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1916

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)C2=CC=CC(=C2)C(F)(F)F)C3=NC4=CC=CC=C4C(=O)N3C5=CC=C(Br)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.871

>  <W2 Pf proliferation inhibition EC50 uM>
0.545

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1920
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
   -7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 10 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 18 28  4  0  0  0  0
  7 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1920

>  <JC_XSMILES>
CC(C)CCNC1=NC=C(C(=O)NCC(C)C)C(NCCC2=CC=CC=C2)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.724

>  <W2 Pf proliferation inhibition EC50 uM>
0.543

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1926
  Mrv1591402191617072D          

 12 12  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1926

>  <JC_XSMILES>
CCC1=CC=CC=C1NC(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.41

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010416667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-194
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 12 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
  8 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
  4 27  4  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-194

>  <JC_XSMILES>
CN(C)C1=CC(C)=[N+](OC(=O)N(C2=CC=CC=C2)C3=CC=CC=C3)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.49

>  <W2 Pf proliferation inhibition EC50 uM>
1.999

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.166666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1946
  Mrv1591402191617072D          

 42 48  0  0  0  0            999 V2000
    1.3363   -4.7113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3073   -3.8868    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5788   -3.4996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1207   -3.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8492   -3.5498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8782   -2.7253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -2.2880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2076   -1.4635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4919   -1.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2204   -1.4133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4629   -0.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1725    0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0841    1.2649    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6349    1.1456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4025    1.4739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8583    0.7254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0550    0.3597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8811    0.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4594   -0.1263    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9973    1.2836    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7337    1.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4240    1.2035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1604    1.5753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8506    1.1234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8044    0.2997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3855   -0.2859    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0083   -1.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1939   -0.8874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0679   -0.0721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3777    0.3798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2637    1.6800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1776    2.5005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8451    2.9853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4239    2.8361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3378    3.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4158    3.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5019    4.8128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1656    5.2976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9193    4.9619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0054    4.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7590    3.8058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5498   -2.6751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 25 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
 20 31  1  0  0  0  0
 14 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 35 40  1  0  0  0  0
 40 41  1  0  0  0  0
  7 42  4  0  0  0  0
  3 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1946

>  <JC_XSMILES>
COC1=CC=CC(NC(=O)C2C3OC4(C=C3)C2C(=O)N(CC5=CC=C6OCOC6=C5)C4C(=O)NC7CCCCC7C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>5.31

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1950
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454    2.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044    2.0361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4744    3.4881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594    4.1556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7440    3.9006    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.0031    4.6839    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5645    3.8144    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7440    3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
  7 13  1  0  0  0  0
  3 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 14 25  1  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1950

>  <JC_XSMILES>
CC1=C(C(=O)NC2CCS(=O)(=O)C2)C3=C(O1)C(=O)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.437

>  <W2 Pf proliferation inhibition EC50 uM>
0.1269

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.402

>  <Powder data?>
Yes

>  <IFI value>
0.297297297

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1959
  Mrv1591402191617072D          

 33 36  0  0  1  0            999 V2000
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 25 12  1  0  0  0  0
 25 26  1  0  0  0  0
  9 26  1  0  0  0  0
 25 27  1  1  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1959

>  <JC_XSMILES>
COC1=CC=CC(=C1)N2CCN(CCNCCOC3=CC=CC=C3)[C@H](C2)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.703

>  <W2 Pf proliferation inhibition EC50 uM>
0.383

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.31

>  <Powder data?>
No

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1962
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  5 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1962

>  <JC_XSMILES>
OC1=CC=C(C=C1CNCCN2CCOCC2)C3=CC=NC4=CC(Cl)=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.984

>  <W2 Pf proliferation inhibition EC50 uM>
0.622

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.89

>  <Powder data?>
No

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1965
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0836    0.5584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9044    0.6403    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3858   -0.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2067    0.0521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6881   -0.6179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3485   -1.3698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5276   -1.4516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0462   -0.7816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2253   -0.8635    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2561   -0.1935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8299   -2.0398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4973   -2.5247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2424   -3.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4174   -3.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1624   -2.5247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3819   -1.4267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1270   -0.6421    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1889   -1.5982    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7409   -0.9851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5479   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0999   -0.5436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9069   -0.7151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1618   -1.4997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6098   -2.1128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8028   -1.9413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2508   -2.5544    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1965

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2(CCCC2)C(=O)NCC3=CC=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
12.01

>  <W2 Pf proliferation inhibition EC50 uM>
5.22

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-197
  Mrv1591402191617072D          

 31 36  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -0.6117    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132    0.1953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277    0.6078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277    1.4328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132    1.8453    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987    1.4328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987    0.6078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856    0.0557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042   -2.9276    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -3.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -4.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -4.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -5.3846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -4.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -4.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481   -3.5950    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  4 12  4  0  0  0  0
  2 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
  1 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 23 31  4  0  0  0  0
M  STY  3   1 DAT   2 DAT   3 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  22
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  SAL   3  1  31
M  SDT   3 MRV_IMPLICIT_H                                        
M  SDD   3     0.0000    0.0000    DR    ALL  0       0  
M  SED   3 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-197

>  <JC_XSMILES>
C(N(CC1=NC2=CC=CC=C2N1)CC3=NC4=CC=CC=C4N3)C5=NC6=CC=CC=C6N5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1906

>  <W2 Pf proliferation inhibition EC50 uM>
5.26

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.68

>  <Powder data?>
Yes

>  <IFI value>
0.137254902

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1972
  Mrv1591402191617072D          

 54 63  0  0  0  0            999 V2000
   -1.8999   -4.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3848   -4.2356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0493   -3.4819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288   -3.3956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7439   -4.0631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0794   -4.8168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -0.5074    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6789   -0.1719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5927    0.6486    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7857    0.8201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4502    1.5738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9351    2.2412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5995    2.9949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2209    3.0812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7059    2.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3703    1.6601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    0.1057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4473    0.0194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9322    0.6869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7527    0.6006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0580   -0.0403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6033   -0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7828   -0.7342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3934   -0.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3934   -1.4094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1079   -1.8219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8525   -1.2967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5368   -1.8219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2513   -1.4094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2513   -0.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5368   -0.1719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8223   -0.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1079   -0.1719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0863   -2.4704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -1.8413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6111   -2.5087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4316   -2.4225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7672   -1.6688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2823   -1.0014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4618   -1.0876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  1  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 13 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 11 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  4  0  0  0  0
 27 36  4  0  0  0  0
  9 37  4  0  0  0  0
 37 38  4  0  0  0  0
  7 38  4  0  0  0  0
 37 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 42 47  4  0  0  0  0
 47 48  4  0  0  0  0
 39 48  4  0  0  0  0
  8 49  1  0  0  0  0
 49 50  4  0  0  0  0
 50 51  4  0  0  0  0
 51 52  4  0  0  0  0
 52 53  4  0  0  0  0
 53 54  4  0  0  0  0
 49 54  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1972

>  <JC_XSMILES>
C1=CC=C(C=C1)C2=C(N(N3C(=NC(C4=CC=CC=C4)=C3C5=CC=CC=C5)C6=CC=C7C=CC=NC7=C6)C(=N2)C8=CC=C9C=CC=NC9=C8)C%10=CC=CC=C%10

>  <PF proliferation inhibition 3D7 EC50 uM>
3.64

>  <W2 Pf proliferation inhibition EC50 uM>
1.505

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.08

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1980
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.1486    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   22.1486    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.8631    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.8631   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.5775   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   22.1486   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1980

>  <JC_XSMILES>
CCCCCCCCC(=O)NCCCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
1.145

>  <W2 Pf proliferation inhibition EC50 uM>
0.2862

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.6

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1981
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    1.4229   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2828    0.5213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5377    1.3059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3447    1.4774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5996    2.2621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4066    2.4336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9586    1.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7037    1.0359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8967    0.8644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6418    0.0797    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  8 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1981

>  <JC_XSMILES>
CC1=CC=C2NC3=C(NCCC4=CC=CC=C4F)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.835

>  <W2 Pf proliferation inhibition EC50 uM>
0.843

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.51

>  <Powder data?>
Yes

>  <IFI value>
0.146341463

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1987
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  7 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 15 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 17 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1987

>  <JC_XSMILES>
CC(C)(C)C1=CC(C=C(S1)C(C)(C)C)=C2C=C(SC(=C2)C(C)(C)C)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.805

>  <W2 Pf proliferation inhibition EC50 uM>
0.506

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036585366

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-199
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
  9 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
  6 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-199

>  <JC_XSMILES>
CCC1=CC=C(CSC2=NC3=CC(OC)=C(OC)C=C3C(=N)N2CCC4=CC=CC=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6.64

>  <W2 Pf proliferation inhibition EC50 uM>
7.62

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.86

>  <Powder data?>
Yes

>  <IFI value>
0.025974026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2007
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1019   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8865   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0580   -1.0192    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.4996   -2.3782    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3281   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9411   -3.7372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5434   -3.4401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9303   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1457   -3.1430    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 10 17  4  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2007

>  <JC_XSMILES>
CC(=O)N1CCNC1=NC2=C(Cl)N=C(C)N=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.444

>  <W2 Pf proliferation inhibition EC50 uM>
0.498

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2015
  Mrv1591402191617072D          

 49 57  0  0  0  0            999 V2000
    2.0424   -6.2759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3749   -5.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6212   -6.1266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0462   -5.6417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0400   -4.8212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7937   -4.4856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4612   -4.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8799   -3.6651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2669   -3.1131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6024   -2.3594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4229   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5944   -3.2526    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0700   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8904   -2.3594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2260   -3.1131    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6129   -3.6651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8984   -3.2526    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6991   -4.4856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4528   -4.8212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5391   -5.6417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8716   -6.1266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1179   -5.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4505   -6.2759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0317   -4.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3029   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8904   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3029   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1279   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5404   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1279   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1899   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6351   -1.6450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0476   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6351   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1899   -0.2160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6024   -0.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 24 25  4  0  0  0  0
 13 25  4  0  0  0  0
 21 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 31 37  4  0  0  0  0
 27 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 38 43  4  0  0  0  0
 10 44  1  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 44 49  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  30
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2015

>  <JC_XSMILES>
OC1=CC=CC(=C1)C2=NC(=C(N2)C3=CC=C4OC5=CC=C(C=C5C4=C3)C6=C(N=C(N6)C7=CC=CC(O)=C7)C8=CC=CC=C8)C9=CC=CC=C9

>  <PF proliferation inhibition 3D7 EC50 uM>
2.353

>  <W2 Pf proliferation inhibition EC50 uM>
1.011

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.43

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2018
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    0.6166    1.9393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0978    1.5268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0978    0.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123    0.2893    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8123   -0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4798   -1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2248   -1.8053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3998   -1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1449   -1.0206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0851   -2.4727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9101   -2.4727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1650   -3.2573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4976   -3.7422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1698   -3.2573    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2644   -0.7657    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
   -3.0490   -0.5108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6621   -1.0628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4467   -0.8079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6182   -0.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0051    0.5512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2205    0.2962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0094    0.0189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5615    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3065    1.4166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4996    1.5882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9475    0.9751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2025    0.1905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5193   -1.5503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9673   -2.1634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2222   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0292   -3.1196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5812   -2.5065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3263   -1.7218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
  6 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 15 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2018

>  <JC_XSMILES>
C=CCSC1=C(N=C(O1)C2=CC=CO2)[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3095

>  <W2 Pf proliferation inhibition EC50 uM>
0.416

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.42

>  <Powder data?>
Yes

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2021
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2021

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC(=NC(=N2)C3=CC=CN=C3)C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.511

>  <W2 Pf proliferation inhibition EC50 uM>
0.494

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2022
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2022

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)C3=CC=CC=C3Br)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.468

>  <W2 Pf proliferation inhibition EC50 uM>
0.494

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2026
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5919   -6.2508    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  2  0  0  0  0
 13 17  2  0  0  0  0
 17 18  1  4  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2026

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)\C=C2/SC(NC2=O)=NC3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.361

>  <W2 Pf proliferation inhibition EC50 uM>
0.493

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2028
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -1.4290    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.3790    0.3412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7143    1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288    0.8251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -0.4124    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4291    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1271    0.5230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3021    1.9520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8874    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4749    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8578   -3.3001    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7308   -3.6020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -2.1731    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
  9 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
  6 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  CHG  4   1  -1   2   1  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2028

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=C(Cl)C(=C1NC2=CC(=CC=C2Cl)C(F)(F)F)[N+]([O-])=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.565

>  <W2 Pf proliferation inhibition EC50 uM>
0.3012

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.13

>  <Powder data?>
No

>  <IFI value>
0.212121212

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2032
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2032

>  <JC_XSMILES>
C1CN(CCC1NC2=NC=NC3=C2SC(=C3)C4=CC=CC=C4)CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
2.059

>  <W2 Pf proliferation inhibition EC50 uM>
4.89

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034722222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2051
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 12 21  4  0  0  0  0
  8 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2051

>  <JC_XSMILES>
CC1=CC=CC=C1C2=CN=NC(NCC3CCCCO3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
11.13

>  <W2 Pf proliferation inhibition EC50 uM>
4.82

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2052
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  3  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
 11 17  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  1  0  0  0  0
  2 18  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2052

>  <JC_XSMILES>
CN1CCC2=C(C#N)C(=NC(N3CCCC3)=C2C1)N4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.125

>  <W2 Pf proliferation inhibition EC50 uM>
4.82

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035087719

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2055
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -1.2546   -5.9861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957   -5.5184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -5.0507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -4.4270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -4.5829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -5.9861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -3.9593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -3.1798    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -2.5561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -1.7766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -1.1529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864   -1.3088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -2.0884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -2.7120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864   -3.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -3.6475    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -4.1152    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -5.5184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -6.4539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2265   -7.2334    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -5.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2265   -5.0507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7666   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -3.6475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -3.0238    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -3.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657   -4.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -3.9593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.1798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -2.5561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -1.7766    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -2.7120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 31 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2055

>  <JC_XSMILES>
CCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=C(Cl)C=C3C)C(=O)C4=CC=CC(F)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.455

>  <W2 Pf proliferation inhibition EC50 uM>
0.48

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2059
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
   -3.8837   -1.4124    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2059

>  <JC_XSMILES>
FC1=CC=C(CSC2=NC3=CC=CN=C3N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.62

>  <W2 Pf proliferation inhibition EC50 uM>
4.8

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2062
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2062

>  <JC_XSMILES>
CC1=CC=CC=C1C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.45

>  <W2 Pf proliferation inhibition EC50 uM>
0.479

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2064
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
    9.0347   -0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3202    0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6057   -0.3509    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8913    0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3762    0.7290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8913   -1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -1.5884    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9632   -1.4308    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783   -0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533   -0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2408   -1.4779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533   -2.1923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783   -2.1923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8908   -2.9068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783   -3.6213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533   -3.6213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2408   -2.9068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158   -2.9068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033   -2.1923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783   -2.1923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2342   -1.4779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783   -0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033   -0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158   -1.4779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9632   -0.0960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083    0.6887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -0.3509    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479    1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479    2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0334    2.5366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0334    3.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768    2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768    1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8913    0.8866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6057    1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  4  0  0  0  0
 22 27  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  2  0  0  0  0
 28 30  4  0  0  0  0
 10 30  4  0  0  0  0
 30 31  1  0  0  0  0
  6 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 32 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2064

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=C4C=CC=CC4=CC5=CC=CC=C35)c(=O)n2C1C6=CC(OC)=CC=C6OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.77

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2068
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2068

>  <JC_XSMILES>
CCCCOC(=O)CC1=CC=C(N)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.462

>  <W2 Pf proliferation inhibition EC50 uM>
0.2841

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.97

>  <Powder data?>
Yes

>  <IFI value>
0.070866142

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2069
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9441   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7511   -5.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1636   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6116   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
  5 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2069

>  <JC_XSMILES>
COC1=CC(=CC=C1N2C=NN=N2)C(=O)NC3=CN=C4C=CC=CC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.98

>  <W2 Pf proliferation inhibition EC50 uM>
4.75

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2085
  Mrv1591402191617072D          

 29 32  0  0  1  0            999 V2000
   -1.3348   -4.7194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5143   -4.6332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5912   -3.1650    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0392   -2.5519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2107   -1.7450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6282   -3.7080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 15 14  1  6  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 20 19  1  0  0  0  0
 20 11  1  6  0  0  0
 15 20  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2085

>  <JC_XSMILES>
CCC1=NN(C)C(=C1)C(=O)N2CCC[C@@H]3CN(CC[C@H]23)C(=O)C4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.67

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2088
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550   -0.0769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070   -0.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945   -1.4045    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875   -1.2330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 22 28  4  0  0  0  0
  5 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2088

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C(=N)N(CCCN3C=CN=C3)C(SCC(C)C)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.822

>  <W2 Pf proliferation inhibition EC50 uM>
0.926

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.87

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2107
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    3.2789    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4539    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    5.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    5.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
  9 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  7 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2107

>  <JC_XSMILES>
FC(F)(F)C1=CC(=NC2=CC(=NN12)C(=O)N3CCN(CC3)CC4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
2.923

>  <W2 Pf proliferation inhibition EC50 uM>
4.59

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2120
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.1434    5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414    4.2355    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164    5.6645    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 13 28  4  0  0  0  0
 22 28  4  0  0  0  0
  8 29  4  0  0  0  0
 29 30  4  0  0  0  0
  5 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2120

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(NC(=O)CN2C3=CC=CC=C3C(=O)C4=CC=C(Cl)C=C24)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
9.87

>  <W2 Pf proliferation inhibition EC50 uM>
4.54

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2126
  Mrv1591402191617072D          

 29 33  0  0  1  0            999 V2000
    5.5117   -4.5798    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0268   -3.9124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2063   -3.9986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7214   -3.3312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2365   -2.6637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7516   -1.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9311   -2.0825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4462   -1.4151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7817   -0.6614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6022   -0.5752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0871   -1.2426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2968    0.0060    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.4718    0.0060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2169    0.7907    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4506    1.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1956    2.0602    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6806    2.7276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5010    2.6414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9860    3.3088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6504    4.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8299    4.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3450    3.4813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6294    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1143    2.7276    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8843    1.2756    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1392    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9642    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2192    1.2756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5517    0.7907    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 12  9  1  6  0  0  0
 12 13  1  0  0  0  0
 14 13  1  1  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 16 23  1  0  0  0  0
 23 24  2  0  0  0  0
 25 23  1  0  0  0  0
 14 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 12 29  1  0  0  0  0
 25 29  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2126

>  <JC_XSMILES>
OCCC#CC1=CC=C(C=C1)[C@@H]2C[C@H]3CN(C4=CC=CC=C4)C(=O)[C@]35CCCN25

>  <PF proliferation inhibition 3D7 EC50 uM>
0.832

>  <W2 Pf proliferation inhibition EC50 uM>
0.757

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.76

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2127
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.5395    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  4  0  0  0  0
 21 28  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2127

>  <JC_XSMILES>
CC[N+](C)(CC)CCSC1=NC2=CC=CC=C2C(=S)N1C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2848

>  <W2 Pf proliferation inhibition EC50 uM>
0.451

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2158
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 18 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2158

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC(Cl)=CC2=C1NC3=CC=C(OC)C(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.668

>  <W2 Pf proliferation inhibition EC50 uM>
4.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-216
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.7078   -7.8139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4528   -7.0293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0049   -6.4162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7499   -5.6315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3020   -5.0184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470   -4.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429   -5.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2203   -0.9238    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 20 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 18 29  4  0  0  0  0
 24 29  4  0  0  0  0
 16 30  1  0  0  0  0
 10 30  1  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-216

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N2C(=O)NC(=O)C(=C/C3=CN(C(C)=O)C4=CC=CC=C34)\C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.864

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.045112782

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2161
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  9  8  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 14 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 30 39  4  0  0  0  0
 34 39  4  0  0  0  0
 28 40  4  0  0  0  0
 12 40  4  0  0  0  0
  8 41  4  0  0  0  0
  4 41  4  0  0  0  0
M  CHG  4   1  -1   2   1  24   1  25  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2161

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(C=NNC2=NC(NN=CC3=CC=CC(=C3)[N+]([O-])=O)=NC(NC4=CC=CC5=CC=CC=C45)=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.509

>  <W2 Pf proliferation inhibition EC50 uM>
0.442

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2165
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
 15 22  4  0  0  0  0
 10 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2165

>  <JC_XSMILES>
CCCCN1CC2=CC=C(C=C2N=C1C3=CC=C(OC)C=C3)C(=O)NCCN4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.01

>  <W2 Pf proliferation inhibition EC50 uM>
4.41

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2180
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.5763   -4.1479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2907   -4.5604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2907   -5.3854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0052   -4.1479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7197   -4.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4342   -4.1479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1486   -4.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1486   -5.3854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8631   -5.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5776   -5.3854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5776   -4.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8631   -4.1479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0346   -3.3410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8551   -3.2547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3400   -2.5873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1605   -2.6735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4961   -3.4272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3165   -3.5134    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.0111   -4.0946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1907   -4.0084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2180

>  <JC_XSMILES>
CN(C)CCNC1=NC=NC2=C1NC3=CC=C(Cl)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.632

>  <W2 Pf proliferation inhibition EC50 uM>
0.886

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.38

>  <Powder data?>
Yes

>  <IFI value>
0.078431373

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2181
  Mrv1591402191617072D          

 40 45  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
  4 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
 23 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 39 40  4  0  0  0  0
 34 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2181

>  <JC_XSMILES>
CC1CN(CCN1S(=O)(=O)C2=CC=C3C=CC=CC3=C2)C(C)C4=NC5=CC=CC=C5C(=O)N4C6=CC=C(Br)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.434

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2190
  Mrv1591402191617072D          

 27 28  0  0  1  0            999 V2000
    4.9698   -6.7255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6843   -6.3130    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3987   -6.7255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1132   -6.3130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8277   -6.7255    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5421   -6.3130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5421   -5.4880    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2566   -6.7255    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   10.0103   -6.3899    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5623   -7.0030    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   10.1498   -7.7175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3428   -7.5460    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7298   -8.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9451   -7.8431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9013   -8.9050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3828   -6.9168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.8677   -7.5842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6882   -7.4980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1731   -8.1654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9936   -8.0792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3292   -7.3255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.4785   -8.7467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1430   -9.5003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3225   -9.5866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8376   -8.9191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1536   -9.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0726   -8.6101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  8  6  1  6  0  0  0
  8  9  1  0  0  0  0
 10  9  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 10 16  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 19 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2190

>  <JC_XSMILES>
COCCNC(=O)[C@@H]1C[C@H](CN1C(C)C)NCCC2=C(C)CCCC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2199
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.8871   -5.0906    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.7311   -5.9305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  3  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
M  CHG  2  14   1  15  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2199

>  <JC_XSMILES>
OCC1=NC(=CS1)C2=CC=C(C=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.27

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008196721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2201
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
  5 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2201

>  <JC_XSMILES>
ClC1=CC=C(COC2=CC=C3C=CC=CC3=C2C=O)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.719

>  <W2 Pf proliferation inhibition EC50 uM>
0.426

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.056338028

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2206
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    1.7281   -4.8514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1761   -4.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4310   -3.4536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2380   -3.2821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8790   -2.8405    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1339   -2.0559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9409   -1.8844    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5819   -1.4428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2251   -1.6144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7771   -1.0013    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5221   -0.2166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0742    0.3965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8192    1.1811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0123    1.3526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5398    0.7395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2848   -0.0451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8369   -0.6582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6438   -0.4867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2427    2.1372    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0273    1.8823    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5420    2.3922    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4976    2.9218    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0127    3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4976    4.2567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822    4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9967    4.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7112    4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7112    3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9967    2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822    3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  2  0  0  0  0
 14 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  1  0  0  0  0
 25 30  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2206

>  <JC_XSMILES>
CCC(C)NC(=O)C1=CNC2=CC=C(C=C2C1=O)S(=O)(=O)N3CCC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.424

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2210
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.4395    1.5774    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4920    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3253    0.8776    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6289    1.6594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4443    1.7853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9610    1.1422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7763    1.2681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0749    2.0371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5582    2.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7429    2.5544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7603    0.2671    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2622    0.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2791   -0.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0497   -0.8176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8029   -0.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0976    0.2895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7611    1.0427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9905    1.3374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2373    1.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7507    0.2525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1945    0.3416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4667   -0.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0852   -1.1089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1700   -1.8934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9770   -2.0647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5289   -1.4515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2737   -0.6669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 12 19  1  0  0  0  0
 18 20  1  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2210

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)NC2CC3CCCC(C2)N3CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.879

>  <W2 Pf proliferation inhibition EC50 uM>
0.423

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.039473684

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2219
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -2.8283   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0033   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5908   -0.2616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7658   -0.2616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3533   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7658   -1.6906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5908   -1.6906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4717   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566   -0.3087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413   -0.5636    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863   -0.0492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906   -0.2328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5485   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906   -1.7194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863   -1.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413   -1.3886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566   -1.6436    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7017   -2.4282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2537   -3.0413    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9988   -3.8259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1918   -3.9974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0631   -4.7820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3602   -3.3843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1053   -2.5997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  CHG  1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2219

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=CN3CCCCCC3=[N+]2C4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.999

>  <W2 Pf proliferation inhibition EC50 uM>
0.459

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.94

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2221
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.4009   -0.2947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4009   -1.3553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.2539    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -2.9684    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -4.3974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079   -3.6829    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
  2 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2221

>  <JC_XSMILES>
CC1(C)OC2=CC=C3C=CC(=O)OC3=C2CC1=NNC(N)=S

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.19

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.038461538

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2229
  Mrv1591402191617072D          

 43 50  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 13 22  4  0  0  0  0
  1 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 27 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 30 43  4  0  0  0  0
 34 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2229

>  <JC_XSMILES>
C(CN1CCN(CC1)C2=CC=NC3=CC4=CC=CC=C4C=C23)CN5CCN(CC5)C6=CC=NC7=CC8=CC=CC=C8C=C67

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0794

>  <W2 Pf proliferation inhibition EC50 uM>
0.417

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2231
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    0.0853   -2.8444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -2.9306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2413   -3.6843    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0483   -3.8558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6614   -3.3038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4899   -2.4968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1030   -1.9448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9314   -1.1378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1778   -0.8022    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4633   -1.2147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2640    0.0182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7120    0.6313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9669    1.4160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7739    1.5875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3259    0.9744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0710    0.1898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4835   -0.5247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2406   -0.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1559   -1.0026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1345   -4.6763    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8490   -5.0888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5635   -4.6763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2780   -5.0888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9924   -4.6763    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7069   -5.0888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4214   -4.6763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7069   -5.9138    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3809   -5.0119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1259   -5.7965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3190   -5.9680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2331   -5.3549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0219   -4.5703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8288   -4.3988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
  4 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 20 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2231

>  <JC_XSMILES>
CC[N+]1=C(\C=C\C=C2/N(C)C3=CC=CC=C3C2(C)C)N(CCCOC(C)=O)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.322

>  <W2 Pf proliferation inhibition EC50 uM>
0.416

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2237
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1481    1.7766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5961    2.3897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2109    2.2182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4658    1.4336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  3 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  1  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2237

>  <JC_XSMILES>
O=C1C(NC2=CC=CC=C2)=C(N3N=NC4=CC=CC=C34)C(=O)C5=CC=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
2.023

>  <W2 Pf proliferation inhibition EC50 uM>
0.2591

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.3

>  <Powder data?>
No

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2248
  Mrv1591402191617072D          

 39 45  0  0  0  0            999 V2000
    5.8078   -6.8942    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.4722   -6.1405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6518   -6.0543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3162   -5.3006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8011   -4.6332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6216   -4.7194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9572   -5.4731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4656   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6586   -3.7080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3260   -2.5519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8781   -3.1650    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6985   -3.0788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0341   -2.3251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8546   -2.2389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3395   -2.9063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0039   -3.6600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1835   -3.7462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 25 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 19 38  4  0  0  0  0
 38 39  4  0  0  0  0
 22 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2248

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2CC(=NN2C3=CC=CC=C3)C4=CC=C5C(=O)N(C6=CC=CC=C6)C(=O)C7=CC=CC4=C57

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.407

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2261
  Mrv1591402191617072D          

 27 30  0  0  1  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
 10  5  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  1  0  0  0
 11 13  1  0  0  0  0
 13  3  1  0  0  0  0
 13 14  1  6  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  8 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2261

>  <JC_XSMILES>
CO[C@H]1O[C@@H]2COC(O[C@H]2[C@@H](O)[C@@H]1OCC3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.376

>  <W2 Pf proliferation inhibition EC50 uM>
0.555

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.84

>  <Powder data?>
No

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2267
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -5.0224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -5.0224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -6.4745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8504   -5.9896    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4845   -6.9594    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6679   -7.1419    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -7.8956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8172   -8.5630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -8.4768    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9733   -7.7231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -7.0557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1226   -9.1442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7871   -9.8979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2720  -10.5654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0925  -10.4791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4280   -9.7254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9431   -9.0580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2267

>  <JC_XSMILES>
BrC1=CC=C(S1)S(=O)(=O)N2CCN(CC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.411

>  <W2 Pf proliferation inhibition EC50 uM>
0.4

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.007936508

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2279
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  1  0  0  0  0
 19 24  4  0  0  0  0
 21 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
  9 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
  8 37  4  0  0  0  0
 37 38  4  0  0  0  0
  5 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2279

>  <JC_XSMILES>
COC(=O)C1=CC=C2C(C3C4=CC=CC=C4C(=O)C5=CC(=CC=C35)C(=O)OC)C6=CC=CC=C6C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.856

>  <W2 Pf proliferation inhibition EC50 uM>
0.397

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2280
  Mrv1591402191617072D          

 33 36  0  0  1  0            999 V2000
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 24 12  1  0  0  0  0
 24 25  1  0  0  0  0
  9 25  1  0  0  0  0
 24 26  1  1  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2280

>  <JC_XSMILES>
COC1=CC=CC(=C1)N2CCN(CCNCCC3=CC=CC=C3)[C@H](C2)CC4=CC=C(O)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.564

>  <W2 Pf proliferation inhibition EC50 uM>
0.397

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024691358

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2282
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -6.6724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -6.6724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760    5.0224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109    5.0224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 19 24  4  0  0  0  0
 20 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 34 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2282

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NCCN2)C3=CC=CC4=C(C=CC=C34)C(=O)NC5=CC=C(C=C5)C6=NCCN6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0839

>  <W2 Pf proliferation inhibition EC50 uM>
0.397

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016806723

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2284
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 13 27  4  0  0  0  0
 27 28  4  0  0  0  0
 10 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2284

>  <JC_XSMILES>
CC(=O)N1CCN(CC1)C2=CC=C(NC(=S)NC(=O)C3=CC=C(C)C=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.79

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>95.69

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2294
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  6 15  4  0  0  0  0
 10 15  4  0  0  0  0
  4 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
 23 28  4  0  0  0  0
 17 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2294

>  <JC_XSMILES>
CC1=CC(NC2=CC=CC3=CC=CC=C23)=NC(NC4=CC=CC5=CC=CC=C45)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2738

>  <W2 Pf proliferation inhibition EC50 uM>
0.395

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2295
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    0.7932   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6033   -4.7389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8734   -6.1421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0632   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9535   -5.2066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4936   -5.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3038   -5.6743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8439   -6.2980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5738   -7.0775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1139   -7.7012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9240   -7.5452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4641   -8.1689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2743   -8.0130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8144   -8.6366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6245   -8.4807    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8945   -7.7012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5443   -9.4162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7342   -9.5721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1941   -8.9484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3839   -9.1043    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8439   -8.4807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0337   -8.6366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6540   -6.1421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1941   -6.7657    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.9240   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7342   -5.2066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0042   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8144   -4.2711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3544   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0844   -5.6743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6245   -6.2980    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.2743   -5.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  2  0  0  0  0
  9 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2295

>  <JC_XSMILES>
CCN(CC)CCCN(CC1=CC2=CC(OC)=CC=C2NC1=O)C(=S)NC3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.798

>  <W2 Pf proliferation inhibition EC50 uM>
0.809

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.49

>  <Powder data?>
Yes

>  <IFI value>
0.080357143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2305
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
  8 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2305

>  <JC_XSMILES>
CCOC(=O)COC1=C(CCCCC2CCCCC2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0581

>  <W2 Pf proliferation inhibition EC50 uM>
1.217

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.04

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2306
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 19 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 10 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
  7 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2306

>  <JC_XSMILES>
CCCNC(=O)C1=CC=C(OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.614

>  <W2 Pf proliferation inhibition EC50 uM>
0.392

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2313
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.2228   -1.9441    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843    0.2692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3821   -2.8503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9868   -3.4115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8032   -4.2158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0149   -4.4590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4101   -3.8978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5937   -3.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843   -2.5075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7001   -2.3845    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829   -3.2754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0973   -3.9204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7959   -4.6884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3103   -5.3334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0089   -6.1014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1931   -6.2244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6787   -5.5793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9801   -4.8114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  1  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2313

>  <JC_XSMILES>
FC1=CC=C2NC(=O)CN(C(C3=CC=CC=C3)C2=C1)C(=O)CCC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.072

>  <W2 Pf proliferation inhibition EC50 uM>
1.295

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.24

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2323
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2323

>  <JC_XSMILES>
CN(C)CCNC1=CC(=NC2=CC=CC=C12)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.692

>  <W2 Pf proliferation inhibition EC50 uM>
0.819

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.22

>  <Powder data?>
Yes

>  <IFI value>
0.016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-233
  Mrv1591402191617072D          

 38 44  0  0  0  0            999 V2000
    5.0650   -2.5745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8934   -1.7675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5065   -1.2155    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2912   -1.4704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4627   -2.2774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8496   -2.8294    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3350   -0.4085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5504   -0.1536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3789    0.6534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9920    1.2054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7766    0.9505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9481    0.1435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8204    2.0124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1530    3.1684    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9600    3.3400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3725    2.6255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1929    2.5392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6779    3.2067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4983    3.1204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8339    2.3668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3490    1.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5285    1.7856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5399    3.7205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7553    3.4655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1422    4.0175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3137    4.8245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0983    5.0795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7114    4.5274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  3  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 15 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 14 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  4  0  0  0  0
 37 38  4  0  0  0  0
 30 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-233

>  <JC_XSMILES>
C1CN(CCO1)C2=CC=C(C=C2)N3C(N(N=C3C4=CC=CC=C4)C5=CC=CC=C5)C6=CC=C7OCOC7=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.68

>  <W2 Pf proliferation inhibition EC50 uM>
1.777

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2330
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2330

>  <JC_XSMILES>
CCC[N+]1=CC=C(\C=C\C2=CC=C(Br)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.645

>  <W2 Pf proliferation inhibition EC50 uM>
0.382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2351
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
  2 20  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2351

>  <JC_XSMILES>
CC1=C(CC(=O)C2=CC=CS2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.237

>  <W2 Pf proliferation inhibition EC50 uM>
0.2901

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.75

>  <Powder data?>
Yes

>  <IFI value>
0.065789474

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-236
  Mrv1591402191617072D          

 47 52  0  0  0  0            999 V2000
   -3.4618   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1118   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
  2 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  2  0  0  0  0
 37 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
 35 45  4  0  0  0  0
 45 46  4  0  0  0  0
 32 46  4  0  0  0  0
 30 47  4  0  0  0  0
 26 47  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-236

>  <JC_XSMILES>
CC(C)(C1=CC=C(OC2=CC=C(NC(=O)C3=CC=CC=C3)C=C2)C=C1)C4=CC=CC(OC5=CC=C(NC(=O)C6=CC=CC=C6)C=C5)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.564

>  <W2 Pf proliferation inhibition EC50 uM>
1.772

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2362
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    1.3296   -5.0356    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.5845   -4.2510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3691   -4.5059    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7999   -3.9960    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8394   -3.4663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2874   -2.8532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5423   -2.0686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3493   -1.8971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9013   -2.5102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6464   -3.2948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083   -2.3387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -1.5540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533   -0.8866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -0.2192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083    0.5655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2603    1.1785    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0054    1.9632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5574    2.5763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3644    2.4047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9164    3.0178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7234    2.8463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9784    2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4263    1.4486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6194    1.6201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0673    1.0070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 11  9  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 17 26  1  0  0  0  0
 15 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 12 32  1  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2362

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(=C1)N=C2C(=O)N(CN3CCC4=CC=CC=C4C3)C5=CC=CC=C25

>  <PF proliferation inhibition 3D7 EC50 uM>
8.38

>  <W2 Pf proliferation inhibition EC50 uM>
3.71

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2365
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.1304   -1.4614    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0412   -0.6544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8481   -0.8260    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7658   -0.4829    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.2127    0.1525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4004    0.7046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2289    1.5115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5557    1.7665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7273    2.5735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5119    2.8284    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6834    3.6354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1314    4.2485    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5439    4.9629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3509    4.7914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4371    3.9709    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1516    3.5584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8660    3.9709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1516    2.7334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5641    2.0189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7391    2.0189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1688    1.2144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9973    0.4075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 20  1  0  0  0  0
  8 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2365

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(CSC2=NCCN2C(=O)C3CC3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6.08

>  <W2 Pf proliferation inhibition EC50 uM>
>3.7

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2369
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    1.3222    7.2402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.2402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    9.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    9.3027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926    1.0206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2369

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)C2=CN=C(NCCCN3C=CN=C3)N=C2NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.611

>  <W2 Pf proliferation inhibition EC50 uM>
0.369

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2371
  Mrv1591402191617072D          

 47 53  0  0  0  0            999 V2000
   -2.6462    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 18 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 14 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 12 33  4  0  0  0  0
 33 34  4  0  0  0  0
 10 34  4  0  0  0  0
  2 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
 35 42  1  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 42 47  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  34
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2371

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NC3=CC(NC(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)=CC=C3N2)C(C6=CC=CC=C6)C7=CC=CC=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
4.45

>  <W2 Pf proliferation inhibition EC50 uM>
3.68

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2379
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    5.7158   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -4.6480    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -6.0770    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1826   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7346    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3221    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5152    0.8205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 15 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 12 30  4  0  0  0  0
 24 30  4  0  0  0  0
  8 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
  5 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2379

>  <JC_XSMILES>
FC(F)(F)C1=CN=C(NCCN2C(=O)C(NCC3=CC=CO3)=NC4=CC(Cl)=CC=C24)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.81

>  <W2 Pf proliferation inhibition EC50 uM>
2.331

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
63.8

>  <Powder data?>
Yes

>  <IFI value>
0.024691358

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2383
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
  7 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2383

>  <JC_XSMILES>
CN1C(=O)N(C)C2=CC(NC(=O)CCl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
1.465

>  <W2 Pf proliferation inhibition EC50 uM>
0.444

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.21

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2384
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.6646    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
 23 24  4  0  0  0  0
  6 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2384

>  <JC_XSMILES>
CCOC(=O)C1=C(C)C2=C(NCC3=CC=C(F)C=C3)N=CN=C2S1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>3.63

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2389
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.1486    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   22.1486    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.8631    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   22.8631   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   23.5775   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   22.1486   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   21.4341    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 18 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2389

>  <JC_XSMILES>
CCCCCCCCCC(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1264

>  <W2 Pf proliferation inhibition EC50 uM>
0.2064

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.71

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-240
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    7.0539    1.6837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2617    1.4534    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0651    0.6522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6606    0.0813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4640   -0.7199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6718   -0.9503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0762   -0.3793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2840   -0.6097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0874   -1.4109    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2952   -1.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0986   -2.4424    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6996   -1.0703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8963   -0.2691    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6601    0.0428    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5995    0.8656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7983    1.0622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3637    0.3610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1045   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2799   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1547   -0.9900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1101    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3245    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1491    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5837    1.8150    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4083    1.7892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8429    2.4905    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2729    0.4219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 26 27  2  0  0  0  0
  7 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-240

>  <JC_XSMILES>
COC1=CC=CC(CNC(=O)CN2N=CC3=C2C4=CC(C)=CC=C4OC3=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.733

>  <W2 Pf proliferation inhibition EC50 uM>
1.763

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2407
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.5572    3.7225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018    4.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1608    4.6056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9368    0.2971    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9937   -0.7363    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904    1.1740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404    1.1740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2407

>  <JC_XSMILES>
CC1=CC(C)=CC(=C1)C(=O)NC2=C3CS(=O)(=O)CC3=NN2C4=CC=CC(C)=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.329

>  <W2 Pf proliferation inhibition EC50 uM>
0.358

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2414
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
  4 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 24 30  4  0  0  0  0
 20 31  4  0  0  0  0
 31 32  4  0  0  0  0
  2 32  4  0  0  0  0
 17 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2414

>  <JC_XSMILES>
CC1=CC(NC2=CC=CC(=C2)C(F)(F)F)=NC3=CC=C(NC(=O)C4=CN=CC(Br)=C4)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
2.452

>  <W2 Pf proliferation inhibition EC50 uM>
3.001

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>84.43

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2416
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033   -5.6645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -4.2355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2416

>  <JC_XSMILES>
CN(CC1=CC=CC=C1)C(=O)CCNS(=O)(=O)C2=CC(Br)=CN=C2N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.614

>  <W2 Pf proliferation inhibition EC50 uM>
0.355

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2423
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 20 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2423

>  <JC_XSMILES>
CCCCCC1=CC=C(C=C1)C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.386

>  <W2 Pf proliferation inhibition EC50 uM>
0.353

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.031578947

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2427
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2427

>  <JC_XSMILES>
CC(=O)NC1=NC(=CS1)C2=CC=C(F)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.52

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2428
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    1.8913   -5.6992    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.0663   -5.6992    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.6538   -6.4137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -2.8414    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
  4 10  4  0  0  0  0
  7 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 21 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 20 35  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2428

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C(Cl)=C1)C(=O)OC2=CC=CC=C2C3=C(NC4CCCCC4)N5C=CC=CC5=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.352

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028037383

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2437
  Mrv1591402191617072D          

 23 23  0  0  0  0            999 V2000
    2.3178   -3.5014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6680   -3.9691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9381   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2081   -4.5927    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0182   -4.4368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2883   -3.6573    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5583   -5.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3685   -4.9046    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -5.5282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7187   -5.3723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2588   -5.9959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0689   -5.8400    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3390   -5.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9887   -6.7755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1786   -6.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385   -6.3077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8284   -6.4637    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2883   -5.8400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6385   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4181   -4.3950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8590   -3.8550    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9086   -3.3454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 10 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 20 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2437

>  <JC_XSMILES>
CCC(C)NC(=O)CN(C1=CC(OC)=CC=C1OC)S(C)(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.438

>  <W2 Pf proliferation inhibition EC50 uM>
0.349

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.04

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2443
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    0.5047    2.7664    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  1   9   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2443

>  <JC_XSMILES>
ClC1=CC=CC=C1C[N+]2=C3CCCN3C(=C2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.327

>  <W2 Pf proliferation inhibition EC50 uM>
3.47

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2449
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -4.5975   -0.5739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5975   -1.3989    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8830   -1.8114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1686   -1.3989    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8830   -2.6364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2156   -3.1214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4705   -3.9060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2955   -3.9060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5505   -3.1214    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4310   -2.8664    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1760   -3.6510    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6859   -2.0818    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6463   -2.6115    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4748   -1.8045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6902   -1.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0771   -2.1016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2486   -2.9086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0332   -3.1635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3645   -3.4606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1714   -3.2891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5839   -4.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0319   -4.6167    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2782   -4.2811    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5070   -2.5354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0221   -1.8680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3576   -1.1143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1781   -1.0281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6630   -1.6955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3275   -2.4492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  6 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 20 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  23
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2449

>  <JC_XSMILES>
COC(=O)C1=C(C=CS1)S(=O)(=O)N2CCCC(C2)C3=C(C=NN3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.028

>  <W2 Pf proliferation inhibition EC50 uM>
3.44

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2451
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    2.4308   -4.1237    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.8787   -3.5106    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0717   -3.6821    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1337   -2.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5816   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1956   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9406   -2.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5743    0.9271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 13 24  1  0  0  0  0
 24 25  3  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1  23
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2451

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)N2C(=N)C(=CC3=C2C4=CC=CC=C4N3)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.53

>  <W2 Pf proliferation inhibition EC50 uM>
3.44

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2454
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309    0.5230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559    1.9520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
  8 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
  5 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2454

>  <JC_XSMILES>
FC(F)(F)C1=CN=C(NCCNC(=O)CCl)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.453

>  <W2 Pf proliferation inhibition EC50 uM>
0.612

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.82

>  <Powder data?>
Yes

>  <IFI value>
0.01369863

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2457
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -6.2621   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5476   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5476   -0.6217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8331   -0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1187   -0.6217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1187   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4042   -1.8592    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6897   -0.6217    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9753   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -1.4467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5463   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5463   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1681   -3.0967    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8826   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5971   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3116   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0260   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7077   -2.6319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4960   -2.8751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7974   -3.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3849   -4.3575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5691   -4.4805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9644   -3.9193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -3.0967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9753   -2.6842    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2608   -3.9217    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.9753   -4.3342    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.5463   -4.3342    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8331   -1.8592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 18 24  1  0  0  0  0
 13 25  4  0  0  0  0
 25 26  4  0  0  0  0
 10 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
  6 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  CHG  2  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2457

>  <JC_XSMILES>
CC1=CC=CC(NC(=O)C2=CC=C(NCCCC3CCCCCC3)C(=C2)[N+]([O-])=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.441

>  <W2 Pf proliferation inhibition EC50 uM>
0.643

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.81

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-246
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    4.8229    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  9 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-246

>  <JC_XSMILES>
CC1=NC2=NN=NN2C(NC3=CC=C(Cl)C=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.642

>  <W2 Pf proliferation inhibition EC50 uM>
1.747

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2460
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
  6 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2460

>  <JC_XSMILES>
OC1=CC=CC2=CC=C(NC3=CC=CC=N3)N=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.679

>  <W2 Pf proliferation inhibition EC50 uM>
0.3023

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.87

>  <Powder data?>
Yes

>  <IFI value>
0.152173913

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2467
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    4.8938    6.6165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1488    5.8318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5967    5.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8517    4.4341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2996    3.8210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025    2.4233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1956    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9406    3.3795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4927    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 17 22  4  0  0  0  0
 14 22  4  0  0  0  0
  8 23  4  0  0  0  0
 23 24  4  0  0  0  0
  5 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2467

>  <JC_XSMILES>
CCCCC1=CC=C(NC2=NC=NC3=C2C4=C(CCCC4)S3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
11.38

>  <W2 Pf proliferation inhibition EC50 uM>
3.39

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2471
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2471

>  <JC_XSMILES>
CN(C)C(=S)NN=C(C)C1=CC=CC=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3107

>  <W2 Pf proliferation inhibition EC50 uM>
0.338

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.198275862

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2475
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570    2.3174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570    0.9826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
  9 28  4  0  0  0  0
  6 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2475

>  <JC_XSMILES>
ClC1=CC=CC(CSC2=NC(NC3=CC=C4OCOC4=C3)=C5C=CC=CC5=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.17

>  <W2 Pf proliferation inhibition EC50 uM>
2.788

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>82.94

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2477
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8171   -2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1527   -1.5818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9732   -1.6680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2477

>  <JC_XSMILES>
CCCCCCN1C2=C(CCCC2)C(=N)C3=C1CCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.364

>  <W2 Pf proliferation inhibition EC50 uM>
0.336

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2485
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2485

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)C3=CC=C(Br)C=C3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2183

>  <W2 Pf proliferation inhibition EC50 uM>
0.291

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.73

>  <Powder data?>
No

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2496
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2496

>  <JC_XSMILES>
COC1=CC=C2N(CC3=CC=CC=C3)C=CC(=C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.451

>  <W2 Pf proliferation inhibition EC50 uM>
0.33

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2504
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2504

>  <JC_XSMILES>
ClC1=CC=C2C(NCCCCNC(=O)CC3=CC=CC=C3)=CC=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.33

>  <W2 Pf proliferation inhibition EC50 uM>
0.3156

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.6

>  <Powder data?>
No

>  <IFI value>
0.048076923

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2505
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3489   -0.6482    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5365    0.7590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8186    1.5343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6311    1.6776    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1614    1.0456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8792    0.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9133    2.4528    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7257    2.5961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0079    3.3713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8204    3.5146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3507    2.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0685    2.1073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2560    1.9641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 19 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 31 32  1  0  0  0  0
 27 32  1  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2505

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2=CC3=CC(=CC=C3O2)C4(O)CCN(CC4)CC5CCC=CC5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.381

>  <W2 Pf proliferation inhibition EC50 uM>
0.824

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.12

>  <Powder data?>
Yes

>  <IFI value>
0.025423729

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2525
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.3222    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -2.8911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 14 23  4  0  0  0  0
 11 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2525

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=CSC(NC3=CC=C(O)C=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.964

>  <W2 Pf proliferation inhibition EC50 uM>
3.21

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2527
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 17 23  4  0  0  0  0
  7 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2527

>  <JC_XSMILES>
CC1=CC(C)=CC(NC(=S)NNC2=CC=NC3=CC(Cl)=CC=C23)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.236

>  <W2 Pf proliferation inhibition EC50 uM>
2.168

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
67.69

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-253
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  2 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-253

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)N2CCCCC2)C3=CC4=CC=CC=C4O3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.297

>  <W2 Pf proliferation inhibition EC50 uM>
0.634

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>3.66

>  <Powder data?>
No

>  <IFI value>
0.109375

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2534
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  6 12  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2534

>  <JC_XSMILES>
CC1=CC(NC2=CC=CC(F)=C2)=NC(NCC3=CC=CC=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0722

>  <W2 Pf proliferation inhibition EC50 uM>
0.664

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.84

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2536
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -1.2546   -5.9861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957   -5.5184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -5.0507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -4.4270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -4.5829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -5.9861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -3.9593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -3.1798    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -2.5561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -1.7766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -1.1529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864   -1.3088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -2.0884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -2.7120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864   -3.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -3.6475    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -4.1152    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -5.5184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -6.4539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4966   -5.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2265   -5.0507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7666   -4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5767   -4.5829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -3.6475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -3.0238    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -3.4916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657   -4.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -3.9593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.1798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -2.5561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -1.7766    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -1.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -2.7120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 31 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2536

>  <JC_XSMILES>
CCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=CC(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.614

>  <W2 Pf proliferation inhibition EC50 uM>
0.318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2539
  Mrv1591402191617072D          

 30 33  0  0  1  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  6  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 19 18  1  0  0  0  0
 19 10  1  6  0  0  0
 14 19  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  6 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2539

>  <JC_XSMILES>
CC1=CC=CC(CC(=O)N2CCC[C@@H]3CN(CC[C@H]23)C(=O)CCC4=CC=CN=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.317

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2541
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.7224    1.4760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099    0.7615    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224    0.0470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971   -2.7326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422   -3.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648   -3.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0198   -4.4734    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8267   -4.6449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619   -2.2910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8242   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2721   -2.7326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5271   -3.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3341   -3.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8861   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6312   -2.2910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1832   -1.6779    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
  7 14  4  0  0  0  0
  6 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 16 27  1  0  0  0  0
  5 27  1  0  0  0  0
 27 28  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2541

>  <JC_XSMILES>
COCCN1C(C2=CC=C(SC)C=C2)C3=C(NN=C3C4=CC=CC=C4O)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
7.39

>  <W2 Pf proliferation inhibition EC50 uM>
2.778

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>87.65

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-255
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8974   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5619   -5.1657    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0468   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8673   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3522   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0166   -7.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1962   -7.2542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8606   -8.0079    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3455   -8.6753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7112   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8974   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 12 19  4  0  0  0  0
  9 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
  6 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-255

>  <JC_XSMILES>
CCOC(=O)C1=C(C)C(CNC2=CC=CC(OC)=C2)=C(C)N1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.506

>  <W2 Pf proliferation inhibition EC50 uM>
1.203

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.98

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2550
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.2331   -0.5675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6499    0.6563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8214    1.4633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2083    2.0153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4237    1.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2522    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.6244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8185   -0.0113    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8796   -1.1764    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.6534   -0.0724    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  4 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
  2 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2550

>  <JC_XSMILES>
OC1(CC(=NN1C2=NN=CC(=N2)C3=CC=CC=C3)C4=CC=CC=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2358

>  <W2 Pf proliferation inhibition EC50 uM>
0.3143

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2551
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    1.4158   -0.5550    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033    0.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783    0.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2342    0.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2342    2.3029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783    3.0173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033    3.0173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158    2.3029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158    0.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2408    0.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533    1.5884    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633    2.2558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633    0.9210    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2551

>  <JC_XSMILES>
OC1=CC=C2C=CC=CC2=C1CNC3=NC4=CC=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.652

>  <W2 Pf proliferation inhibition EC50 uM>
0.45

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.33

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2553
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.8340    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1195    1.5137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1195    0.6887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4050    0.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6906    0.6887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4050   -0.5488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0725   -1.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8175   -1.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9925   -1.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.0338    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5076   -2.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7625   -3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5472   -3.5254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0951   -3.7554    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5723   -3.2704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3174   -2.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8023   -1.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4668   -1.0647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9517   -0.3973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6161    0.3564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1010    1.0239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7722   -0.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2571    0.1839    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9215    0.9376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1077   -1.2372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6228   -1.9046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9584   -2.6583    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2553

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(O1)C2=C(C)ON=C2C3=CC(CC)=C(OC)C=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.927

>  <W2 Pf proliferation inhibition EC50 uM>
0.433

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.82

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2557
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 16 25  4  0  0  0  0
 11 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2557

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNCCCN(C)C)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.26

>  <W2 Pf proliferation inhibition EC50 uM>
0.67

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.43

>  <Powder data?>
Yes

>  <IFI value>
0.025641026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2558
  Mrv1591402191617072D          

 40 45  0  0  0  0            999 V2000
    0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109  -11.6224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559  -12.4070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309  -12.4070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760  -11.6224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 33 36  1  0  0  0  0
 36 37  2  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 36 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2558

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NCCN2)C3=CC=C(C=C3)C4=CC=C(C=C4)C(=O)NC5=CC=C(C=C5)C6=NCCN6

>  <PF proliferation inhibition 3D7 EC50 uM>
1.318

>  <W2 Pf proliferation inhibition EC50 uM>
0.364

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.66

>  <Powder data?>
No

>  <IFI value>
0.043956044

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2572
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2572

>  <JC_XSMILES>
COC1=CC=C2N=C3C=CC=CC3=C(N)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.133

>  <W2 Pf proliferation inhibition EC50 uM>
0.1756

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.72

>  <Powder data?>
Yes

>  <IFI value>
0.00990099

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2584
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936    0.1410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782    0.3960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782    1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3457    1.7059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936    1.4759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -1.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -2.7246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710   -2.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161   -3.6807    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3909   -3.8522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -0.8853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -1.0568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2584

>  <JC_XSMILES>
CCOC(=O)N1CCC2=C(C1)SC(NCC3=CC=C(C)O3)=C2C(=O)NC4=CC=C(OC)C=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
9.1

>  <W2 Pf proliferation inhibition EC50 uM>
3.006

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2609
  Mrv1591402191617072D          

 34 35  0  0  0  0            999 V2000
    1.5489   -6.7595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9453   -5.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9360   -6.4163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1342   -7.2172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5397   -7.7892    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7379   -8.5900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5305   -8.8189    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.1621    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3508   -8.9333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5581   -8.7045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1220   -9.7259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5796   -8.1406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9268   -7.4460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1250   -8.2468    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5213   -6.8739    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3140   -7.1028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5121   -7.9036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3047   -8.1324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8992   -7.5604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6919   -7.7892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8900   -8.5900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2955   -9.1621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5029   -8.9333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9084   -6.5307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7103   -5.7299    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7011   -6.7595    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2955   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0882   -6.4163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6826   -5.8443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4753   -6.0731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6734   -6.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0790   -7.4460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2863   -7.2172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 10 13  1  0  0  0  0
  5 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 17 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2609

>  <JC_XSMILES>
CC(C)CC(NC(=O)OC(C)(C)C)C(=O)NC(CC1=CC=CC=C1)C(=O)OCC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.947

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2612
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 15 23  1  0  0  0  0
 11 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2612

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2C(=C(C)NC3=C2C(=O)CC(C)(C)C3)C(=O)OCCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
10.72

>  <W2 Pf proliferation inhibition EC50 uM>
2.935

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2613
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 23 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2613

>  <JC_XSMILES>
CN(CC1=CC=CC=C1)C(=O)C2=CN(C(=O)C3=CC=CC=C23)C4=CC=C(C)C(C)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.84

>  <W2 Pf proliferation inhibition EC50 uM>
2.934

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2618
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -3.3904    0.1995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7230   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9384   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9384   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7230   -1.1104    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -1.5229    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 10 26  4  0  0  0  0
  7 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2618

>  <JC_XSMILES>
CC1=NC(=CS1)C2=NC3=C(CN(CC3)C(=O)COC4=CC=C(Cl)C=C4)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.66

>  <W2 Pf proliferation inhibition EC50 uM>
2.923

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2624
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 18 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 14 31  4  0  0  0  0
 31 32  4  0  0  0  0
 11 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 35 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2624

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)C2=CN=C(NCCC(C3=CC=CC=C3)C4=CC=CC=C4)N=C2NCC5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.527

>  <W2 Pf proliferation inhibition EC50 uM>
0.2915

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038834951

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-263
  Mrv1591402191617072D          

 40 42  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -13.2000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4138  -12.0730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5888  -13.5020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -13.2000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559  -13.5020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309  -12.0730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 19 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 12 31  4  0  0  0  0
  8 31  4  0  0  0  0
  7 32  1  0  0  0  0
 32 33  2  0  0  0  0
  3 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 38 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-263

>  <JC_XSMILES>
CCN1C(=O)NC(C2=CC=CC(NC(=O)NC3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)=C2)C(=C1C)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
8.42

>  <W2 Pf proliferation inhibition EC50 uM>
6.01

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.3

>  <Powder data?>
Yes

>  <IFI value>
0.064516129

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2633
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    2.2465   -2.7473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6944   -3.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9494   -4.1450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3973   -4.7581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5904   -4.5866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6523   -5.5427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1673   -6.2102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3423   -6.2102    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0702   -6.9246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3423   -7.6391    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8952   -6.9246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3077   -6.2102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3077   -7.6391    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1327   -7.6391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5452   -6.9246    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3702   -6.9246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7827   -7.6391    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3702   -8.3536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5452   -8.3536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -9.1382    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9577   -9.6231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0439  -10.4436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7976  -10.7792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4650  -10.2942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3788   -9.4738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6251   -9.1382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6523   -6.8776    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369   -6.6227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369   -5.7977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -5.5427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7064   -6.2102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2215   -6.8776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
 21 26  4  0  0  0  0
  7 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  6 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2633

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)C(C)SC2=NC=NC3=C2OC4=CC=CC=C34)SC5=C1CCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.81

>  <W2 Pf proliferation inhibition EC50 uM>
2.901

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.085714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-264
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 25 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-264

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC(OC)=CC2=C1NC3=CC=C(C=C3)N4CCN(C)CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.091

>  <W2 Pf proliferation inhibition EC50 uM>
>1.701

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014084507

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2648
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
M  CHG  2  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2648

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C(Cl)C(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1371

>  <W2 Pf proliferation inhibition EC50 uM>
0.2261

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.92

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2653
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2653

>  <JC_XSMILES>
CNC(=O)C1=NN(C)C2=C1CC(CC2)NCC3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.834

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048780488

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2654
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
   -0.5912   -0.9600    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -0.2455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6282   -0.4170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0392   -1.5731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  1  5  4  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2654

>  <JC_XSMILES>
S1C=CC(=C1)C2=NC3=CC4=CC=CC=C4C=C3N=C2C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
3.44

>  <W2 Pf proliferation inhibition EC50 uM>
2.834

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2658
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.0366   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0366   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3692   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5686    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7546   -3.1497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2396   -3.8172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0601   -3.7309    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4725   -3.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2795   -3.1879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3658   -4.0084    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6121   -4.3440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4887   -1.5290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8174    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1695   -4.5710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9900   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4749   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2954   -4.0760    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.9628   -3.5910    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.6310   -4.8296    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0285   -2.0812    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4130   -0.7222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3716   -0.4673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5432    0.3397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0699    0.8918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8545    0.6369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0261   -0.1701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
  5 14  1  0  0  0  0
  2 14  1  0  0  0  0
 14 15  2  0  0  0  0
  4 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
  3 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  CHG  2  22   1  23  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2658

>  <JC_XSMILES>
OC1=C(C(N(CCCN2C=CN=C2)C1=O)C3=CC=CC=C3[N+]([O-])=O)C(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.83

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2663
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.2540   -4.7940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3591   -4.2420    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1876   -3.4350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5970   -3.1801    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -2.8830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -3.0545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -2.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -1.7269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2663

>  <JC_XSMILES>
COC(=O)C1CCCN1S(=O)(=O)C2=CC=C3C=CC=CC3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>4.94

>  <W2 Pf proliferation inhibition EC50 uM>
2.817

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2664
  Mrv1591402191617072D          

 31 37  0  0  0  0            999 V2000
    3.4130   -3.8099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9280   -3.1424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5925   -2.3888    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7640   -1.5818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0495   -1.1693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4364   -1.7213    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7720   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6005   -3.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3149   -3.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3149   -4.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0294   -4.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0294   -5.7570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3149   -6.1695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6005   -5.7570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6005   -4.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860   -4.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1715   -4.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5429   -4.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5429   -3.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1715   -3.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860   -3.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -2.7299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -1.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -1.4924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0714   -1.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7859   -1.4924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5004   -1.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5004   -2.7299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7859   -3.1424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0714   -2.7299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -3.1424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  3  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 16 21  4  0  0  0  0
  2 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 22 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2664

>  <JC_XSMILES>
OC1(N2CCN=C2C3=C1C4=CC=CC=C4C5=CC=CC=C35)C6=CC=C7C=CC=CC7=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2516

>  <W2 Pf proliferation inhibition EC50 uM>
0.2808

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.032520325

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2670
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2670

>  <JC_XSMILES>
CC(C)NCC(O)C1=CC=C2C=CC=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.455

>  <W2 Pf proliferation inhibition EC50 uM>
0.366

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.11

>  <Powder data?>
Yes

>  <IFI value>
0.008849558

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2672
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -3.9605    3.4011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1401    3.3149    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6551    3.9824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8347    3.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4991    3.1424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9840    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8045    2.5612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4991    1.8076    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 14 28  4  0  0  0  0
  9 28  4  0  0  0  0
 13 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2672

>  <JC_XSMILES>
CN1CCC2=C(C1)SC3=C2C(=O)N(C(SCC(=O)NCCC4=CC=CC=C4)=N3)C5=CC=C(Cl)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.307

>  <W2 Pf proliferation inhibition EC50 uM>
1.91

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.5

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2677
  Mrv1591402191617072D          

 38 44  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    4.8105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3921    4.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6470    4.1028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4540    3.9313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0060    4.5444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7511    5.3290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9441    5.5006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5316    6.2150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7866    6.9996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2345    7.6127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4276    7.4412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1726    6.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7246    6.0435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 10 22  1  0  0  0  0
 17 22  4  0  0  0  0
  2 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 24 38  4  0  0  0  0
 32 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2677

>  <JC_XSMILES>
OC(CN1CCN(CC1)C2C3=CC=CC=C3C4=CC=CC=C24)CN5C6=CC=C(Cl)C=C6C7=CC(Cl)=CC=C57

>  <PF proliferation inhibition 3D7 EC50 uM>
1.202

>  <W2 Pf proliferation inhibition EC50 uM>
0.2782

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2684
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -5.0013    9.6151    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   10.0276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8743    9.3132    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6993   10.7421    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   10.4401    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   10.0276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   10.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   10.0276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    9.2026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.7901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    7.9651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.5526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    6.7276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.3151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.4901    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.0776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.4901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.2526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.5382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.5382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    6.7276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.5526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    8.7901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    9.2026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 20  1  0  0  0  0
 14 21  4  0  0  0  0
 21 22  4  0  0  0  0
 11 22  4  0  0  0  0
  9 23  4  0  0  0  0
 23 24  4  0  0  0  0
  6 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2684

>  <JC_XSMILES>
FC(F)(F)OC1=CC=C(OC2=CC=C(NC(=O)C3CC3)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.67

>  <W2 Pf proliferation inhibition EC50 uM>
2.771

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015748031

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2686
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    0.9130   -0.8764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0171    0.3498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7621    1.1344    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0368   -2.7887    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8438   -2.9602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0987   -3.7449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5467   -4.3580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7397   -4.1864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4848   -3.4018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8017   -5.1426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6086   -5.3141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8636   -6.0987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3115   -6.7118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5046   -6.5403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2496   -5.7557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  3  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2686

>  <JC_XSMILES>
CC1=C(C#N)C2=NC3=CC=CC=C3N2C(=C1)N4CCN(CC4)C5=CC=CC=N5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.405

>  <W2 Pf proliferation inhibition EC50 uM>
2.764

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2692
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2692

>  <JC_XSMILES>
CCOC(=O)C1=CNC2=CC=C(C)C=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.704

>  <W2 Pf proliferation inhibition EC50 uM>
2.756

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2702
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  5 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  2  0  0  0  0
 14 20  1  0  0  0  0
  2 20  1  0  0  0  0
  3 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2702

>  <JC_XSMILES>
CC1=C(C(C2=CC=C(F)C(F)=C2)C3=C(CCCC3=O)N1)C(=O)OC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
6.23

>  <W2 Pf proliferation inhibition EC50 uM>
2.727

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2706
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -5.4178   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6077   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0676    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2575   -0.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9874   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1773   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6372   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8271   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5570   -1.3480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2870    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5231   -0.1007    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0632    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7932    1.3025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3333    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5420    2.4925    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9783    3.0949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2312    2.7448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4135    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2236    0.8348    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8734    0.3671    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6033   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8734   -1.8157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6835   -1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2236   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0337   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3038   -2.2834    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5738   -0.8802    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3839   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9240   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7342   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2743    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0844   -0.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3544   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8144   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0042   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5275   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3377   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 12 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
  5 38  4  0  0  0  0
 38 39  4  0  0  0  0
  2 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2706

>  <JC_XSMILES>
CC1=CC=C(CNC(=O)CSC2=NC3=C(SC=C3)C(=O)N2CCCCCC(=O)NCCC4=CC=CC=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.43

>  <W2 Pf proliferation inhibition EC50 uM>
2.716

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2713
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
  6 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2713

>  <JC_XSMILES>
CC1=CC=CC2=C(C)N=C(NC(N)=N)N=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3014

>  <W2 Pf proliferation inhibition EC50 uM>
0.443

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.38

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2720
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
 22 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2720

>  <JC_XSMILES>
COCCCNC(=O)C1=CC(NC(=O)CCCCl)=CC=C1N2CCC3=CC=CC=C3C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.331

>  <W2 Pf proliferation inhibition EC50 uM>
0.03042

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.128

>  <Powder data?>
No

>  <IFI value>
0.02173913

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2724
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -7.8230   -3.7646    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -7.1556   -3.2797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2418   -2.4592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5744   -1.9743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8207   -2.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7344   -3.1303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4019   -3.6152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -1.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -0.9999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -0.7450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -2.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  30
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2724

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=CC=C(O2)C(=O)NC3=CC=C(C=C3)C4=NC5=CC=CC=C5N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1927

>  <W2 Pf proliferation inhibition EC50 uM>
0.444

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.57

>  <Powder data?>
Yes

>  <IFI value>
0.119402985

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-273
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -5.2520    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -3.8230    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-273

>  <JC_XSMILES>
CN(C)CCNC1=CC(=NC(=N1)C2=CC=NC=C2)C3=CC=CC(=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.68

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2735
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
  6 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2735

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(C2=CC=CC=C2)C3=CC=C(O)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
1.697

>  <W2 Pf proliferation inhibition EC50 uM>
2.655

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025423729

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2746
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    3.1465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9900    2.8916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8185    3.6986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1806    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5306    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.9979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 13  1  0  0  0  0
  5 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2746

>  <JC_XSMILES>
BrC1=CC2=C(N(CC2)C(=O)C3CC3)C(=C1)S(=O)(=O)N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
8.14

>  <W2 Pf proliferation inhibition EC50 uM>
2.636

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2755
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665    3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376    3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2755

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)N2C(C)=CC=C2C

>  <PF proliferation inhibition 3D7 EC50 uM>
2.932

>  <W2 Pf proliferation inhibition EC50 uM>
1.326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
50.92

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2756
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
  3 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  2  0  0  0  0
 30 32  4  0  0  0  0
 22 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2756

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)C2=CC=C(C)C=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.418

>  <W2 Pf proliferation inhibition EC50 uM>
0.174

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.69

>  <Powder data?>
No

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2759
  Mrv1591402191617072D          

 21 21  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 13 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2759

>  <JC_XSMILES>
CCCCCCC1=CC=C(C=C1)\C(=C/N(C)C)C=[N+](C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.335

>  <W2 Pf proliferation inhibition EC50 uM>
0.2596

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2770
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
 12 22  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2770

>  <JC_XSMILES>
CCOC1=CC=C2N=C(C)C=C(NC3=CC=C(C)C(Cl)=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.24

>  <W2 Pf proliferation inhibition EC50 uM>
0.348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.55

>  <Powder data?>
Yes

>  <IFI value>
0.078431373

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2778
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
   -3.3286   -3.1332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6440   -2.6728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7004   -1.8497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0158   -1.3893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2748   -1.7520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5902   -1.2916    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6467   -0.4685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3877   -0.1058    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0379   -0.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0185    0.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6661    1.2753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4071    0.9127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0917    1.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8327    1.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8891    0.1873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2045   -0.2731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4635    0.0896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7789   -0.3708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8785    0.1873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1939   -0.2731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5471    0.0896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6035    0.9127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0811    1.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8221    1.0104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2184   -2.5750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9030   -3.0354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 11 24  1  0  0  0  0
 19 24  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2778

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2CC3C4=CC=CC=C4C2C5=CC=CC=C35)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.551

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2785
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.7445   -3.8255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195   -3.8255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -4.5399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -4.5399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -3.8255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -3.1110    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4271   -2.3264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6425   -2.0714    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0294   -2.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7552   -2.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3683   -2.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1529   -2.6656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3245   -1.8586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7114   -1.3066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9268   -1.5615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0945   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7620   -2.3264    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -3.1110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0945   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3801   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3801    0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0945    0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8090    0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8090   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5235   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2380   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2380    0.2211    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9524   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6669   -0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3814   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0958   -0.6039    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
  6 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2785

>  <JC_XSMILES>
CC1=CC=CN2C(NCC3=CC=CC=C3)=C(N=C12)C4=CC=CC=C4OC(=O)CCCCl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.781

>  <W2 Pf proliferation inhibition EC50 uM>
0.2534

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038095238

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2790
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    6.4235    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615    2.8649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614   -0.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2163   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0233   -1.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5753   -1.2298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3204   -0.4451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8724    0.1680    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.5134   -0.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  2  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
 14 28  4  0  0  0  0
  9 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2790

>  <JC_XSMILES>
CN(C)CCN1C=NC2=C(C1=O)C3=C(CC(CC3)NCC4=CC=CC(Cl)=C4)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.748

>  <W2 Pf proliferation inhibition EC50 uM>
0.479

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.94

>  <Powder data?>
Yes

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2793
  Mrv1591402191617072D          

 31 32  0  0  0  0            999 V2000
    1.3333  -10.6893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8734  -10.0657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6835  -10.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2236   -9.5980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9535   -8.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8734   -7.8829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0337   -9.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5738   -9.1302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3839   -9.2861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9240   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7342   -8.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2743   -8.1948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0844   -8.3507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3544   -9.1302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8144   -9.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0042   -9.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4641  -10.2216    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.6540  -10.0657    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.7342  -11.0012    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1646   -9.2861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4346  -10.0657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7047   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.5148   -8.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0549   -8.1948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8650   -8.3507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1351   -9.1302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9452   -9.2861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5950   -9.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8650  -10.5334    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.7848   -9.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 15 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2793

>  <JC_XSMILES>
CCCN(CCC)CCCNC1=CC=C(C=C1[N+]([O-])=O)C(=O)NC2=CC=C(C)C(F)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1463

>  <W2 Pf proliferation inhibition EC50 uM>
0.2676

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.61

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2798
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
  6 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2798

>  <JC_XSMILES>
COC1=CC=C(C=C1OC2CCN(CC2)C(C)=O)C(=O)NCCC3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.06

>  <W2 Pf proliferation inhibition EC50 uM>
2.515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2803
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543   -7.9099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -8.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -8.6945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194   -7.9099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2803

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)C2=CN=C(NCCCN3C=CN=C3)N=C2NCCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2048

>  <W2 Pf proliferation inhibition EC50 uM>
0.32

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.76

>  <Powder data?>
Yes

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2806
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    6.1368    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.0051    1.8414    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  CHG  2  23   1  24  -1
M  STY  1   1 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2806

>  <JC_XSMILES>
COC1=CC=C(NC2=NC=NC3=C2C=C(N3)C4=CC=CC(=C4)[N+]([O-])=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.493

>  <W2 Pf proliferation inhibition EC50 uM>
2.503

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2807
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
  4 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2807

>  <JC_XSMILES>
CCOC1=CC=C2N=C(C)C=C(NC3=CC=C(Br)C=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1135

>  <W2 Pf proliferation inhibition EC50 uM>
0.1819

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.29

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2815
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.0470    2.8379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
  7 31  4  0  0  0  0
  2 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2815

>  <JC_XSMILES>
CC1=CC=C(O)C(NC(=O)C2=C3N=C(C=C(N3N=C2)C(F)(F)F)C4=CC=C(Br)C=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.45

>  <W2 Pf proliferation inhibition EC50 uM>
2.482

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2822
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2822

>  <JC_XSMILES>
COC(=O)C1=CC=NN(C2=CC=CC=C2)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.694

>  <W2 Pf proliferation inhibition EC50 uM>
0.319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.94

>  <Powder data?>
No

>  <IFI value>
0.025974026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2825
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0572   -6.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2502   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8377   -5.6400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3897   -5.0269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2182   -4.2200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4336   -3.9650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2621   -3.1581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8752   -2.6060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6598   -2.8610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8313   -3.6679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9146   -7.1082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5791   -7.8619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1610   -6.7726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6683   -7.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2825

>  <JC_XSMILES>
CC(C)CN(CC(=O)NC1=CC(=NN1C2=CC=CC=C2)C(C)(C)C)C(=O)COC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.773

>  <W2 Pf proliferation inhibition EC50 uM>
0.432

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.55

>  <Powder data?>
Yes

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2834
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -7.5962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -1.4124    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -0.5874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  2  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 27 35  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  35
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2834

>  <JC_XSMILES>
CN(C1=CC=CC=C1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3=CC=C(C=C3)C4=NC5=CC=CC=C5N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.788

>  <W2 Pf proliferation inhibition EC50 uM>
1.044

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.77

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-284
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.0145   -1.0164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6789    2.5951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2920    3.1471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0065    2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8350    1.9277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    2.5559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  7 11  4  0  0  0  0
  6 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
  2 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-284

>  <JC_XSMILES>
NC1=C(C#N)C(C2=COC=C2)C3=C(O1)C4=CC=CC=C4OC3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.158

>  <W2 Pf proliferation inhibition EC50 uM>
>1.663

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2840
  Mrv1591402191617072D          

 43 48  0  0  0  0            999 V2000
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 23 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 34 43  4  0  0  0  0
 38 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2840

>  <JC_XSMILES>
CCOC1=CC=CC=C1N2C(=O)C3=CC=CC=C3N=C2C(C)N(CC4=CC=CC=C4)C(=O)NC5=CC=CC6=CC=CC=C56

>  <PF proliferation inhibition 3D7 EC50 uM>
0.855

>  <W2 Pf proliferation inhibition EC50 uM>
0.2425

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2841
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
  6 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2841

>  <JC_XSMILES>
OC1=CC=CC(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2746

>  <W2 Pf proliferation inhibition EC50 uM>
0.2793

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.52

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2847
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.0367    2.8259    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8617    2.0009    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2117    2.0009    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -5.0116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0837   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3387   -6.2812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1637   -6.2812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4186   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 13 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2847

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(=C1)C2=CC(NCCCN3C=CN=C3)=NC(=N2)C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2043

>  <W2 Pf proliferation inhibition EC50 uM>
0.1856

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.72

>  <Powder data?>
No

>  <IFI value>
0.020408163

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-285
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-285

>  <JC_XSMILES>
CC1=CC=C(NC2=NC3=C(N)N=NC(N)=C3N=C2NC4=CC=C(C)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6.12

>  <W2 Pf proliferation inhibition EC50 uM>
2.209

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.29

>  <Powder data?>
Yes

>  <IFI value>
0.029850746

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2851
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.2498   -4.0609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7326    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8 23  4  0  0  0  0
 19 23  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2851

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=C[N+](CC3=CC=CC(C)=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.568

>  <W2 Pf proliferation inhibition EC50 uM>
0.493

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.56

>  <Powder data?>
Yes

>  <IFI value>
0.073170732

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2855
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4675    0.6985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2522    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9199   -1.5096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
  4 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2855

>  <JC_XSMILES>
O=C1OC(=NN1CC2=CC=CC=C2C#N)C3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2856
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -2.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0058   -3.1236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9620   -2.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1335   -1.2547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9181   -0.9998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5312   -1.5518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3597   -2.3588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5751   -2.6137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2856

>  <JC_XSMILES>
COC(=O)C1=C(C=NOC(=O)C2=CC=CC=C2)N(N=C1)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.29

>  <W2 Pf proliferation inhibition EC50 uM>
2.375

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010752688

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2860
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  7 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
  5 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 19 26  4  0  0  0  0
 17 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2860

>  <JC_XSMILES>
COC(=O)C1=CN(CC2=CC=C(Cl)C=C2)C=C(C1C3=CC=C(Cl)C(Cl)=C3)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.19

>  <W2 Pf proliferation inhibition EC50 uM>
2.361

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035294118

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2861
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -2.1082    0.1995    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4407   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6561   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2861

>  <JC_XSMILES>
BrC1=CC=C(O1)C2=[N+](CC3=CC=CC=C3)C4=CC=CC=C4N2CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1669

>  <W2 Pf proliferation inhibition EC50 uM>
0.2598

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.01

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2868
  Mrv1591402191617072D          

 16 15  0  0  0  0            999 V2000
   -5.9072    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1927    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4783    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7638    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7638    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0493    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3349    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6204    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9059    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1914    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  2  0  0  0  0
  9  8  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2868

>  <JC_XSMILES>
CCOC(=O)NN=CC=NNC(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1989

>  <W2 Pf proliferation inhibition EC50 uM>
0.2348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010869565

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2873
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    2.7474   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -2.9980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8099   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2224   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4599   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2849   -4.4270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6974   -5.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5224   -5.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9349   -5.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7599   -5.8559    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.1724   -6.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5224   -6.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9349   -7.2849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7599   -7.2849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6974   -6.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2849   -5.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4599   -5.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9078   -6.4690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1541   -6.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2404   -5.3130    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -5.1414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4397   -6.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4397   -7.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7252   -7.7834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0107   -7.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0107   -6.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7252   -6.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
 21 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2873

>  <JC_XSMILES>
CCN(CC)CCNC1=NC2=CC(OC)=C(OC)C=C2C3=NC(=NN13)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.672

>  <W2 Pf proliferation inhibition EC50 uM>
1.802

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
77.22

>  <Powder data?>
Yes

>  <IFI value>
0.068181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2874
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    3.5881    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    3.1465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2483    3.9535    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0947    2.3396    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7302    3.3181    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -0.1006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0947    0.7063    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.2483   -0.9076    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7302   -0.2722    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  4 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 14 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 12 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 31 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2874

>  <JC_XSMILES>
CN1N=C(C2=CC=CC=C2)C3=C(C=C(C(=O)C(F)(F)F)C3=C1C4=CC=CC=C4)C(=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
8.23

>  <W2 Pf proliferation inhibition EC50 uM>
2.332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015384615

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2879
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 15 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
 23 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 39 40  4  0  0  0  0
 34 40  4  0  0  0  0
 40 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2879

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)C2=CC=CC(OC)=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=C(Cl)C=C5C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.519

>  <W2 Pf proliferation inhibition EC50 uM>
0.2321

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028301887

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2882
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  2  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 20 29  4  0  0  0  0
  7 29  4  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2882

>  <JC_XSMILES>
C=CCNC(=O)C1=CC2=C(N=C3C=CC=CN3C2=O)N(CCC4=CC=CC=C4)C1=N

>  <PF proliferation inhibition 3D7 EC50 uM>
1.527

>  <W2 Pf proliferation inhibition EC50 uM>
2.315

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2889
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -0.3444    0.7556    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8543    2.3248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1092    3.1094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5572    3.7225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8121    4.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6191    4.6787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8740    5.4633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3220    6.0764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5150    5.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2601    5.1202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  4 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2889

>  <JC_XSMILES>
O=C(C[N+]1=C2CCCN2C(=C1)C3=CC=CC=C3)C4=CC=C(C=C4)C5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3125

>  <W2 Pf proliferation inhibition EC50 uM>
0.393

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.12

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2895
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 22 29  4  0  0  0  0
 16 30  4  0  0  0  0
 12 30  4  0  0  0  0
  6 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2895

>  <JC_XSMILES>
COC1=CC=C(OCC(=O)NC2=CC=CC(NC(=O)COC3=CC=C(OC)C=C3)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6.84

>  <W2 Pf proliferation inhibition EC50 uM>
2.287

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2898
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -2.8579    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
  8 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 27 32  1  0  0  0  0
  5 33  4  0  0  0  0
 33 34  4  0  0  0  0
  2 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2898

>  <JC_XSMILES>
ClC1=CC=C(CSC2=NC3=CC=CC=C3C(=O)N2C4=CC=C(C=C4)C(=O)N5CCOCC5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.281

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-291
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
  9 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-291

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)NC(=S)N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.277

>  <W2 Pf proliferation inhibition EC50 uM>
>1.648

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2917
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2917

>  <JC_XSMILES>
CC(=O)NC1=CC=CC(=C1)C2=CN=CC(=N2)C3=CC=C(C=C3)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.153

>  <W2 Pf proliferation inhibition EC50 uM>
2.249

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2921
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    3.6130   -0.7926    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.0255   -0.0781    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8505   -0.0781    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2630   -0.7926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0880   -0.7926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5729   -0.1252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3575   -0.3801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3575   -1.2051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5729   -1.4600    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6130    0.6363    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7880    0.6363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4300    1.3796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6257    1.5632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9807    1.0488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9807    0.2238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6257   -0.2905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4300   -0.1070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3940    0.6363    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5690    0.6363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1565    1.3508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6685    1.3508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0810    2.0653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6685    2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1565    2.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5690    2.0653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2921

>  <JC_XSMILES>
S=C(NCC1=CC=CO1)NC2CC3CCC(C2)N3CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.865

>  <W2 Pf proliferation inhibition EC50 uM>
2.244

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2926
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.1875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145    6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 10 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
  8 30  4  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2926

>  <JC_XSMILES>
CN1CCN(CC1)C2=NC(NCCNC3=CC=C(C=C3)[N+]([O-])=O)=C4C=CC=CC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.537

>  <W2 Pf proliferation inhibition EC50 uM>
0.424

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.96

>  <Powder data?>
Yes

>  <IFI value>
0.19047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2933
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.8837   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -4.2703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 24 32  4  0  0  0  0
 18 33  4  0  0  0  0
  7 33  4  0  0  0  0
 33 34  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  32
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2933

>  <JC_XSMILES>
CC(C)NC(=O)C1=CN(CC2=CC=CC=C2)C=C(C(=O)NCCC3=NC4=CC=CC=C4N3)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.34

>  <W2 Pf proliferation inhibition EC50 uM>
2.216

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2938
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  7 24  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2938

>  <JC_XSMILES>
CC1=CC=C(NC2=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1837

>  <W2 Pf proliferation inhibition EC50 uM>
0.2407

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.9

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2939
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.3593    5.7762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6989    5.0243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2175    4.3543    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3966    4.4362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9152    3.7662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5571    3.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0757    2.9324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4153    2.1805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.1236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  1  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2939

>  <JC_XSMILES>
CCN(CC)C\C=C\C1(O)C2=CC=CC=C2C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
1.012

>  <W2 Pf proliferation inhibition EC50 uM>
0.2208

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-294
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    1.6974    6.2831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2277    5.6511    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0402    5.7944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3224    6.5696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1348    6.7129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6651    6.0809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    5.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9133    4.6737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6311    3.8984    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1614    3.2664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8792    2.4912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3489    1.5727    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5365    2.9799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8186    3.7552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5705    5.1624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 21 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
  7 35  4  0  0  0  0
  3 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-294

>  <JC_XSMILES>
COC1=CC=CC(CN2CCC(O)(CC2)C3=CC=C4OC(=CC4=C3)C(=O)NC5=CC=C(Cl)C=C5)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.159

>  <W2 Pf proliferation inhibition EC50 uM>
4.06

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.67

>  <Powder data?>
Yes

>  <IFI value>
0.038095238

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2943
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    5.0013    3.4661    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868    3.0536    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724    3.4661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.2286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543    1.7437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    0.9590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.9590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194    1.7437    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3894    0.2916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5689    0.3778    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0840   -0.2896    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2635   -0.2034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7786   -0.8708    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0419   -0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5268   -1.4520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3473   -1.3658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8322   -2.0332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6527   -1.9470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9882   -1.1933    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5033   -0.5259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6828   -0.6121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3774   -0.0309    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1075    0.6365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2281    1.3902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2568    2.0576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0787    2.8113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4062    3.4788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2267    3.3925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5622    2.6389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0773    1.9714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9280    0.5503    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  9  7  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 14 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 23 31  4  0  0  0  0
 12 31  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2943

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(O1)C=NNC2=NC(NC3=CC=CC=C3)=NC(NC4=CC=CC=C4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.625

>  <W2 Pf proliferation inhibition EC50 uM>
0.454

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.69

>  <Powder data?>
Yes

>  <IFI value>
0.064748201

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2944
  Mrv1591402191617072D          

 21 21  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  4 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  2 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2944

>  <JC_XSMILES>
CC1CC(CCC=C(C)C)=CCC1CNCCCN(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.753

>  <W2 Pf proliferation inhibition EC50 uM>
0.415

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.92

>  <Powder data?>
Yes

>  <IFI value>
0.089552239

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2968
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  4  0  0  0  0
 14 24  4  0  0  0  0
 19 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 25 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2968

>  <JC_XSMILES>
CCOC1=CC=CC=C1NC(=O)NC2=CC=C3N=C(C=C(C)C3=C2)N4CCN(C)CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.165

>  <W2 Pf proliferation inhibition EC50 uM>
0.456

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.41

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2974
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2974

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1266

>  <W2 Pf proliferation inhibition EC50 uM>
0.2124

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2983
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  4  0  0  0  0
  6 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2983

>  <JC_XSMILES>
CCOC(=O)C1=CC=CC(OC(=O)C2=CC=CC=C2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.67

>  <W2 Pf proliferation inhibition EC50 uM>
2.115

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2987
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9049   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 31 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2987

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NCCN2)NC3=CC=CC(=C3)C(=O)NC4=CC=C(C=C4)C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.108

>  <W2 Pf proliferation inhibition EC50 uM>
0.2113

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009009009

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3001
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 12 18  1  0  0  0  0
 11 19  4  0  0  0  0
  7 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
 10 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3001

>  <JC_XSMILES>
CCOC1=CC=C2N=CC(=C(N3CCN(C)CC3)C2=C1)S(=O)(=O)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1002

>  <W2 Pf proliferation inhibition EC50 uM>
2.082

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3009
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    6.5519   -5.4229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.2970   -4.6383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4900   -4.4668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2351   -3.6821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8490   -4.0252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9127   -0.8644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6272   -0.4519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2402   -1.0039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9047   -1.7576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 19 24  4  0  0  0  0
  8 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3009

>  <JC_XSMILES>
FC1=CC=C(C=C1)C(CCNC2=NC=NC3=C2NC4=CC=CC=C34)C5=CC=CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2159

>  <W2 Pf proliferation inhibition EC50 uM>
0.419

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.2

>  <Powder data?>
Yes

>  <IFI value>
0.166666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3010
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 13 25  1  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3010

>  <JC_XSMILES>
CC1=CC=CC(C)=C1NC(=O)CN2C(=O)C(C)(C)OC3=CC=C(C=C23)C(=O)NC(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.24

>  <W2 Pf proliferation inhibition EC50 uM>
2.069

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3014
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 20 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3014

>  <JC_XSMILES>
CCCCCC1=CC=C(C=C1)C(=O)N(C)CCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2497

>  <W2 Pf proliferation inhibition EC50 uM>
0.3103

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.07

>  <Powder data?>
Yes

>  <IFI value>
0.074766355

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3022
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -2.1434    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665    3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376    3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3022

>  <JC_XSMILES>
CC1CCN(CC1)C(=O)C2=CC=C(C=C2)N3C(C)=CC=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
5.12

>  <W2 Pf proliferation inhibition EC50 uM>
2.037

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3023
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    4.6664   -3.4021    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1815   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6664   -2.0672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4115   -1.2826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9635   -0.6695    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7086    0.1151    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2606    0.7282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0891    1.5352    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8035    1.9477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9751    2.7547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7597    3.0096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3728    2.4576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2012    1.6506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4166    1.3957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0811    0.6420    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4510   -2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1655   -1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8800   -2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8800   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1655   -3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4510   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  4  3  1  4  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
  3 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  1 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1   1
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  15
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3023

>  <JC_XSMILES>
N1C=C(C=NNC2=NC3=CC=CC=C3N2)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.33

>  <W2 Pf proliferation inhibition EC50 uM>
0.391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.21

>  <Powder data?>
Yes

>  <IFI value>
0.131386861

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3024
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2271    0.6260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4407   -0.1709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6438   -0.3844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 20 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3024

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3CCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1915

>  <W2 Pf proliferation inhibition EC50 uM>
0.093

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.57

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3026
  Mrv1591402191617072D          

 45 48  0  0  0  0            999 V2000
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7250   -0.1085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8965    0.6985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2834    1.2505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4549    2.0575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2395    2.3124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8526    1.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6811    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4111    3.1194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7980    3.6714    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1957    3.3743    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3672    4.1813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1293   -3.5832    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2226   -2.8490    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3951   -4.4899    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 10 29  4  0  0  0  0
 29 30  2  0  0  0  0
 28 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 35 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 37 40  1  0  0  0  0
  7 41  4  0  0  0  0
 41 42  4  0  0  0  0
  4 42  4  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
 44 45  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3026

>  <JC_XSMILES>
CCOC1=CC=C(CCN2C(CC(=O)NC3=CC=C(C=C3)C(=O)OC)C(=O)N(C2=S)C4=CC=CC(=C4)C(F)(F)F)C=C1OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.736

>  <W2 Pf proliferation inhibition EC50 uM>
0.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.52

>  <Powder data?>
Yes

>  <IFI value>
0.032608696

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-305
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -2.1730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -3.6020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  7 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-305

>  <JC_XSMILES>
CCOCCCN(C(C(=O)NC1CCCCC1)C2=CC=NC=C2)C(=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.873

>  <W2 Pf proliferation inhibition EC50 uM>
>1.62

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3059
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3059

>  <JC_XSMILES>
CCC1=CC=C(C=C1)C2=CC=C(C=C2)C(=O)NC(C)(C)C#C

>  <PF proliferation inhibition 3D7 EC50 uM>
3.031

>  <W2 Pf proliferation inhibition EC50 uM>
1.971

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.031007752

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3062
  Mrv1591402191617072D          

 42 47  0  0  0  0            999 V2000
   11.4828    1.6084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8732    1.0524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0498    0.2466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4402   -0.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6540   -0.0594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4774    0.7465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6912    0.9964    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0816    0.4405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2582   -0.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2954    0.6905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6858    0.1346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8996    0.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7229    1.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9367    1.4403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8667    2.2624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2360    2.7942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1662    1.6853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5828    0.7397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4049    0.8096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9521    1.2715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2752    0.7999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5283    1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4584    1.9723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353    2.4439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0654    3.2660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8822    2.0935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4140    2.7242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3325    1.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1558    2.5522    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7654    3.1081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5516    2.8581    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5888    3.9139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1983    4.4698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0217    5.2757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2355    5.5257    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.6313    5.8316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4175    5.5817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5941    4.7758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9846    4.2199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1612    3.4140    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    1.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0870    1.3024    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
 16 27  1  0  0  0  0
 13 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 33 39  4  0  0  0  0
 39 40  1  0  0  0  0
 28 41  4  0  0  0  0
 10 41  4  0  0  0  0
  6 42  4  0  0  0  0
  2 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3062

>  <JC_XSMILES>
CC1=CC=CC(NC(=O)C2=CC=C(N3CC4CC(C3)C5=CC=CC(=O)N5C4)C(NC(=O)CC6=C(F)C=CC=C6Cl)=C2)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.45

>  <W2 Pf proliferation inhibition EC50 uM>
0.1969

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3070
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
  4 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  2  0  0  0  0
 15 21  1  0  0  0  0
  2 21  1  0  0  0  0
  3 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
M  CHG  2  11   1  12  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3070

>  <JC_XSMILES>
CC1=C(C(C2=CC=CC(=C2)[N+]([O-])=O)C3=C(CCCC3=O)N1)C(=O)OC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.64

>  <W2 Pf proliferation inhibition EC50 uM>
1.333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.4

>  <Powder data?>
Yes

>  <IFI value>
0.014492754

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3074
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    4.8946   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5620   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3071   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7920   -3.2361    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2272   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4425   -1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8294   -2.0811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0010   -2.8881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3879   -3.4401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6032   -3.1852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4317   -2.3782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6471   -2.1233    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4756   -1.3163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3091   -1.0614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4806   -0.2544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1325    0.2976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9171    0.0427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0887   -0.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0448   -1.8262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  4  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  4  0  0  0  0
  9 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3074

>  <JC_XSMILES>
O=C1NC(=S)NC1=CC2=CC=CC(OC3=CC=CC=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.89

>  <W2 Pf proliferation inhibition EC50 uM>
1.945

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3078
  Mrv1591402191617072D          

 45 50  0  0  1  0            999 V2000
    9.3953    0.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4176    1.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7145    1.8770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9892    1.4840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2861    1.9156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3084    2.7403    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5607    1.5226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5385    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8131    0.3048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1100    0.7364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1323    1.5611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8577    1.9542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1429    1.8384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1652    2.6631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.8460    1.4068    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.5714    1.7999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2593    1.4839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2521    0.5435    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.9998    1.7613    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   12.4018    2.3297    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.7576    3.0740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9801    3.3500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9509    3.8760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5754    2.9656    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.7251    2.1543    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   14.3231    1.5859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9673    0.8416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2824    0.0791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.1002   -0.0292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4153   -0.7917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.9126   -1.4458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.2276   -2.2082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.7249   -2.8623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0400   -3.6248    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.9070   -2.7540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5919   -1.9915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0947   -1.3374    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   13.2314   -0.8820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7796   -0.5750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   13.2768   -1.2291    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   12.9618   -0.4666    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   12.4590   -1.1207    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.6467    0.2959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1494    0.9500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   12.3474    1.1432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  2 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 19 17  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 25 24  1  6  0  0  0
 19 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 32 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 35 36  2  0  0  0  0
 37 36  1  0  0  0  0
 37 31  1  0  0  0  0
 37 38  1  1  0  0  0
 39 37  1  0  0  0  0
 39 28  1  0  0  0  0
 39 40  1  6  0  0  0
 39 41  1  0  0  0  0
 41 42  1  1  0  0  0
 41 43  1  0  0  0  0
 44 43  1  0  0  0  0
 19 44  1  0  0  0  0
 44 27  1  0  0  0  0
 44 45  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3078

>  <JC_XSMILES>
CC(CNC(=O)C1=CC=CC=C1)C(=O)OCC(=O)[C@@]23OC(C)(C)O[C@@H]2CC4C5CCC6=CC(=O)C=C[C@]6(C)[C@@]5(F)[C@@H](O)C[C@]34C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1649

>  <W2 Pf proliferation inhibition EC50 uM>
0.1588

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.22

>  <Powder data?>
Yes

>  <IFI value>
0.137614679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3079
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   12.4456    0.5525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8361   -0.0034    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.0498    0.2466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4402   -0.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6540   -0.0594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0444   -0.6153    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2211   -1.4212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4774    0.7465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6912    0.9964    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0816    0.4405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2582   -0.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2954    0.6905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6858    0.1346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8996    0.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7229    1.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9367    1.4403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8667    2.2624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2360    2.7942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1662    1.6853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5828    0.7397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4049    0.8096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9521    1.2715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2752    0.7999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5283    1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4584    1.9723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353    2.4439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0654    3.2660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8822    2.0935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4140    2.7242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3325    1.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    1.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1558    2.5522    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.7654    3.1081    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.3696    2.8021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0870    1.3024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8732    1.0524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4828    1.6084    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  2  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
 28 29  1  0  0  0  0
 18 29  1  0  0  0  0
 15 30  4  0  0  0  0
 30 31  4  0  0  0  0
 12 31  4  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
  8 35  4  0  0  0  0
 35 36  4  0  0  0  0
  3 36  4  0  0  0  0
 36 37  1  0  0  0  0
M  CHG  2  32   1  33  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3079

>  <JC_XSMILES>
COC1=CC(OC)=C(NC(=O)C2=CC=C(N3CC4CC(C3)C5=CC=CC(=O)N5C4)C(=C2)[N+]([O-])=O)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
9.69

>  <W2 Pf proliferation inhibition EC50 uM>
1.931

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-308
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    4.9279   -2.1896    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6260   -1.0626    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8010   -2.4915    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
  9 28  4  0  0  0  0
  5 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-308

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC2=NC3=NON=C3N=C2NC4=CC=C(Cl)C=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.312

>  <W2 Pf proliferation inhibition EC50 uM>
1.614

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.227272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3084
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  6 15  4  0  0  0  0
  2 15  4  0  0  0  0
  4 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3084

>  <JC_XSMILES>
CC1=CC(=NC(NCC2=CC=CC=C2)=N1)N3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
5.76

>  <W2 Pf proliferation inhibition EC50 uM>
0.739

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.39

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3096
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -9.4875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 19 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 15 29  2  0  0  0  0
 26 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3096

>  <JC_XSMILES>
COC1=CC=C(Cl)C=C1NC(=O)CSC2=C(C#N)C(C3=CC=CC=C3)C(=C(C)N2)C(=O)NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.76

>  <W2 Pf proliferation inhibition EC50 uM>
1.911

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3097
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3097

>  <JC_XSMILES>
CC(=O)NC1=CC=C2CCCCC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.131

>  <W2 Pf proliferation inhibition EC50 uM>
0.1911

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3102
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  2  0  0  0  0
 23 25  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3102

>  <JC_XSMILES>
CC(N1CCN(CC1)C(=O)C(C)(C)C)C2=NC3=CC=CC=C3C(=O)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1847

>  <W2 Pf proliferation inhibition EC50 uM>
0.1906

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3105
  Mrv1591402191617072D          

 34 35  0  0  0  0            999 V2000
   -7.1447  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -11.9625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -9.4875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -10.7250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 24 31  4  0  0  0  0
 31 32  1  0  0  0  0
  7 33  4  0  0  0  0
  3 33  4  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3105

>  <JC_XSMILES>
COC1=CC=CC(CNCCCCCCCCCCCCNCC2=CC=CC(OC)=C2O)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.819

>  <W2 Pf proliferation inhibition EC50 uM>
1.014

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.48

>  <Powder data?>
Yes

>  <IFI value>
0.060150376

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3110
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -2.2244   -0.3066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4398   -0.5616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2683   -1.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4836   -1.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3121   -2.4304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7098   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8814   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -4.9455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -5.1170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -4.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -4.3163    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 19 24  4  0  0  0  0
 10 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  9 27  4  0  0  0  0
 27 28  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  26
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3110

>  <JC_XSMILES>
COC1=CC=C(C=C1)n2c(CNC(=O)C3=CC=CC4=CC=CC=C34)n[nH]c2=S

>  <PF proliferation inhibition 3D7 EC50 uM>
1.103

>  <W2 Pf proliferation inhibition EC50 uM>
1.887

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3112
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    4.0954   -3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -3.1895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7809   -3.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1678   -4.4952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4534   -4.0827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6249   -3.2757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6997   -4.4182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6135   -5.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2809   -5.7236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1402   -5.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2264   -6.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3866   -6.9468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0511   -7.7005    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7694   -7.6142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9409   -6.8073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 19 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3112

>  <JC_XSMILES>
OC(CN1CCC(C1)NC(=O)CC2=CSC=C2)CN(CC3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.411

>  <W2 Pf proliferation inhibition EC50 uM>
0.1883

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3116
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
    7.9234   -6.5109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5434   -5.7787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7276   -5.6557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.5925   -4.8418    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8546   -4.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8053   -3.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4938   -3.1948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0674   -3.2803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6133   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2665   -2.8408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6355   -2.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -1.4898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -1.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245   -1.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175   -1.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3655   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4415   -0.7782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9935   -0.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7386    0.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0684    0.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6204    0.1779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1454   -0.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6975   -1.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4425   -1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0798   -2.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    0.2510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154    0.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    1.5858    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    1.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    0.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3247   -4.4618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9125   -5.0408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 13 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
 26 27  1  0  0  0  0
  8 27  1  0  0  0  0
 24 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 28 36  4  0  0  0  0
 31 36  4  0  0  0  0
  4 37  4  0  0  0  0
 37 38  4  0  0  0  0
  2 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3116

>  <JC_XSMILES>
CC1=NN(CC(=O)N2CCOC3=C(OCCC4=CC=CC=N4)C=C(C=C3C2)C5=CSC6=CC=CC=C56)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.823

>  <W2 Pf proliferation inhibition EC50 uM>
0.73

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.97

>  <Powder data?>
Yes

>  <IFI value>
0.04

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-312
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -4.5876   -2.5424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7671   -2.4562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4316   -1.7025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6111   -1.6163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -2.2837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4617   -3.0374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2822   -3.1236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -2.1975    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288   -0.7293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -1.6545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -2.8106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -3.6175    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 12 23  1  0  0  0  0
  8 23  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-312

>  <JC_XSMILES>
CC1=CC=C(C=C1)N2C(=O)CC(NCCCN3CCOCC3)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.292

>  <W2 Pf proliferation inhibition EC50 uM>
1.607

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3130
  Mrv1591402191617072D          

 16 19  0  0  0  0            999 V2000
   -0.0456   -4.4201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4393   -3.7527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1843   -2.9682    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8516   -2.4833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5191   -2.9681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2642   -3.7526    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8516   -1.6583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5656   -1.2418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5656   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3011   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0366   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0366   -1.2418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3011   -1.6154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5871   -2.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8516   -0.9110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
 11 12  1  0  0  0  0
 10 11  1  0  0  0  0
  9 14  1  0  0  0  0
  7 15  1  0  0  0  0
 13 14  1  0  0  0  0
 11 16  1  0  0  0  0
 13 15  1  0  0  0  0
 12 13  1  0  0  0  0
  7 16  1  0  0  0  0
  9 10  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3130

>  <JC_XSMILES>
CC1=NC(=CS1)C23CC4CC(CC(C4)C2)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.856

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02020202

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3137
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
    0.9736   -0.8913    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3258   -1.5829    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0433   -0.7618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2760   -2.2527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0698   -2.9165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4822   -3.5296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2273   -4.3142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5797   -4.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8346   -5.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6415   -5.4420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1936   -4.8289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9387   -4.0443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1317   -3.8727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9070   -3.2008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6542   -2.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2113   -1.4661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6945   -0.8556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3339   -1.5180    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2794    0.0335    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9801   -2.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7435   -1.7581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3960   -2.2629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2851   -3.0805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5217   -3.3932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8692   -2.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 17 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 16 35  4  0  0  0  0
 30 35  4  0  0  0  0
  2 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3137

>  <JC_XSMILES>
O=S(=O)(OC1=CC=C2C=CC=CC2=C1CC3=C(OS(=O)(=O)C4=CC=CC=C4)C=CC5=CC=CC=C35)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.843

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3146
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.9239    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 13 27  4  0  0  0  0
 21 27  4  0  0  0  0
  7 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3146

>  <JC_XSMILES>
CC1=CC(C)=CC(NCC(O)CN2C3=CC=C(Cl)C=C3C4=CC(Cl)=CC=C24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.216

>  <W2 Pf proliferation inhibition EC50 uM>
0.569

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.21

>  <Powder data?>
Yes

>  <IFI value>
0.05

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3153
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033   -1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 15 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3153

>  <JC_XSMILES>
CC(NC1=CC=CC=C1)C(=O)NC2=CC(=CC=C2Cl)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.221

>  <W2 Pf proliferation inhibition EC50 uM>
1.289

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
71.4

>  <Powder data?>
Yes

>  <IFI value>
0.075

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3158
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    8.3536    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    4.4104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.0940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.0940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 18 32  4  0  0  0  0
 32 33  4  0  0  0  0
 16 33  4  0  0  0  0
 33 34  4  0  0  0  0
 13 34  4  0  0  0  0
  9 35  4  0  0  0  0
 35 36  4  0  0  0  0
  6 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3158

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(NC(=O)C2=CC=C3N=C(NC(=O)C4=CC=C(C=C4)C(=O)OC)SC3=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.51

>  <W2 Pf proliferation inhibition EC50 uM>
1.795

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014925373

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3159
  Mrv1591402191617072D          

 50 57  0  0  0  0            999 V2000
    4.3028    2.7677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    2.0532    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353   -0.8278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0763    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    3.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1125    0.6243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4911   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4911    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403   -0.8047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3653   -0.8047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -1.5191    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 16 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 12 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 25 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 38 39  4  0  0  0  0
 33 39  4  0  0  0  0
 32 40  2  0  0  0  0
 16 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  1  0  0  0  0
 44 46  4  0  0  0  0
 46 47  4  0  0  0  0
 41 47  4  0  0  0  0
  6 48  1  0  0  0  0
 48 49  1  0  0  0  0
 48 50  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3159

>  <JC_XSMILES>
COC1=CC=C(C=C1N2C(=O)C3C(C2=O)C5(C4=CC=CC=C4)C(=O)C3(C6=CC=CC=C6)C(C7=CC=C(C)C=C7)=C5C8=CC=C(C)C=C8)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.464

>  <W2 Pf proliferation inhibition EC50 uM>
1.795

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3166
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3166

>  <JC_XSMILES>
OC1=CC=C(Br)C(=C1)C(NC2=CC=CC=N2)C3=CC=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.555

>  <W2 Pf proliferation inhibition EC50 uM>
0.2813

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.73

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3171
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.4441    0.2957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3683    0.4390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8986   -0.1930    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7111   -0.0498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9933    0.7255    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -0.6817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -2.3317    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2414   -3.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -3.5692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8125   -4.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0980   -4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0980   -3.5692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6165   -3.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8125   -3.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7717   -0.0498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5842   -0.1930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1145    0.4390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9269    0.2957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2091   -0.4795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6788   -1.1115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8663   -0.9683    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3171

>  <JC_XSMILES>
CCOC(=O)C1(CCN(CC1)CC2=CC=CC(C)=N2)CC3CCCCO3

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.37

>  <W2 Pf proliferation inhibition EC50 uM>
1.783

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3181
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    7.4854    0.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025    2.4233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615    2.8649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9136    3.4780    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7206    3.3064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  4  0  0  0  0
 13 20  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 21 27  1  0  0  0  0
 22 28  4  0  0  0  0
  8 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3181

>  <JC_XSMILES>
COCCSC1=NC2=C(C(=O)N1C3=CC=C(OC)C=C3)C4=C(CN(C)CC4)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
3.025

>  <W2 Pf proliferation inhibition EC50 uM>
1.77

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3183
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3183

>  <JC_XSMILES>
OC1=CC=C(Cl)C=C1CNC2=NC3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.921

>  <W2 Pf proliferation inhibition EC50 uM>
0.768

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
43.46

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3191
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.7322   -8.1395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -6.7105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
  7 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3191

>  <JC_XSMILES>
COC(=O)CNC(C1=CC=CC=C1Cl)C2=CC(Br)=CC=C2NS(=O)(=O)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.925

>  <W2 Pf proliferation inhibition EC50 uM>
1.757

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3196
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8997   -4.2019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4517   -4.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0392   -5.5295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2322   -5.3580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  4  0  0  0  0
 14 24  4  0  0  0  0
 19 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 25 29  1  0  0  0  0
  6 30  1  0  0  0  0
 30 31  1  0  0  0  0
  3 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3196

>  <JC_XSMILES>
CCN1CCN(CCCNC(=S)NC2=CC=C3N=C(C=C(C)C3=C2)N4CCCC4)CC1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2558

>  <W2 Pf proliferation inhibition EC50 uM>
0.773

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
44.22

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3205
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4257   -5.3493    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
  5 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3205

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1O)C2=NC(=C(N2)C3=CC=CC=C3)C4=CC=CC(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.583

>  <W2 Pf proliferation inhibition EC50 uM>
0.749

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
43.17

>  <Powder data?>
Yes

>  <IFI value>
0.033707865

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3210
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5152   -1.6545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3221   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7346   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1826   -2.8106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  9 19  2  0  0  0  0
 19 20  1  4  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3210

>  <JC_XSMILES>
CC(C)CC(NC(=O)C(NC(=O)C1=CC=CC=C1)=CC2=CC=CO2)C(=O)OCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.73

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3213
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  6 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3213

>  <JC_XSMILES>
OCCC1CN(CCN1CC2=CC=CC=C2)CC3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.728

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3229
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    6.5888    3.9139    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7654    3.1081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5516    2.8581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7283    2.0522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    1.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3325    1.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7229    1.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9367    1.4403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8667    2.2624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2360    2.7942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1662    1.6853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5828    0.7397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4049    0.8096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9521    1.2715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2752    0.7999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5283    1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4584    1.9723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353    2.4439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0654    3.2660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8822    2.0935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4140    2.7242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1558    2.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 10 21  1  0  0  0  0
  6 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3229

>  <JC_XSMILES>
OC1=CC=CC(CN2CC3CC(C2)C4=CC=CC(=O)N4C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.46

>  <W2 Pf proliferation inhibition EC50 uM>
1.704

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3233
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -1.4924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -0.1576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  5 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 12 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3233

>  <JC_XSMILES>
COC1=CC(=CC(Br)=C1OC)C2C3=CC4=C(OCO4)C=C3OC(N)=C2C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
3.118

>  <W2 Pf proliferation inhibition EC50 uM>
1.694

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3237
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4712   -0.6979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.1271    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -1.5229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018   -3.0331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  1  0  0  0  0
 11 16  4  0  0  0  0
  8 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3237

>  <JC_XSMILES>
CC1=CC=C(NC2=C(C(=O)C3=CC=CC=C23)C4=CC=C(C=C4)C(F)(F)F)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.236

>  <W2 Pf proliferation inhibition EC50 uM>
1.693

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3239
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
   -0.9429   -5.4600    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 11 16  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3239

>  <JC_XSMILES>
ClC1=CC=C(NCN2N=NC3=CC=CC=C23)N=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.2

>  <W2 Pf proliferation inhibition EC50 uM>
1.69

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3242
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
   -5.9985   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1735   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7610   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9360   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5235   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9360   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7610   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6985   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -1.3951    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860    2.0445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420    1.3770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565    4.9886    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -2.7299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 19 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 12 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 10 32  4  0  0  0  0
 32 33  4  0  0  0  0
  8 33  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  33
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3242

>  <JC_XSMILES>
NC1=CC=C(C=C1)C2=NC3=CC(OC4=CC=C5NC(=NC5=C4)C6=CC=C(N)C=C6)=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.683

>  <W2 Pf proliferation inhibition EC50 uM>
0.357

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.35

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3257
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
  7 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3257

>  <JC_XSMILES>
CCCC(=O)NC(C1=CC=C(Cl)C=C1)C2=CC=C3C=CC=NC3=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2876

>  <W2 Pf proliferation inhibition EC50 uM>
0.1705

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.34

>  <Powder data?>
Yes

>  <IFI value>
0.16

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3258
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
   -1.9851   -7.0904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5002   -6.4229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8328   -6.9078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1677   -5.9380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0154   -5.7555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3509   -5.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8661   -4.3343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0456   -4.4205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2900   -5.1742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1949   -5.8417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4393   -3.7531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1843   -2.9685    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5192   -2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2643   -3.7530    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 20 21  1  0  0  0  0
 19 20  1  0  0  0  0
 18 23  1  0  0  0  0
 16 24  1  0  0  0  0
 22 23  1  0  0  0  0
 20 25  1  0  0  0  0
 22 24  1  0  0  0  0
 21 22  1  0  0  0  0
 16 25  1  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3258

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(C=C1)C2=NC(=CS2)C34CC5CC(CC(C5)C3)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.648

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010989011

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-326
  Mrv1591402191617072D          

 28 31  0  0  1  0            999 V2000
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.2102    4.4104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.0347    3.5567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6474    2.8858    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    7.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    8.1229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  2  0  0  0  0
  5 10  1  1  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  3 17  1  1  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-326

>  <JC_XSMILES>
CN1[C@H](C[C@H](NS1(=O)=O)C2=CC=C(F)C=C2)C(=O)NC3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.955

>  <W2 Pf proliferation inhibition EC50 uM>
>1.57

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3261
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
  5 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
  3 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3261

>  <JC_XSMILES>
COC1=NC(NC2=CC=C(C=C2)C(C)C)=NC(OC)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.677

>  <W2 Pf proliferation inhibition EC50 uM>
0.935

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
56.94

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3271
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -2.1546   -6.3940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4401   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4401   -7.6315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7256   -6.3940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0112   -6.8065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7033   -6.3940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4178   -6.8065    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1323   -6.3940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1323   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8467   -5.1565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8467   -4.3315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5612   -5.5690    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5612   -6.3940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8467   -6.8065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0182   -7.6135    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8387   -7.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3237   -8.3672    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1441   -8.2810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4797   -7.5273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3002   -7.4410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7851   -8.1085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4495   -8.8622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2500   -9.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3920   -9.6852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6291   -8.9484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9948   -6.8598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1743   -6.9461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 18 25  1  0  0  0  0
 19 26  4  0  0  0  0
 26 27  4  0  0  0  0
 13 27  4  0  0  0  0
 16 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3271

>  <JC_XSMILES>
CN(C)CCCNC1=NC(C)=NC2=C1SC3=NC4=C(COC(C)(C)C4)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.633

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029850746

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3278
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3278

>  <JC_XSMILES>
COC1=CC=CC(OC)=C1C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.449

>  <W2 Pf proliferation inhibition EC50 uM>
0.1977

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.21

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3280
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    5.9950    0.3610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1704    0.3867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7804    1.1137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2150    1.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9558    1.1395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5212    0.4383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9112   -0.2887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4766   -0.9900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6520   -0.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7698   -1.7808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8683   -1.2220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2620   -0.2372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6966    0.4640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1640    1.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4002    0.7822    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4608   -0.0406    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3606    1.8953    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1528    2.1256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3495    2.9268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7539    3.4977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1417    3.1571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3383    3.9584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7372    2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5406    1.7850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7484    1.5547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7358   -0.3145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
  6 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 14 17  2  0  0  0  0
 17 18  1  4  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 18 25  4  0  0  0  0
  7 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3280

>  <JC_XSMILES>
CC1=C(C)C=C2C(NC(C)(C)C3=C2C(SS3)=NC4=C(C)C(C)=CC=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
8.59

>  <W2 Pf proliferation inhibition EC50 uM>
1.618

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3281
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    4.2575   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633    1.9817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2046    1.9817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6024    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8573    2.9379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3053    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5017    3.3795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7566    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 14 21  1  0  0  0  0
  9 21  4  0  0  0  0
 21 22  4  0  0  0  0
  7 22  4  0  0  0  0
  8 23  4  0  0  0  0
  2 23  4  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3281

>  <JC_XSMILES>
CN1C(=O)N(C)C2=C(N3CC(O)CN(C4=CC=CC=C4)C3=N2)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0726

>  <W2 Pf proliferation inhibition EC50 uM>
0.1617

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3291
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6144   -3.1605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2788   -2.4068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4584   -2.4930    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.5737   -5.7750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  2  0  0  0  0
  5 36  4  0  0  0  0
 36 37  4  0  0  0  0
  2 37  4  0  0  0  0
M  CHG  2  33   1  34  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3291

>  <JC_XSMILES>
CC1=CC=C(CNC(=O)CCCCCN2C(=O)C3=C(C=CS3)N=C2SCC4=CC=CC(=C4)[N+]([O-])=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6.28

>  <W2 Pf proliferation inhibition EC50 uM>
1.598

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3293
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    3.0844   -9.1504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5324   -8.5373    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7873   -7.7527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2353   -7.1396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4902   -6.3549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2972   -6.1834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8492   -6.7965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5943   -7.5811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5521   -5.3988    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0672   -4.7313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5521   -4.0639    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3367   -4.3188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0512   -3.9063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7657   -4.3188    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4801   -3.9063    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4801   -3.0813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1946   -2.6688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2809   -1.8484    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.0878   -1.6768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5003   -0.9624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3253   -0.9624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7378   -1.6768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3253   -2.3913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5003   -2.3913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9483   -3.0044    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1198   -3.8114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7657   -5.1438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0512   -5.5563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3367   -5.1438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
 25 26  1  0  0  0  0
 14 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  9 29  4  0  0  0  0
 12 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3293

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C=NC3=CC(NCC4=NC5=CC=CC=C5N4C)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.912

>  <W2 Pf proliferation inhibition EC50 uM>
0.906

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
56.75

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3299
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
  8 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
 18 28  4  0  0  0  0
  6 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3299

>  <JC_XSMILES>
CCN(CC)C1=NC(NC2=CC=CC=C2O)=NC(NC3=CC(C)=CC=C3C)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.439

>  <W2 Pf proliferation inhibition EC50 uM>
0.1591

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3306
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -4.3874    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -5.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8839   -5.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2721   -4.9686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7571   -5.6360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5775   -5.5498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9131   -4.7961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4282   -4.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7637   -3.3750    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6077   -4.2149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
 12 24  4  0  0  0  0
  9 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3306

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NOC(CNC(=O)C3=CC=CC(I)=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.582

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3311
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 13 28  4  0  0  0  0
 28 29  4  0  0  0  0
 10 29  4  0  0  0  0
  5 30  1  0  0  0  0
 30 31  1  0  0  0  0
  2 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3311

>  <JC_XSMILES>
CN1CCC(CCNCC2=CC=C(OCC(O)CN(C)CC3=CC=CC=C3)C=C2)CC1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.111

>  <W2 Pf proliferation inhibition EC50 uM>
1.081

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.59

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-332
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6750    1.7895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0106    2.5432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8311    2.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-332

>  <JC_XSMILES>
CN(C)CCCNC1=C2CCCC2=NC3=CC=C(C)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.935

>  <W2 Pf proliferation inhibition EC50 uM>
1.557

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3329
  Mrv1591402191617072D          

 40 45  0  0  0  0            999 V2000
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3428   -1.8076    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0702   -3.9674    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5551   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3801   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7926   -4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3801   -4.7289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7926   -5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6176   -5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0301   -4.7289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6176   -4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0702   -2.6326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3251   -1.8479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  4  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  1  0  0  0  0
  6 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 23 34  4  0  0  0  0
 29 34  4  0  0  0  0
  7 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3329

>  <JC_XSMILES>
CCOC(=O)C1=C(N=c2sc(=CC3=CC=CN=C3)c(=O)n2C1C4=C(OC)C=CC5=CC=CC=C45)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
4.15

>  <W2 Pf proliferation inhibition EC50 uM>
1.553

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3336
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3336

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)CCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1361

>  <W2 Pf proliferation inhibition EC50 uM>
0.1866

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>12.08

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3341
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6499    0.6563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8214    1.4633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2083    2.0153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3798    2.8223    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4237    1.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2522    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4675    0.6985    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0968   -3.8419    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9445   -3.6594    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2793   -2.6896    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
  5 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
  4 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3341

>  <JC_XSMILES>
CN1N=C(C(=C1NC(=O)NC2=CC=C(F)C=C2F)C3=CC=C(F)C=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2914

>  <W2 Pf proliferation inhibition EC50 uM>
0.448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.15

>  <Powder data?>
Yes

>  <IFI value>
0.024793388

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3344
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 19 34  4  0  0  0  0
 34 35  4  0  0  0  0
  6 35  4  0  0  0  0
 16 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3344

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(C2=CC=CC=C2)C3=CC=C(OC(=O)C4=CC=CC=C4NC(=O)CC)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
1.064

>  <W2 Pf proliferation inhibition EC50 uM>
1.532

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3346
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3346

>  <JC_XSMILES>
COC1=CC=C2C(C)=NC(NC(N)=N)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.417

>  <W2 Pf proliferation inhibition EC50 uM>
1.016

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
66.35

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3349
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    0.6411   -3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3349

>  <JC_XSMILES>
N=C1C2=C(CCCC2)N(CCC3=CC=CC=C3)C4=C1CCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0587

>  <W2 Pf proliferation inhibition EC50 uM>
0.2336

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.27

>  <Powder data?>
Yes

>  <IFI value>
0.081967213

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-335
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  9 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 20 29  4  0  0  0  0
  6 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-335

>  <JC_XSMILES>
NCCCNC1=NC=C(C(=O)NCC2=CC=CC=C2)C(NCC3CCCCC3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0912

>  <W2 Pf proliferation inhibition EC50 uM>
0.799

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.14

>  <Powder data?>
Yes

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3355
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    5.0352    1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4951    2.5952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6850    2.4393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4149    1.6598    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6048    1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0647    2.1275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3347    0.7243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8748    0.1007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6048   -0.6789    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1449   -1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550   -1.1466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2251   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0352   -0.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3052    0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7651    1.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9550    1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6850    0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7946   -0.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5246   -1.6143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2546   -0.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4444   -0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0957    0.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1744    1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9845    1.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5246    0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1449    3.0630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4149    3.8425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2251    3.9984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7651    3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5753    3.5307    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.8453    4.3103    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.1154    2.9071    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  1  0  0  0  0
 12 17  4  0  0  0  0
  9 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  7 25  1  0  0  0  0
 20 25  4  0  0  0  0
  3 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
M  CHG  2  30   1  31  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3355

>  <JC_XSMILES>
CC1=C(NC(=O)C2C3N(CCC4=CC=CC=C34)C(=O)C5=CC=CC=C25)C=CC=C1[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
4.07

>  <W2 Pf proliferation inhibition EC50 uM>
1.52

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3357
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -2.0367   -0.4741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4492   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9341   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5986   -3.9898    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7546   -3.1499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2395   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9040   -4.5710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3889   -5.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2094   -5.1522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5449   -4.3985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0600   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1393   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3188   -3.1499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4748   -3.9898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9899   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1694   -4.5710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4715   -4.3985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1360   -5.1522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3155   -5.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0201   -5.9921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3556   -6.7458    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7737   -5.6565    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7336   -6.3276    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  4 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3357

>  <JC_XSMILES>
OC1CC(N(C1)C(=O)NC2=CC=CC=C2)C(=O)NCC3=CC=CC=C3C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.1515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3359
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -2.6462   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -7.1282    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -7.8427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -7.8427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -6.4137    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
  4 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 24 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3359

>  <JC_XSMILES>
O=C(NC1=CC=C(OC2=CC=CN=C2)C=C1)C3CCN(CC3)CC4=CC5=CC=CC=C5O4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.367

>  <W2 Pf proliferation inhibition EC50 uM>
1.511

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3360
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    4.6086   -5.3141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8017   -5.1426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5467   -4.3580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7397   -4.1864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4848   -3.4018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0368   -2.7887    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8438   -2.9602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0987   -3.7449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9130   -0.8764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0171    0.3498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7621    1.1344    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
 13 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  4  0  0  0  0
 16 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3360

>  <JC_XSMILES>
CCN1CCN(CC1)C2=CC(C)=C(C#N)C3=NC4=CC=CC=C4N23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.798

>  <W2 Pf proliferation inhibition EC50 uM>
1.509

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3370
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    0.6078   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.1848    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.6402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -1.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -0.5973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -2.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -3.0723    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -3.0723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -2.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -1.8348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.4223    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -2.6598    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -3.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -3.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -3.9294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -3.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 18 29  4  0  0  0  0
 29 30  4  0  0  0  0
 15 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3370

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)C3=CC=C(NC(=O)C4=CC=C(F)C=C4)C=C3C(=O)N5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.1494

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009174312

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3374
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1100   -0.3837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2773    0.2871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8986   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1808   -3.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6505   -3.6892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1620   -3.5460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4441   -2.7707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0862   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
  4 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 12 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3374

>  <JC_XSMILES>
CC(=O)N1C2=CC=C(C)C=C2C(C)(CC1(C)C)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.776

>  <W2 Pf proliferation inhibition EC50 uM>
0.674

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.37

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3377
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4199   -4.2590    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1650   -5.0437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3400   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8551   -5.7111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0850   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6499   -5.7111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4704   -5.6249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9553   -6.2923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6197   -7.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1047   -7.7134    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.9251   -7.6272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2607   -6.8735    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4101   -8.2946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.2306   -8.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7155   -8.8758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3799   -9.6295    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.5594   -9.7157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0745   -9.0483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8648  -10.2969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5293  -11.0506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.0142  -11.7180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6786  -12.4717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8582  -12.5580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3732  -11.8905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7088  -11.1368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7993   -7.1322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3143   -6.4648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  2  7  4  0  0  0  0
  4  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 11 28  4  0  0  0  0
 28 29  4  0  0  0  0
  8 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3377

>  <JC_XSMILES>
CC1=NN(C(C)=C1)C2=CC=C(NC(=O)C3CCN(CC3)CC4=CC=NC=C4)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.282

>  <W2 Pf proliferation inhibition EC50 uM>
1.483

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3387
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   -9.0147   -0.1793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6119   -0.9093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8116   -0.9160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4172   -1.6124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6358   -1.7853    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5588   -2.5819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2926   -2.9013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7580   -3.6289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4025   -4.2082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0977   -5.0140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9419   -3.5909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1552   -4.6198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4105   -5.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.6107   -6.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5653   -5.5663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.2425   -5.3324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8231   -2.3022    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6234   -2.2955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.0177   -1.5991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8691   -2.9878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8758   -3.7881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1861   -4.1941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4897   -3.7998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4830   -2.9994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1727   -2.5935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7493   -1.9283    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0298   -1.5078    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7504   -1.0574    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4319   -2.0538    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4402   -0.9718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7665   -0.2043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5003    0.0868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5564    1.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7431    1.3761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0617    0.9565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0845    0.1565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2603   -0.0458    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5659    0.5705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3908    0.5548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2008    1.3299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  0  0  0  0
 36 37  2  0  0  0  0
 34 38  1  0  0  0  0
 31 38  1  0  0  0  0
 38 39  1  0  0  0  0
 38 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3387

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OS(=O)(=O)CC45CCC(CC4=O)C5(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.36

>  <W2 Pf proliferation inhibition EC50 uM>
0.1474

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3391
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
   -0.2056   -1.3269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5739   -1.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2507   -1.1256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9085   -1.6236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7333   -1.6398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2973   -1.0377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1008   -1.2251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3402   -2.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7762   -2.6167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9727   -2.4293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2959   -2.9010    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2796   -3.7258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9858   -4.1523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9695   -4.9772    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6273   -5.4752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3569   -6.2546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5321   -6.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2927   -5.4489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6381   -2.4030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8133   -2.3868    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 11 19  4  0  0  0  0
  4 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3391

>  <JC_XSMILES>
CC1=CN2C3=CC=CC=C3N(CCN4CCCC4)C2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.995

>  <W2 Pf proliferation inhibition EC50 uM>
0.889

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
60.46

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3396
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 20 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3396

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C(Cl)C(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0366

>  <W2 Pf proliferation inhibition EC50 uM>
0.1222

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.36

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3407
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    5.7663   -2.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044   -1.2111    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454   -1.6527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3407

>  <JC_XSMILES>
CCOC(=O)C1=C(C)OC2=C1C(=O)C3=CC=CC=C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.959

>  <W2 Pf proliferation inhibition EC50 uM>
0.71

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.28

>  <Powder data?>
Yes

>  <IFI value>
0.031746032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3413
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3413

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=CC(Br)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0596

>  <W2 Pf proliferation inhibition EC50 uM>
0.137

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.59

>  <Powder data?>
No

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3415
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.9979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1806    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.5306    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507   -1.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957   -2.7246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7478   -3.3376    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6112   -2.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -0.8853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3415

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C(=O)NC4=CC(Cl)=CC=C4O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.876

>  <W2 Pf proliferation inhibition EC50 uM>
1.428

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3427
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
   -2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 21 26  4  0  0  0  0
 11 27  4  0  0  0  0
 27 28  4  0  0  0  0
  8 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3427

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC=C(NC3=C4C=CC=CC4=NC5=CC=CC=C35)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0567

>  <W2 Pf proliferation inhibition EC50 uM>
0.0955

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.76

>  <Powder data?>
Yes

>  <IFI value>
0.155555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3428
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.5356    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    1.1759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2932   -3.4086    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  2  0  0  0  0
 13 17  2  0  0  0  0
 17 18  1  4  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3428

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C=C2SC(NC2=O)=NC3=CC=CC=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.713

>  <W2 Pf proliferation inhibition EC50 uM>
1.412

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3442
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    3.3523   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9317   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3442   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1692   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5817   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1692   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3442   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 10 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3442

>  <JC_XSMILES>
OC1=C2CCCCC2=NC3=CC(=NN13)C4=CC=C(C=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.137

>  <W2 Pf proliferation inhibition EC50 uM>
1.024

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>73.82

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3445
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.8882   -8.7526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1738   -9.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1738   -9.9901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4593   -8.7526    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7448   -9.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7448   -9.9901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0303   -8.7526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6841   -9.1651    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3986   -8.7526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4848   -7.9322    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2918   -7.7606    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7043   -8.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5248   -8.5613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0097   -7.8939    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8302   -7.9801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3822   -7.3670    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1359   -7.7026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0497   -8.5231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2427   -8.6946    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8504   -7.2901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8504   -6.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5648   -6.0526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2793   -6.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2793   -7.2901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5648   -7.7026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1523   -9.0882    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3238   -9.8952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 12 26  4  0  0  0  0
  9 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3445

>  <JC_XSMILES>
CC(C)OC(=O)CSC1=NN=C(CNC2=NC(=CS2)C3=CC=CC=C3)N1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.393

>  <W2 Pf proliferation inhibition EC50 uM>
1.382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3447
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 13 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 21 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3447

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(NC(=O)C2=CC=CC(OC)=C2)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.983

>  <W2 Pf proliferation inhibition EC50 uM>
1.376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3451
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    2.0367    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.6509    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1331   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8781   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0531   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7982   -1.7840    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3631   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0275   -3.9898    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1836   -3.1499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5191   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3396   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8245   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4890   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6685   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -4.5710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8178   -5.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4823   -5.9921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6618   -6.0783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1769   -5.4109    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5124   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  7 29  4  0  0  0  0
 29 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3451

>  <JC_XSMILES>
CC(=O)C1=CC=C(OCC2=CC(=NO2)C(=O)N3CCCCC3C4=CC=CN=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.21

>  <W2 Pf proliferation inhibition EC50 uM>
1.372

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3456
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398   -9.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9049   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 28 32  4  0  0  0  0
 11 33  2  0  0  0  0
  7 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3456

>  <JC_XSMILES>
COC1=CC=CC2=C1OCC(CN3CCC(CC3)C(=O)NC4=CC=C(C=C4)N5C=CC=N5)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.817

>  <W2 Pf proliferation inhibition EC50 uM>
>1.365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3463
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -1.6258   -7.8457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8008   -7.8457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3883   -7.1313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4367   -7.1313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8492   -6.4168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4367   -5.7023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8492   -4.9878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4367   -4.2734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8492   -3.5589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6742   -6.4168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0867   -5.7023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9117   -5.7023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3242   -4.9878    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1492   -4.9878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5617   -5.7023    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3867   -5.7023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7992   -4.9878    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3867   -4.2734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5617   -4.2734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3067   -3.4888    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9742   -3.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0604   -2.1834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8141   -1.8478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4815   -2.3327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2352   -1.9972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3953   -3.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6416   -3.4888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3463

>  <JC_XSMILES>
CCCCN(CCCC)CCCNC1=NC=NC2=C1NC3=CC=C(C)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1481

>  <W2 Pf proliferation inhibition EC50 uM>
0.1003

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.41

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3466
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    5.7663   -2.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044   -1.2111    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454   -1.6527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3649    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1899    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6024    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1899   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3649   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  2  0  0  0  0
  7 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3466

>  <JC_XSMILES>
CCOC(=O)C1=C(OC2=C1C(=O)C3=CC=CC=C3C2=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.128

>  <W2 Pf proliferation inhibition EC50 uM>
1.349

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014705882

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3472
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    4.5063    0.8732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0716    1.5745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2470    1.5487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8124    2.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    2.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5978    1.4972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0325    0.7959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8571    0.8217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917    0.1205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1163    0.1462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7732    1.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2406    0.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5232    1.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4626    1.9760    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3386    2.1727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7286    2.8997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2940    3.6009    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6840    4.3279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2494    5.0291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6394    5.7562    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2048    6.4574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5948    7.1844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4194    7.2102    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8540    6.5089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4640    5.7819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5532    2.9254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2244    0.7186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1986   -0.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8999   -0.5406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6269   -0.1506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6526    0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9514    1.1086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 16 26  4  0  0  0  0
  5 26  4  0  0  0  0
 13 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3472

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C3=NC(=NN3C(NCCN4CCOCC4)=N2)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1136

>  <W2 Pf proliferation inhibition EC50 uM>
0.1337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3481
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -4.0145   -2.6664    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -3.9039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5855   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8711   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1566   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421   -3.0789    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2724   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2724   -1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9868   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5743   -3.7934    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7013   -3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4158   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1302   -3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1302   -4.3164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4158   -4.7289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7013   -4.3164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3993   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3993   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2243   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6368   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2243   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3481

>  <JC_XSMILES>
OC(=O)CCCNC(=O)C(O)(C1=CC=CC=C1)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.327

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3482
  Mrv1591402191617072D          

 37 39  0  0  0  0            999 V2000
   -5.8284   -0.1363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0182    0.0196    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4782   -0.6041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6680   -0.4482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1279   -1.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3980   -1.8514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0477   -2.3191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5077   -2.9427    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6975   -2.7868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4275   -2.0073    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1574   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6527   -3.2546    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1928   -3.8782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0029   -3.7223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5430   -4.3459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2730   -5.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8131   -5.7491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6232   -5.5932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4628   -5.2814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1928   -6.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3827   -6.2168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9227   -4.6577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9227   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7023   -2.7450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1432   -2.2050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1928   -1.6954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6527   -1.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9227   -0.2923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -0.1363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0029    0.6432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2730   -0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0029   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2081   -2.0073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7482   -1.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5583   -1.5395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0984   -0.9159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 14 23  4  0  0  0  0
 13 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
  6 34  4  0  0  0  0
 34 35  4  0  0  0  0
  3 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3482

>  <JC_XSMILES>
COC1=CC=C(CCNC(=O)CN(C2=CC=C(OC)C(OC)=C2)S(=O)(=O)C3=CC=C(C)C=C3)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3494
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0032   -5.3493    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3390   -2.3346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11  6  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
 16 17  2  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  1  0  0  0  0
 14 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3494

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C=C2N=C(N(C2=O)C3=CC(Cl)=CC=C3C)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.48

>  <W2 Pf proliferation inhibition EC50 uM>
1.315

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3510
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
  6 27  4  0  0  0  0
 27 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  26
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3510

>  <JC_XSMILES>
COC1=CC=C2C=C(CNC3CCN(CC3)CC4=CC=CC=C4)C(=O)NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.671

>  <W2 Pf proliferation inhibition EC50 uM>
0.856

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>65.91

>  <Powder data?>
Yes

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3530
  Mrv1591402191617072D          

 42 45  0  0  0  0            999 V2000
    4.2867   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9104   -5.2719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6249   -4.8595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3394   -5.2720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0573   -6.0300    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3626    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1251    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3626    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5736   -6.6001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  7 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 24 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3530

>  <JC_XSMILES>
COC(=O)CNC(C1=CC=CC=C1)C2=CC(Br)=CC=C2NC(=O)C(CC3=CC=CC=C3)NC(=O)OCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
4.08

>  <W2 Pf proliferation inhibition EC50 uM>
1.275

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3542
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    7.5449    4.1799    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.7245    4.0936    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.2395    4.7611    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3889    3.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8014    2.6255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2494    2.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819    3.1684    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3542

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(O1)C(=O)NC2=CC=C3OC(=NC3=C2)C4=CC=CC=C4F

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.26

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3547
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    4.7812    4.4104    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3547

>  <JC_XSMILES>
ClC1=CC=CC(=C1)N2CN=C3SCC(=O)N3C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.256

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3551
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3551

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC(OC)=CC2=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
2.757

>  <W2 Pf proliferation inhibition EC50 uM>
1.252

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3554
  Mrv1591402191617072D          

 31 34  0  0  1  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -16.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 16 15  1  0  0  0  0
 16 11  1  0  0  0  0
 16 17  1  6  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3554

>  <JC_XSMILES>
COC1=CC=C(CNCCN2CCN(C[C@@H]2C3=CC=CC=C3)C4=CC=C(C)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.909

>  <W2 Pf proliferation inhibition EC50 uM>
0.125

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.0375

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-356
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    3.7638   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0638   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0638   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4283   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5388   -3.3809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013   -4.0954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -4.8099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3013   -5.5243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -5.5243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0638   -4.8099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -4.0954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0638   -3.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -3.3809    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 10 23  1  0  0  0  0
 23 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-356

>  <JC_XSMILES>
CCOC(=O)CN(N=O)C1=C(N2CC2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2058

>  <W2 Pf proliferation inhibition EC50 uM>
3.85

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.41

>  <Powder data?>
Yes

>  <IFI value>
0.308411215

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3560
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2398   -9.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -9.9320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9049   -9.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1203   -8.8925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5072   -9.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7226   -9.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5511   -8.3826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2336   -8.1277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4051   -7.3207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2080   -6.7687    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1897   -7.0658    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8028   -7.6178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6313   -8.4248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2444   -8.9768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0290   -8.7219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6421   -9.2739    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4267   -9.0189    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5982   -8.2120    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0398   -9.5710    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8244   -9.3160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4375   -9.8681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2222   -9.6131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3937   -8.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7806   -8.2541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9960   -8.5091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1783   -8.5512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8457   -9.0361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -9.5132   -8.5512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2582   -7.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4332   -7.7666    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9483   -7.0992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2005   -7.9149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5874   -7.3628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1641   -7.8306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9488   -8.0855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  1  0  0  0  0
 33 34  1  0  0  0  0
 18 35  4  0  0  0  0
 35 36  4  0  0  0  0
 15 36  4  0  0  0  0
 10 37  4  0  0  0  0
 37 38  4  0  0  0  0
  7 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3560

>  <JC_XSMILES>
CN1CCN=C1C2=CC=C(NC(=O)NC3=CC=C(NC(=O)NC4=CC=C(C=C4)C5=NCCN5C)C=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1576

>  <W2 Pf proliferation inhibition EC50 uM>
0.124

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008928571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3562
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3562

>  <JC_XSMILES>
CC1=CC(NC2=CC=CC=C2)=NC(NC3=CC=CC=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2589

>  <W2 Pf proliferation inhibition EC50 uM>
0.2478

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.02

>  <Powder data?>
Yes

>  <IFI value>
0.029850746

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3563
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.9625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184  -11.9625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684  -11.9625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -14.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -14.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -14.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 22 29  1  0  0  0  0
  9 30  4  0  0  0  0
 30 31  4  0  0  0  0
  6 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3563

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(NC(=O)C2=CC=C(C=C2)S(=O)(=O)N3CC(C)CC(C)C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.666

>  <W2 Pf proliferation inhibition EC50 uM>
1.237

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3565
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -1.3222    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -1.7116    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1472   -1.7116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4972   -1.7116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9897   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7743   -2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3874   -3.3186    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1720   -3.0637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3435   -2.2567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7851   -3.6157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6136   -4.4227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2267   -4.9747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0113   -4.7198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1828   -3.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5697   -3.3608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9674   -3.6579    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -7.5805   -4.2099    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -7.1390   -2.8509    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  2  9  4  0  0  0  0
  6 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  2  0  0  0  0
M  CHG  2  28   1  29  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3565

>  <JC_XSMILES>
CC1=CC(C)=C(C(C)=C1)S(=O)(=O)N2CCCC2CNC(=O)C3=CC=CC(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.914

>  <W2 Pf proliferation inhibition EC50 uM>
1.234

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3568
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5658    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2802    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8513    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3568

>  <JC_XSMILES>
CCCC1=[N+](CC(=O)C2=CC=C(OC)C=C2)C=CN3C(C)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.806

>  <W2 Pf proliferation inhibition EC50 uM>
1.231

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3577
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    8.5003   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3577

>  <JC_XSMILES>
CCOC(=O)C1CCN(CC1)C(=S)NC2=CC3=NSN=C3C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.347

>  <W2 Pf proliferation inhibition EC50 uM>
0.37

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
30.32

>  <Powder data?>
Yes

>  <IFI value>
0.12962963

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3583
  Mrv1591402191617072D          

 45 49  0  0  0  0            999 V2000
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.9625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184  -12.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684  -12.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -16.0875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184  -16.0875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684  -16.0875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -16.9125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -17.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -18.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -18.5625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -18.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -17.3250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -19.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -19.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -20.6250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -21.0375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -20.6250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -19.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -19.3875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
  8 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  2  0  0  0  0
 28 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  0  0  0  0
 34 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 42 43  1  0  0  0  0
  6 44  4  0  0  0  0
 44 45  4  0  0  0  0
  3 45  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3583

>  <JC_XSMILES>
COC1=CC=C(CN(CC2=CC=C(C=C2)C(C)C)S(=O)(=O)C3=CC=C(C=C3)S(=O)(=O)N4CCN(CC4)C5=CC=CC=C5F)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.213

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010416667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3584
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6131    1.3770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2775    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5429    2.0445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6900    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5150    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9275    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5150    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6900    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2775    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 16 25  4  0  0  0  0
  5 25  4  0  0  0  0
 13 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3584

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C3=NC(=NN3C(NCCCOC(C)C)=N2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.793

>  <W2 Pf proliferation inhibition EC50 uM>
1.212

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3586
  Mrv1591402191617072D          

 30 35  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4681   -2.5519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0202   -3.1650    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6077   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8626   -4.6641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3106   -5.2772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5036   -5.1057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2487   -4.3211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8007   -3.7080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
  9 14  4  0  0  0  0
  5 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  1  0  0  0  0
 15 20  4  0  0  0  0
  4 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 21 30  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3586

>  <JC_XSMILES>
CN1C=C(C(C2=CNC3=CC=CC=C23)C4=CC=CC=C14)C5=CC=C6C=CC=CC6=N5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.144

>  <W2 Pf proliferation inhibition EC50 uM>
1.21

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.065693431

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3597
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1612   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3597

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C(C=C3)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0812

>  <W2 Pf proliferation inhibition EC50 uM>
0.0465

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.89

>  <Powder data?>
No

>  <IFI value>
0.074766355

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3598
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  4 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3598

>  <JC_XSMILES>
CC1=CC2=C(NC3=CC=CC(Cl)=C3C)N=CN=C2S1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.914

>  <W2 Pf proliferation inhibition EC50 uM>
1.194

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3608
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -2.9980    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -4.4270    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3608

>  <JC_XSMILES>
CCN1CCN(CC1)C2=C(Cl)C=CC=C2NC(=O)C(Cl)(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
1.667

>  <W2 Pf proliferation inhibition EC50 uM>
1.185

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3609
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9441   -0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7511   -0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1636   -0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6116    0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  9 30  4  0  0  0  0
 30 31  4  0  0  0  0
  2 31  4  0  0  0  0
  6 31  4  0  0  0  0
  4 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 32 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3609

>  <JC_XSMILES>
CC1=CC(=NC2=CC=C(NC(=S)NCCCN3CCN(CC3)CC4=CC=CC=C4)C=C12)N5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1164

>  <W2 Pf proliferation inhibition EC50 uM>
0.658

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
55.54

>  <Powder data?>
Yes

>  <IFI value>
0.117647059

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-363
  Mrv1591402191617072D          

 44 50  0  0  0  0            999 V2000
    4.9082    0.4435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0230    0.5711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3685    0.0689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6063    0.3846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8487    1.2025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1532    1.7047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154    1.5057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7364    1.5182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0750    0.6255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9000    0.6255    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4833    1.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1978    0.7963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9123    1.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9123    2.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1978    2.4463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4833    2.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9000    2.6172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0750    2.6172    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4916    2.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2229    2.4463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9373    2.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9373    1.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2229    0.7963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4916    1.2088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9576    3.5910    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.1737    3.0578    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6450    3.8993    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4435    4.1416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3714    4.0134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8899    4.6551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5935    5.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1120    6.0667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2215    5.5532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7400    4.9115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8134   -0.2232    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2120   -1.0623    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8146   -0.6854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5314   -0.8989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3100   -0.6261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9356   -1.1639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7826   -1.9746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4081   -2.5124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0040   -2.2474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3784   -1.7096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  9 24  1  0  0  0  0
 19 24  4  0  0  0  0
 18 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
 10 35  1  0  0  0  0
 35 36  2  0  0  0  0
 35 37  2  0  0  0  0
 35 38  1  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  1  0  0  0  0
 41 43  4  0  0  0  0
 43 44  4  0  0  0  0
 38 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-363

>  <JC_XSMILES>
CC1=CC=C(C=C1)N2C3N(C4=CC=CC=C4C2N(C5=CC=CC=C35)S(=O)(=O)C6=CC=C(C)C=C6)S(=O)(=O)C7=CC=C(C)C=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
0.72

>  <W2 Pf proliferation inhibition EC50 uM>
1.492

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3645
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
  6 15  4  0  0  0  0
 15 16  2  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3645

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC(=CC2=C1O)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.151

>  <W2 Pf proliferation inhibition EC50 uM>
1.138

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3652
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2494   -1.1874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8014   -1.8005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3889   -2.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819   -2.3434    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 23 27  4  0  0  0  0
 19 28  4  0  0  0  0
 28 29  4  0  0  0  0
  6 29  4  0  0  0  0
 16 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3652

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(C2=CC=CC=C2)C3=CC=C(OC(=O)C4=CC=CO4)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.607

>  <W2 Pf proliferation inhibition EC50 uM>
1.136

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3655
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849    2.9980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599    4.4270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 10 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
  9 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 33 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3655

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2C(C(=O)NC3=CC=CC(=C3)C(F)(F)F)C4=CC=CC=C4C(=O)N2C5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.833

>  <W2 Pf proliferation inhibition EC50 uM>
1.129

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3666
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405    1.9856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925    1.3725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800    0.6580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731    0.8295    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3666

>  <JC_XSMILES>
CCC1=CC=C(NC(=O)COC(=O)C2=CC=CS2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
4.64

>  <W2 Pf proliferation inhibition EC50 uM>
1.11

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3679
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  9  6  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 12 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3679

>  <JC_XSMILES>
COC1=CC=C(C=C1)C=NNC2=CC(C)=NC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2276

>  <W2 Pf proliferation inhibition EC50 uM>
0.2074

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.86

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-368
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 18 22  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-368

>  <JC_XSMILES>
COC1=CC(=CC(Cl)=C1O)\C=C2\C(=O)NC(=S)N(CC=C)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.111

>  <W2 Pf proliferation inhibition EC50 uM>
>1.482

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3688
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -2.9980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7439   -4.5195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5644   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8999   -3.8520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1918   -5.1326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4468   -5.9172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3849   -4.9610    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3688

>  <JC_XSMILES>
CCCCN(CCCC)S(=O)(=O)C1=CC(Br)=CC2=C1N(CC2)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.29

>  <W2 Pf proliferation inhibition EC50 uM>
1.093

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3690
  Mrv1591402191617072D          

 48 54  0  0  0  0            999 V2000
    4.2301    4.6638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8397    5.2197    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6259    4.9698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2355    5.5257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0217    5.2757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6313    5.8316    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4175    5.5817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1983    4.4698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5888    3.9139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8025    4.1639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7654    3.1081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5516    2.8581    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1558    2.5522    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3325    1.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    1.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2954    0.6905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6858    0.1346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8996    0.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7229    1.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9367    1.4403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8667    2.2624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2360    2.7942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1662    1.6853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5828    0.7397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4049    0.8096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9521    1.2715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2752    0.7999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5283    1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4584    1.9723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353    2.4439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0654    3.2660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8822    2.0935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4140    2.7242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0816    0.4405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6912    0.9964    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2582   -0.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0444   -0.6153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2211   -1.4212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6115   -1.9771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8253   -1.7271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6486   -0.9213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7882   -2.7830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1786   -3.3389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3552   -4.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7457   -4.7006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9594   -4.4507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7828   -3.6448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3924   -3.0889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  2  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  1  0  0  0  0
 22 33  1  0  0  0  0
 16 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 36 41  1  0  0  0  0
 39 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 43 48  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3690

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)C(=O)NC2=CC(=CC=C2N3CC4CC(C3)C5=CC=CC(=O)N5C4)C(=O)N6CCC(CC6)CC7=CC=CC=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
1.872

>  <W2 Pf proliferation inhibition EC50 uM>
0.548

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
50.29

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3696
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  3  0  0  0  0
  5  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
  8 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3696

>  <JC_XSMILES>
CC1=CC=C(C#N)C(SCC2=NN=C(O2)C3=CC=C(Cl)C=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.1084

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3708
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -6.2929   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8804   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0554   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8179   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4054   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -2.6499    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1679   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5804   -1.2210    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1129   -3.3875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086   -4.0704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0536   -4.8550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2286   -4.8550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0263   -4.0704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8179   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6429   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 14 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
  6 29  4  0  0  0  0
 29 30  4  0  0  0  0
  3 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3708

>  <JC_XSMILES>
CCC1=CC=C(NC(=O)C2=C(N)C3=C(C4=C(CCCC4)N=C3S2)C5=CC=CO5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.816

>  <W2 Pf proliferation inhibition EC50 uM>
1.072

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3722
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4243    2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4743    2.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9894    3.6115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5044    4.2789    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
 11 16  1  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3722

>  <JC_XSMILES>
COC1=CC=C2N(C)C(=O)C(C)(CC#N)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
5.64

>  <W2 Pf proliferation inhibition EC50 uM>
1.062

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3731
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3731

>  <JC_XSMILES>
ClC1=CC=C2C(=C1)N=CC=C2N3CCC(CC3)N4C=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.018

>  <W2 Pf proliferation inhibition EC50 uM>
1.052

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016806723

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3735
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875   -0.4170    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945   -0.2455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070   -0.9600    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550   -1.5731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9265   -2.3800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7111   -2.6350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8826   -3.4419    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6673   -3.6969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  4  0  0  0  0
  4 14  4  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 15 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3735

>  <JC_XSMILES>
CCOC1=CC=C2NC(=O)C(=CC2=C1)C(N3CCCC3)C4=NN=NN4CCOC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.05

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3746
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.8837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  2  0  0  0  0
  5 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3746

>  <JC_XSMILES>
COC1=CC(NC(C)=C2C(=O)C3=CC=CC=C3C2=O)=C(OC)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
2.404

>  <W2 Pf proliferation inhibition EC50 uM>
1.04

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3752
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -13.6125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -14.0250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315  -14.8500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
 10  5  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 24 23  1  4  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 26 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3752

>  <JC_XSMILES>
COC1=CC(=CC=C1O)C=NNC(=O)C2=CC=C(C=C2)C(=O)NN=CC3=CC=C(O)C(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.652

>  <W2 Pf proliferation inhibition EC50 uM>
1.03

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3753
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -2.8579   12.9536    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   10.4786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    9.2411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.2911    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0405   11.7930    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5925   12.4061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1800   13.1206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3731   12.9491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
 20 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 24 28  1  0  0  0  0
  4 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  2 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 32 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3753

>  <JC_XSMILES>
ClC1=CC(NC(=O)C2=CC=CC(=C2)C(=O)NC3=CC=C(C(Cl)=C3)C4=NCCN4)=CC=C1C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.307

>  <W2 Pf proliferation inhibition EC50 uM>
0.1029

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009174312

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3759
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
  6 22  4  0  0  0  0
  2 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3759

>  <JC_XSMILES>
CC1=CC=CC(NS(=O)(=O)C2=CC=C3NC(=O)C=CC3=C2)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.838

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
81.84

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-376
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-376

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NC3=CC=C(Cl)C=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.226

>  <W2 Pf proliferation inhibition EC50 uM>
2.685

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.28

>  <Powder data?>
Yes

>  <IFI value>
0.033707865

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3767
  Mrv1591402191617072D          

 14 14  0  0  0  0            999 V2000
    2.4489   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1634   -2.9519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1634   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8779   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5923   -2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3068   -3.3644    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3068   -4.1894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0213   -2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7357   -3.3644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4894   -3.0288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0414   -3.6419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8619   -3.5557    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.6289   -4.3564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8220   -4.1848    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3767

>  <JC_XSMILES>
CN(C)CCN(C)CC1=CC(Br)=CS1

>  <PF proliferation inhibition 3D7 EC50 uM>
>2.338

>  <W2 Pf proliferation inhibition EC50 uM>
1.014

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3775
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4515    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2585    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5134   -0.2736    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8105    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6175    0.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1695    1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9146    2.3503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1076    2.5218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5556    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243    1.9817    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 13 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
  7 27  4  0  0  0  0
 11 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3775

>  <JC_XSMILES>
CCCN1CCC2=C(C1)SC3=NC(SCC(=O)C4=CC=CC=C4)=NC(N)=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
1.415

>  <W2 Pf proliferation inhibition EC50 uM>
1.008

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.08

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3792
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5303   -1.8430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5303   -1.8430    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3428   -1.9863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8731   -1.3543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6249   -2.7615    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 11 18  1  0  0  0  0
  7 19  1  0  0  0  0
  2 19  1  0  0  0  0
 19 20  2  0  0  0  0
  4 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3792

>  <JC_XSMILES>
CC1CC(C)(CC(C(O)CC2CC(=O)NC(=O)C2)C1=O)OC(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0747

>  <W2 Pf proliferation inhibition EC50 uM>
0.0587

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>5.89

>  <Powder data?>
No

>  <IFI value>
0.226415094

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3795
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  1  0  0  0  0
  5 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
  3 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3795

>  <JC_XSMILES>
COC1=CC(NCC2=CN=C(N)N=C2N)=CC(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.33

>  <W2 Pf proliferation inhibition EC50 uM>
0.0992

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3804
  Mrv1591402191617072D          

 44 49  0  0  0  0            999 V2000
    4.7624    5.0280    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.7624    4.2030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4768    3.7905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4768    2.9655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7624    2.5530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0479    2.9655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0479    3.7905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7624    1.7280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4298    1.2431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1749    0.4585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3499    0.4585    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0949    1.2431    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3103    1.4980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1388    2.3050    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6972    0.9460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9126    1.2010    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2995    0.6489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3857   -0.1716    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6320   -0.5071    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0800    0.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7405    0.0197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0760   -0.7339    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8965   -0.8202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3814   -0.1527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2321   -1.5738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0525   -1.6601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3881   -2.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2086   -2.5000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6935   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3580   -1.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5375   -0.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4925    0.8204    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1570    1.5741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6419    2.2416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3063    2.9952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7912    3.6627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6117    3.5764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9473    2.8228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4624    2.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6598   -0.2090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4848   -0.2090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7397   -0.9936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0723   -1.4785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4048   -0.9936    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 20 32  4  0  0  0  0
 17 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 10 40  1  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 40 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3804

>  <JC_XSMILES>
FC1=CC=C(C=C1)C2CC(=NN2C(=O)CSC3=NN=C(CNC(=O)CC4=CC=CC=C4)N3CC5=CC=CC=C5)C6=CC=CS6

>  <PF proliferation inhibition 3D7 EC50 uM>
8.85

>  <W2 Pf proliferation inhibition EC50 uM>
0.984

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3806
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  4 13  4  0  0  0  0
  9 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3806

>  <JC_XSMILES>
OC(=O)C1=CC=C2CN(C=NC2=C1)C3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2675

>  <W2 Pf proliferation inhibition EC50 uM>
0.0983

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.0125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3810
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -4.7651   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2251   -2.0171    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4149   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -1.0816    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560    1.1012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.2571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758    2.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.6603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    2.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    1.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    3.4398    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358    3.5957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    4.0635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -0.6139    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -2.0171    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845   -2.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -4.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -3.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3347   -3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1449   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  5 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3810

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(C=C2)N(C)C)C(=O)C(Cl)Cl)=C3N=CC=CC3=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.948

>  <W2 Pf proliferation inhibition EC50 uM>
0.0666

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.79

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3817
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    3.2278   -3.1094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5133   -3.5219    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5133   -4.3469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2278   -4.7594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2278   -5.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5133   -5.9969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5133   -6.8219    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7989   -7.2344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7989   -5.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7989   -4.7594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0844   -5.9969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0844   -6.8219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3699   -7.2344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3445   -6.8219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0590   -7.2344    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3445   -5.9969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0590   -5.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7735   -5.9969    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4880   -5.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1696   -6.0491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9579   -5.8060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2594   -5.0380    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8469   -4.3235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0311   -4.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4263   -4.7617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3699   -5.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 19 25  1  0  0  0  0
 16 26  4  0  0  0  0
 11 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3817

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CNC3CCCCCC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.364

>  <W2 Pf proliferation inhibition EC50 uM>
0.0975

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02970297

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3829
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1995   -0.5701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 11 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 16 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
 15 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3829

>  <JC_XSMILES>
CC(C)C1=CC=C(C=C1C)N(C(C)=O)C2=C(N3CCOCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02558

>  <W2 Pf proliferation inhibition EC50 uM>
0.0881

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.15

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3838
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  3 16  4  0  0  0  0
 11 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3838

>  <JC_XSMILES>
CCN1C2=C(CCC2)C(=N)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.341

>  <W2 Pf proliferation inhibition EC50 uM>
0.954

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3859
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.5837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  9  8  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3859

>  <JC_XSMILES>
OC1=CC=C(Br)C=C1C=NNC2=NC3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.536

>  <W2 Pf proliferation inhibition EC50 uM>
0.504

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.98

>  <Powder data?>
Yes

>  <IFI value>
0.014285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3870
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -3.5558    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 23 29  4  0  0  0  0
 29 30  4  0  0  0  0
 13 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3870

>  <JC_XSMILES>
CC(Cl)C(=O)OC1=CC=CC=C1C2=C(NCC3=CC=CC=C3)N4C=CC=C(C)C4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.764

>  <W2 Pf proliferation inhibition EC50 uM>
0.925

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3876
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.8734   -3.6671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9535   -2.7316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6033   -2.2639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7932   -2.4198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2531   -1.7961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5570   -1.9520    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971   -1.3284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8271   -0.5488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0169   -0.3929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2531    0.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0632    0.5425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3333    1.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7932    1.9457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2194    2.6521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0229    2.4650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0933    1.6430    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0169    1.7898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2870    1.0103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971    0.8543    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3672    0.0748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1773   -0.0811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8271   -2.7316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2870   -3.3552    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6372   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9073   -3.6671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7174   -3.8230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9874   -4.6025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4473   -5.2262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6372   -5.0702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0971   -5.6939    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.3672   -4.2907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 14 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  2  0  0  0  0
  7 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3876

>  <JC_XSMILES>
CN(C)CCCN(CC1=CC2=CC3=C(OCO3)C=C2NC1=O)C(=S)NC4=CC=CC(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.978

>  <W2 Pf proliferation inhibition EC50 uM>
0.918

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.049586777

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3878
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  4  0  0  0  0
 22 27  4  0  0  0  0
 12 28  4  0  0  0  0
 28 29  4  0  0  0  0
  9 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3878

>  <JC_XSMILES>
CCN1CCN(CC1)C2=CC=C(NC3=C4C=CC=CC4=NC5=CC=CC=C35)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0507

>  <W2 Pf proliferation inhibition EC50 uM>
0.1597

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.42

>  <Powder data?>
Yes

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3879
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   10.3046   -0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.1296   -1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
 15 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  2  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3879

>  <JC_XSMILES>
CCCCNC(=O)C1CCC(CC1)CN(CC2=C(Cl)C=CC=C2Cl)S(=O)(=O)C3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.546

>  <W2 Pf proliferation inhibition EC50 uM>
0.916

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3880
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.2576   -8.4615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3438   -7.6410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0975   -7.3054    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7649   -7.7904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5186   -7.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1837   -6.4850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9374   -6.1494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0236   -5.3289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3562   -4.8440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6025   -5.1796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5163   -6.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4424   -4.0235    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7750   -3.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -2.3056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042   -1.4986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481   -2.1661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 12  9  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3880

>  <JC_XSMILES>
CCN(CC)C1=CC=C(C=C1)N=CC2=CC=C(O2)SC3=NC4=CC=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2706

>  <W2 Pf proliferation inhibition EC50 uM>
0.0988

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.79

>  <Powder data?>
Yes

>  <IFI value>
0.093023256

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3883
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
   -3.3497   -6.5631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6353   -6.1506    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6353   -5.3256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9208   -4.9131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9208   -4.0881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6353   -3.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3497   -4.0881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3497   -4.9131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9947   -5.4275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7990   -5.2439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1570   -4.5006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7990   -3.7573    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9947   -3.5738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3134   -3.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0120   -2.3444    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1292   -3.2353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6436   -2.5903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4594   -2.7132    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8394   -3.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.6533   -3.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2410   -3.8893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.7762   -2.4946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0384   -2.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9032   -1.3117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2063   -3.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2063   -2.8506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4918   -2.4381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4918   -1.6131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2226   -2.8506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9371   -2.4381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9371   -1.6131    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2226   -1.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6516   -2.8506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6516   -3.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9371   -4.0881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9371   -4.9131    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2226   -5.3256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2226   -3.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4918   -4.0881    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 29 38  4  0  0  0  0
 38 39  4  0  0  0  0
 25 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3883

>  <JC_XSMILES>
COC1=CC(=CC2=C1OCCN(C2)C(=O)CCN3N=C(C)C=C3C)C4=CC(C)=C5C(OC)=CC=C(OC)C5=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.709

>  <W2 Pf proliferation inhibition EC50 uM>
0.913

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-389
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 10 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-389

>  <JC_XSMILES>
CCCCN1CC2=CC=C(C=C2N=C1C3=CC=C(F)C=C3)C(=O)NCC=C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.191

>  <W2 Pf proliferation inhibition EC50 uM>
2.45

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.88

>  <Powder data?>
Yes

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3897
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    1.4229   -2.4457    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2828    0.5213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5377    1.3059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3447    1.4774    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.5996    2.2621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4066    2.4336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9586    1.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7037    1.0359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8967    0.8644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3897

>  <JC_XSMILES>
FC1=CC=C2NC3=C(NCCN4CCCCC4)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1544

>  <W2 Pf proliferation inhibition EC50 uM>
0.2141

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.73

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3900
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    5.0645   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842    2.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8912    2.6679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4432    2.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2502    2.2263    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1883    1.2701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813    1.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.3140    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  2  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
  9 15  1  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3900

>  <JC_XSMILES>
CCN1C(=O)C2=C(SC3=C2CCN(C)C3)N=C1SCC4=CC=C(Cl)C=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.942

>  <W2 Pf proliferation inhibition EC50 uM>
0.9

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.117647059

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3903
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -4.4270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -2.9980    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3903

>  <JC_XSMILES>
CN(C)CCNC(=S)NC1=CC=CC(=C1)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
4.03

>  <W2 Pf proliferation inhibition EC50 uM>
0.897

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3918
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3918

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1217

>  <W2 Pf proliferation inhibition EC50 uM>
0.0756

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.53

>  <Powder data?>
No

>  <IFI value>
0.064814815

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-393
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    4.8946   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5620   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3071   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9972   -3.3593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1767   -3.2731    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6918   -3.9405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8713   -3.8543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5357   -3.1006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0206   -2.4332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8411   -2.5194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7152   -3.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3797   -2.2607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4408   -2.1744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7764   -1.4208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2914   -0.7533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5291   -0.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8646   -1.5932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2272   -1.9072    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  5 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-393

>  <JC_XSMILES>
CC1=CC=C(CN2CCN(CC2)CC3=CC=CC=C3)O1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.3

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>8.97

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3950
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.1018    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5364    2.7327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1464    2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5810    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4056    1.3302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9295   -2.2275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7541   -2.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0751   -2.3078    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6535    0.9668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3119    1.3749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
  7 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  2  0  0  0  0
 16 21  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3950

>  <JC_XSMILES>
CCCC(=O)N1C2=CC=C(OC)C=C2C3=C(SSC3=S)C1(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.791

>  <W2 Pf proliferation inhibition EC50 uM>
0.867

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3951
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  8 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
  7 23  1  0  0  0  0
 23 24  2  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3951

>  <JC_XSMILES>
FC1=CC=C(NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.335

>  <W2 Pf proliferation inhibition EC50 uM>
0.319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.82

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3954
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -0.7027    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  2  0  0  0  0
 12 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3954

>  <JC_XSMILES>
CC(=O)NC1=CC=C(C=C1)N2C(SCC2=O)C3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.326

>  <W2 Pf proliferation inhibition EC50 uM>
0.865

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3955
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9543   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6194   -5.4349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  6 12  4  0  0  0  0
 10 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 30 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3955

>  <JC_XSMILES>
CC1=CC=CN2C(=O)C3=C(N=C12)N(CCC4=CC=CC=C4)C(=N)C(=C3)C(=O)NCC5=CC=CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.388

>  <W2 Pf proliferation inhibition EC50 uM>
0.865

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.078125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3973
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 15 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  4  0  0  0  0
 31 32  4  0  0  0  0
  9 32  4  0  0  0  0
M  CHG  2  26   1  27  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3973

>  <JC_XSMILES>
CCN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)C4=CC=C(F)C(=C4)[N+]([O-])=O)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.158

>  <W2 Pf proliferation inhibition EC50 uM>
0.365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.94

>  <Powder data?>
Yes

>  <IFI value>
0.066666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3974
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -0.1145   -4.4153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5917   -3.9888    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5755   -3.1640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1470   -2.7656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1633   -1.9408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5429   -1.5143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2654   -1.9126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9716   -1.4861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9554   -0.6613    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6131   -0.1633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3427    0.6162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0005    1.1142    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6774    0.6425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4568    0.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4379   -0.1470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5179    0.5999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2785   -0.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4750   -0.3770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2356   -1.1665    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0890    0.2251    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8924    0.0377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1505    1.0146    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539    1.2020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2817   -2.7374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 10 15  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 16 23  4  0  0  0  0
  7 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3974

>  <JC_XSMILES>
COC1=CC=CC(CN2C3=C(SC(C)=C3)C4=C2C(=O)N(C)N=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.497

>  <W2 Pf proliferation inhibition EC50 uM>
0.583

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.6

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3982
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3982

>  <JC_XSMILES>
CC1=NC2=CC=CC=C2C(O)=C1CC=C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.707

>  <W2 Pf proliferation inhibition EC50 uM>
0.844

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3988
  Mrv1591402191617072D          

 43 46  0  0  0  0            999 V2000
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6144   -3.1605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2788   -2.4068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4584   -2.4930    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -11.9625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 38 41  4  0  0  0  0
 32 41  4  0  0  0  0
  6 42  4  0  0  0  0
 42 43  4  0  0  0  0
  3 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3988

>  <JC_XSMILES>
COC1=CC=C(NC(=O)CCCCCN2C(=O)C3=C(C=CS3)N=C2SCC(=O)NCCC4=CC=C(OC)C(OC)=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.31

>  <W2 Pf proliferation inhibition EC50 uM>
0.837

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3992
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3992

>  <JC_XSMILES>
C1CCC(CC1)CN2CCC3=C(C2)SC(=N3)N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2536

>  <W2 Pf proliferation inhibition EC50 uM>
0.0832

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-401
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -1.5246   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -1.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -1.3480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -0.5684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -1.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -0.1007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3657    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.4584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.2380    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860    0.8348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    0.9907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164    1.3025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    1.9262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662    1.7702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    2.3939    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    3.1734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -1.8157    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -2.7512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -3.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261   -4.1543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -4.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -5.0898    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -3.6866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459   -2.9071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-401

>  <JC_XSMILES>
CCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OC)C(=O)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.022

>  <W2 Pf proliferation inhibition EC50 uM>
0.633

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>4.4

>  <Powder data?>
No

>  <IFI value>
0.028846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4010
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    3.1619   -9.1108    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6098   -8.4977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8028   -8.6692    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2508   -8.0562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5058   -7.2715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3127   -7.1000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8648   -7.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5677   -6.3154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0827   -5.6479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5677   -4.9805    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -6.4729    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -7.2979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -6.0604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825   -7.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3956   -7.8500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0601   -8.6037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2396   -8.5174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -7.7104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536   -7.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -6.4729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -6.0604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
 14 29  4  0  0  0  0
 29 30  4  0  0  0  0
  8 30  4  0  0  0  0
 11 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4010

>  <JC_XSMILES>
FC1=CC=CC(=C1)C2=NN=C3C=CC(SCC(=O)NC4=CC=C5OCOC5=C4)=NN23

>  <PF proliferation inhibition 3D7 EC50 uM>
2.107

>  <W2 Pf proliferation inhibition EC50 uM>
0.819

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4018
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  9 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4018

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2N(CC3=CC=CC=C3)C4=CC=CC=C4N2CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.561

>  <W2 Pf proliferation inhibition EC50 uM>
0.431

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.03

>  <Powder data?>
Yes

>  <IFI value>
0.2

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4022
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    4.5063    0.8732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0716    1.5745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2470    1.5487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8124    2.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    2.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5978    1.4972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0325    0.7959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8571    0.8217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917    0.1205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1163    0.1462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7732    1.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2406    0.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5232    1.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4626    1.9760    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3386    2.1727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7286    2.8997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2940    3.6009    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5306    3.5751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9652    4.2764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7898    4.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2244    4.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8344    5.6789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0098    5.7046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5752    5.0034    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5532    2.9254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2244    0.7186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1986   -0.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8999   -0.5406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6269   -0.1506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6526    0.6740    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9514    1.1086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 16 25  4  0  0  0  0
  5 25  4  0  0  0  0
 13 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4022

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C3=NC(=NN3C(NCC4=CC=CC=C4)=N2)C5=CC=CN=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.81

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4024
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  9  8  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
  8 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4024

>  <JC_XSMILES>
COC1=CC=C(O)C(C=NNC2=NC3=CC=CC=C3N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.576

>  <W2 Pf proliferation inhibition EC50 uM>
0.355

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
43.89

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4027
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    1.8670   -1.3925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1525   -1.8050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1525   -2.6300    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4380   -3.0425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2764   -2.6300    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4380   -3.8675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1055   -4.3524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8901   -4.0975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8505   -5.1370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0255   -5.1370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4594   -5.8045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2799   -5.7182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8319   -6.3313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6604   -7.1383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5856   -5.9958    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4993   -5.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1124   -4.6233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6924   -5.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -6.4083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -7.2333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0145   -7.6458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7290   -7.2333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7290   -6.4083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4434   -5.9958    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -4.0145   -5.9958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2294   -4.3524    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0140   -4.0975    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
 15 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 19 25  4  0  0  0  0
 10 26  1  0  0  0  0
  6 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4027

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC(=CC2=C(C)N(C(C)=C2)C3=CC=CC(Br)=C3)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.877

>  <W2 Pf proliferation inhibition EC50 uM>
0.805

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-403
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-403

>  <JC_XSMILES>
CCOC(=O)C1=C(Cl)N=NC(C2=CC=CC=C2)=C1C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.797

>  <W2 Pf proliferation inhibition EC50 uM>
>1.438

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4032
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -0.1067    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    6.4152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0051    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3551    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
  8 11  1  0  0  0  0
  6 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  4 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4032

>  <JC_XSMILES>
CCNC1=NC(NC(C)(C)C)=NC(=N1)N2CCCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.451

>  <W2 Pf proliferation inhibition EC50 uM>
0.802

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4034
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4034

>  <JC_XSMILES>
CC1=CC=C2C=CC(C(NC3=CC=CC=N3)C4=CC=C(Br)C=C4)=C(O)C2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.221

>  <W2 Pf proliferation inhibition EC50 uM>
0.8

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4041
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    0.7932   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6033   -4.7389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8734   -6.1421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0632   -6.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9535   -5.2066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4936   -5.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3038   -5.6743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8439   -6.2980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5738   -7.0775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1139   -7.7012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9240   -7.5452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4641   -8.1689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2743   -8.0130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8144   -8.6366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5443   -9.4162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0844  -10.0398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7342   -9.5721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1941   -8.9484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3839   -9.1043    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8439   -8.4807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0337   -8.6366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6540   -6.1421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1941   -6.7657    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.9240   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7342   -5.2066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0042   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8144   -4.2711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3544   -4.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0844   -5.6743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6245   -6.2980    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.2743   -5.8302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  2  0  0  0  0
  9 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4041

>  <JC_XSMILES>
CCN(CC)CCCN(CC1=CC2=CC=C(C)C=C2NC1=O)C(=S)NC3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.7

>  <W2 Pf proliferation inhibition EC50 uM>
0.1759

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.1

>  <Powder data?>
Yes

>  <IFI value>
0.094017094

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4048
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4712   -0.6979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.1271    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -1.5229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018   -3.0331    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  1  0  0  0  0
 11 16  4  0  0  0  0
  8 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4048

>  <JC_XSMILES>
CC1=CC=C(NC2=C(C(=O)C3=CC=CC=C23)C4=CC=C(C=C4)C(F)(F)F)C=C1F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.541

>  <W2 Pf proliferation inhibition EC50 uM>
0.79

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4049
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.1599    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  6 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
  3 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
  2 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4049

>  <JC_XSMILES>
CC1=C2C=NN(CC(O)=O)C(=O)C2=C(C)N1CC3=CC=CC(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.789

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4051
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4051

>  <JC_XSMILES>
ClC1=NC(NC2=CC=CC=C2)=NC(=N1)N3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.381

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.32

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4059
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
  8 25  4  0  0  0  0
 25 26  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 34 37  1  0  0  0  0
 37 38  2  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 37 42  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4059

>  <JC_XSMILES>
CNC(=O)C1=CC=C(NC(=O)NC2=CC=C(C=C2)C3=NCCCN3)C=C1NC(=O)NC4=CC=C(C=C4)C5=NCCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1256

>  <W2 Pf proliferation inhibition EC50 uM>
0.0783

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4069
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4069

>  <JC_XSMILES>
CC(NCC1=CC(=CC=C1O)C2=CC=CC=C2)C3=CC=CC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
1.212

>  <W2 Pf proliferation inhibition EC50 uM>
0.0773

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016949153

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4072
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    3.8989   -4.4309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919   -4.6024    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4712   -0.6979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.1271    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -1.5229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  1  0  0  0  0
 12 17  4  0  0  0  0
  9 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
  6 28  4  0  0  0  0
 28 29  4  0  0  0  0
  3 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4072

>  <JC_XSMILES>
COC1=CC=C(NC2=C(C(=O)C3=CC=CC=C23)C4=CC=C(C=C4)C(F)(F)F)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.339

>  <W2 Pf proliferation inhibition EC50 uM>
0.772

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4077
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    4.2187    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
  6 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4077

>  <JC_XSMILES>
CCN(CC)C1=CC=C(NC(=O)C2=CC=CS2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.414

>  <W2 Pf proliferation inhibition EC50 uM>
0.77

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.070921986

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4080
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    6.1368    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 13 18  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4080

>  <JC_XSMILES>
CCC1=CC=C(NC2=CC(C)=NC3=NC(C)=NN23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.574

>  <W2 Pf proliferation inhibition EC50 uM>
0.768

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4094
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 11 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
  7 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  CHG  4  16   1  17  -1  19   1  20  -1
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4094

>  <JC_XSMILES>
CC1=CC(C)=NC(NNC2=C(C=CC=C2[N+]([O-])=O)[N+]([O-])=O)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.803

>  <W2 Pf proliferation inhibition EC50 uM>
0.1671

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.96

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4104
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  1  0  0  0  0
  9 14  4  0  0  0  0
  6 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
 15 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4104

>  <JC_XSMILES>
CCCNC1=C(C(=O)C2=CC=CC=C12)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.38

>  <W2 Pf proliferation inhibition EC50 uM>
0.754

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4115
  Mrv1591402191617072D          

 39 44  0  0  0  0            999 V2000
    3.2789    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4539    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    5.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    5.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    4.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6551    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4615   -0.0769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0136   -0.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6011   -1.4045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7941   -1.2330    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  1  0  0  0  0
  9 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 22 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
  7 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 35 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4115

>  <JC_XSMILES>
FC(F)(F)C1CC(NC2=CC(=NN12)C(=O)N3CCN(CC3)C(C4=CC=CC=C4)C5=CC=CC=C5)C6=CC=CS6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.341

>  <W2 Pf proliferation inhibition EC50 uM>
0.745

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4116
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.4507    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
  9 15  1  0  0  0  0
 16  7  1  4  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 18 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4116

>  <JC_XSMILES>
CCOC(=O)C1=C(SC2=C1CCN(C)C2)N=CC3=CC=CC(OC)=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.744

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4118
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    1.4290   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1995   -0.5701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 17 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
 16 32  1  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4118

>  <JC_XSMILES>
CCCCOC1=CC=C(C=C1)N(C(C)=O)C2=C(N3CCOCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2315

>  <W2 Pf proliferation inhibition EC50 uM>
0.3044

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
41.01

>  <Powder data?>
Yes

>  <IFI value>
0.162162162

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4133
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  7 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4133

>  <JC_XSMILES>
CN(C)CCNC1=CC(=NC2=CC=CC=C12)C3=CC=C4C=CC=CC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.81

>  <W2 Pf proliferation inhibition EC50 uM>
0.729

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045112782

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4135
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 13 12  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 11 20  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4135

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NN=CC3=CC=CS3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1575

>  <W2 Pf proliferation inhibition EC50 uM>
0.1337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.36

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4138
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
  6 22  4  0  0  0  0
 13 22  4  0  0  0  0
  9 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  CHG  1   9   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4138

>  <JC_XSMILES>
CCOC(=O)C1=C(C)[N+](=C(CC)C2=CC(OC)=C(OC)C=C12)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.702

>  <W2 Pf proliferation inhibition EC50 uM>
0.683

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>93.99

>  <Powder data?>
Yes

>  <IFI value>
0.022900763

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4140
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780   -4.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 11 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4140

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=CSC3=NC=NC(Cl)=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
2.317

>  <W2 Pf proliferation inhibition EC50 uM>
0.723

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.061538462

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4153
  Mrv1591402191617072D          

 42 45  0  0  0  0            999 V2000
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 12 23  4  0  0  0  0
 11 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
  9 27  1  0  0  0  0
 24 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 10 33  1  0  0  0  0
  6 33  2  0  0  0  0
 33 34  1  0  0  0  0
  7 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4153

>  <JC_XSMILES>
CCOC(=O)C1C(CC2=C(C(C3=CC(OC)=C(OC)C(OC)=C3)C(=C(C)N2)C(=O)OCC)C1=O)C4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.713

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4157
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 20 27  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  3 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4157

>  <JC_XSMILES>
COC1=CC2=C(CC(=O)NC3=CC=CC=C3)C(O)=CC(N4CCOCC4)=C2C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.626

>  <W2 Pf proliferation inhibition EC50 uM>
0.712

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.044117647

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4161
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -2.9279   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5154   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  1  16   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4161

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=CN3CCSC3=[N+]2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.582

>  <W2 Pf proliferation inhibition EC50 uM>
0.709

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4169
  Mrv1591402191617072D          

 44 51  0  0  0  0            999 V2000
    5.5403    2.0532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353   -0.8278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0764    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    3.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1125    0.6243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 11 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 24 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 31 38  2  0  0  0  0
 15 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4169

>  <JC_XSMILES>
CC1=CC=CC(=C1)N2C(=O)C3C(C2=O)C5(C4=CC=CC=C4)C(=O)C3(C6=CC=CC=C6)C(C7=CC=CC=C7)=C5C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
1.64

>  <W2 Pf proliferation inhibition EC50 uM>
0.7

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4174
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -6.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -6.8007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4824   -6.0471    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -7.4682    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -7.3820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -8.0494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -8.8031    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -8.8893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -8.2219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -9.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9070   -9.3843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3919  -10.0517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0564  -10.8054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5413  -11.4728    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.2359  -10.8916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7510  -10.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -5.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -6.8870    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.2890   -6.8007    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.8671   -7.6407    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  CHG  4   1  -1   2   1  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4174

>  <JC_XSMILES>
[O-][N+](=O)C1=CN(CC(=O)N2CCN(CC2)C3=CC=C(F)C=C3)C(=N1)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.067

>  <W2 Pf proliferation inhibition EC50 uM>
0.2335

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.63

>  <Powder data?>
Yes

>  <IFI value>
0.042553191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4177
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 13 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4177

>  <JC_XSMILES>
CC1=CC=C(F)C=C1NC(=O)CN2C3=CC=CC=C3C(=O)C4=CC(Cl)=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
1.18

>  <W2 Pf proliferation inhibition EC50 uM>
0.694

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4179
  Mrv1591402191617072D          

 42 45  0  0  0  0            999 V2000
   15.0039  -13.6125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907  -13.6125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762  -14.8500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
  2 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 34 37  1  0  0  0  0
 37 38  2  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 37 42  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4179

>  <JC_XSMILES>
O=C(NCCCCCCCCCCNC(=O)NC1=CC=C(C=C1)C2=NCCCN2)NC3=CC=C(C=C3)C4=NCCCN4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0542

>  <W2 Pf proliferation inhibition EC50 uM>
0.0693

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018348624

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4195
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.0937   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5417   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7966   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6036   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8585   -4.0609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3065   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4995   -4.5024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2446   -3.7178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0937    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5417    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7966    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6036    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1556    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9007    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  6 15  4  0  0  0  0
  3 15  4  0  0  0  0
 15 16  1  0  0  0  0
  1 16  1  0  0  0  0
  4 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4195

>  <JC_XSMILES>
C1CN2C(=C[N+](CCC3=CC=CC=C3)=C2C1)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.66

>  <W2 Pf proliferation inhibition EC50 uM>
0.684

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4208
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  3 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4208

>  <JC_XSMILES>
CCC(C(=O)N1CCN(CC1)CC2=CC=CC=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
6.91

>  <W2 Pf proliferation inhibition EC50 uM>
0.677

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016129032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4209
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 10 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
  8 18  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4209

>  <JC_XSMILES>
CCCN1N=C(OC2=NC(NCC)=CC(OC)=N2)C=CC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.384

>  <W2 Pf proliferation inhibition EC50 uM>
0.677

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-421
  Mrv1591402191617072D          

 45 52  0  0  0  0            999 V2000
    6.3653    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    2.0532    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353   -0.8278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0764    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    3.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1125    0.6243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 16 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 12 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 25 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 32 39  2  0  0  0  0
 16 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 40 45  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-421

>  <JC_XSMILES>
CC1=CC=C(C=C1Br)N2C(=O)C3C(C2=O)C5(C4=CC=CC=C4)C(=O)C3(C6=CC=CC=C6)C(C7=CC=CC=C7)=C5C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
1.437

>  <W2 Pf proliferation inhibition EC50 uM>
1.409

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4220
  Mrv1591402191617072D          

 45 49  0  0  0  0            999 V2000
    6.3468   -4.9628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3468   -5.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0613   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0613   -7.0253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3468   -7.4378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3468   -8.2628    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6324   -8.6753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9179   -8.2628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9179   -7.4378    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2034   -8.6753    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4890   -8.2629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7745   -8.6754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0600   -8.2629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3456   -8.6754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6311   -8.2629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6311   -7.4379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3455   -7.0254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0600   -7.4379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6324   -9.5003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3469   -9.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3469  -10.7378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6324  -11.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6324  -11.9753    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9179  -10.7378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9179   -9.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0613   -8.6753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0613   -9.5003    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7758   -8.2628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5295   -8.5983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7010   -9.4053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0815   -7.9852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6690   -7.2708    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8620   -7.4423    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.9020   -8.0714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2375   -8.8251    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3869   -7.4040    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.2074   -7.4902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6923   -6.8228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.5128   -6.9090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8483   -7.6627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3634   -8.3301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5429   -8.2439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6324   -7.0253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8119   -6.9391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6323   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  7 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
  6 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 37 42  1  0  0  0  0
  5 43  4  0  0  0  0
 43 44  1  0  0  0  0
 43 45  4  0  0  0  0
  2 45  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4220

>  <JC_XSMILES>
CC1=CC=C(N(C(C(=O)NCCC2=CC=CC=C2)C3=CC=C(O)C=C3)C(=O)C4=C(N)C(=NS4)C(=O)NC5CCCCC5)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.476

>  <W2 Pf proliferation inhibition EC50 uM>
0.672

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.052083333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4225
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.2302   -5.1030    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3249   -4.2835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0819   -3.9556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1766   -3.1361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9337   -2.8083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0283   -1.9887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7854   -1.6609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4478   -2.1526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3532   -2.9722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0156   -3.4639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9210   -4.2835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1639   -4.6113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5015   -4.1196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7444   -4.4474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5141   -2.6444    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7571   -2.9722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0946   -2.4804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6624   -2.8083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7571   -3.6278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0946   -4.1196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6624   -3.7917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  3 14  1  0  0  0  0
  4 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4225

>  <JC_XSMILES>
O=C1C2=C(CCCCCCCCCC2)NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2766

>  <W2 Pf proliferation inhibition EC50 uM>
0.671

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4228
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.0828   -2.5015    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0828   -3.3265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7973   -3.7390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7973   -4.5640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0828   -4.9765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3683   -4.5640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3683   -3.7390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3461   -3.3265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1586   -3.1832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4408   -2.4080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9105   -1.7760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980   -1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1842   -2.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6283   -4.1017    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4408   -4.2450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9711   -3.6130    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7229   -5.0202    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5354   -5.1635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8176   -5.9387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6300   -6.0820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1603   -5.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8782   -4.6748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0657   -4.5315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4228

>  <JC_XSMILES>
OC1CCCCC1C2(CCCCC2)NC(=S)NC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2108

>  <W2 Pf proliferation inhibition EC50 uM>
0.1526

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.79

>  <Powder data?>
Yes

>  <IFI value>
0.021276596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4229
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  4  3  1  4  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  1  0  0  0  0
  3 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4229

>  <JC_XSMILES>
CN1C(N=NC2=CC=C(C)C=C2C)=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0875

>  <W2 Pf proliferation inhibition EC50 uM>
0.02408

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.6

>  <Powder data?>
Yes

>  <IFI value>
0.193548387

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4237
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4237

>  <JC_XSMILES>
COC1=CC=C(Cl)C=C1NC(=S)NNC(=O)C2=CC=CN=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.536

>  <W2 Pf proliferation inhibition EC50 uM>
0.664

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4239
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    4.5063    0.8732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0716    1.5745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2470    1.5487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8124    2.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    2.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5978    1.4972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0325    0.7959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8571    0.8217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2917    0.1205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1163    0.1462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7732    1.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2406    0.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5232    1.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4626    1.9760    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3386    2.1727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7286    2.8997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2940    3.6009    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5306    3.5751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9652    4.2764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7880    4.3370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9846    5.1382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2834    5.5728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6533    5.0402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5532    2.9254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2244    0.7186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1986   -0.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8999   -0.5406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6269   -0.1506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6526    0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9514    1.1086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
 16 24  4  0  0  0  0
  5 24  4  0  0  0  0
 13 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4239

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C3=NC(=NN3C(NCC4CCCO4)=N2)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2932

>  <W2 Pf proliferation inhibition EC50 uM>
0.662

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-424
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.1105   -0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039   -1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -4.7289    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -5.5539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -4.7289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.7289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.1579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -6.8724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -6.8724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -6.1579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -4.7289    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.2375   -4.0145    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.4750   -4.7289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-424

>  <JC_XSMILES>
CC(=O)NC1=CC=C(C=C1)S(=O)(=O)NC2=CC=CC=C2[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.677

>  <W2 Pf proliferation inhibition EC50 uM>
1.403

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-425
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    1.4358   -6.8365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -6.2234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -5.4388    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -6.9540    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6787   -7.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -8.7435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -7.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -6.2865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4236   -6.0234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7322   -5.4665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -4.1039    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838   -3.3193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -3.1478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -2.3631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.7501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.9216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -5.5964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -5.5964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
  4 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-425

>  <JC_XSMILES>
CC[N+]1=C(\C=C\C=C2/N(C)C3=CC=CC=C3C2(C)C)N(C4=CC=CC=C4)C5=CC=C(C)C=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
1.534

>  <W2 Pf proliferation inhibition EC50 uM>
1.401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4276
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    3.0373   -3.0079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6903   -2.2594    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8686   -2.1857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1650   -1.5847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8180   -0.8362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2928   -0.1615    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1177   -0.1489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3606    0.6395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6859    1.1142    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0259    0.6192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2672    0.9433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5187    0.5963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2758   -0.1921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4715   -0.3759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0898    0.2287    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1532    1.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9575    1.2009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3590    1.9216    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1685    1.7623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8285    2.2573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7298    3.0764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6311    3.8955    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5872    1.9333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2472    2.4283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  3  0  0  0  0
 20 23  4  0  0  0  0
  9 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4276

>  <JC_XSMILES>
CN(C)CCN1CCC2=C1N3C4=CC=CC=C4N=C3C(C#N)=C2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.419

>  <W2 Pf proliferation inhibition EC50 uM>
0.638

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4277
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.6085   -2.3888    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2494   -2.3888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5850   -3.1424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9719   -3.6945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0581   -4.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8118   -4.8505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4792   -4.3656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2329   -4.7011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3191   -5.5216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6517   -6.0065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8980   -5.6710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2574   -3.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  5 13  1  0  0  0  0
  2 13  1  0  0  0  0
  2 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4277

>  <JC_XSMILES>
OC1(CCN(CC2=CC=CC=C2)C1)C3=CC=CC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.457

>  <W2 Pf proliferation inhibition EC50 uM>
0.1475

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.13

>  <Powder data?>
Yes

>  <IFI value>
0.02173913

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4283
  Mrv1591402191617072D          

 24 28  0  0  0  0            999 V2000
    2.7455    0.3751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9859   -0.4141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7656   -0.6836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4201   -0.1813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.3798    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5649   -1.1296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3886   -1.0832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8406   -1.7734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4689   -2.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6452   -2.5563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1932   -1.8661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3856   -2.0347    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7503   -1.5084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9611   -1.7488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6116   -2.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7896   -2.5671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3172   -1.8907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6667   -1.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4886   -1.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2514    0.6263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    0.9646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5882    1.7848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3958    1.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8057    1.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
  3 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  1  0  0  0  0
 14 19  4  0  0  0  0
  4 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4283

>  <JC_XSMILES>
OC1=C2C(SC3=CC=CC=C3N=C2C4=CC=CC=C14)C5=CC=CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2508

>  <W2 Pf proliferation inhibition EC50 uM>
0.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
55.29

>  <Powder data?>
Yes

>  <IFI value>
0.015037594

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4288
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  3  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  8 23  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
  4 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4288

>  <JC_XSMILES>
CC1=CC2=CC(C3C4=C(OC(N)=C3C#N)C5=CC=CC=C5C=C4)=C(Cl)N=C2C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2402

>  <W2 Pf proliferation inhibition EC50 uM>
0.629

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.051020408

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4290
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 17 28  1  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4290

>  <JC_XSMILES>
COC1=CC=C(Br)C=C1CNC(=O)CCCN2C(=O)COC3=CC=C(C)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
1.878

>  <W2 Pf proliferation inhibition EC50 uM>
0.628

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4306
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
  9 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 10 24  1  0  0  0  0
  5 24  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4306

>  <JC_XSMILES>
COC(=O)C1C(C)CC2=C(C(CC(=O)N2)C3=CC=CC(Cl)=C3Cl)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.814

>  <W2 Pf proliferation inhibition EC50 uM>
0.617

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4310
  Mrv1591402191617072D          

 48 55  0  0  0  0            999 V2000
    5.9528   -1.5191    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403   -0.8047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2548   -0.3922    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.8258   -1.2172    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3653    0.6243    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353   -0.8278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0763    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    3.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1125    0.6243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 19 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 15 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 28 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
 35 42  2  0  0  0  0
 19 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 43 48  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4310

>  <JC_XSMILES>
FC(F)(F)C1=CC(=CC=C1Cl)N2C(=O)C3C(C2=O)C5(C4=CC=CC=C4)C(=O)C3(C6=CC=CC=C6)C(C7=CC=CC=C7)=C5C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
0.442

>  <W2 Pf proliferation inhibition EC50 uM>
0.616

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4312
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  8 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4312

>  <JC_XSMILES>
CC1=CC=C(C=C1)N2C(C)=C(C(=O)C3=CC=CC=C3)C4=CC(O)=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.508

>  <W2 Pf proliferation inhibition EC50 uM>
0.615

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4316
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
  2 18  4  0  0  0  0
  6 18  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4316

>  <JC_XSMILES>
CC1=CC=CC2=C(O)C(CC=C(Cl)Cl)=C(C)N=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
1.114

>  <W2 Pf proliferation inhibition EC50 uM>
0.609

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4324
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  9 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4324

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(NC2=CC(C)=CC=N2)C3=CC=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.114

>  <W2 Pf proliferation inhibition EC50 uM>
0.562

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>93.48

>  <Powder data?>
Yes

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4337
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   5
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4337

>  <JC_XSMILES>
OC1=CC(=NC2=CC=CC=C12)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.06

>  <W2 Pf proliferation inhibition EC50 uM>
0.547

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>93.22

>  <Powder data?>
Yes

>  <IFI value>
0.070921986

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-435
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.1067   -2.9815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -3.6960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -3.6960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -4.4104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -3.7430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -6.4729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -6.4729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -6.4729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -5.0779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -5.8625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 11 25  4  0  0  0  0
  7 25  4  0  0  0  0
 25 26  1  0  0  0  0
  5 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-435

>  <JC_XSMILES>
COCCN1CC2=CC=CC(C(=O)NC3=CC=C4OCCOC4=C3)=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.452

>  <W2 Pf proliferation inhibition EC50 uM>
1.386

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4352
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.5724   13.3661    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   12.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   13.3661    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   12.1286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
  8 30  4  0  0  0  0
 30 31  4  0  0  0  0
  5 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4352

>  <JC_XSMILES>
FC(F)OC1=CC=C(CN2CCC(CC2)C(=O)NC3=CC=C(C=C3)N4C=NN=N4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.594

>  <W2 Pf proliferation inhibition EC50 uM>
0.2662

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.28

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4357
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076    1.3686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3444    0.7556    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473    2.1533    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8543    2.3248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1092    3.1094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5572    3.7225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
  9 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4357

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C[N+](CC(=O)C3=CC=CC=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
1.195

>  <W2 Pf proliferation inhibition EC50 uM>
0.571

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4362
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -0.8251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4124    0.0000 Te  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.8874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.2999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 23 22  1  4  0  0  0
 23 24  2  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4362

>  <JC_XSMILES>
OC1=CC=CC=C1C=NC2=CC=CC=C2[Te]C3=CC=CC=C3N=CC4=CC=CC=C4O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00349

>  <W2 Pf proliferation inhibition EC50 uM>
0.003141

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.552

>  <Powder data?>
Yes

>  <IFI value>
0.082089552

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4368
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.4125    2.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    3.2704    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.9355    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    4.0954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 22  1  0  0  0  0
 17 22  1  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4368

>  <JC_XSMILES>
CC(C)(C[N+](C)(C)C)C1OC2CCCCC2C3C=CCCC13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.999

>  <W2 Pf proliferation inhibition EC50 uM>
0.565

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.068965517

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4369
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6918   -3.9591    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0244   -4.4440    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3570   -3.9591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5723   -4.2140    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -0.7027    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6919    0.1043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
 17 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4369

>  <JC_XSMILES>
CCOC(=O)C1=C(N(N=N1)C2=NON=C2N)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.653

>  <W2 Pf proliferation inhibition EC50 uM>
0.564

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4372
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.4944    6.0604    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    4.4104    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4372

>  <JC_XSMILES>
ClC1=CC=C(SC2=CC=CC(Cl)=C2CNC(=O)C3=CC=C4OCCC4=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0691

>  <W2 Pf proliferation inhibition EC50 uM>
0.0562

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.078947368

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4380
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    4.2868    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    6.7661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.2911    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408    1.5291    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    2.1965    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914    3.2361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
 10  9  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  2  0  0  0  0
  9 18  4  0  0  0  0
  4 18  4  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4380

>  <JC_XSMILES>
CCOC1=CC(Br)=CC(C=C2NC(=S)NC2=O)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.68

>  <W2 Pf proliferation inhibition EC50 uM>
0.554

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4390
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
  8 15  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4390

>  <JC_XSMILES>
CCC1=NN2C(NC3=CC=C(F)C(Cl)=C3)=CC(C)=NC2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.543

>  <W2 Pf proliferation inhibition EC50 uM>
0.547

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4395
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9732   -7.4070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1527   -7.4932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8171   -6.7395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7402   -8.2077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1527   -8.9221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7402   -9.6366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9152   -9.6366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5027   -8.9221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9152   -8.2077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
 19 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4395

>  <JC_XSMILES>
COCCCNC1=NC2=CC(OC)=C(OC)C=C2C3=NC(=NN13)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.621

>  <W2 Pf proliferation inhibition EC50 uM>
0.541

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4396
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1106   -0.4647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8989   -0.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2003    0.5464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7878    1.2609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9721    1.3838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3673    0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  2  0  0  0  0
  5 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 13 19  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4396

>  <JC_XSMILES>
FC1=CC2=C(NC=CC2=O)C=C1N3CCCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.311

>  <W2 Pf proliferation inhibition EC50 uM>
0.497

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>92

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4400
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.4917    1.7684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917    0.9434    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062    0.5309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206    0.9434    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -2.7691    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -0.2941    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9373   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6517   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3662   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0807   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0807    0.5309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7951    0.9434    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3662    0.9434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6517    0.5309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5529   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654   -1.8336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7904   -1.8336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2029   -2.5481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7904   -3.2626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654   -3.2626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5529   -2.5481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  6 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
  9 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4400

>  <JC_XSMILES>
COC(=O)C1=C2CCN(CCN2C(=O)C=C1OCC3=CC=C(F)C=C3)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.94

>  <W2 Pf proliferation inhibition EC50 uM>
0.538

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-441
  Mrv1591402191617072D          

 35 40  0  0  0  0            999 V2000
    2.6435    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4235    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9755    2.5218    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7825    2.3503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0374    1.5657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4854    0.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614   -0.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5134   -0.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2585    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4515    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3204   -0.4451    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5753   -1.2298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3823   -1.4013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9343   -0.7882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6794   -0.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8724    0.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  3 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 29 34  1  0  0  0  0
 18 35  4  0  0  0  0
 15 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-441

>  <JC_XSMILES>
O=C1N(CCCC2=CC=CC=C2)C=NC3=C1C4=C(CC(CC4)N5CCC(CC5)N6CCCCC6)S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.386

>  <W2 Pf proliferation inhibition EC50 uM>
2.024

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.81

>  <Powder data?>
Yes

>  <IFI value>
0.02238806

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4416
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4760   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8109   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4416

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCCN2CCCCC2C)N=C1NC3CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.91

>  <W2 Pf proliferation inhibition EC50 uM>
0.0528

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4418
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  7 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 11 17  4  0  0  0  0
  6 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
  5 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4418

>  <JC_XSMILES>
CCCNC1=C(N(C(C)=O)C2=CC=CC(F)=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02896

>  <W2 Pf proliferation inhibition EC50 uM>
0.02845

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.39

>  <Powder data?>
Yes

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4427
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
    3.6250    3.1206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4623    2.3118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2997    1.5030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9189    0.9577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7006    1.2213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3198    0.6761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1571   -0.1327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3754   -0.3963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7562    0.1489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9745   -0.1146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8119   -0.9235    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4310   -1.4687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2684   -2.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8875   -2.8228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7249   -3.6316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9431   -3.8951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3240   -3.3499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4866   -2.5411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3553    0.4306    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5359    0.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0583   -0.3374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2369   -0.2602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1069    0.4897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3706    1.1624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1920    1.0852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7990    1.6440    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5180    1.2394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
 19 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4427

>  <JC_XSMILES>
N#CC1=C2CCCCC2=C(NCC3=CC=CC=N3)N4C5=CC=CC=C5N=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2229

>  <W2 Pf proliferation inhibition EC50 uM>
0.522

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-443
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
  6 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-443

>  <JC_XSMILES>
OC(=O)CSC(C(=O)NC1=CC=C(Cl)C=C1)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.62

>  <W2 Pf proliferation inhibition EC50 uM>
>1.364

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4442
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -3.3538   -2.3780    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9413   -1.6635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1163   -1.6635    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7038   -0.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1163   -0.2346    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8788   -0.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4663   -0.2346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3587   -0.2346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7712   -0.9491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3587   -1.6635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4663   -1.6635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5962   -0.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0087   -1.6635    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0087   -0.2346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8337   -0.2346    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3186    0.4328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0637    1.2175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2790    1.4724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2790    2.2974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0637    2.5523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3992    3.3060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2197    3.3923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7046    2.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3691    1.9711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5486    1.8849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1032    0.1779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8177    0.5904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322    0.1779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -0.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8177   -1.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1032   -0.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3186   -0.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0637   -1.6867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
 20 25  4  0  0  0  0
 16 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
 15 32  1  0  0  0  0
 32 33  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4442

>  <JC_XSMILES>
CCOC(=O)C1CCN(CC1)C(=O)CN2C(C3=CNC4=CC=CC=C34)C5=CC=CC=C5C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.519

>  <W2 Pf proliferation inhibition EC50 uM>
0.513

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.066666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4445
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4445

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.688

>  <W2 Pf proliferation inhibition EC50 uM>
0.01336

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.611

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-445
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
   -0.6782    0.7019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6782   -0.1231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.6081    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2657   -1.3927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0907   -1.3926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3456   -0.6080    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -2.0601    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2401   -2.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7251   -3.4812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5456   -3.3949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8811   -2.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3961   -1.9738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5189   -1.6476    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    1.3035   -1.9026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9166   -1.3506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7012   -1.6056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8727   -2.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2596   -2.9645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4750   -2.7096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2639   -2.4322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8159   -3.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5610   -3.8300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2460   -4.0015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7980   -3.3884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5431   -2.6037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7739   -0.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2218   -0.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4768    0.5347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2838    0.7062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8358    0.0931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5808   -0.6915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
  4 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 13 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 13 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  CHG  1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-445

>  <JC_XSMILES>
CC1=NC(=C(O1)N2CCCCC2)[P+](C3=CC=CC=C3)(C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.761

>  <W2 Pf proliferation inhibition EC50 uM>
0.967

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.12

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4453
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 19 26  1  0  0  0  0
 14 27  4  0  0  0  0
 27 28  4  0  0  0  0
 11 28  4  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
  7 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  CHG  2  29   1  30  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4453

>  <JC_XSMILES>
COC1=CC=CC(NC(=O)C2=CC=C(NCCCN3CC(C)CC(C)C3)C(=C2)[N+]([O-])=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2753

>  <W2 Pf proliferation inhibition EC50 uM>
0.509

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4463
  Mrv1591402191617072D          

 26 31  0  0  0  0            999 V2000
    1.6328    0.4263    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4577    0.4222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9459    1.0873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7293    0.8285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4458    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1582    0.8215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1542   -0.0035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4377   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7253    0.0035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9394   -0.2476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4884   -0.8634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2296   -1.6467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7786   -2.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5199   -3.0459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7121   -3.2135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1630   -2.5977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4218   -1.8143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8728   -1.1985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0478   -1.1945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7967   -0.4086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0447   -0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0375    0.7515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6323    1.2332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3843    0.8939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4665    0.0730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1316   -0.4151    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 10 26  1  0  0  0  0
 18 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4463

>  <JC_XSMILES>
O=C1NC2=CC=CC=C2C13NC4=CC=CC=C4C5=NC6=CC=CC=C6N35

>  <PF proliferation inhibition 3D7 EC50 uM>
1.093

>  <W2 Pf proliferation inhibition EC50 uM>
0.502

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4466
  Mrv1591402191617072D          

 21 25  0  0  0  0            999 V2000
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3276   -1.7895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9920   -2.5432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1715   -2.4570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  7 11  1  0  0  0  0
  8 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  1  0  0  0  0
  2 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  1  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4466

>  <JC_XSMILES>
CN1CCC2=CC3=C(OCO3)C4=C2C1CC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0931

>  <W2 Pf proliferation inhibition EC50 uM>
0.1115

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
22.31

>  <Powder data?>
Yes

>  <IFI value>
0.061728395

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4471
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2522    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4675    0.6985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088   -3.6695    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.7938   -4.3369    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.6444   -2.9158    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  3  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  6 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4471

>  <JC_XSMILES>
CSC1=NN=C(N1CC2=CC=CC=C2)C3=CC=CC(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.652

>  <W2 Pf proliferation inhibition EC50 uM>
0.495

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4473
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    5.6479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089    7.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 10 23  4  0  0  0  0
 23 24  1  0  0  0  0
  6 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
 28 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 33 37  4  0  0  0  0
 25 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4473

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC=CC=C3O)c(=O)n2C1C4=CC=C(OCC=C)C(OCC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.608

>  <W2 Pf proliferation inhibition EC50 uM>
0.2631

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
53.29

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4478
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    1.4229   -2.4457    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4758    0.3498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9237    0.9629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1787    1.7475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6267    2.3606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8816    3.1452    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3296    3.7583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5845    4.5429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3915    4.7144    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9435    4.1014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6886    3.3167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  8 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4478

>  <JC_XSMILES>
ClC1=CC=C2NC3=C(NCCCN4CCOCC4)N=CN=C3C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1089

>  <W2 Pf proliferation inhibition EC50 uM>
0.1525

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
31.25

>  <Powder data?>
Yes

>  <IFI value>
0.117647059

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4481
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    7.1162    0.2943    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1162    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4018    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6873    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9728    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2584    1.1193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1721    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3652    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9527    0.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5047    1.4548    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8307    1.5318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5452    1.1193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2989    1.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5538    2.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3608    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9128    1.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.7198    1.9694    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   10.6579    1.0133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8509    0.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4384    0.1273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6933   -0.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1413   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3962   -2.0551    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.3343   -1.0989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0794   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6314    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4481

>  <JC_XSMILES>
OC(CNCC1CCCO1)CN2C3=CC=C(Br)C=C3C4=CC(Br)=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.261

>  <W2 Pf proliferation inhibition EC50 uM>
0.099

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.34

>  <Powder data?>
Yes

>  <IFI value>
0.116883117

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4484
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  9 24  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  3 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4484

>  <JC_XSMILES>
COC1=CC2=NC=NC(NC3CCN(CC3)CC4=CC=CC=C4)=C2C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.4

>  <W2 Pf proliferation inhibition EC50 uM>
0.485

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4490
  Mrv1591402191617072D          

 19 22  0  0  0  0            999 V2000
    1.4229   -2.4457    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464    0.7035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4609    1.1160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8734    1.8305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2859    1.1160    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0700   -2.4457    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 10  1  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4490

>  <JC_XSMILES>
ClC1=CC=C2N(CC3CO3)C4=CC=C(Cl)C=C4C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.341

>  <W2 Pf proliferation inhibition EC50 uM>
0.2771

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
57.36

>  <Powder data?>
Yes

>  <IFI value>
0.169811321

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4493
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376    3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507    2.6841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1792    1.8771    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353    2.9390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8027    2.4541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4702    2.9390    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2152    3.7236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3902    3.7236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4493

>  <JC_XSMILES>
CCOC1=CC=C(C=C1OCC)C2=NON=C2NC(=O)C3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.59

>  <W2 Pf proliferation inhibition EC50 uM>
0.481

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4501
  Mrv1591402191617072D          

 44 51  0  0  0  0            999 V2000
    6.3653    0.6243    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.5403    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028   -0.0902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8903    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3028    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1278    1.3388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0653    0.6243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804   -0.0431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353   -0.8278    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5804    1.2917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8353    2.0764    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813    3.9243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2875    0.6243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1125    0.6243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7957   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0813   -2.6757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -2.2632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621   -1.4382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -1.0257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766   -0.2007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    0.2118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3668    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    1.0368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    1.4493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7766    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0621    2.6868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3477    2.2743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 11 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 24 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 31 38  2  0  0  0  0
 15 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 39 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4501

>  <JC_XSMILES>
FC1=CC=C(C=C1)N2C(=O)C3C(C2=O)C5(C4=CC=CC=C4)C(=O)C3(C6=CC=CC=C6)C(C7=CC=CC=C7)=C5C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
0.563

>  <W2 Pf proliferation inhibition EC50 uM>
0.474

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4504
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.9625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184  -11.9625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684  -11.9625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -14.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4504

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(=O)NC2CCN(CC2)S(=O)(=O)C3=C(C)C=C(C)C=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.445

>  <W2 Pf proliferation inhibition EC50 uM>
0.472

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.038461538

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-451
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    3.3847   -7.9725    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7716   -7.4205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9647   -7.5920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5522   -6.8775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1042   -6.2644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6207   -4.8776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8756   -4.0930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7006   -4.0930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9556   -4.8776    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 17 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-451

>  <JC_XSMILES>
O=C1CCCN1CCCNC(=O)C(=O)NCC(N2CCOCC2)C3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.022222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4521
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   12.8605   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -7.7606    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -7.1475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -6.4330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -6.6045    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1865   -9.9769    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.7385  -10.5900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.3260  -11.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.5191  -11.1330    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  1  0  0  0  0
  2 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  2  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 34 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4521

>  <JC_XSMILES>
O=C(NCCCCCCCCNC(=O)NC1=CC=C(C=C1)C2=NCCN2)NC3=CC=C(C=C3)C4=NCCN4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0854

>  <W2 Pf proliferation inhibition EC50 uM>
0.0459

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4543
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    3.7778    3.7927    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5615    3.5349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1766    4.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9603    3.8269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1289    3.0193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5138    2.4695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7301    2.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6824    1.6619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4832    1.4634    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8273    0.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6509    0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1029    0.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7312   -0.6667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9076   -0.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4556   -0.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6480   -0.1915    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0126    0.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0279    1.1596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2482    1.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0079    2.2183    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7510    0.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9290    0.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5795   -0.0475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0520   -0.7239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8739   -0.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2234    0.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  1  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4543

>  <JC_XSMILES>
FC1=CC=CC(=C1)C2SC3=CC=CC=C3N=C4C2C(=O)C5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0867

>  <W2 Pf proliferation inhibition EC50 uM>
0.1348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
30.32

>  <Powder data?>
Yes

>  <IFI value>
0.032258065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4560
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    8.4669   -6.6616    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -5.0116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -7.4866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -6.2491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -7.4866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -7.9715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -7.9715    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  4 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4560

>  <JC_XSMILES>
ClC1=CC(=CC=C1OC2CCN(CC2)CC3=CC=NC=C3)C(=O)NCC4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.683

>  <W2 Pf proliferation inhibition EC50 uM>
0.427

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4561
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 10 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
  7 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4561

>  <JC_XSMILES>
CCCNC(=O)C1=CC=C(OC2CCN(CC2)CC3CCCCC3)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2871

>  <W2 Pf proliferation inhibition EC50 uM>
0.1811

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.42

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4565
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5292    0.7796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3335    0.5961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9785    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9785    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3335    2.4498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5292    2.2662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7218    2.2934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7834    3.1161    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4034    1.8287    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1467    2.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8284    1.7219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5717    2.0798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6333    2.9025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9517    3.3673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2084    3.0093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4565

>  <JC_XSMILES>
ClC1=CC=C2N=C(SC2=C1)N3CCCN(CC3)C(=S)NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.506

>  <W2 Pf proliferation inhibition EC50 uM>
0.37

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>86.94

>  <Powder data?>
Yes

>  <IFI value>
0.056910569

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4575
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    4.8105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    7.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0674    7.6980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0674    8.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    8.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    8.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    7.6980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 11 10  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 20 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4575

>  <JC_XSMILES>
OC(CN1CCN(CC1)CC=CC2=CC=CC=C2)CN3C4=CC=C(Cl)C=C4C5=CC(Cl)=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1813

>  <W2 Pf proliferation inhibition EC50 uM>
0.075

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.92

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4579
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  1  0  0  0  0
 12 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4579

>  <JC_XSMILES>
CCCCNC1=CC(=O)C(=O)C2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.481

>  <W2 Pf proliferation inhibition EC50 uM>
0.324

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>77.85

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4583
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
    2.7455    0.3751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9859   -0.4141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7656   -0.6836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4201   -0.1813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.3798    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5649   -1.1296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3886   -1.0832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8406   -1.7734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4689   -2.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6452   -2.5563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1932   -1.8661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3856   -2.0347    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7503   -1.5084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9611   -1.7488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6116   -2.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7896   -2.5671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3172   -1.8907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6667   -1.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4886   -1.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2514    0.6263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4678    0.8841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2991    1.6917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9142    2.2415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6979    1.9837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8665    1.1761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
  3 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  1  0  0  0  0
 14 19  4  0  0  0  0
  4 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4583

>  <JC_XSMILES>
OC1=C2C(SC3=CC=CC=C3N=C2C4=CC=CC=C14)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0467

>  <W2 Pf proliferation inhibition EC50 uM>
0.1122

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
27.08

>  <Powder data?>
Yes

>  <IFI value>
0.02247191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4585
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.6614   -2.1655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0483   -1.6135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2413   -1.7850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058   -2.5387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5702   -3.2924    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8288   -1.0705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0219   -0.8990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2331   -0.1144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3190    0.4987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1259    0.3272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3809   -0.4574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1345   -0.7930    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5635   -0.7930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5635   -1.6180    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2780   -0.3805    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9924   -0.7930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7069   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4214   -0.7930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1358   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8503   -0.7930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8503   -1.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1358   -2.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4214   -1.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  3  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4585

>  <JC_XSMILES>
CC1=C(C#N)C2=CC=CC=C2N1CC(=O)NCCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.398

>  <W2 Pf proliferation inhibition EC50 uM>
0.411

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4596
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -0.4663   -0.8077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9966   -0.1757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8091   -0.3190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8091    0.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5269   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0572   -1.7262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3428   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6283   -1.7262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0862   -2.1387    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8006   -1.7262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5151   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296   -1.7262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441   -2.9637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296   -3.3762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5151   -2.9637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8006   -3.3762    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8697   -1.5830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1519   -0.8077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6216   -0.1757    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3394   -2.5015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8091   -3.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0913   -3.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9037   -4.0520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4340   -3.4200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1519   -2.6447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6822   -2.0127    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4000   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  6 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
  3 20  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4596

>  <JC_XSMILES>
CCC1(C)CC(CCNCC2=CC=CC=C2O)(CCO1)C3=CC=CC=C3OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.348

>  <W2 Pf proliferation inhibition EC50 uM>
0.0961

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.92

>  <Powder data?>
Yes

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-460
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    1.3222    3.2384    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.8884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    3.6509    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.4134    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5620    0.6910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3071   -0.0937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -0.0937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2272    0.6910    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.4134    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
  6 16  4  0  0  0  0
  2 16  4  0  0  0  0
 16 17  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-460

>  <JC_XSMILES>
ClC1=CC=CC(C(=O)NCC2=CC=CO2)=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.341

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4620
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -3.5724    1.2375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  4  0  0  0
 15 16  2  0  0  0  0
 16 17  1  4  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 13 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4620

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C(=O)NC(=CC=CC2=CC=CC=C2)C(=O)N3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
8.29

>  <W2 Pf proliferation inhibition EC50 uM>
0.392

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4625
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 13 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4625

>  <JC_XSMILES>
OC1=CC=C(C=C1)C2CC(=O)NC3=C2C(=O)CC(C3)C4=CC=CC=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.672

>  <W2 Pf proliferation inhibition EC50 uM>
0.391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4628
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7631    1.2132    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9346    2.0202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2201    2.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3930    1.8806    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6883    2.3557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3557    1.8708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1094    2.2064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1956    3.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5282    3.5118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7745    3.1762    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  9 22  4  0  0  0  0
  6 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4628

>  <JC_XSMILES>
FC1=CC=CC2=C1N=C(NC3=NC(=CS3)C4=CC=CC=N4)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.321

>  <W2 Pf proliferation inhibition EC50 uM>
0.0958

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.69

>  <Powder data?>
Yes

>  <IFI value>
0.166666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4631
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4631

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)COC3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0592

>  <W2 Pf proliferation inhibition EC50 uM>
0.0785

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.28

>  <Powder data?>
Yes

>  <IFI value>
0.018691589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4637
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.8212    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    1.8053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486    0.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991    2.0602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4637

>  <JC_XSMILES>
CC1CCN(CC1)C2=CC(C)=NC(=N2)N3N=C(C)C=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.095

>  <W2 Pf proliferation inhibition EC50 uM>
0.382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016129032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4638
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 12 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4638

>  <JC_XSMILES>
OC1=C(C=CC2=CC=CN=C12)C(NC(=O)CC3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.423

>  <W2 Pf proliferation inhibition EC50 uM>
0.382

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.130434783

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4646
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -6.6724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -6.6724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 16  4  1  4  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4646

>  <JC_XSMILES>
CC1=CC(=CC=C1NC(=O)C2=CC=CO2)N=NC3=CC=CC=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.402

>  <W2 Pf proliferation inhibition EC50 uM>
0.2723

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
72.17

>  <Powder data?>
Yes

>  <IFI value>
0.037878788

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-466
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    2.8806    1.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0556    1.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6431    0.3427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8181    0.3427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4056   -0.3717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4194   -0.3717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8319   -1.0862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4194   -1.8007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4056   -1.8007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8181   -2.5151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6431   -2.5151    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0556   -3.2296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8806   -3.2296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0556   -1.8007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8806   -1.8007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6569   -1.0862    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2089   -1.6993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1227   -2.5198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7901   -3.0047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5438   -2.6691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6301   -1.8487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9626   -1.3637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8764   -0.5433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0694   -0.3717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6569    0.3427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0694    1.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4819    1.7717    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8319    0.3427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4194    1.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  3  0  0  0  0
 25 28  4  0  0  0  0
  6 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-466

>  <JC_XSMILES>
CCCCCC1=C(NCCN(CC)CC)N2C3=CC=CC=C3N=C2C(C#N)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.324

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4664
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    5.1170    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8315    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5459    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2604    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9749    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9749    1.3607    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6894    0.1232    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4038    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4038    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183    1.7732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8328    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8328    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183   -0.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7857   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5704   -0.9317    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1835   -1.4838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6314   -2.0969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7355   -0.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7966   -2.0358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5812   -1.7809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3658   -1.5259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8361   -2.5655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3262   -0.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5308   -1.9713    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.9433   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5308   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7058   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2933   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7058   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4509   -1.1867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 14 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4664

>  <JC_XSMILES>
CCCCC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2956

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0071

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.922

>  <Powder data?>
No

>  <IFI value>
0.047169811

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4668
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6918   -3.9591    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0244   -4.4440    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3570   -3.9591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5723   -4.2140    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -0.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4668

>  <JC_XSMILES>
CCOC(=O)C1=C(N(N=N1)C2=NON=C2N)C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3035

>  <W2 Pf proliferation inhibition EC50 uM>
0.367

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4669
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.8957    3.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0647    3.0873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8485    2.8298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0175    2.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8013    1.7649    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9703    0.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7541    0.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698    1.1102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0812    0.5562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432   -0.1964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9230   -0.1075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3082   -0.6576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4772   -1.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6461   -2.2727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5244   -0.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8086   -0.8104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1973   -0.2565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3765   -0.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1063    0.3289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2317    1.0815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0524    1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5352    0.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3554    0.4073    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  7 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  3  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
 15 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4669

>  <JC_XSMILES>
CCCCNC1=C2CCCC2=C(C#N)C3=NC4=CC=CC=C4N13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1131

>  <W2 Pf proliferation inhibition EC50 uM>
0.367

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4673
  Mrv1591402191617072D          

 31 36  0  0  0  0            999 V2000
    1.9788    2.5867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5919    2.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4123    2.1209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8973    1.4534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5617    0.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7412    0.6135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2563    1.2810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2643    2.1742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5106    2.5097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1568    2.0248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9105    2.3604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9967    3.1809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3293    3.6658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4244    3.3302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 10 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
  8 25  4  0  0  0  0
  1 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   1
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4673

>  <JC_XSMILES>
N1C2=CC=CC=C2C(\C=C3/C4=CC=CC=C4N=C3C5=CC=CC=C5)=C1C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2101

>  <W2 Pf proliferation inhibition EC50 uM>
0.0364

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4688
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    7.1447   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 21 22  1  0  0  0  0
  3 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
  2 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4688

>  <JC_XSMILES>
OC1=C(CN2CCN(CC2)CC3=CC=C4C=CC=NC4=C3O)C=CC5=CC=CN=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
0.561

>  <W2 Pf proliferation inhibition EC50 uM>
0.318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>89.28

>  <Powder data?>
Yes

>  <IFI value>
0.128

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4693
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860    2.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3340    2.6576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4730    2.4860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7279    1.7014    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0250    3.0991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8535    3.9061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5680    4.3186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1811    3.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9880    3.9381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8455    3.0129    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420    1.3770    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440    2.8452    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    3.5596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 18 23  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 26 27  4  0  0  0  0
 10 27  4  0  0  0  0
 24 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4693

>  <JC_XSMILES>
CCOC(=O)CN(C)CC1=CC=C2C(NC(=O)C3=CC=C(C)S3)=C(SC2=N1)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.766

>  <W2 Pf proliferation inhibition EC50 uM>
0.354

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4694
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
   -5.9985   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1735   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7610   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9360   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5235   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9360   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7610   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6985   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -1.3951    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8860    2.0445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    2.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0420    1.3770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1190    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440    4.2741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565    4.9886    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3565    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440    2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -2.7299    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 19 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 12 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 10 32  4  0  0  0  0
 32 33  4  0  0  0  0
  8 33  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  33
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4694

>  <JC_XSMILES>
NC1=CC=C(C=C1)C2=NC3=CC(CC4=CC=C5NC(=NC5=C4)C6=CC=C(N)C=C6)=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2427

>  <W2 Pf proliferation inhibition EC50 uM>
0.0634

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.94

>  <Powder data?>
Yes

>  <IFI value>
0.102941176

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4696
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 14 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
M  CHG  1  14   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4696

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2=CC(C)=[N+](CCO)C(=C2)C3=CC=C(OCC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.082

>  <W2 Pf proliferation inhibition EC50 uM>
0.352

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.072727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4703
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 33 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4703

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(F)C=C4)C(=O)OC5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1375

>  <W2 Pf proliferation inhibition EC50 uM>
0.053

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.2

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4704
  Mrv1591402191617072D          

 33 34  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5395   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
  8 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
  3 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 27 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
M  CHG  2  31   1  32  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4704

>  <JC_XSMILES>
CCC(OC1=CC=C(C=C1C(C)(C)CC)C(C)(C)CC)C(=O)NC2=CC=C(C=C2O)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.26

>  <W2 Pf proliferation inhibition EC50 uM>
0.348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4709
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4709

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(Br)=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.322

>  <W2 Pf proliferation inhibition EC50 uM>
0.0744

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.59

>  <Powder data?>
Yes

>  <IFI value>
0.088607595

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4718
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4718

>  <JC_XSMILES>
CCC(=O)N(C)CCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.467

>  <W2 Pf proliferation inhibition EC50 uM>
0.341

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4734
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328   -2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 15 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4734

>  <JC_XSMILES>
CN(C)CCNCC1=CC(=CC=C1O)C2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1201

>  <W2 Pf proliferation inhibition EC50 uM>
0.1519

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.55

>  <Powder data?>
Yes

>  <IFI value>
0.01754386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4741
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 14 21  4  0  0  0  0
 10 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
  9 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 31 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4741

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2C(C(=O)NC3=CC=CC(OC)=C3)C4=CC=CC=C4C(=O)N2C5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.108

>  <W2 Pf proliferation inhibition EC50 uM>
0.332

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-475
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    5.7158    9.6536    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    9.6536    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   11.7161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    7.1786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.7036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704    3.4340    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    7.1786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    8.4161    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7716    7.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9647    7.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5522    7.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1042    8.3391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 14 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 27 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-475

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)C2=CN=C(NCCCN3C=CN=C3)N=C2NC4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.624

>  <W2 Pf proliferation inhibition EC50 uM>
1.315

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4755
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    3.9934    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1520    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9770    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1542   -0.3497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6080   -0.6654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3702   -0.3497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6859    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3702    1.1747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6080    1.4904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1542    1.1747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  4  6  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 22 29  1  0  0  0  0
 21 30  1  0  0  0  0
 17 30  1  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4755

>  <JC_XSMILES>
O=C(NC1CC1)C2CCN(CC2)C3=CC=CC4=C3C(=O)N(C5CCCCCCC5)C4=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2027

>  <W2 Pf proliferation inhibition EC50 uM>
0.1689

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>51.83

>  <Powder data?>
Yes

>  <IFI value>
0.059405941

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-477
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  3 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-477

>  <JC_XSMILES>
CCN(CC1=CC=CC=C1)C2=NC=NC3=CC=C(Br)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
7.44

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
95.28

>  <Powder data?>
Yes

>  <IFI value>
0.015625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4779
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 15 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
 23 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4779

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)C2=CC=CC(OC)=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.08

>  <W2 Pf proliferation inhibition EC50 uM>
0.03112

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036697248

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4788
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
   -0.6101    1.4427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0581    0.8296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3130    0.0450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2390   -0.5681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0460   -0.3966    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0159   -1.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4690   -2.0202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2940   -2.0202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065   -2.7346    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5315   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9440   -3.4491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7690   -3.4491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1815   -4.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0065   -4.1636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1815   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0065   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0159   -2.6876    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2390   -3.4722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8006   -2.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5150   -2.8452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2295   -2.4327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9440   -2.8452    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.2295   -1.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9440   -1.1952    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9440   -0.3702    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6584    0.0423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2295    0.0423    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5150   -1.1952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8006   -1.6077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
  7 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
  6 29  4  0  0  0  0
 19 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4788

>  <JC_XSMILES>
CCOC(=O)C1=C(CNCCN(CC)CC)N(C)C2=CC(Br)=C(OC(C)=O)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.833

>  <W2 Pf proliferation inhibition EC50 uM>
0.3093

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4791
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 10 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  7 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4791

>  <JC_XSMILES>
CC1=CC=C2C=C3C(N)=C4C(C)=CC=C(C)C4=NC3=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.431

>  <W2 Pf proliferation inhibition EC50 uM>
0.3082

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.072072072

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4797
  Mrv1591402191617072D          

 32 36  0  0  1  0            999 V2000
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  3  2  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  3  7  1  6  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 23 31  4  0  0  0  0
 31 32  4  0  0  0  0
 20 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4797

>  <JC_XSMILES>
O=C1[C@@H]2CCCN2C(=O)C(N1CCC3=CC=CC=N3)C4=CC=C(OC5=CC=CC=C5)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.03043

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02739726

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4799
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  2  0  0  0  0
  7 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  6 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
  5 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4799

>  <JC_XSMILES>
CCCNC1=C(N(C(C)=O)C2=CC=C(C)C=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01298

>  <W2 Pf proliferation inhibition EC50 uM>
0.01314

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.33

>  <Powder data?>
Yes

>  <IFI value>
0.184

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4801
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4801

>  <JC_XSMILES>
CCCCCC1CCCC2=C1NC3=CC(Cl)=CC=C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.475

>  <W2 Pf proliferation inhibition EC50 uM>
0.3023

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4807
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4807

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=NC(CN3CCCCC3)=CC=C2O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1313

>  <W2 Pf proliferation inhibition EC50 uM>
0.02999

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4819
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 14 20  4  0  0  0  0
  2 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 28 38  4  0  0  0  0
 32 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4819

>  <JC_XSMILES>
OC(CN1CCN(CC1)C2=CC=NC3=CC(Cl)=CC=C23)CN4CCN(CC4)C5=CC=NC6=CC(Cl)=CC=C56

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0856

>  <W2 Pf proliferation inhibition EC50 uM>
0.02962

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.066666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4825
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.9279   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5154   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6904   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529    0.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4529   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2779   -0.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736   -2.1486    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637   -3.7178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088   -4.5024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1608   -5.1155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9059   -5.9001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4579   -6.5132    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2030   -7.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0989   -6.0717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8440   -6.8563    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3960   -7.4694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5469   -5.4586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2601   -5.6301    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8121   -5.0170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 20 18  1  4  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 22 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4825

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2N=C3CSCC3=C2NC(=O)C=CC4=CC(OC)=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.392

>  <W2 Pf proliferation inhibition EC50 uM>
0.2938

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4828
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4828

>  <JC_XSMILES>
CN(C)CCN1CCN(CC1)C2=CC=CC(=N2)C3=CC=CC4=CC=CN=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01802

>  <W2 Pf proliferation inhibition EC50 uM>
0.0552

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.82

>  <Powder data?>
Yes

>  <IFI value>
0.04

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4833
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  4  0  0  0  0
 12 25  1  0  0  0  0
 16 25  4  0  0  0  0
 13 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
  9 36  4  0  0  0  0
 36 37  4  0  0  0  0
  6 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4833

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(OCC2N(CCC3=CC(OC)=C(OC)C=C23)C(=O)NC4=CC=C(Cl)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.969

>  <W2 Pf proliferation inhibition EC50 uM>
0.2923

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048387097

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4836
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
    0.7787    4.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1367    3.9719    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9594    3.9102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4241    4.5919    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3173    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1400    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8526    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1094    2.3620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3968    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7548    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5775    2.5469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0422    1.8653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6842    1.1220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8616    1.0603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9049    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0625   -1.3914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2461   -2.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6413   -2.7569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1471   -2.5137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7518   -3.0749    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3306   -1.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2741   -1.1483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 11 34  1  0  0  0  0
 28 34  1  0  0  0  0
 30 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  1  0  0  0  0
 38 40  4  0  0  0  0
 40 41  4  0  0  0  0
 35 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4836

>  <JC_XSMILES>
COC(=O)C1=CC=C(C=C1)C2N(C(=O)C3=CC=CC=C3)C4=CC=CC=C4N=C5CC(CC(O)=C25)C6=CC=C(F)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.332

>  <W2 Pf proliferation inhibition EC50 uM>
0.2904

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4838
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    5.4151   -2.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9001   -1.4261    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6847   -1.6810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3991   -1.2685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1136   -1.6810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1136   -2.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8281   -2.9185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8281   -3.7435    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5426   -4.1560    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5426   -4.9810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2100   -5.4660    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.9551   -6.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3676   -6.9651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9551   -7.6795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1301   -7.6795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7176   -6.9651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1301   -6.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8751   -5.4660    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3991   -2.9185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6847   -2.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9001   -2.7610    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
 20 21  1  0  0  0  0
  1 21  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4838

>  <JC_XSMILES>
C1OC2=CC=C(C=NNC3=NC4=CC=CC=C4N3)C=C2O1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1843

>  <W2 Pf proliferation inhibition EC50 uM>
0.2893

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4843
  Mrv1591402191617072D          

 14 14  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    0.3020    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -1.1270    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  2  9  4  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4843

>  <JC_XSMILES>
NC1=C(Cl)C(Cl)=NC(=C1Cl)C(Cl)(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.448

>  <W2 Pf proliferation inhibition EC50 uM>
0.286

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4848
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  5 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4848

>  <JC_XSMILES>
OC1=CC=C(C=C1CNCCCN2CCOCC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.706

>  <W2 Pf proliferation inhibition EC50 uM>
0.02842

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008695652

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4862
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4862

>  <JC_XSMILES>
COC1=CC=C(CNC2CCN(CC2)CC3=CC=CC=C3)C=C1OCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.028

>  <W2 Pf proliferation inhibition EC50 uM>
0.02788

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-487
  Mrv1591402191617072D          

 37 41  0  0  1  0            999 V2000
   10.2578    1.4697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4732    1.2147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3016    0.4078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5170    0.1528    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3455   -0.6541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5609   -0.9091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9478   -0.3570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1193    0.4499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9039    0.7049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1631   -0.6120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9082   -1.3966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0832   -1.3966    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.8283   -0.6120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -0.1271    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5983   -2.0640    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7778   -1.9778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3841   -2.7028    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5931   -2.9371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8681   -2.5435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6338   -1.7525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0274   -1.0274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8185   -0.7931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5435   -1.1868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 10  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
 12 29  1  1  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 30 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-487

>  <JC_XSMILES>
CCCN1CCC(CC1)N2C[C@H](C[C@H]2C(=O)NCCC3=CC=C4OCOC4=C3)NC5CCCCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.358

>  <W2 Pf proliferation inhibition EC50 uM>
>1.295

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00990099

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4879
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    5.0013   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -12.7875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145  -13.6125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289  -12.3750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 16 15  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  CHG  4   1  -1   2   1  24   1  25  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4879

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C=NNC(=N)NN=CC2=CC=C(C=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2803

>  <W2 Pf proliferation inhibition EC50 uM>
0.271

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4881
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -12.7875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145  -13.6125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289  -12.3750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
 17 30  4  0  0  0  0
 13 30  4  0  0  0  0
M  CHG  4   1  -1   2   1  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4881

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C(=O)NC2=CC=CC(OC(=O)C3=CC=C(C=C3)[N+]([O-])=O)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.2699

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4892
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0652   -3.2570    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8498   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0213   -2.1951    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8059   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9775   -1.1332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4190   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2475   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8606   -3.8512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4629   -3.5541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -2.7050    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8498   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4629   -3.5541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0213   -2.1951    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
  7 14  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4892

>  <JC_XSMILES>
CCN1C(CSC2=NC(C)=CC(C)=N2)=NN=C1SCC(N)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027027027

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4893
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -1.8624   -2.5307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0778   -2.7856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9063   -3.5926    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5619   -3.5157    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -3.5157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -2.6907    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7053   -3.9282    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4197   -3.5157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4197   -2.6907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1342   -2.2782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8487   -2.6907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8487   -3.5157    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5632   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1342   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2388   -4.7486    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0458   -4.9202    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4583   -4.2057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2788   -4.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7637   -4.7869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5842   -4.7007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9198   -3.9470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4348   -3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6144   -3.3658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 10 16  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  3 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4893

>  <JC_XSMILES>
CCN1C(SCC(=O)NC2=CC=CC(C)=C2)=NN=C1C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036697248

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4899
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0470   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3819   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1665   -3.9425    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  4 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
  8 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
  2 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4899

>  <JC_XSMILES>
CC(CC1=NC2=CC(=CC=C2CN1CCCN3CCCC3=O)C(=O)NCC=C)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4900
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  5 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  9 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4900

>  <JC_XSMILES>
CC(C)CC1=NC2=CC(=CC=C2CN1CC3=CC=CN=C3)C(=O)NCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037974684

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4908
  Mrv1591402191617072D          

 37 38  0  0  1  0            999 V2000
    9.5863   -0.6831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4826    0.1354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7220    0.4549    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.0151   -0.1066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8431   -0.9135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0226   -0.9993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6875   -0.2455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2837    0.3248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8796    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2016   -0.3124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7938    0.9781    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0403    1.3141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3726    0.8295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6191    1.1654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9514    0.6808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5333    1.9859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2010    2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1152    3.2911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7829    3.7756    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.6971    4.5962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5364    3.4397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2041    3.9243    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.1183    4.7448    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7859    5.2294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9576    3.5883    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.6253    4.0729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0434    2.7678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3757    2.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7969    2.4319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8827    1.6113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2150    1.1267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6362    1.2754    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    9.3039    1.7600    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0574    1.4240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1432    0.6035    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7251    1.9086    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9545    2.1346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  4  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 19 18  1  0  0  0  0
 19 20  1  1  0  0  0
 19 21  1  0  0  0  0
 22 21  1  0  0  0  0
 22 23  1  6  0  0  0
 23 24  1  0  0  0  0
 25 22  1  0  0  0  0
 25 26  1  6  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 29 27  1  4  0  0  0
 29 30  2  0  0  0  0
 30 31  1  0  0  0  0
 32 30  1  0  0  0  0
  3 32  1  0  0  0  0
 32 33  1  6  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  2  0  0  0  0
 17 37  4  0  0  0  0
 12 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4908

>  <JC_XSMILES>
CO[C@H]1CCC=C(C)C(=O)NC2=CC(O)=CC(C[C@@H](C)C[C@H](OC)[C@H](O)C(C)C=C(C)[C@@H]1OC(N)=O)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.096153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4909
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -0.5874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7087   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  5 11  4  0  0  0  0
  3 12  2  0  0  0  0
 12 13  1  4  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4909

>  <JC_XSMILES>
CN1C(SC2=CC(Cl)=CC=C12)=NC(=O)C3=CC=C(C=C3)S(=O)(=O)N4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4915
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    1.0468   -8.3081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -7.8956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -8.3081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -7.8956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9047   -8.3081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6191   -7.8956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7054   -7.0751    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5124   -6.9036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9249   -7.6181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7453   -7.7043    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2303   -7.0369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8947   -6.2832    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0507   -7.1231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5357   -6.4557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3561   -6.5419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6917   -7.2956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2068   -7.9630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3863   -7.8768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5122   -7.3818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9971   -6.7144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8176   -6.8006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1531   -7.5543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9736   -7.6405    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4585   -6.9731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6682   -8.2217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8477   -8.1355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3728   -8.2312    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
  9 27  4  0  0  0  0
  6 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4915

>  <JC_XSMILES>
CCCCCC1=NN=C(NC(=O)C2=CC=C(C=C2)C3=CC=C(OC)C=C3)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.457

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.06557377

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4921
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    5.6479    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 16 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 14 25  4  0  0  0  0
 12 26  4  0  0  0  0
 26 27  2  0  0  0  0
 26 28  4  0  0  0  0
 10 28  4  0  0  0  0
 28 29  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 30 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4921

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC(CC=C)=C(O)C(OC)=C3)c(=O)n2C1C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.546

>  <W2 Pf proliferation inhibition EC50 uM>
0.264

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4926
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 13 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4926

>  <JC_XSMILES>
CCOC1=C(Br)C=C(C=C1OC)C2C(=CN(C)C=C2C(=O)OC)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2925

>  <W2 Pf proliferation inhibition EC50 uM>
0.2627

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045977011

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4931
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0368    1.2084    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0583    0.5729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6722    0.2299    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4931

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)C(=O)NCc2n[nH]c(=S)n2C3=CC=CC(=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2577

>  <W2 Pf proliferation inhibition EC50 uM>
0.2606

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4934
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    0.2211    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9355    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9355    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645    0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  7 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4934

>  <JC_XSMILES>
CCCCNCC(O)(C1=CC=C(Cl)C=C1)C2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.72

>  <W2 Pf proliferation inhibition EC50 uM>
0.0997

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.53

>  <Powder data?>
Yes

>  <IFI value>
0.012658228

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4935
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    1.6500   -5.3329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -4.6184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.3329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -5.3329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.1895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7125   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750    0.3829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -0.3316    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    0.3829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.3829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    1.0974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.8118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    1.8118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    1.0974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625    1.0974    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 12 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  2  0  0  0  0
 28 30  4  0  0  0  0
 20 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 36 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4935

>  <JC_XSMILES>
COC1=CC=CC=C1NC(=O)N(CCC(C)C)C(C)C2=NC3=CC=CC=C3C(=O)N2C4=CC=CC=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.817

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02576

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009174312

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4941
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  5 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4941

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC2CCCCC2)C3=CC=NC4=CC(Cl)=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1186

>  <W2 Pf proliferation inhibition EC50 uM>
0.0152

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.94

>  <Powder data?>
Yes

>  <IFI value>
0.043103448

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4947
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4947

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)C(=O)NCc2n[nH]c(=S)n2C3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.325

>  <W2 Pf proliferation inhibition EC50 uM>
0.2521

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-495
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 10 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-495

>  <JC_XSMILES>
OC1=CC=CC=C1C2=NC(=NC(=N2)C3=CC=C(Br)C=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.164

>  <W2 Pf proliferation inhibition EC50 uM>
>1.285

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4951
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    0.8097   -9.5248    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0952   -9.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6193   -9.5248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -9.1123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -8.2873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6193   -7.8748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0952   -8.2873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6193   -7.0498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -6.6373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -5.8123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6193   -5.3998    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0952   -5.8123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0952   -6.6373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6193   -4.5748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -4.1623    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0952   -4.1623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8097   -4.5748    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0952   -3.3373    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8097   -2.9248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8097   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5241   -1.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2386   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9531   -1.6873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6675   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3125   -1.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1169   -1.7690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4748   -2.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1169   -3.2556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3125   -3.4391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6675   -2.9248    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9531   -3.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9531   -4.1623    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2386   -2.9248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5241   -3.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 24 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
 22 33  4  0  0  0  0
 33 34  4  0  0  0  0
 19 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4951

>  <JC_XSMILES>
ClC1=CC=CC(=C1)N2CCN(CC2)C(=O)C(=O)NC3=CC=C4N=C5CCCCCN5C(=O)C4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.808

>  <W2 Pf proliferation inhibition EC50 uM>
0.2497

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.043478261

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4955
  Mrv1591402191617072D          

 31 36  0  0  0  0            999 V2000
    3.6461    3.0977    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4772    2.2901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3082    1.4826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9230    0.9325    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432    1.0214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0812    0.2688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698   -0.2852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7541    0.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9703   -0.1324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8013   -0.9399    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4161   -1.4900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2472   -2.2975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4633   -2.5549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8485   -2.0048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0175   -1.1973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2944   -3.3624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5106   -3.6199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3416   -4.4274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5578   -4.6848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0571   -4.1347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1119   -3.3272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8957   -3.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3554    0.4177    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5352    0.3289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0524   -0.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2317   -0.2565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1063    0.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3765    1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1973    1.0815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8086    1.6354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5244    1.2252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  9 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
 23 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4955

>  <JC_XSMILES>
N#CC1=C2CCCC2=C(N3CCN(CC3)CC4=CC=CC=C4)N5C6=CC=CC=C6N=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3109

>  <W2 Pf proliferation inhibition EC50 uM>
0.2484

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4971
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  3  0  0  0  0
  7 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4971

>  <JC_XSMILES>
ClC1=CC=C(Cl)C(NC(=S)NCC2=CC=C(C=C2)C#N)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.421

>  <W2 Pf proliferation inhibition EC50 uM>
0.2377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-498
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3018   -2.1741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5314   -1.9238    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  5 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-498

>  <JC_XSMILES>
COC(=O)C1N(C(=O)OC)C2=CC=C(C=C2S1(=O)=O)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.362

>  <W2 Pf proliferation inhibition EC50 uM>
>1.28

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4995
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 13 23  4  0  0  0  0
 17 23  4  0  0  0  0
 11 24  4  0  0  0  0
 24 25  4  0  0  0  0
  8 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4995

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC=C(NC3=CC=NC4=CC(Cl)=CC=C34)C=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0358

>  <W2 Pf proliferation inhibition EC50 uM>
0.0547

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>23.67

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4997
  Mrv1591402191617072D          

 29 32  0  0  1  0            999 V2000
   -0.4317   -1.6637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3804   -1.5185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6607   -0.7426    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9122   -2.1492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7243   -2.0040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2561   -2.6347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9758   -3.4106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0683   -2.4895    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.1278   -3.3123    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8390   -1.6970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5218   -1.2340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1731   -1.7404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9853   -1.5952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2655   -0.8192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0777   -0.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6095   -1.3047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4216   -1.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9534   -1.7902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7655   -1.6450    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6731   -2.5662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8610   -2.7114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3292   -2.0807    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.0489   -2.8566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5171   -2.2259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2368   -3.0018    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.7686   -3.6325    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4247   -3.1470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8928   -2.5163    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5330   -3.2587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  8  6  1  1  0  0  0
  8  9  1  6  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 22 21  1  0  0  0  0
 22 16  1  0  0  0  0
 22 23  1  1  0  0  0
 22 24  1  0  0  0  0
 13 24  1  0  0  0  0
 25 24  1  0  0  0  0
 25 26  1  1  0  0  0
 25 27  1  0  0  0  0
 28 27  1  0  0  0  0
 28  8  1  0  0  0  0
 28 12  1  0  0  0  0
 28 29  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4997

>  <JC_XSMILES>
CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)C3[C@@H](O)C[C@]12C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02301

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.007692308

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5005
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    1.3494   -2.3445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6488   -1.5757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1327   -0.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4321   -0.1633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9160    0.4804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1005    0.3553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2705    1.0921    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3157    1.6727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0553    2.4096    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0490    1.2946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0961    2.1182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4064    2.5709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2833    3.0236    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8330    2.4892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8802    3.3129    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5227    2.0365    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4756    1.2129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7387    0.8419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6915    0.0183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9547   -0.3527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3813   -0.4344    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1181   -0.0634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8079   -0.5161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1653    0.7602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0941    1.1393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9046    1.9423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8520    1.4653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5468    0.4496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1758   -0.2873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6528   -0.9605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1989   -0.4135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3172   -1.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  3  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 10 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 17 24  4  0  0  0  0
  7 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
  6 31  4  0  0  0  0
 31 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5005

>  <JC_XSMILES>
CCC1=CC2=C3N(C(=O)C24C(C#N)=C(N)OC5=C4C(=O)OC(C)=C5)C(C)(C)CC(C)C3=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.474

>  <W2 Pf proliferation inhibition EC50 uM>
0.2277

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5006
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2243   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1347   -1.5983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6867   -2.2114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4937   -2.0399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7486   -1.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1966   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2163    2.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 20 25  4  0  0  0  0
  9 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5006

>  <JC_XSMILES>
CN1CCC2=C(C1)SC3=C2C(=O)N(C4=CC=CC=C4)C(SCC=C)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.632

>  <W2 Pf proliferation inhibition EC50 uM>
0.2276

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.075471698

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5011
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5011

>  <JC_XSMILES>
CC1=CC=C(C=C1)S(=O)(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.575

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02035

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.02

>  <Powder data?>
No

>  <IFI value>
0.021052632

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5028
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5028

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(NC(=O)C2=CC=CC=C2)C3=CC=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1337

>  <W2 Pf proliferation inhibition EC50 uM>
0.2159

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.106060606

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5030
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4257   -5.3493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
  5 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 17 24  4  0  0  0  0
 14 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 25 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5030

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1O)C2=NC(=C(N2)C3=CC=C(C)C(C)=C3)C4=CC=C(C)C(C)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.093

>  <W2 Pf proliferation inhibition EC50 uM>
0.1315

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
61.22

>  <Powder data?>
Yes

>  <IFI value>
0.087912088

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5034
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    2.7948   -5.2257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -5.8387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4977   -6.6234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9457   -7.2365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -7.0649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -6.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -5.6672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -4.8826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963   -4.6277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963   -3.8027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6658   -4.2152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 19 24  4  0  0  0  0
 17 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5034

>  <JC_XSMILES>
OC1=CC=CC=C1C2=NNC(=C2)C(=O)NC3=C(OC4=CC=CC=C34)C(=O)NC5=CC=CC(Cl)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2716

>  <W2 Pf proliferation inhibition EC50 uM>
0.0742

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
35.13

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5040
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.3371   -0.6915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3370   -1.5165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0515   -1.9291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0514   -2.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3369   -3.1665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3368   -3.9915    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8888   -4.6047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4408   -5.2178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1858   -6.0024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7378   -6.6155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5448   -6.4441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7998   -5.6595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2478   -5.0463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5020   -4.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2866   -4.3077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8997   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7282   -2.9487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9436   -2.6937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3305   -3.2457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2757   -5.1566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4911   -4.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1221   -5.4536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0494   -6.2606    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8340   -6.5156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4471   -5.9636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6225   -2.7540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6225   -1.9290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0919   -1.5164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  7 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  7 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5040

>  <JC_XSMILES>
CC1=CC=C(NC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.439

>  <W2 Pf proliferation inhibition EC50 uM>
0.2067

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5042
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  4  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  5 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
  2 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5042

>  <JC_XSMILES>
CC(=NNC1=NC(=NC2=CC=CC=C12)C3=CC=CC=C3O)C4=CC=CC=C4O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.742

>  <W2 Pf proliferation inhibition EC50 uM>
0.2064

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5044
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6839    0.7846    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6675    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521    1.0550    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652    1.6070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.0945    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8974    2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5044

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=C(SC)SC(C)=C3)C(=O)CC(C2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.671

>  <W2 Pf proliferation inhibition EC50 uM>
0.2049

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5045
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  5 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5045

>  <JC_XSMILES>
OC1=CC=C(C=C1CN2CCC(CC2)C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.42

>  <W2 Pf proliferation inhibition EC50 uM>
0.2045

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5048
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 14 22  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  4 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5048

>  <JC_XSMILES>
CCOC1=CC=C(NC2=CC(C)=NC3=CC=C(OCC)C=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.02029

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034482759

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5049
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5049

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)CSC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00717

>  <W2 Pf proliferation inhibition EC50 uM>
0.02029

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5052
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018    1.6373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
  9 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5052

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(NC3=CC=C(Br)C(C)=C3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1851

>  <W2 Pf proliferation inhibition EC50 uM>
0.2018

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5056
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -4.3992   -1.1244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7862   -0.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9577    0.2346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0015   -0.8273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3884   -0.2753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6038   -0.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4323   -1.3372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6477   -1.5921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4761   -2.3991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2775   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9920   -2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4209   -2.3221    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1354   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499   -2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1354   -3.5596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1913   -3.5551    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6157   -3.7267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0282   -4.4411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8532   -4.4411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2657   -3.7267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8532   -3.0122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0282   -3.0122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0454   -1.8892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8300   -1.6343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
 10 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  9 23  4  0  0  0  0
 18 23  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5056

>  <JC_XSMILES>
CC(C)C1=CC=C(CN2C(CCNC(C)=O)=NC3=CC=CC=C23)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.764

>  <W2 Pf proliferation inhibition EC50 uM>
0.0981

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.7

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5061
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  9  6  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5061

>  <JC_XSMILES>
COC1=CC=C(C=C1)N=NC2=NC3=CC=C(Br)C=C3N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1971

>  <W2 Pf proliferation inhibition EC50 uM>
0.1994

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.092592593

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5070
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5070

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC(Cl)=C4)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0713

>  <W2 Pf proliferation inhibition EC50 uM>
0.0318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.05

>  <Powder data?>
Yes

>  <IFI value>
0.060240964

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5072
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
  3 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5072

>  <JC_XSMILES>
COC1=CC(NC2=CN=CC(=N2)C3=CC=C(C=C3)C(N)=O)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02952

>  <W2 Pf proliferation inhibition EC50 uM>
0.0501

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.33

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5073
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 14 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5073

>  <JC_XSMILES>
CCN(CC)CCCNC1=CC=NC2=CC3=CC=CC=C3C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0338

>  <W2 Pf proliferation inhibition EC50 uM>
0.0518

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.21

>  <Powder data?>
Yes

>  <IFI value>
0.048387097

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5075
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    4.8105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    7.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    7.6980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    7.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 18 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5075

>  <JC_XSMILES>
OC(CN1CCN(CC1)CC2=CC=CC=C2)CN3C4=CC=C(Br)C=C4C5=CC(Br)=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2956

>  <W2 Pf proliferation inhibition EC50 uM>
0.0573

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
29.01

>  <Powder data?>
Yes

>  <IFI value>
0.040816327

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5076
  Mrv1591402191617072D          

 35 37  0  0  1  0            999 V2000
   -0.4341   -2.8673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9742   -2.2437    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7042   -1.4641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1059   -1.3082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3760   -0.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1641    0.0950    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9881    0.1356    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.4701    0.8051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2825    0.6614    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2472    1.5994    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4872    1.9204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5083    2.7451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1954    3.1758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9202    2.7817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6239    3.2123    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6028    4.0370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3065    4.4676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    4.4311    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9413    1.9569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2376    1.5263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3814    0.7139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1757    0.4910    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3822   -0.5892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9516   -1.2929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3457   -2.0177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1704   -2.0387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6010   -1.3351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2069   -0.6103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1861   -0.3727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4562    0.4068    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7262   -0.9964    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5363   -0.8405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0764   -1.4641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8866   -1.3082    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8064   -2.2436    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  2  0  0  0  0
  7 23  1  1  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  5 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5076

>  <JC_XSMILES>
CSCCC(N1[C@H](C(=O)NC2=CC=C(NC(C)=O)C=C2C1=O)C3=CC=CC=C3)C(=O)NCC(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.01532

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.76

>  <Powder data?>
No

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5077
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    3.5881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595    4.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7667    3.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7056    4.2012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507    4.9858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957    5.7704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3339    4.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2353    5.2408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    4.3808    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    3.6664    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  7 17  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5077

>  <JC_XSMILES>
CC1=CC2=NC(=C(NC(C)(C)CC(C)(C)C)N2C=C1)C3=CC=CC=C3OC(=O)C4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.74

>  <W2 Pf proliferation inhibition EC50 uM>
0.1476

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
74.95

>  <Powder data?>
Yes

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5080
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    4.4025    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1170    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8315    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5459    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2604    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9749    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9749    1.3607    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6894    0.1232    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.4038    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4038    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183    1.7732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8328    1.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8328    0.5357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183    0.1232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1183   -0.7018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7857   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5704   -0.9317    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1835   -1.4838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6314   -2.0969    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7355   -0.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7966   -2.0358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5812   -1.7809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.3658   -1.5259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.8361   -2.5655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3262   -0.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5308   -1.9713    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.9433   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5308   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7058   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2933   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7058   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4509   -1.1867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 16 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 15 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5080

>  <JC_XSMILES>
CCCCCC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.701

>  <W2 Pf proliferation inhibition EC50 uM>
0.01951

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5081
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 15 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  1  0  0  0  0
 26 31  4  0  0  0  0
 14 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 38 39  4  0  0  0  0
 32 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5081

>  <JC_XSMILES>
CCCCN(CC)CCNC(=O)C1C(N(CC2=CC=C(F)C=C2)C(=O)C3=CC=CC=C13)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.27

>  <W2 Pf proliferation inhibition EC50 uM>
0.1951

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5082
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
   -0.8827   -3.9729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6743   -3.7408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2712   -4.3103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0629   -4.0782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2577   -3.2765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6608   -2.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8691   -2.9391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2722   -2.3696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4806   -2.6017    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0493   -3.0443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6462   -3.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4379   -3.3817    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6327   -2.5800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0358   -2.0105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2441   -2.2427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 13 19  1  0  0  0  0
 12 13  1  0  0  0  0
 11 12  1  0  0  0  0
 10 18  1  0  0  0  0
 15 16  1  0  0  0  0
 18 19  1  0  0  0  0
 15 17  1  0  0  0  0
 14 15  1  0  0  0  0
 17 18  1  0  0  0  0
 11 16  1  0  0  0  0
 13 14  1  0  0  0  0
  5 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5082

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC2C3CC4CC(C3)CC2C4)C5=CC=CN=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.459

>  <W2 Pf proliferation inhibition EC50 uM>
0.1949

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5086
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    8.7277    2.6356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2133    1.9906    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3976    2.1136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8832    1.4686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0674    1.5915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7660    2.3595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502    2.4825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    1.8374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7938    1.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    0.3508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    0.1673    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    0.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    1.9191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    2.0210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8431    1.9191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2556    2.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4306    1.2047    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1286    2.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1286    3.1566    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5859    3.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8431    3.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2804    3.0045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0961    2.8815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6105    3.5266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  8 18  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5086

>  <JC_XSMILES>
COC1=CC=C(CN2CCOC3=CC=C(C=C3C2)C(C)(O)CN(C)C)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.823

>  <W2 Pf proliferation inhibition EC50 uM>
0.1933

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5092
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
  7 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
  5 25  1  0  0  0  0
 25 26  2  0  0  0  0
  6 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5092

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=CC=C(C)C=C2Cl)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.305

>  <W2 Pf proliferation inhibition EC50 uM>
0.1908

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.032258065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5095
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    1.3099    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 11 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 10 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5095

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CS3)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.833

>  <W2 Pf proliferation inhibition EC50 uM>
0.189

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5102
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6236   -1.8980    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0652   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8498   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0213   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8059   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4190   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2475   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4629   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8606   -3.8512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4737   -4.4032    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.3086   -4.4643    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4126   -3.2381    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  6 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5102

>  <JC_XSMILES>
FC1=CC(F)=C(C2SCCN2C(=S)NC3=CC=CC(=C3)C(F)(F)F)C(F)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2727

>  <W2 Pf proliferation inhibition EC50 uM>
0.1867

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5107
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
  5 32  4  0  0  0  0
 32 33  4  0  0  0  0
  2 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5107

>  <JC_XSMILES>
CC1=CC=C(CN2C(=NC3=CC=CC=C23)N4CCC(CC4)C(=O)NCC5=CC=CC=N5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.484

>  <W2 Pf proliferation inhibition EC50 uM>
0.1854

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5111
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -0.7145    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6081   -2.8265    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  9 25  4  0  0  0  0
  5 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5111

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC(=S)N2CCCC2C3=CC=CC=C3Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1868

>  <W2 Pf proliferation inhibition EC50 uM>
0.1847

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036363636

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5113
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  1  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 10 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5113

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3Cl)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2806

>  <W2 Pf proliferation inhibition EC50 uM>
0.1213

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
66

>  <Powder data?>
Yes

>  <IFI value>
0.058139535

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-512
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
   -2.8875    5.8263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730    5.4138    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730    4.5888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4586    4.1763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4586    3.3513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730    2.9388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730    2.1138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    1.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    0.8763    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6020    0.4638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3164    0.8763    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6020   -0.3612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875   -0.7737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875   -1.5987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6020   -2.0112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3164   -1.5987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3164   -0.7737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0309   -0.3612    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7454   -0.7737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7454   -1.5987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4599   -2.0112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1743   -1.5987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8888   -2.0112    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1743   -0.7737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4599   -0.3612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730   -2.0112    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4586   -2.4237    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5855   -2.7257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7605   -1.2967    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730   -0.5823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7605    0.1322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730    0.8467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    0.1322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -0.5823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.5823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -1.2967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    3.3513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    4.1763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6020    4.5888    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6020    5.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 14 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  2  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 29 36  1  0  0  0  0
  6 37  4  0  0  0  0
 37 38  4  0  0  0  0
  3 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-512

>  <JC_XSMILES>
COC1=CC=C(CCNC(=O)C2=CC(=CC=C2SC3=CC=C(F)C=C3)S(=O)(=O)N4CC(C)CC(C)C4)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.054

>  <W2 Pf proliferation inhibition EC50 uM>
1.262

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5122
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    2.9084   -2.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1015   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5494   -2.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8465   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4211    0.9744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0886    1.4593    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8422    1.1237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0023    2.2798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -2.4454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
  9 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
  6 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5122

>  <JC_XSMILES>
CC(C)CCN1C(=O)N(CCN(C)C)C(=O)C12CCN(CC2)CC3=CC=C(O)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.74

>  <W2 Pf proliferation inhibition EC50 uM>
0.1226

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.45

>  <Powder data?>
Yes

>  <IFI value>
0.024691358

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5125
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    3.2720    6.2154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0557    5.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2243    5.1501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0080    4.8923    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1766    4.0847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9603    3.8269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1289    3.0193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5138    2.4695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7301    2.7273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5615    3.5349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7778    3.7927    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6092    4.6002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6824    1.6619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4832    1.4634    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.8273    0.7136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6509    0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1029    0.0698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7312   -0.6667    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9076   -0.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4556   -0.0229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6480   -0.1915    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0126    0.3348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2234    0.0944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8739   -0.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0520   -0.7239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5795   -0.0475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9290    0.6998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7510    0.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2482    1.4291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0079    2.2183    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0279    1.1596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 13 31  1  0  0  0  0
 22 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5125

>  <JC_XSMILES>
CCCOC1=CC=C(C=C1OC)C2SC3=CC=CC=C3N=C4C5=CC=CC=C5C(O)=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.483

>  <W2 Pf proliferation inhibition EC50 uM>
0.1776

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.033333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-513
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    7.7525    1.0527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    1.4652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    0.2277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -1.0098    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2765   -1.4947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0216   -2.2794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1966   -2.2794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9416   -1.4947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    0.2277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -1.0098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -1.0098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    2.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    3.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    2.7027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    2.2902    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.0544    1.5757    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8794    3.0047    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
  4 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-513

>  <JC_XSMILES>
O=C(NC(CN1CCCC1)C2=CC=CC=C2)C3CCCCN3S(=O)(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.632

>  <W2 Pf proliferation inhibition EC50 uM>
1.261

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-514
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -1.4289    4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2539    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  3  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 21 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-514

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(C=C1)C(C#N)C2=CC=C3C(=N2)N=C(C=C3C(F)(F)F)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.413

>  <W2 Pf proliferation inhibition EC50 uM>
0.3156

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.506

>  <Powder data?>
No

>  <IFI value>
0.263157895

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5140
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 19 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  2  0  0  0  0
  7 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5140

>  <JC_XSMILES>
COC1=CC=CC(NC(=O)C2=CC=CC3=C2NC4=C(CCCC4)C3=O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.957

>  <W2 Pf proliferation inhibition EC50 uM>
0.1685

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5144
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -5.0013    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 20 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 11 33  4  0  0  0  0
 33 34  4  0  0  0  0
  8 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5144

>  <JC_XSMILES>
COCC(=O)NCC1=CC=C(OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.46

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01666

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014084507

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5145
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5145

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(F)C=C4)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01264

>  <W2 Pf proliferation inhibition EC50 uM>
0.01926

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.57

>  <Powder data?>
Yes

>  <IFI value>
0.084337349

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5149
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.3406   -6.9661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0551   -7.3786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7696   -6.9661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4841   -7.3786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4841   -8.2036    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1985   -6.9661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9130   -7.3786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6275   -6.9661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3419   -7.3786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0564   -6.9661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0564   -6.1411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7709   -7.3786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5246   -7.0430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6961   -6.2360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4807   -5.9811    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.7356   -5.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5606   -5.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8156   -5.9811    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1481   -6.4660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0766   -7.6561    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6641   -8.3706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9997   -9.1242    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8571   -8.1990    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 12 23  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  23
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5149

>  <JC_XSMILES>
CCOC(=O)CCCCC(=O)C1=C(CN2C=CN=C2)NC(=O)N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1519

>  <W2 Pf proliferation inhibition EC50 uM>
0.1646

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.01459854

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5151
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    7.1253   -1.7257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3184   -1.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7663   -2.1672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9594   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7044   -1.2111    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2564   -0.5980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0634   -0.7695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8974   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3454   -1.6527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5151

>  <JC_XSMILES>
CC1CCN(CC1)C(=O)C2=C(C)OC3=C2C(=O)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2217

>  <W2 Pf proliferation inhibition EC50 uM>
0.0792

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.27

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5153
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  9 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5153

>  <JC_XSMILES>
CCC1=CC=C(C=C1)C(NC2=CC(C)=CC=N2)C3=CC=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.468

>  <W2 Pf proliferation inhibition EC50 uM>
0.1629

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5157
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 22 23  1  0  0  0  0
 12 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 10 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
  6 37  4  0  0  0  0
 37 38  4  0  0  0  0
  3 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5157

>  <JC_XSMILES>
COC1=CC=C(CCNC2=NC(NCCCN3CCCCC3C)=NC=C2C(=O)NCC4=CC=CC=C4)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.323

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01614

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038095238

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5158
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
 19 28  4  0  0  0  0
 15 28  4  0  0  0  0
 28 29  2  0  0  0  0
 18 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5158

>  <JC_XSMILES>
CCN1CCN(CC1)CC2=C(O)C=CC3=C2OC(=C(OC4=CC=CC(C)=C4)C3=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.127

>  <W2 Pf proliferation inhibition EC50 uM>
0.1613

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5162
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6918   -3.9591    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0244   -4.4440    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3570   -3.9591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5723   -4.2140    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -0.7027    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5162

>  <JC_XSMILES>
CCOC(=O)C1=C(N(N=N1)C2=NON=C2N)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.397

>  <W2 Pf proliferation inhibition EC50 uM>
0.1595

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5165
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -6.1283   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8427   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5572   -0.9355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5572   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8427   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1283   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4138   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4138   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1283   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8427   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8427    0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5572    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5572    1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8427    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8427    2.7770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5572    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5572    4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2717    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2717    5.2520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9862    5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9862    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2717    6.9020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5572    6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5572    5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9862    4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9862    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7006    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.4151    3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.4151    4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7006    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1283    1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.1283    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4138    0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4138   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8263   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  2 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 18 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 14 31  4  0  0  0  0
 31 32  4  0  0  0  0
 11 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5165

>  <JC_XSMILES>
O=C(NCC1=CC=CC=C1)C2=CN=C(NCCC(C3=CC=CC=C3)C4=CC=CC=C4)N=C2NC5CC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.161

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01579

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.058252427

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5167
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  2  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5167

>  <JC_XSMILES>
CCN(CC)CCN1C(NC2=CC=CC=C2C1=O)C3=CC=C(C=C3)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2848

>  <W2 Pf proliferation inhibition EC50 uM>
0.157

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5169
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  2  0  0  0  0
 30 32  4  0  0  0  0
 22 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 33 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5169

>  <JC_XSMILES>
COC1=CC=CC=C1NC(=O)N(CC2=CC=CC=C2)C(C)C3=NC4=CC=CC=C4C(=O)N3C5=CC(C)=CC=C5OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.344

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01559

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5188
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1842   -7.6445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2448   -7.6445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 11 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 17 23  1  0  0  0  0
 12 24  4  0  0  0  0
  7 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5188

>  <JC_XSMILES>
CCCCCCC1=CC(O)=C2C(OC(C)(C)C3=C2CCN(C)C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0484

>  <W2 Pf proliferation inhibition EC50 uM>
0.03128

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.6

>  <Powder data?>
Yes

>  <IFI value>
0.057692308

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5189
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    1.2413   -4.2600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6282   -3.7080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5912   -4.5940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4162   -4.5940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8287   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4162   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5912   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0392   -2.5519    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5189

>  <JC_XSMILES>
CN1C2=CC=CC=C2N=C1C(=O)C3=CC=CC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00692

>  <W2 Pf proliferation inhibition EC50 uM>
0.0326

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.47

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5192
  Mrv1591402191617072D          

 20 20  0  0  0  0            999 V2000
   -0.1467    2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.9393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5678    1.1143    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2352    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0198    0.8843    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1913    1.6913    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9760    1.9462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1475    2.7532    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5891    1.3942    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.9803   -0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4652   -0.8227    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2857   -0.7365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7706   -1.4039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5911   -1.3177    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4350   -2.1576    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.1553   -0.1553    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3297   -0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1501   -0.7365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0997    0.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8843    0.8843    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  4 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  1  0  0  0  0
  3 19  1  0  0  0  0
 19 20  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5192

>  <JC_XSMILES>
CCN1C(NNC(N)=S)C(NNC(N)=S)N(CC)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1229

>  <W2 Pf proliferation inhibition EC50 uM>
0.1515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.044444444

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5193
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 11 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5193

>  <JC_XSMILES>
CCOC(=O)C1=C(CC)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.459

>  <W2 Pf proliferation inhibition EC50 uM>
0.1514

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045977011

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5198
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822    0.4841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371    1.2687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441    1.4402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8961    0.8271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7031    0.9987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9580    1.7833    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4060    2.3964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5990    2.2248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470    2.8379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3020    3.6226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7499    4.2357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2551    0.3856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0002   -0.3991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5522   -1.0122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3592   -0.8406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6141   -0.0560    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0621    0.5571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 15 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
  4 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
  2 36  1  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5198

>  <JC_XSMILES>
O=C1CC(C(=O)N2CCC(CC2)C3=NC(=NC=C3C4=CC=CC=C4)C5=CC=CN=C5)C6=CC=CC=C16

>  <PF proliferation inhibition 3D7 EC50 uM>
0.459

>  <W2 Pf proliferation inhibition EC50 uM>
0.1502

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.026086957

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5209
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
   -0.6549   -1.4747    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2203   -0.7735    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141   -2.3078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0097   -2.8787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8019   -2.6484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3974   -3.2193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2008   -4.0205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4086   -4.2508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8130   -3.6799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5597   -2.2275    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2649   -2.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9440    0.1607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7978    0.9726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4278    1.5052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2041    1.2259    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3503    0.4140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7203   -0.1186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9082    1.3045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0836    1.3302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6936    2.0573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1310    2.0830    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.1282    2.7585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9528    2.7327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3428    2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1674    1.9800    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  4  0  0  0  0
  8 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  3 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
  6 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
 37 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5209

>  <JC_XSMILES>
COC1=CC2=C(N=C3N(N=C(CC4=CC=CC=C4)C3=C2C=C1OC)C5=CC=CC=C5)C6=CC(Br)=CC=C6O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.146

>  <W2 Pf proliferation inhibition EC50 uM>
0.1452

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5212
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    3.1754   -3.1791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3684   -3.0076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7553   -3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0409   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2124   -2.3402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.2539    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8416   -4.3801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1741   -4.8651    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5953   -4.7157    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6815   -5.5362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4352   -5.8717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5214   -6.6922    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2359   -7.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0643   -7.9117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2439   -7.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9083   -7.2442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
  3 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5212

>  <JC_XSMILES>
CC1=C(C=NN1C2=NC=C3CSC4=CC=CC=C4C3=N2)C(=O)NCCN5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.525

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0143

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025862069

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5217
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1599   -1.3480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9849   -2.7770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0405   -1.9856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5925   -1.3725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1800   -0.6580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3731   -0.8295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  6 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  2  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5217

>  <JC_XSMILES>
CC1=CC(Cl)=C(C=C1OCC(=O)NC2CCCCC2)S(=O)(=O)N3CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0956

>  <W2 Pf proliferation inhibition EC50 uM>
0.1411

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-522
  Mrv1591402191617072D          

 27 31  0  0  0  0            999 V2000
   -1.7086   -1.6665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8988   -1.8243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6305   -2.6044    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1793   -2.7622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4476   -3.5423    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0939   -4.1648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1743   -4.9449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3672   -5.5673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1769   -5.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7184   -6.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5282   -5.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7965   -5.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6063   -4.9364    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2550   -4.4717    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4452   -4.6294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9037   -4.0070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7208   -2.1398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5456   -2.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7872   -1.3368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5545   -1.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2698   -1.4448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3945   -2.2603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8346   -2.8663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0118   -2.8064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1116   -0.8634    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4525   -1.3596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3573   -1.2019    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
  4 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 18 24  1  0  0  0  0
 19 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-522

>  <JC_XSMILES>
CC1=NC(OC2=CC=C3C=CC(=O)OC3=C2)=C4C5=C(CCCCC5)SC4=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.301

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5220
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
  8 15  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5220

>  <JC_XSMILES>
CCC1=NN2C(NC3=CC=C(C)C(F)=C3)=CC(C)=NC2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2485

>  <W2 Pf proliferation inhibition EC50 uM>
0.1405

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.018181818

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5221
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 16 21  4  0  0  0  0
  2 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
 22 33  4  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5221

>  <JC_XSMILES>
CC(N1CCN(CC1)S(=O)(=O)C2=CC=CC3=CC=CC=C23)C4=NC5=CC=C(Cl)C=C5C(=O)N4C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1468

>  <W2 Pf proliferation inhibition EC50 uM>
0.1397

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5222
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
   -4.4336   -6.4306    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7191   -6.0181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7191   -5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0047   -4.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -4.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -3.9556    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -2.3056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481   -2.1661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042   -1.4986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9562   -0.8856    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -6.0181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0047   -6.4306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0047   -7.2556    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 14 25  1  0  0  0  0
 10 25  1  0  0  0  0
 25 26  2  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
 28 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5222

>  <JC_XSMILES>
FC1=CC=C(CN2CCN3C(C2)CN(CC4=CC5=CC=CC=C5S4)C3=O)C=C1F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2393

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01389

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5227
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    3.5724   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5227

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(=C1)C(=O)NCCCCNC2=CC=NC3=CC(Cl)=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1706

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01383

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5234
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
  6 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 19 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5234

>  <JC_XSMILES>
CCOC1=CC(=CC=C1OC(C)C)C2CC(=O)NC3=C2C(=O)CC(C)(C)C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2835

>  <W2 Pf proliferation inhibition EC50 uM>
0.1365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5235
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5235

>  <JC_XSMILES>
OC1=CC=CC=C1NC2=NC(=NC3=CC=CC=C23)C4=CC=CC=C4O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.577

>  <W2 Pf proliferation inhibition EC50 uM>
0.1362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5237
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5237

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)COCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1096

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0135

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5238
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  2  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  1  0  0  0  0
 18 33  4  0  0  0  0
 33 34  4  0  0  0  0
 15 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5238

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NCCN2)C3=CC=C(NC(=O)C4=CC=C(C=C4)C5=NCCN5)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0819

>  <W2 Pf proliferation inhibition EC50 uM>
0.01349

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5242
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    2.1072    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3218    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1464    2.0057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5364    2.7327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1018    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2772    3.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8426    4.1095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8872    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5452    0.1607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  3  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 10 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5242

>  <JC_XSMILES>
CN(C1=CC=CC(C)=C1)C2=NC3=CC=CC=C3C4=NN=C(C)N24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1188

>  <W2 Pf proliferation inhibition EC50 uM>
0.1339

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5246
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   16.4328    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.1473    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   17.8618    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   19.2907    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.0052   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   20.7197   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   19.2907   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   18.5762    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 16 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5246

>  <JC_XSMILES>
CCCCC(CC)C(=O)NCCCCNC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2971

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01344

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.14

>  <Powder data?>
No

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-525
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  9  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 15 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 24 32  4  0  0  0  0
 13 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-525

>  <JC_XSMILES>
CCOC1=CC=CC=C1C=NNC2=NC(NC3=CC=CC=C3)=NC(NC4=CC=CC=C4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.054

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038961039

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5265
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  4  0  0  0  0
 19 20  4  0  0  0  0
 13 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5265

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(SC)C=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3019

>  <W2 Pf proliferation inhibition EC50 uM>
0.1266

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5272
  Mrv1591402191617072D          

 31 33  0  0  1  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4647   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0778   -4.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8624   -4.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4755   -4.9131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4824   -3.5721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9070   -6.9093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -5.8331    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -5.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
  7 19  1  1  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 22 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5272

>  <JC_XSMILES>
COC(=O)[C@@H]1C[C@H](CN1CC2=CC=C(C)C=C2C)NC(=O)C3=CC=C(OC)C=C3OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3032

>  <W2 Pf proliferation inhibition EC50 uM>
0.1255

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.00877193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5283
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
   -2.2252    4.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9702    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633    3.1080    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    2.1896    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    4.6646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    5.0771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    3.4271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 17 33  4  0  0  0  0
 33 34  4  0  0  0  0
 14 34  4  0  0  0  0
 34 35  2  0  0  0  0
 33 36  1  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 39 41  4  0  0  0  0
 41 42  4  0  0  0  0
 36 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5283

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N2C(=S)SC3=C2N=C(SCC(=O)NC4=CC(OC)=CC=C4OC)N(C3=O)C5=CC=C(C)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2854

>  <W2 Pf proliferation inhibition EC50 uM>
0.1228

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-529
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-529

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C=NNC2=NC(N)=NC(N)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.998

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5302
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    3.1650   -0.5912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8795   -0.1787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8795    0.6463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5940   -0.5912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3084   -0.1787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3084    0.6463    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0229   -0.5912    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7374   -0.1787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7374    0.6463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519    1.0588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1663    0.6463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1663   -0.1787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519   -0.5912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4519   -1.4162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1193   -1.9012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9039   -1.6462    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.5170   -2.1983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9650   -2.8113    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0691   -1.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1301   -2.7503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.9147   -2.4953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6994   -2.2404    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1697   -3.2800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6598   -1.7107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8644   -2.6858    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2769   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8644   -4.1147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0394   -4.1147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6269   -4.8292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6269   -3.4003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0394   -2.6858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7844   -1.9012    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
 31 32  4  0  0  0  0
 14 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5302

>  <JC_XSMILES>
CC(C)CC(=O)OC1=CC=CC=C1C2=C(NC(C)(C)CC(C)(C)C)N3C=CC(C)=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.772

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01153

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5306
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
  4 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  3 24  1  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5306

>  <JC_XSMILES>
COC1=C(NC2=CC=CC(=C2)C(F)(F)F)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2631

>  <W2 Pf proliferation inhibition EC50 uM>
0.1136

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-531
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-531

>  <JC_XSMILES>
COC1=CC=C(Cl)C=C1N2C(=S)NN=C2C3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.868

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5310
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 10 19  4  0  0  0  0
  5 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5310

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(O)C(CNC2CCCCC2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2505

>  <W2 Pf proliferation inhibition EC50 uM>
0.0678

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
60.07

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5317
  Mrv1591402191617072D          

 20 23  0  0  0  0            999 V2000
   -0.6897    1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6505    0.5108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0828    0.1328    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1333   -0.4567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5792   -1.0689    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7843   -1.2206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6063   -1.1502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8710   -0.3172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1666   -0.7466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4595   -0.2093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1420    0.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6803    0.4855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4362    0.8343    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0672    0.3029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7439    0.7749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4910    0.4249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5614   -0.3970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3085   -0.7470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8848   -0.8691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1377   -0.5191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  3 12  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  1  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5317

>  <JC_XSMILES>
CCN1C(=S)NC2C3CCCC13OC4=CC=C(C)C=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1643

>  <W2 Pf proliferation inhibition EC50 uM>
0.1114

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5324
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 11 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5324

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C=C3Cl)C(=O)CC(C2)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.484

>  <W2 Pf proliferation inhibition EC50 uM>
0.1091

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036585366

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-533
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.6021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -4.2521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.0146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
  1 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 28 36  4  0  0  0  0
 36 37  4  0  0  0  0
 25 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-533

>  <JC_XSMILES>
N(C1=CC=C(OC2=CC=CC=C2)C=C1)C3=NC4=NON=C4N=C3NC5=CC=C(OC6=CC=CC=C6)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.761

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5333
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 13 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 10 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5333

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(Cl)C(Cl)=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2291

>  <W2 Pf proliferation inhibition EC50 uM>
0.1048

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.05952381

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5334
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.8756   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.7006    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.6842    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.0342    2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
 22 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5334

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0868

>  <W2 Pf proliferation inhibition EC50 uM>
<0.01044

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5337
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -0.5701    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  5 11  4  0  0  0  0
  4 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 12 28  1  0  0  0  0
 28 29  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5337

>  <JC_XSMILES>
CC(=O)N(C1=CC=C(F)C=C1)C2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1549

>  <W2 Pf proliferation inhibition EC50 uM>
0.0345

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
33.33

>  <Powder data?>
Yes

>  <IFI value>
0.08

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5338
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
    5.5434   -1.1007    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3031   -0.3115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8003    0.3468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6223    0.4178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9718    1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4993    1.8415    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6774    1.7705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3279    1.0232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5386    0.7828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5233   -0.0420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8689   -0.5443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0681   -0.3458    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7240    0.4040    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9003    0.3576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4483    1.0478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8200    1.7843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6437    1.8307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0957    1.1405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9033    1.3091    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0375   -1.3519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8212   -1.6097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9898   -2.4173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3747   -2.9671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5433   -3.7747    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3270   -4.0324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4956   -4.8400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2793   -5.0978    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4479   -5.9054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8328   -6.4552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0491   -6.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8805   -5.3898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5910   -2.7093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4224   -1.9017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
  9 19  2  0  0  0  0
 11 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 23 32  4  0  0  0  0
 32 33  4  0  0  0  0
 20 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5338

>  <JC_XSMILES>
O=C1C2=CC=CC=C2C3=C1C(SC4=CC=CC=C4N3)C5=CC=C(OCC6=CC=CC=C6)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.479

>  <W2 Pf proliferation inhibition EC50 uM>
0.1034

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.181818182

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5342
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -0.4366   -0.0605    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.2779   -0.4730    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9923   -0.0605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -1.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1511   -1.2980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8327   -1.7627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6211   -1.5196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9225   -0.7516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5100   -0.0371    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6942    0.0858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0894   -0.4753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9747    0.6445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6168    1.3878    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7974    0.5829    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2622    1.2645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0849    1.2029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5496    1.8845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1916    2.6278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3689    2.6895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9042    2.0078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7068   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4213   -3.3605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2943   -3.6625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1193   -2.2335    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
  6 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5342

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=CC=C1N2CCCN(CC2)C(=S)NC3=CC=CC=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0878

>  <W2 Pf proliferation inhibition EC50 uM>
0.1025

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.033613445

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5349
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.1635    2.1918    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    2.1918    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    3.0168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    3.4293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    4.2543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944    4.6668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944    5.4918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    5.9043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    5.4918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    4.6668    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    0.9543    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6717    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  3  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 15 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5349

>  <JC_XSMILES>
S=C(NN=CC1=CC=CC=N1)NC2CC3CC2C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0385

>  <W2 Pf proliferation inhibition EC50 uM>
0.0448

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
44.32

>  <Powder data?>
Yes

>  <IFI value>
0.196721311

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5353
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    8.4669   -6.6616    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -5.0116    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -7.4866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -6.2491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -7.4866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -7.9715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -7.9715    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
  4 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5353

>  <JC_XSMILES>
ClC1=CC(=CC=C1OC2CCN(CC2)CC3CCCCC3)C(=O)NCC4=CC=CO4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0951

>  <W2 Pf proliferation inhibition EC50 uM>
0.02358

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.51

>  <Powder data?>
Yes

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5356
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5356

>  <JC_XSMILES>
NC(=O)C1=CC=C(C=C1)C2=NC(=CN=C2N)C3=CC=C(C=C3)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0603

>  <W2 Pf proliferation inhibition EC50 uM>
0.0998

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-537
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -0.6636   -2.0230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2156   -2.6361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9607   -3.4207    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5127   -4.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3197   -3.8622    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2578   -4.8184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7427   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5677   -5.4858    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9802   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5677   -6.9148    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8052   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2177   -6.9148    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0427   -6.9148    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5276   -6.2473    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3123   -6.5023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3123   -7.3273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5276   -7.5822    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2727   -8.3668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4657   -8.5384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8247   -8.9799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0267   -7.7398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0267   -8.5648    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7412   -7.3273    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4557   -7.7398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7412   -6.5023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4557   -6.0898    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0267   -6.0898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0267   -5.2648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2578   -6.1533    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4732   -5.8983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4732   -5.0733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2413   -4.6608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9558   -5.0733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9558   -5.8983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2413   -6.3108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 16 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  2  0  0  0  0
 25 27  4  0  0  0  0
 15 27  4  0  0  0  0
 27 28  1  0  0  0  0
  7 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  6 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 30 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-537

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)CSC2=NC3=C(N2C(C)C)C(=O)N(C)C(=O)N3C)SC4=C1CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.559

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017699115

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5371
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -1.6500    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4934   -5.3625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0809   -6.0770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9059   -4.6480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2079   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9224   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7605   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9980   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4105   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9980   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
  9 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  4  0  0  0  0
 25 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5371

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(OCCS(=O)(=O)CCO)(C2=CC=CC=C2)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0703

>  <W2 Pf proliferation inhibition EC50 uM>
0.0489

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.65

>  <Powder data?>
Yes

>  <IFI value>
0.007462687

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5376
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    2.3143   -4.9627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5073   -4.7911    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2523   -4.0065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4454   -3.8350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1904   -3.0504    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7425   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4875   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -0.4849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4211    0.9744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5074    0.1539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0886    1.4593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0396    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5494   -2.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8044   -3.3934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5376

>  <JC_XSMILES>
COC1=CC=C(CCN2C(=O)N(CC(C)C)C(=O)C23CCN(CC3)CC4=CC=CC=C4O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2249

>  <W2 Pf proliferation inhibition EC50 uM>
0.0931

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.073170732

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5378
  Mrv1591402191617072D          

 21 23  0  0  1  0            999 V2000
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  6  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  0  0  0  0
  6  7  1  1  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 10 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
  8 20  1  0  0  0  0
  6 21  1  0  0  0  0
  2 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5378

>  <JC_XSMILES>
C[C@@H]1CCC[C@@H](C[C@H]2CC3=CC(O)=CC(O)=C3C(=O)O2)O1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0454

>  <W2 Pf proliferation inhibition EC50 uM>
0.0927

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.017857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5386
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 12 26  1  0  0  0  0
 21 26  4  0  0  0  0
 13 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 27 31  4  0  0  0  0
  8 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5386

>  <JC_XSMILES>
COC1=CC(OC)=C(NC(=O)C2C(N(CC(C)C)C(=O)C3=CC=CC=C23)C4=CC=CS4)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.114

>  <W2 Pf proliferation inhibition EC50 uM>
0.0905

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.060606061

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5388
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -0.4366   -0.0605    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.2779   -0.4730    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9923   -0.0605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -1.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -2.5355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -3.7730    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0212   -4.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2047   -4.9353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6904   -5.5803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1346   -5.5803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6490   -4.9353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4654   -4.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4926   -6.3236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3153   -6.3852    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0279   -7.0052    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3858   -7.7485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0789   -8.4302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2790   -9.1735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1017   -9.2351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4597   -9.9784    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5665   -8.5535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2085   -7.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6732   -7.1285    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5388

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(N=C1)N2CCCN(CC2)C(=S)NC3=CC=C(F)C=C3Br

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1104

>  <W2 Pf proliferation inhibition EC50 uM>
0.0903

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008403361

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-539
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    5.0013    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-539

>  <JC_XSMILES>
O=C(C1CCC=CC1)N2CCCC(C2)C3=NC=NC=C3C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.368

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5390
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 20 29  4  0  0  0  0
 14 30  4  0  0  0  0
  9 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5390

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CN(C)CCC3=CC=C(OC)C(OC)=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.337

>  <W2 Pf proliferation inhibition EC50 uM>
0.0523

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
57.94

>  <Powder data?>
Yes

>  <IFI value>
0.025641026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5391
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  4  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 11 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 10 26  1  0  0  0  0
 26 27  2  0  0  0  0
  8 28  4  0  0  0  0
 28 29  4  0  0  0  0
  5 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5391

>  <JC_XSMILES>
CC(=NO)C1=CC=C(NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0941

>  <W2 Pf proliferation inhibition EC50 uM>
0.09

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5404
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    4.0954   -3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -3.1895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7809   -3.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1678   -4.4952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4534   -4.0827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6249   -3.2757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6997   -4.4182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6135   -5.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2809   -5.7236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1402   -5.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3117   -6.3812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1322   -6.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4678   -5.7138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8547   -5.1618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 18 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  2  0  0  0  0
 26 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5404

>  <JC_XSMILES>
OC(CN1CCC(C1)NC(=O)C2=CSC=C2)CN(CC3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1199

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00862

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-541
  Mrv1591402191617072D          

 42 45  0  0  0  0            999 V2000
    6.9829    0.3829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -0.3316    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2204   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2671   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6796   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5046   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9171   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5046   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6796   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9171   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3296   -0.3316    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2026   -0.6336    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6316   -1.4586    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
 12 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-541

>  <JC_XSMILES>
COC1=CC=CC=C1\C=C\CN(CCN2CCN(CC2)S(=O)(=O)C3=CC=CC(=C3)C(F)(F)F)C(=O)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.321

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5421
  Mrv1591402191617072D          

 31 35  0  0  1  0            999 V2000
    0.8106   -3.8791    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -3.0541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -1.8166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    0.6584    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2396    1.0709    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.2396    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.3084    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0915    1.7584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0915    1.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.6584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.8959    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.3830    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.8959    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 11 10  1  6  0  0  0
 12 11  1  6  0  0  0
 12 13  1  0  0  0  0
 14 13  1  1  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 19 18  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  1  0  0  0
 20 21  2  0  0  0  0
 11 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 22 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5421

>  <JC_XSMILES>
FC1=CC=C(C=C1)C(=O)O[C@@H]([C@@H]2C[C@@H]3CCN2C[C@@H]3C=C)C4=CC=NC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.777

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00808

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008403361

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5425
  Mrv1591402191617072D          

 12 13  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  6 12  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5425

>  <JC_XSMILES>
NC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.415

>  <W2 Pf proliferation inhibition EC50 uM>
0.0576

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
71.97

>  <Powder data?>
Yes

>  <IFI value>
0.01754386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5434
  Mrv1591402191617072D          

 37 39  0  0  1  0            999 V2000
    2.8579   -8.6329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -7.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -7.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.2039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -6.4895    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -5.0605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -6.4895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -7.2039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -7.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -7.9184    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -7.2039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -7.2039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -7.2039    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.7454   -6.4895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -5.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -4.3461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -3.6316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.6316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -4.3461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -5.0605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -7.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -7.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -8.6329    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.2684   -9.0454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6974   -8.2204    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -9.3474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2204   -9.3474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6329  -10.0618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2204  -10.7763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954  -10.7763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829  -10.0618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  1  6  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
  5 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 18 17  1  1  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 18 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  2  0  0  0  0
 29 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5434

>  <JC_XSMILES>
CC(C)C[C@H](NC(=O)N1CCOCC1)C(=O)N[C@@H](CCC2=CC=CC=C2)\C=C\S(=O)(=O)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2104

>  <W2 Pf proliferation inhibition EC50 uM>
0.0377

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.8

>  <Powder data?>
Yes

>  <IFI value>
0.044444444

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5436
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 33 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5436

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(Cl)C=C4)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02902

>  <W2 Pf proliferation inhibition EC50 uM>
0.01666

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.64

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5438
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    6.8513    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4223    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4539    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179    2.0361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 21 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5438

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N(CC)S(=O)(=O)C2=CC(Br)=CC3=C2N(CC3)C(C)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1251

>  <W2 Pf proliferation inhibition EC50 uM>
0.0761

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5439
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    4.0865    6.0497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990    5.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240    5.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865    4.6208    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990    3.9063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240    3.9063    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865    3.1918    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990    2.4774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865    1.7629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615    1.7629    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490    2.4774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615    3.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490    3.9063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490    1.0484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0240    1.0484    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615    0.3340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0240   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7545   -0.7930    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7545    0.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1414    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3129    1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0975    1.6459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7106    1.0939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.2869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865    0.3340    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -1.0950    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240   -0.3805    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7365   -1.0950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5615   -1.0950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9740   -1.8094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5615   -2.5239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7365   -2.5239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240   -3.2384    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.3240   -1.8094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -1.8094    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
 21 26  4  0  0  0  0
 16 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 31 37  4  0  0  0  0
 37 38  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5439

>  <JC_XSMILES>
CC(C)NC(=O)N1CCN(CC1C)C(=O)C(CC2=CNC3=CC=CC=C23)NC(=O)NC4=CC=CC(Cl)=C4Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02723

>  <W2 Pf proliferation inhibition EC50 uM>
0.0439

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
57.72

>  <Powder data?>
Yes

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5445
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 24 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5445

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Br)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1362

>  <W2 Pf proliferation inhibition EC50 uM>
0.0731

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048192771

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5450
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  2  8  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5450

>  <JC_XSMILES>
CC1CN(CC(C)O1)C(=O)C2=C(Cl)C3=CC=C(C)C=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1016

>  <W2 Pf proliferation inhibition EC50 uM>
0.072

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5457
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    4.2135   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.9979    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1806    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.5306    3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -0.1006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.5422    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4507   -1.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1957   -2.7246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7478   -3.3376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6112   -2.8961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633   -2.2830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -0.8853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 16 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5457

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C2=NC3=C(C=NN3C(=C2)C(F)(F)F)C(=O)NC4=CC(C)=CC=C4O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1797

>  <W2 Pf proliferation inhibition EC50 uM>
0.07

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5461
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -1.3144    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  1  0  0  0  0
 19 24  4  0  0  0  0
 11 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5461

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2C(N(CC(C)C)C(=O)C3=CC=CC=C23)C4=CC=CS4)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.076

>  <W2 Pf proliferation inhibition EC50 uM>
0.0688

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5462
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    8.7471   -2.5945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6863   -1.7718    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9434   -1.4130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8827   -0.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1398   -0.2315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4576   -0.6954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7147   -0.3367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6516    0.5185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8652    0.9752    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5884    1.8275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5310    2.0900    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.4068    2.4290    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5849    2.5009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1661    1.5539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1311    1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8162    1.1540    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3524    2.6702    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7485    3.2322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9598    2.9902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3558    3.5522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5405    4.3562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9366    4.9182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3292    4.5983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9332    4.0362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7219    4.2783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2332    0.4448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3839   -0.4088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4114    0.5167    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8811    1.1487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1334    0.8000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0059   -0.0776    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2435   -0.4481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4576    1.2732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5294    2.0951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2771    2.4437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9529    1.9706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5184   -1.5182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2613   -1.8770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3220   -2.6997    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0649   -3.0585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  1  0  0  0  0
 14 26  1  0  0  0  0
  9 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 13 36  1  0  0  0  0
 29 36  4  0  0  0  0
  6 37  4  0  0  0  0
 37 38  4  0  0  0  0
  3 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5462

>  <JC_XSMILES>
COC1=CC=C(CCN2C(=S)NC3C(C(=O)NC4=CC=C(C)C=C4C)C2(C)OC5=C(OC)C=CC=C35)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.32

>  <W2 Pf proliferation inhibition EC50 uM>
0.0687

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5463
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 28  4  0  0  0  0
  6 28  4  0  0  0  0
M  CHG  1  16   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5463

>  <JC_XSMILES>
CCCCCC1=CC=C(OCCOCC[N+]2=CC=CC=C2)C(CCCCC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00708

>  <W2 Pf proliferation inhibition EC50 uM>
0.00685

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
Yes

>  <IFI value>
0.045454545

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5474
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.2085    0.3661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9988    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2085   -0.1075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2050    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4906    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4906   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2050   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2050   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9195   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9195    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6340   -0.6957    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3484   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0629   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7774   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4919   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4919   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7774   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0629   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3484   -1.9332    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5474

>  <JC_XSMILES>
CC1(C)C2CCC1(C)C(C2)NCC3=CC=CC=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1067

>  <W2 Pf proliferation inhibition EC50 uM>
0.0318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.62

>  <Powder data?>
Yes

>  <IFI value>
0.014925373

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5476
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    1.1367   -9.4649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8012   -8.7112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2137   -7.9967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6616   -7.3836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8332   -6.5767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0920   -7.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0058   -8.5397    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0342   -7.9105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9479   -7.0900    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1204   -8.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8546   -7.8243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -7.0706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7053   -6.4032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8848   -6.4894    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -5.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3396   -8.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0040   -9.2454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4889   -9.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1534  -10.6665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3329  -10.7527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8480  -10.0853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1835   -9.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  3  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 24 33  4  0  0  0  0
 28 33  4  0  0  0  0
 11 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 35 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5476

>  <JC_XSMILES>
CC1=C(C(C)=NO1)S(=O)(=O)N(CC(O)CN2CCC(C2)NC(=O)C3=CC=CC4=CC=CC=C34)CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1271

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00652

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5480
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 17 27  4  0  0  0  0
 21 27  4  0  0  0  0
  6 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5480

>  <JC_XSMILES>
COC1=CC=C(CNCC2=CC(=CC=C2O)C3=CC=NC4=CC(Cl)=CC=C34)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.951

>  <W2 Pf proliferation inhibition EC50 uM>
0.0383

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
59.15

>  <Powder data?>
Yes

>  <IFI value>
0.034782609

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5488
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 19 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  1  0  0  0  0
 32 34  4  0  0  0  0
 34 35  4  0  0  0  0
 29 35  4  0  0  0  0
 35 36  4  0  0  0  0
 18 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5488

>  <JC_XSMILES>
COC1=CC=CC(=C1)C(=O)OC2=CC=CC=C2C3=C(NC(C)(C)CC(C)(C)C)N4C=CC(C)=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.986

>  <W2 Pf proliferation inhibition EC50 uM>
0.00615

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5491
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1100   -0.3837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2773    0.2871    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8986   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1808   -3.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6505   -3.6892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1620   -3.5460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4441   -2.7707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0862   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
  4 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  8 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
M  CHG  2  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5491

>  <JC_XSMILES>
CC(=O)N1C2=CC=C(C=C2C(C)(CC1(C)C)C3=CC=CC=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.102

>  <W2 Pf proliferation inhibition EC50 uM>
0.0612

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5501
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -3.5723   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1060   -2.8013    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
 13 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 12 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 28 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5501

>  <JC_XSMILES>
COCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(Cl)=C3Cl)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1782

>  <W2 Pf proliferation inhibition EC50 uM>
0.058

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5503
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -2.9114   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1969   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4824   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7680   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0535   -3.4137    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -2.1762    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -3.0012    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0283   -2.1785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2603   -1.8771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1373   -1.0613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6330   -1.6173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3899   -0.8290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4488   -1.7403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8613   -2.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6771   -2.3318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1915   -2.9768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8901   -3.7448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4045   -4.3898    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2203   -4.2668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5217   -3.4989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3374   -3.3759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8518   -4.0209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5504   -4.7889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7346   -4.9119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0743   -3.8677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5599   -3.2227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7716   -3.4659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6486   -4.2817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -4.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -4.6512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -5.8887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0535   -5.8887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7680   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -4.6512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 19 27  4  0  0  0  0
 27 28  4  0  0  0  0
 16 28  4  0  0  0  0
 28 29  1  0  0  0  0
  9 29  1  0  0  0  0
 29 30  2  0  0  0  0
  8 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
 31 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5503

>  <JC_XSMILES>
CCCCNC(=O)C(N1C(CO)C(=O)NC2=CC=C(OC3=CC=CC=C3)C=C2C1=O)C4=CC=CC(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1811

>  <W2 Pf proliferation inhibition EC50 uM>
<0.008

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>13.98

>  <Powder data?>
No

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5506
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 14 22  4  0  0  0  0
  9 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5506

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CN3CCCCC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.469

>  <W2 Pf proliferation inhibition EC50 uM>
0.0547

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>95.79

>  <Powder data?>
Yes

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5516
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -3.2381    0.8447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4320    0.6689    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1812   -0.1171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3752   -0.2929    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1244   -1.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6797   -1.6890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4858   -1.5132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7365   -0.7272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5426   -0.5515    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7934    0.2345    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9440   -3.1424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.8099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -3.5549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2136   -2.7299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
M  CHG  2  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5516

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2(CCCC2)CNCC(O)C3=CC=CC(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.49

>  <W2 Pf proliferation inhibition EC50 uM>
0.0525

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5525
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
  6 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 10 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  4  0  0  0  0
 25 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5525

>  <JC_XSMILES>
CCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC(F)=C3)C(=O)CC(C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1374

>  <W2 Pf proliferation inhibition EC50 uM>
0.0504

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5548
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 14 23  4  0  0  0  0
  8 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5548

>  <JC_XSMILES>
CCC(=O)NC1=CC(NC(=O)CSC2=NC(C)=C(CC)C(O)=N2)=CC=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.001614

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.92

>  <Powder data?>
No

>  <IFI value>
0.054545455

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5560
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 12 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 27 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5560

>  <JC_XSMILES>
COCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(F)C=C3)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0382

>  <W2 Pf proliferation inhibition EC50 uM>
0.01774

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.81

>  <Powder data?>
Yes

>  <IFI value>
0.073170732

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5566
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -1.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -2.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
 21 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 34 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5566

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(SC)C=C4)C(=O)OC5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2491

>  <W2 Pf proliferation inhibition EC50 uM>
0.0365

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5569
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    3.8974   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6425   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1274    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9524    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3649    1.1270    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.6425    1.0799    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.8974    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  2  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  2  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5569

>  <JC_XSMILES>
CN1C(CCl)=[N+](C)C2=C1C(=O)C3=CC=CC=C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.003102

>  <W2 Pf proliferation inhibition EC50 uM>
0.00355

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.357142857

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5570
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    6.2102    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7405    6.6924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5529    6.5492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8351    5.7739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3048    5.1419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4923    5.2852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6799    6.6924    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8674    6.5492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3371    7.1812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6193    7.9564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4317    8.0997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9620    7.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
  5 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 26 30  4  0  0  0  0
 30 31  4  0  0  0  0
 23 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5570

>  <JC_XSMILES>
OC1=CC=C(C=C1CNCC2(CCCCC2)N3CCCCC3)C4=CC=C5OCOC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2908

>  <W2 Pf proliferation inhibition EC50 uM>
0.0354

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008547009

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-558
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4694   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0215    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8465    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2590    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8465    1.7065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0215    1.7065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6090    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8020    0.8205    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
  7 22  4  0  0  0  0
 22 23  4  0  0  0  0
  4 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-558

>  <JC_XSMILES>
CCCC1=CC2=C(OC=C(C2=O)C3=CC4=CC=CC=C4O3)C=C1OC(C)C(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.174

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5588
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
 21 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 35 37  1  0  0  0  0
M  CHG  2  29   1  30  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5588

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=C(C=C4)[N+]([O-])=O)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0319

>  <W2 Pf proliferation inhibition EC50 uM>
0.0318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.043010753

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5589
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  9 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 24 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5589

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3C)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1249

>  <W2 Pf proliferation inhibition EC50 uM>
0.0317

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5596
  Mrv1591402191617072D          

 29 32  0  0  1  0            999 V2000
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.7184   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 13 12  1  0  0  0  0
 13  8  1  0  0  0  0
 13 14  1  6  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 20 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5596

>  <JC_XSMILES>
CCCCNCCN1CCN(C[C@@H]1C2=CC=CC=C2)C3=CC=C4C=CC=CC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0345

>  <W2 Pf proliferation inhibition EC50 uM>
0.00245

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.16

>  <Powder data?>
No

>  <IFI value>
0.073170732

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5597
  Mrv1591402191617072D          

 47 53  0  0  0  0            999 V2000
    5.3696    2.8021    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1930    3.6080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4067    3.8579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2301    4.6638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8397    5.2197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6259    4.9698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2355    5.5257    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.8025    4.1639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5888    3.9139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7654    3.1081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5516    2.8581    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1558    2.5522    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3325    1.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    1.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2954    0.6905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6858    0.1346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8996    0.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7229    1.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9367    1.4403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8667    2.2624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2360    2.7942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1662    1.6853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5828    0.7397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4049    0.8096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9521    1.2715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2752    0.7999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5283    1.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4584    1.9723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1353    2.4439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0654    3.2660    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8822    2.0935    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4140    2.7242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0816    0.4405    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6912    0.9964    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2582   -0.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.0444   -0.6153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2211   -1.4212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6115   -1.9771    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8253   -1.7271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6486   -0.9213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7882   -2.7830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1786   -3.3389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3552   -4.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7457   -4.7006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9594   -4.4507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7828   -3.6448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3924   -3.0889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  2  0  0  0  0
 29 31  4  0  0  0  0
 25 31  4  0  0  0  0
 31 32  1  0  0  0  0
 21 32  1  0  0  0  0
 15 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 35 40  1  0  0  0  0
 38 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 42 47  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5597

>  <JC_XSMILES>
FC1=CC=CC(Cl)=C1CC(=O)NC2=CC(=CC=C2N3CC4CC(C3)C5=CC=CC(=O)N5C4)C(=O)N6CCN(CC6)CC7=CC=CC=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0672

>  <W2 Pf proliferation inhibition EC50 uM>
0.03

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012048193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5601
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0012   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
  9 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 19 20  1  0  0  0  0
 13 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 19 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5601

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4Br)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.062

>  <W2 Pf proliferation inhibition EC50 uM>
0.02848

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045977011

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5604
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2629    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2426   -0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5604

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=C3CCCC3=NC4=C2C(N)=C(S4)C(=O)NC5=CC=C(F)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0688

>  <W2 Pf proliferation inhibition EC50 uM>
0.02715

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5612
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    9.8154   -3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9869   -2.8594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7715   -2.6045    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3738   -2.3074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5892   -2.5623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9761   -2.0103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1476   -1.2033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5345   -0.6513    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7499   -0.9062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5784   -1.7132    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368   -0.3542    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3522   -0.6091    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.7391   -0.0571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8253    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0717    1.0990    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5196    0.4859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9321   -0.2286    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5196   -0.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6946   -0.9431    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2821   -0.2286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6946    0.4859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1426    1.0990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3889    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4752   -0.0571    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3141    1.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7010    2.4580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8726    3.2649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6572    3.5199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8287    4.3268    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2703    2.9678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0988    2.1609    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9323   -0.9484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5454   -1.5004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
  7 32  4  0  0  0  0
 32 33  4  0  0  0  0
  4 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5612

>  <JC_XSMILES>
CC(=O)C1=CC=C(NC(=O)CSC2=NN=C3N2C=NC4=C3C(=CS4)C5=CC=C(F)C=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.02391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5632
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
   -4.7651   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2251   -2.0171    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4149   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -1.0816    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560    1.1012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.2571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758    2.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.6603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    3.4398    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    2.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    1.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362    0.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763    0.7893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6864    0.6334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9565   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4164   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8763   -3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845   -2.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -4.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -3.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3347   -3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1449   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 23 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
  5 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 36 41  4  0  0  0  0
 41 42  4  0  0  0  0
  3 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5632

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(F)C=C2)C(=O)C(C3=CC=CC=C3)C4=CC=CC=C4)=C5N=CC=CC5=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.092

>  <W2 Pf proliferation inhibition EC50 uM>
<0.000572

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>3.47

>  <Powder data?>
No

>  <IFI value>
0.046728972

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5636
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.9233   -2.7604    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  9  8  1  4  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
 11 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 10 22  1  0  0  0  0
 17 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
M  CHG  2  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5636

>  <JC_XSMILES>
CCC1=CC=CC=C1N=C2C(C(C)=O)C(=O)C3=CC=CC(=C23)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01129

>  <W2 Pf proliferation inhibition EC50 uM>
0.01541

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-564
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.5597   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5574    1.2530    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4141   -2.3078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6219   -2.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0264   -1.9672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4253   -3.3393    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6331   -3.5696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4364   -4.3709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6442   -4.6012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0487   -4.0303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7435   -4.2606    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.2453   -3.2290    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0375   -2.9987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2342   -2.1975    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 11 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
 10 26  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-564

>  <JC_XSMILES>
CC1=CC=C2OC(=O)C3=C(N(CC(=O)NC4=CC=C(F)C=C4Cl)N=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.151

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5640
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0012   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5640

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4C)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00998

>  <W2 Pf proliferation inhibition EC50 uM>
0.0145

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5643
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
   -0.5230   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -5.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -4.4270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7605   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -5.1414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -5.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -5.8559    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -6.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -6.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -7.2849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -7.9993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -7.9993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -7.2849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -7.2849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.9993    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.5704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -6.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -5.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -5.8559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7605   -6.5704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -7.2849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -7.2849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -7.9993    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -8.7138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  3 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
 23 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5643

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)CCC2=CC=CC=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1345

>  <W2 Pf proliferation inhibition EC50 uM>
<0.000572

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.17

>  <Powder data?>
No

>  <IFI value>
0.02247191

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5656
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -4.2869    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7157   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5656

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3Br)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0766

>  <W2 Pf proliferation inhibition EC50 uM>
0.01123

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5661
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -5.9849    0.6523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1644    0.5661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8289   -0.1876    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0084   -0.2738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5235    0.3936    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6728   -1.0275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8659   -1.1990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2528   -0.6470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7796   -2.0195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0783   -2.0195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7927   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5072   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2217   -2.4320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2217   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5072   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7927   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5072   -4.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2217   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7927   -4.9070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5333   -2.3551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0853   -1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7048   -3.1620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0917   -3.7141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2633   -4.5211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0479   -4.7760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2194   -5.5830    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0040   -5.8379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6610   -4.2240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4894   -3.4170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
  6 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  4  0  0  0  0
 26 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5661

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(CCC(=O)NC2=CC=CC(=C2)C(C)=O)C(=C1)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02175

>  <W2 Pf proliferation inhibition EC50 uM>
0.00849

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5662
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    1.4290   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1995   -0.5701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7146    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 17 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
 16 32  1  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5662

>  <JC_XSMILES>
CCCCOC1=CC=C(C=C1)N(C(C)=O)C2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00564

>  <W2 Pf proliferation inhibition EC50 uM>
0.00414

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.41

>  <Powder data?>
Yes

>  <IFI value>
0.067567568

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5673
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -3.5723    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1435   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4288   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1061   -2.9738    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2376    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0012   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5673

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC=C4Cl)C(=O)OC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00621

>  <W2 Pf proliferation inhibition EC50 uM>
0.00411

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047619048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5675
  Mrv1591402191617072D          

 12 11  0  0  0  0            999 V2000
    2.4750    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0625    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5675

>  <JC_XSMILES>
COC(OC)C(C)=NNC(N)=S

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00892

>  <W2 Pf proliferation inhibition EC50 uM>
0.00362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.168141593

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5677
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
  6 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5677

>  <JC_XSMILES>
CCC1=NN2C(NC3=CC=C(I)C=C3)=CC(C)=NC2=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2595

>  <W2 Pf proliferation inhibition EC50 uM>
<0.003003

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-568
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8443   -1.5291    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -2.5687    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5052   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1696   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3491   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0136   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4985   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3190   -5.4109    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6546   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0598   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  1  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-568

>  <JC_XSMILES>
COC1=CC=CC(=C1)N2C(=S)S\C(=C/C3=CC=CN=C3)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.141

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-571
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.7145   11.7161    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    5.4562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    4.6715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    4.6715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    5.4562    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  5  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-571

>  <JC_XSMILES>
BrC1=CC=C(C=C1)C=NNC(=O)C2=CC=CO2

>  <PF proliferation inhibition 3D7 EC50 uM>
11.36

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-583
  Mrv1591402191617072D          

 44 46  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  7 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 19 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 24 29  1  0  0  0  0
 16 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
 18 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 36 41  1  0  0  0  0
  5 42  1  0  0  0  0
 42 43  1  0  0  0  0
 42 44  2  0  0  0  0
M  CHG  4  10   1  11  -1  42   1  43  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-583

>  <JC_XSMILES>
CN(C)C1=C(C=C(C=C1[N+]([O-])=O)C(=O)NC2OC(C(OC(C)=O)C(OC(C)=O)C2OC(C)=O)C(=O)N3CCOCC3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.091

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-586
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 12 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 11 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-586

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2C(C(O)=O)C3=CC=CC=C3C(=O)N2C4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.078

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-593
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    5.6110    5.3735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0235    4.6590    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6110    3.9445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0235    3.2301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6110    2.5156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7860    2.5156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3735    1.8011    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5485    1.8011    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906    1.0578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863    0.8742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413    1.3886    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413    2.2136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863    2.7280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906    2.5444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566    2.4686    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4717    1.8011    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566    1.1337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7017    0.3491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2537   -0.2640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9988   -1.0487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5508   -1.6618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2959   -2.4464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4889   -2.6179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0631   -2.0048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1918   -1.2202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3735    3.2301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5485    3.2301    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.7860    3.9445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-593

>  <JC_XSMILES>
COC1=CC=C(CN2CCN3C(CC2)=NN=C3CCC4=CC=CC=C4)C(F)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.059

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-596
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -0.9083    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -4.9848    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.6909   -5.6992    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.9284   -4.9848    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
  7 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-596

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)CC2=CC=C(C=C2)[N+]([O-])=O)SC3=C1CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.057

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-604
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  2  0  0  0  0
 17 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-604

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)N2C(=S)NC3=CC(=CC=C3C2=O)C(=O)NC4=CC=CC(C)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.037

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-605
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6704   -4.8067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1401   -5.7252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
  5 16  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 19 30  1  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-605

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C(NC(C)(C)C2)=NN=C3NC(C)(C)CC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
1.035

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016393443

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-607
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 11 18  4  0  0  0  0
 18 19  4  0  0  0  0
  8 19  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-607

>  <JC_XSMILES>
COC1=CC(CNC2=CC=C3N=C(N)N=C(N)C3=C2)=CC(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.033

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-612
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   -6.8159    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4034    2.1599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5784    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    2.8744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5784    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4034    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
 24 33  4  0  0  0  0
 19 33  4  0  0  0  0
 33 34  2  0  0  0  0
  6 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 35 38  4  0  0  0  0
  3 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-612

>  <JC_XSMILES>
COC1=CC=C(CN2CCN(CC2)C(=O)C3=C(C)C4=C(S3)N=CN(CC5=CC=CC=C5F)C4=O)C(OC)=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.008

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011494253

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-622
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -2.1434    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414    1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164    3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -2.3645    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.9355    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 13 16  1  0  0  0  0
 10 17  4  0  0  0  0
 17 18  4  0  0  0  0
  7 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-622

>  <JC_XSMILES>
FC(F)(F)COC1=CC=C(OCC(F)(F)F)C(=C1)C2=NC=NN2C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.91

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.012820513

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-64
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -6.3587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 22 33  4  0  0  0  0
 33 34  4  0  0  0  0
 19 34  4  0  0  0  0
 34 35  4  0  0  0  0
 17 35  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  35
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-64

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)C3=NC4=CC=C(NC(=O)C5=CC=C(C)C=C5)C=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.568

>  <W2 Pf proliferation inhibition EC50 uM>
>5.78

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.891

>  <Powder data?>
Yes

>  <IFI value>
0.174418605

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-648
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    5.1436    3.0270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3402    2.8396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1008    2.0501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2973    1.8627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7333    2.4648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9727    3.2543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2959    3.7260    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6381    3.2280    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8133    3.2118    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.5739    2.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2056    2.1519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3612    1.3417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2028    0.7396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1955    0.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0057    0.1727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1081    0.9914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6078   -0.3913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4204   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0225   -1.7587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8120   -1.5193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9994   -0.7159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3973   -0.1519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5847    0.6516    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2507    1.9506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2670    1.1257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9085    2.4486    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7762    3.4417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0156    4.2312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  4  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
 10 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
  5 26  4  0  0  0  0
  8 26  4  0  0  0  0
  6 27  4  0  0  0  0
  2 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-648

>  <JC_XSMILES>
Cc1ccc2c(nc3sc(=CC4=CC=C(O4)C5=CC=CC=C5F)c(=O)n23)c1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.921

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-655
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -5.4349    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -6.2195    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -6.2195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -5.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -6.8870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -6.8007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -7.4682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -8.2219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -8.8893    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -8.8031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -8.0494    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -9.4705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9070   -9.3843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3919  -10.0517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0564  -10.8054    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2359  -10.8916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7510  -10.2242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5413  -11.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2057  -12.2265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6182  -12.9410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0662  -13.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2377  -14.3610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3125  -13.2185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5981  -13.6310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3988  -12.3980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -8.3081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -7.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  2  7  4  0  0  0  0
  4  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
 11 29  4  0  0  0  0
 29 30  4  0  0  0  0
  8 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-655

>  <JC_XSMILES>
CC1=NN(C(C)=C1)C2=CC=C(NC(=O)C3CCN(CC3)CC4=CC(C)=C(C)O4)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.888

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-675
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    4.2868    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4303   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2869   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.9501    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2368   -2.1338    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  3  0  0  0  0
 10 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
 15 25  4  0  0  0  0
  8 25  4  0  0  0  0
 25 26  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-675

>  <JC_XSMILES>
ClC1=CC=C(C=C1)N2C=C(C#N)C(=O)N(CC3=C(Cl)C=CC=C3Cl)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.816

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.034782609

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-698
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.1710    3.7912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4259    3.0066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8739    2.3935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1288    1.6089    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9358    1.4374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1907    0.6527    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6387    0.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8317    0.2112    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936   -0.7450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8936   -2.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782   -1.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6782   -0.9999    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4878    2.0505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2948    1.8789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2329    2.8351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 10 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
  5 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  11
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  25
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-698

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2=C(NC=N2)C(=O)NC3=NC4=CC=CC=C4N3)C(C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.29

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.046875

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-700
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3260    0.9019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8781    1.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4656    2.2295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6586    2.0580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  6 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-700

>  <JC_XSMILES>
CC(C)CNC1=NC(NCCCN2CCCC2)=NC=C1C(=O)NCCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.719

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019047619

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-701
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.0177   -1.3480    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -2.7770    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
  6 21  4  0  0  0  0
  2 21  4  0  0  0  0
 21 22  1  0  0  0  0
  4 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-701

>  <JC_XSMILES>
CC1=NC(=NC(NCCNC2=CC=C(C=N2)C(F)(F)F)=C1Cl)C3=CC=NC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.714

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-708
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
    1.3222    4.7652    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2032    2.0602    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    1.0206    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991    2.0602    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-708

>  <JC_XSMILES>
ClC1=CC=CC(=C1)N2C(=O)CSC2=S

>  <PF proliferation inhibition 3D7 EC50 uM>
6.87

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-71
  Mrv1591402191617072D          

 39 44  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4694   -1.3144    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0215   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8465   -1.9275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2590   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8465   -3.3565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0215   -3.3565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6090   -2.6420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8020   -2.4705    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
 19 31  4  0  0  0  0
 31 32  4  0  0  0  0
 15 32  4  0  0  0  0
 32 33  4  0  0  0  0
 12 33  4  0  0  0  0
 18 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  30
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-71

>  <JC_XSMILES>
O=C(NCCC1=CCCCC1)C2=CC=C3C(=O)N(C(SCC4=NC5=CC=CC=C5N4)=NC3=C2)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.46

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>0.912

>  <Powder data?>
No

>  <IFI value>
0.011904762

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-712
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
  8 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  4  0  0  0  0
 19 28  4  0  0  0  0
 28 29  1  0  0  0  0
  6 30  4  0  0  0  0
  2 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-712

>  <JC_XSMILES>
CC1=CC=NC(NC(C2=CC=C3C=CC=CC3=C2)C4=CC=C5C=CC=NC5=C4O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
6.75

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-738
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-738

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)NC2=NN=C(O2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
5.18

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-755
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 21 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 15 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 13 33  4  0  0  0  0
 33 34  4  0  0  0  0
  9 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-755

>  <JC_XSMILES>
CCN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)\C=C\C4=CC(OC)=CC=C4OC)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.397

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-759
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.1067    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6791    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6791    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    2.4134    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7479   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9275   -5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4425   -4.8297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7781   -4.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 18  5  1  4  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 21 25  2  0  0  0  0
 25 26  1  4  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-759

>  <JC_XSMILES>
COC1=CC(=CC=C1OCC2=CC=CC=C2F)C=C3SC(NC3=O)=NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.67

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-775
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -4.9808   -3.4659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7344   -3.1303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4019   -3.6152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1556   -3.2797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2418   -2.4592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5744   -1.9743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8207   -2.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -1.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -0.9999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -0.7450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -2.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8230   -3.7646    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -7.7368   -4.5851    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -8.5767   -3.4290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
  4 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
M  CHG  2  31   1  32  -1
M  STY  1   1 DAT
M  SAL   1  1  30
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-775

>  <JC_XSMILES>
CC1=CC(=CC=C1C2=CC=C(O2)C(=O)NC3=CC=C(C=C3)C4=NC5=CC=CC=C5N4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.794

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-778
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
   -2.0945    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5082    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0395    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320    1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5695    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7445    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9820    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8070    2.5559    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2195    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8070    3.9849    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9820    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5695    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7445    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070    3.9849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0945    3.2704    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5070    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3320    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
 11 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
  4 14  1  0  0  0  0
 14 15  2  0  0  0  0
  2 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-778

>  <JC_XSMILES>
O=C(CN1C(=O)C2C3CCC(C3)C2C1=O)N4CCCC(C4)C5=NC=NC=C5C6=CC=NC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2463

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-783
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819    0.9475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3889    1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8014    0.4046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2494   -0.2085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6219    0.3184    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.1068    0.9858    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.9574   -0.4353    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 12 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 10 26  4  0  0  0  0
 26 27  4  0  0  0  0
  8 27  4  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-783

>  <JC_XSMILES>
CC1=CC=CC(=C1)C2=NC3=CC(NC(=O)C4=CC=C(O4)[N+]([O-])=O)=CC=C3O2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.72

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-788
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  8 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
M  CHG  2  18   1  19  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-788

>  <JC_XSMILES>
CC1=CC=C2OCC(=NC2=C1)C3=CC=C(C=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.3

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.051724138

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-796
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
  5 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  2  0  0  0  0
 14 20  1  0  0  0  0
  2 20  1  0  0  0  0
  3 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-796

>  <JC_XSMILES>
CC1=C(C(C2=CC=C(Cl)C(Cl)=C2)C3=C(CCCC3=O)N1)C(=O)OC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.735

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.057471264

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-813
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    0.4507    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -2.8414    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6329   -3.6421    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4614   -4.4490    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1759   -4.8615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2621   -5.6820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0158   -6.0176    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1020   -6.8381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4346   -7.3230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8557   -7.1736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0272   -7.9806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8477   -8.0668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1833   -7.3131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5702   -6.7611    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7890   -4.3095    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5960   -4.4810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8509   -5.2657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6579   -5.4372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2099   -4.8241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9550   -4.0395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5070   -3.4264    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.1480   -3.8679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
 16 26  4  0  0  0  0
 13 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 27 33  4  0  0  0  0
  7 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
  6 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 35 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-813

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)CSC2=NN=C(CNC(=O)C3=CC=CS3)N2C4=CC=CC(Cl)=C4)SC5=C1CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.14

>  <W2 Pf proliferation inhibition EC50 uM>
>1.245

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.0125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-814
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -3.7881   -1.4849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0448   -1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0448   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3998    0.2124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5955    0.0288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5955   -1.4578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3998   -1.6414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.4289    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -2.4454    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -4.5888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -4.5888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -3.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  2  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-814

>  <JC_XSMILES>
CN1CCCN(CC1)C(=O)C2CC23CCN(CC3)CC4=CC=C(C=C4)N(C)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.32

>  <W2 Pf proliferation inhibition EC50 uM>
2.583

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.78

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-82
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -0.8546   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1723   -0.2924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7854    0.2596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6992    1.0801    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4999   -0.1529    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3284   -0.9598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8804   -1.5729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2536    0.1827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3398    1.0032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0935    1.3387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7609    0.8538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5146    1.1894    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.6747    0.0333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9210   -0.3022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -3.1895    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -3.9039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
  9 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
  6 33  4  0  0  0  0
 33 34  4  0  0  0  0
  3 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-82

>  <JC_XSMILES>
COC1=CC=C(CCN(C2CC(=O)N(C2=O)C3=CC=C(F)C=C3)C(=S)NC4=CC=CC=C4)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.742

>  <W2 Pf proliferation inhibition EC50 uM>
1.563

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>1.907

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-820
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4888   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -2.8911    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
  9 22  1  0  0  0  0
 22 23  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-820

>  <JC_XSMILES>
CC1=CC=C(C)C(=C1)N2C(=O)CC(CC3=CC=C(Cl)C=C3)C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.234

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-823
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-823

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C(OC)=CC=CC2=C1NC3=CC(C)=C(Cl)C=C3OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.539

>  <W2 Pf proliferation inhibition EC50 uM>
>1.231

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-828
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    4.4691   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3130   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991   -2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6860   -3.3186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1276   -1.9596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3430   -1.7047    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1714   -0.8977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6132   -0.6428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7847    0.1642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5693    0.4191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1716    0.7162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6130    0.4613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2261    1.0133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7845   -0.3457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2698   -1.8666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3032   -1.9235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8552   -1.3104    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.9163   -2.4755    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6901   -1.3715    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 11 18  4  0  0  0  0
  6 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
  4 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-828

>  <JC_XSMILES>
CC(C)C1=NN(C(=O)COC2=CC(C)=CC(C)=C2)C(O)(C1)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.746

>  <W2 Pf proliferation inhibition EC50 uM>
>1.221

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-831
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    1.4358   -6.8365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -6.2234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -5.4388    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -6.9540    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6787   -7.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -8.7435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -7.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -6.2865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4236   -6.0234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7322   -5.4665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -4.1039    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838   -3.3193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -3.1478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -2.3631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.7501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.9216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -5.5964    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -5.5964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
  4 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-831

>  <JC_XSMILES>
CC[N+]1=C(\C=C\C=C2/N(C)C3=CC=CC=C3C2(C)C)N(C4=CC=CC=C4)C5=CC=C(Cl)C=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.501

>  <W2 Pf proliferation inhibition EC50 uM>
>1.22

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-834
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 13 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 11 29  4  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-834

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)N2N=C(C(=O)NC3CCCCC3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.218

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-836
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-836

>  <JC_XSMILES>
CCCN1C2=CC=CC=C2N=C1C3=CC=CC(Br)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.138

>  <W2 Pf proliferation inhibition EC50 uM>
>1.218

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-84
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  8 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  2  0  0  0  0
 20 22  4  0  0  0  0
  3 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-84

>  <JC_XSMILES>
CCC1=NC2=CC=C(NC(=O)C3=CC=NC=C3)C=C2C(=O)N1CC4=CC=CC(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.566

>  <W2 Pf proliferation inhibition EC50 uM>
0.427

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>0.57

>  <Powder data?>
No

>  <IFI value>
0.051282051

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-842
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539    0.0000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  3 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-842

>  <JC_XSMILES>
COC(F)(C(=O)NC1=C(C)N(C)N(C1=O)C2=CC=CC=C2)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.549

>  <W2 Pf proliferation inhibition EC50 uM>
>1.101

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>9.06

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-849
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587    0.8085    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    2.2374    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 28 29  1  0  0  0  0
  8 30  4  0  0  0  0
  2 30  4  0  0  0  0
 30 31  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-849

>  <JC_XSMILES>
CN1C(=O)N(C)C2=C(N(C)C(=N2)N3CCN(CC3)C(=O)NC4=CC=C(F)C=C4F)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.205

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-858
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
    0.4262    3.3215    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1587    2.9420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8536    3.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5862    3.0071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6238    2.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3563    1.8035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0512    2.2481    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7838    1.8686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4787    2.3132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2112    1.9337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2488    1.1096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9813    0.7301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0190   -0.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3240   -0.5387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5915   -0.1592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539    0.6649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8214    1.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1264    0.5998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9919   -0.2141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1762   -0.3377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8066    0.3999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3939    0.9793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9288    1.7383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9664    0.9142    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1963    2.1178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  6 22  1  0  0  0  0
 18 22  1  0  0  0  0
  5 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-858

>  <JC_XSMILES>
ClC1=CC=C(C2NC3=CC=C4C=CC=CC4=C3C5C=CCC25)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.196

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-861
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    0.8905    5.4981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2261    6.2517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0466    6.3380    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4591    7.0525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2660    6.8809    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    6.0604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986    5.7249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4271    4.9179    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1235    7.8061    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3030    7.8924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9675    8.6460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4524    9.3135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1168   10.0672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2729    9.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6084    8.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
  6 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  2  0  0  0  0
  4 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-861

>  <JC_XSMILES>
CCn1c(nn(CN2CCN(CC2)CC3=CC=C4OCOC4=C3)c1=S)C5=CC=C(O)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.195

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-867
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    3.8021    6.6744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6305    5.8674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2436    5.3154    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0283    5.5703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6414    5.0183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0721    4.5084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6852    3.9564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5137    3.1494    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7291    2.8945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1160    3.4465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2875    4.2535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5575    2.0875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7729    1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4524    2.1805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3389    2.2293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 27 28  1  0  0  0  0
 14 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-867

>  <JC_XSMILES>
CCN(CC)C1=CC=C(C=C1)\C=C\C23NC(=O)CCN2C4=CC=C(C)C=C4C3(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.622

>  <W2 Pf proliferation inhibition EC50 uM>
1.209

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.13

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-87
  Mrv1591402191617072D          

 43 47  0  0  0  0            999 V2000
    0.3391    3.5800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5941    2.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0421    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4011    2.6239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9531    3.2371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7600    3.0656    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0150    2.2809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4630    1.6678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7180    0.8832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1660    0.2701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5250    0.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6560    1.8393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1040    1.2262    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2970    1.3977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3704    1.8826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2550    0.7846    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3169    1.7407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1239    1.9122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3789    2.6968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8269    3.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0199    3.1384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7649    2.3538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8580   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4291   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7143   -2.8876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4288   -2.4751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433   -2.8876    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
  8 12  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 16 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  2  0  0  0  0
 34 36  4  0  0  0  0
 26 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  1  0  0  0  0
 40 42  4  0  0  0  0
 42 43  4  0  0  0  0
 37 43  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-87

>  <JC_XSMILES>
CC(C)C1=CC=CC(C(C)C)=C1NC(=O)N(CC2=CC=CC=C2)C(C)C3=NC4=CC=CC=C4C(=O)N3C5=CC=C(Cl)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.985

>  <W2 Pf proliferation inhibition EC50 uM>
1.019

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>1.46

>  <Powder data?>
No

>  <IFI value>
0.042105263

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-871
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-871

>  <JC_XSMILES>
FC1=CC=CC=C1C=NNC(=O)COC2=CC=CC(Br)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.191

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-872
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760    5.0224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    5.8070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109    5.0224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  2  0  0  0  0
  2 12  1  0  0  0  0
  4 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
  3 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-872

>  <JC_XSMILES>
CC1=C(C(N2C(=O)CCSC2=N1)C3=CC=C(OC(=O)C4=CC=CO4)C=C3)C(=O)OCC=C

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.36

>  <W2 Pf proliferation inhibition EC50 uM>
>11.91

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-876
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-876

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=CN=CC3=CC=C(N=C23)C(=O)NCC4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.348

>  <W2 Pf proliferation inhibition EC50 uM>
1.189

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-88
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -4.2868   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  8 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 18 24  4  0  0  0  0
 16 25  4  0  0  0  0
 12 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-88

>  <JC_XSMILES>
OCCCNC1=CC(=CC=N1)C2=CC=NC(NC3=CC=CC(Cl)=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2318

>  <W2 Pf proliferation inhibition EC50 uM>
0.1864

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.2694

>  <Powder data?>
Yes

>  <IFI value>
0.308219178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-887
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 27 33  4  0  0  0  0
 25 34  4  0  0  0  0
  4 34  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-887

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(OC2=CC=C(C=C2)C(=O)NC3=CC=C(Br)C=N3)=CC(OC4=CC=CC(Cl)=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.183

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-891
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0525   -1.8980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8372   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0087   -0.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7933   -0.5812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4064   -1.1332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2349   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4502   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1910   -0.8783    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.9756   -0.6233    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4460   -1.6629    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9361   -0.0936    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 15 18  2  0  0  0  0
  6 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
  5 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-891

>  <JC_XSMILES>
CC(=O)NC1=C(N=NC2=CC=C(C=C2)S(O)(=O)=O)C(C)=C(C)S1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.153

>  <W2 Pf proliferation inhibition EC50 uM>
>1.178

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-896
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.1569    2.5988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    1.7738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5149    1.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    0.2872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    0.1036    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    0.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    0.3631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4380    1.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    1.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    1.4430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    1.9574    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6713   -0.3578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4871   -0.2349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0015   -0.8799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7001   -1.6478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8843   -1.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3699   -1.1258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9612    1.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2044    2.7457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0087    2.9293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5699    2.3245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3267    1.5362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5224    1.3526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  1  0  0  0  0
  2 11  1  0  0  0  0
  4 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-896

>  <JC_XSMILES>
CC1(CC(=NC2=NON=C2N1)C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.586

>  <W2 Pf proliferation inhibition EC50 uM>
1.174

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-903
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    2.5645    8.2500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    1.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    5.7750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 23 31  1  0  0  0  0
 19 31  1  0  0  0  0
 31 32  2  0  0  0  0
  5 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
  2 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-903

>  <JC_XSMILES>
FC1=CC=C(CC(=O)N2CCN(CC2)C3=CC=CC4=C3C(=O)N(CC5=CC=CC=N5)C4=O)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.167

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-904
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 13 12  1  4  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-904

>  <JC_XSMILES>
CC(C)C1=CC=C(OCC(=O)NN=CC2=CC=CC(=C2)[N+]([O-])=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.167

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-906
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -1.8111   -6.6581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8111   -5.8331    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0966   -5.4206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0966   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3822   -4.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0468   -4.1831    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -4.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -3.3581    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -4.5956    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9047   -4.1831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9909   -3.3626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3778   -2.8106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7979   -3.1911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1334   -2.4374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2104   -3.9056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6583   -4.5187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8299   -5.3256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0309   -3.9918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5158   -3.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3363   -3.4106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6718   -4.1643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1869   -4.8317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3664   -4.7455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3323   -5.4206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-906

>  <JC_XSMILES>
COC1=CC=C(OCC(=O)NC2=C(C)N(C)N(C2=O)C3=CC=CC=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.165

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-923
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-923

>  <JC_XSMILES>
CC1=C(Cl)C=CC=C1NC(=O)C2=CC=CN=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.145

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-932
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -2.2216    0.2288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8345    0.5720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0418    0.3432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5526    0.9153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3453    0.6864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9398    1.2585    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7416    2.0593    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3361    2.6314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1287    2.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9490    2.2881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3545    1.7161    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4381    1.9449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0326    1.3729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8253    1.6017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0234    2.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.9746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6363    2.7458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0418    3.3178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2400    4.1186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7508    3.0890    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3453    3.6610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1471    4.4619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7416    5.0339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5342    4.8051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7324    4.0042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5250    3.7754    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1379    3.4322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7324    1.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3269    1.6017    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9305    0.2288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7232    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9213   -0.8008    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7140   -1.0297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9121   -1.8305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3177   -2.4025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5158   -3.2034    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5250   -2.1737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3269   -1.3729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
  7 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  1  0  0  0  0
 36 38  4  0  0  0  0
 38 39  4  0  0  0  0
 33 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-932

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC(Cl)=C3)C(=O)COC4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.433

>  <W2 Pf proliferation inhibition EC50 uM>
1.139

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-937
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    3.6511    1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1912    1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5414    0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3515    0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8916    0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7017    0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9718    1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7819    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3220    0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4317    1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6216    1.5493    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0815    2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2713    2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7313    2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8114    3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3515    2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1617    3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4317    3.8880    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7017    2.4848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5119    2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7819    3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5921    3.5762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1321    2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8621    2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4022    1.5493    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    9.0520    2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2418   -0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0520   -0.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9718   -1.1012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5119   -1.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2418   -2.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4317   -2.6603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1617   -3.4398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3515   -3.5957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8114   -2.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0815   -2.1925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8916   -2.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1617   -1.2571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  2  0  0  0  0
 19 21  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
  7 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  4  0  0  0  0
 31 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-937

>  <JC_XSMILES>
CCCCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC(Cl)=C3)C(=O)C4=CC=C5C=CC=CC5=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.134

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.036697248

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-941
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    5.7158   12.1286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   11.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   11.6055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   10.1766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    9.2411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    4.2187    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315    2.7666    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8671    2.0129    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.2890    2.8528    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 14 26  4  0  0  0  0
 26 27  4  0  0  0  0
 11 27  4  0  0  0  0
  9 28  4  0  0  0  0
 28 29  4  0  0  0  0
  6 29  4  0  0  0  0
M  CHG  2  23   1  24  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-941

>  <JC_XSMILES>
CCC(C)(C)C1=CC=C(OC2=CC=C(NC(=O)C3=CC=C(O3)[N+]([O-])=O)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.67

>  <W2 Pf proliferation inhibition EC50 uM>
6.51

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
57.56

>  <Powder data?>
Yes

>  <IFI value>
0.151515152

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-949
  Mrv1591402191617072D          

 47 54  0  0  0  0            999 V2000
   -3.4088    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944    2.1918    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944   -1.9332    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4088   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    0.7967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320    1.5814    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8620    0.1293    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771   -0.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -1.3228    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6870    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3370    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    3.4293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6717    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1533    0.1293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -3.1707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 11 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 21 33  1  0  0  0  0
  9 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 33 40  1  0  0  0  0
 19 40  1  0  0  0  0
 40 41  2  0  0  0  0
 19 42  1  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 42 47  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-949

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(C3=CC=C(OC)C=C3)C4(C5C(C(=O)N(C5=O)C6=CC=CC=C6)C2(C7=CC=CC=C7)C4=O)C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
1.395

>  <W2 Pf proliferation inhibition EC50 uM>
>1.127

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-95
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    1.3222    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.4134    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5620   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3071   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2272   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    3.6509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.0009    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242    2.7154    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492    1.2864    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5686    1.9240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3970    2.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0165    1.3109    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4290    0.5964    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2360    0.7679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8491    0.2159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  5 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  2  0  0  0  0
 29 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-95

>  <JC_XSMILES>
CC(C)CN(C(C(=O)NC(CN1CCCC1)C2=CC=CC=C2)C3=CC=CC=C3)S(=O)(=O)C4=C(C)ON=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.775

>  <W2 Pf proliferation inhibition EC50 uM>
1.655

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.818

>  <Powder data?>
No

>  <IFI value>
0.01980198

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-957
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -1.1067   -0.5065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-957

>  <JC_XSMILES>
CC(C)NC(=O)C1=CC2=CC3=CC=C(C)C=C3N=C2S1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.989

>  <W2 Pf proliferation inhibition EC50 uM>
1.118

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.043478261

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-958
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.7474   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -3.8230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -5.2520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 12 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-958

>  <JC_XSMILES>
CC1=CC=C(C=C1)S(=O)(=O)NC(=NS(=O)(=O)C2=CC=C(C)C=C2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>11.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-961
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
 17 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
 15 33  4  0  0  0  0
  9 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-961

>  <JC_XSMILES>
COC1=CC=C(OC)C(NC(=O)CSC2=NC(NCC3=CC=C(Cl)C=C3)=C4C=CC=CC4=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>11.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-979
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-979

>  <JC_XSMILES>
CCC1=[N+](CC(=O)C2=CC=C(Br)C=C2)C3=CC=CC=C3N1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.658

>  <W2 Pf proliferation inhibition EC50 uM>
1.102

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-985
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    5.6091   -2.5366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -6.2491    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -6.2491    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -7.4866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -7.9715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -8.7562    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -7.9715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-985

>  <JC_XSMILES>
O=C(CCC1CCCN(C1)C(=O)C2=CSC=C2)N3CCN(CC3)C4=CC=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.098

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-986
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
    0.6097   -7.2496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0577   -6.7646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8114   -7.1002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4789   -6.6153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3926   -5.7948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6389   -5.4592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5527   -4.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2010   -4.3032    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2872   -3.4827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3802   -2.9978    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0409   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2124   -2.3402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6604   -1.7271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1243   -1.4721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4888   -0.9201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.2539    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3684   -3.0076    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7553   -3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079    0.6039    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0285   -5.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 15  1  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 11 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
 22 31  4  0  0  0  0
 31 32  4  0  0  0  0
 19 32  4  0  0  0  0
  6 33  1  0  0  0  0
  2 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-986

>  <JC_XSMILES>
CN1CCCC(CNC(=O)C2=C(C3CC3)N(N=C2)C4=NC=C5CSC6=CC=CC=C6C5=N4)C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.976

>  <W2 Pf proliferation inhibition EC50 uM>
1.098

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-995
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    8.8756   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.7006    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-995

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3=CC=CC(=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0851

>  <W2 Pf proliferation inhibition EC50 uM>
0.278

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.549

>  <Powder data?>
No

>  <IFI value>
0.037383178

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-996
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
   -7.5962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.4271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    2.1896    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 24 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 22 40  4  0  0  0  0
 40 41  4  0  0  0  0
 20 41  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  41
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-996

>  <JC_XSMILES>
COC(=O)C1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)C3=NC4=CC(NC(=O)C5=CC=C(C=C5)C(=O)OC)=CC=C4N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.855

>  <W2 Pf proliferation inhibition EC50 uM>
1.09

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-997
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
  5 30  4  0  0  0  0
 30 31  4  0  0  0  0
  2 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-997

>  <JC_XSMILES>
CC1=CC=C(CNC(=O)C2=CC(=O)NC3=CC=C(C=C23)S(=O)(=O)N4CCOCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.434

>  <W2 Pf proliferation inhibition EC50 uM>
>1.088

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2952
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2952

>  <JC_XSMILES>
FC1=CC=CC(=C1)C(=O)N2CCN(CC2)CC3=CC=NC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>9.94

>  <W2 Pf proliferation inhibition EC50 uM>
2.174

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3192
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    3.3523    6.0604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    7.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.8854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3192

>  <JC_XSMILES>
O=C(N1CCN(CC1)CC2=CC=C3OCOC3=C2)C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.964

>  <W2 Pf proliferation inhibition EC50 uM>
0.1755

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-982
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.0001   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1435   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6510   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7310   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5560   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5955   -1.4674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9441    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3310    1.3725    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7511    0.9921    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1636    0.2776    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6116   -0.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7831   -1.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
  9 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  STY  4   1 DAT   2 DAT   3 DAT   4 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  14
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  SAL   3  1  20
M  SDT   3 MRV_IMPLICIT_H                                        
M  SDD   3     0.0000    0.0000    DR    ALL  0       0  
M  SED   3 IMPL_H1
M  SAL   4  1  21
M  SDT   4 MRV_IMPLICIT_H                                        
M  SDD   4     0.0000    0.0000    DR    ALL  0       0  
M  SED   4 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-982

>  <JC_XSMILES>
COC1=CC=CC=C1C(C2=C(O)NN=C2C)C3=C(O)NN=C3C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.1

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
