GNF-Pf-2408
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -4.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
  7 23  4  0  0  0  0
  5 24  4  0  0  0  0
 24 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2408

>  <JC_XSMILES>
BrC1=CC=C(NC2=NC(NCC3CCCO3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.468

>  <W2 Pf proliferation inhibition EC50 uM>
0.349

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.78

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2511
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
  8 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2511

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(N3CCCC3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2845

>  <W2 Pf proliferation inhibition EC50 uM>
0.334

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.24

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2610
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
  6 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  5 17  4  0  0  0  0
 17 18  4  0  0  0  0
  3 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2610

>  <JC_XSMILES>
CCC1=CC2=C(NC3=CC=NC=C3)N=CN=C2S1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.497

>  <W2 Pf proliferation inhibition EC50 uM>
2.94

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-270
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
 11 22  4  0  0  0  0
  7 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-270

>  <JC_XSMILES>
NC(=N)NN=CC1=CC=CC(OCC2=CC=C(Cl)C(Cl)=C2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.986

>  <W2 Pf proliferation inhibition EC50 uM>
1.686

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028301887

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3539
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.5474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 10 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
  6 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3539

>  <JC_XSMILES>
ClC1=CC=CC(NC2=NC(NCC3=CC=CO3)=C4C=CC=CC4=N2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1116

>  <W2 Pf proliferation inhibition EC50 uM>
0.2027

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.05

>  <Powder data?>
Yes

>  <IFI value>
0.096774194

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3723
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  8 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3723

>  <JC_XSMILES>
CN1CCN(CC1)C2=NC(NC3=CC=C(O)C=C3)=NC4=CC=CC=C24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.626

>  <W2 Pf proliferation inhibition EC50 uM>
0.443

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
41.76

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3760
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    3.0919   -4.6024    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399   -3.9893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710    3.7211    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  2  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
 10 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  7 27  4  0  0  0  0
 22 27  4  0  0  0  0
  5 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3760

>  <JC_XSMILES>
CC1=CC=C(CN2C(=N)N(CC(O)C3=CC=C(Cl)C(Cl)=C3)C4=CC=CC=C24)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1074

>  <W2 Pf proliferation inhibition EC50 uM>
0.0613

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4102
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
  5 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4102

>  <JC_XSMILES>
COC1=CC2=NC(NC3=CC=C(F)C=C3)=NC(N)=C2C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1174

>  <W2 Pf proliferation inhibition EC50 uM>
0.1393

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.45

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4525
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.6204    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    1.6204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    0.9059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.1914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 10 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  8 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 27 31  4  0  0  0  0
 31 32  4  0  0  0  0
 24 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4525

>  <JC_XSMILES>
CCCCCCCC(O)(C(CN1CCCCC1)C2=CC=CC=C2)C3=CC=C(OCC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.183

>  <W2 Pf proliferation inhibition EC50 uM>
0.456

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028571429

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4600
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    5.3203    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0347    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0347    3.3129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7492    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4637    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1782    2.0754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8926    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6071    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6071    1.2504    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3216    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0360    2.0754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7897    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0447    3.1956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8516    3.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4037    2.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1487    1.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3417    1.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9292    1.0834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1842    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6322   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8252   -0.1428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5702    0.6419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1223    1.2550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 11 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4600

>  <JC_XSMILES>
CC(C)CCNCC(O)CN1C2=CC=CC=C2C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2009

>  <W2 Pf proliferation inhibition EC50 uM>
0.0323

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.06

>  <Powder data?>
Yes

>  <IFI value>
0.014084507

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5020
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 15 30  4  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  3 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5020

>  <JC_XSMILES>
COC1=CC=C2N=C3C=C(Cl)C=CC3=C(NCCCN(CCCN)CCCCN)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0786

>  <W2 Pf proliferation inhibition EC50 uM>
0.02229

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.029126214

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5574
  Mrv1591402191617072D          

 25 28  0  0  1  0            999 V2000
    6.5264   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8119   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975   -1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -2.7209    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396   -0.2459    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.5251    0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    0.1666    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9540    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.4041    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.8060    0.8541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8060    0.3041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -0.2459    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    0.9916    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.0975    1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0975    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540   -1.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685   -1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  1  0  0  0
 14 12  1  6  0  0  0
 14 15  1  0  0  0  0
 16 15  1  1  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 19 20  1  0  0  0  0
 21 20  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  1  0  0  0
 22 23  1  0  0  0  0
 11 24  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5574

>  <JC_XSMILES>
CCOC1=CC=C2N=CC=C([C@@H](O)[C@@H]3C[C@@H]4CCN3C[C@@H]4CC)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.039

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038216561

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5620
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.7948   -3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.6021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    2.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  6 27  4  0  0  0  0
 13 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5620

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(C)=O)SC2=C(O)C(CNC3CCCCC3)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0805

>  <W2 Pf proliferation inhibition EC50 uM>
0.02135

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-808
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8245   -4.0962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4372   -3.4254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
 16 17  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-808

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)N2C(N)=NC(N)=NC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.079

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrochloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1231
  Mrv1591402191617072D          

 53 58  0  0  1  0            999 V2000
    6.2195   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -2.4454    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -1.7309    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.1570   -1.7309    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.7445   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445   -1.0164    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.8388    0.5105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -1.0164    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.2195   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7573   -0.0198    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    6.3893   -0.5501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9006    0.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6758    1.0748    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2686    1.3230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195   -1.0164    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.5070   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.8205    0.7388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1715    1.6320    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.9252    1.9675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8390    2.7880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0320    2.9595    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.2869    3.7442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3805    2.2451    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7217    3.2951    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8932    4.1021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7137    4.1883    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0492    3.4346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4362    2.8826    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.5224    2.0621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1262    4.9028    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.7137    5.6172    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1262    6.3317    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.3509    6.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2694    7.1442    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9512    6.3317    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.3637    7.0462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3637    5.6172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9512    4.9028    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.3637    4.1883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9195    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  1  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  8  9  1  6  0  0  0
 10  8  1  0  0  0  0
  3 10  1  0  0  0  0
 10 11  1  1  0  0  0
  8 12  1  1  0  0  0
 12 13  1  1  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  2  0  0  0  0
  6 17  1  1  0  0  0
 17 18  1  6  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 21 20  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 24 23  1  0  0  0  0
 24 25  1  6  0  0  0
 24 26  1  0  0  0  0
 21 26  1  6  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 30 29  1  0  0  0  0
 30 31  1  6  0  0  0
 30 32  1  0  0  0  0
 27 32  1  1  0  0  0
 33 30  1  6  0  0  0
 33 34  1  0  0  0  0
 35 34  1  1  0  0  0
 35 36  1  0  0  0  0
 37 36  1  0  0  0  0
 33 37  1  0  0  0  0
 37 38  1  6  0  0  0
 39 35  1  1  0  0  0
 39 40  1  0  0  0  0
 41 40  1  0  0  0  0
 41 42  1  1  0  0  0
 41 43  1  6  0  0  0
 41 44  1  0  0  0  0
 44 45  1  6  0  0  0
 44 46  1  0  0  0  0
 47 46  1  0  0  0  0
 39 47  1  0  0  0  0
 47 48  1  6  0  0  0
 21 49  1  0  0  0  0
 50 49  1  0  0  0  0
 50 51  1  6  0  0  0
 52 50  1  0  0  0  0
 52 19  1  0  0  0  0
 52 53  1  6  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1231

>  <JC_XSMILES>
CO[C@H]1[C@@H](C)[C@H](O[C@](O)([C@H]1C)[C@H](C)C(O)=O)[C@H](C)C2O[C@@]3(CC[C@](C)(O3)[C@H]4CC[C@](C)(O4)[C@@H]5O[C@H](C[C@@H]5C)[C@H]6O[C@](C)(O)[C@H](C)C[C@@H]6C)C[C@H](O)[C@@H]2C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.135

>  <W2 Pf proliferation inhibition EC50 uM>
0.938

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.063492063

>  <Salt>
Sodium

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3913
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
   -0.0404   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2300    1.4521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2300    2.2771    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    2.5320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    3.3166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0765    3.4881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3315    4.2728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1384    4.4443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6905    3.8312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4355    3.0466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6285    2.8751    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4995    1.8646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  2  9  4  0  0  0  0
  3 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 13 21  4  0  0  0  0
 10 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3913

>  <JC_XSMILES>
CC1=C(N2C=CSC2=N1)C3=CSC(NC4=CC=CC=N4)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.381

>  <W2 Pf proliferation inhibition EC50 uM>
0.889

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.067669173

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3934
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3934

>  <JC_XSMILES>
CC(C)(C)C(=O)CN1C=CC(=N)C2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
2.027

>  <W2 Pf proliferation inhibition EC50 uM>
0.877

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5300
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -2.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1728   -1.5563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
 12 22  4  0  0  0  0
  9 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5300

>  <JC_XSMILES>
CC1=CC=C(C)C(=C1)C2=CSC(NC3=CC=C(C)C(C)=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.493

>  <W2 Pf proliferation inhibition EC50 uM>
0.116

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
Hydrobromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-238
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    3.6656   -2.4500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8372   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6218   -1.3881    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2349   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0633   -2.7471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2787   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6261   -1.9204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8191   -1.7488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5642   -0.9642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1162   -0.3511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9232   -0.5226    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1781   -1.3073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1359   -3.4896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9429   -3.6611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1979   -4.4458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6458   -5.0588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -4.8873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5839   -4.1027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  3  7  4  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  8 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  8 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
  1 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-238

>  <JC_XSMILES>
C(SC1=C(N=CS1)[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.335

>  <W2 Pf proliferation inhibition EC50 uM>
0.563

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.19

>  <Powder data?>
Yes

>  <IFI value>
0.277777778

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3766
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
  7 14  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  3 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3766

>  <JC_XSMILES>
CC[N+]1=C(\C=C\C2=CC=C(SC)C=C2)C=CC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0436

>  <W2 Pf proliferation inhibition EC50 uM>
0.1015

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.084210526

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4408
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  3 14  4  0  0  0  0
 14 15  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4408

>  <JC_XSMILES>
CCC1=C(C)C(=N)C2=CC=CC=C2N1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.701

>  <W2 Pf proliferation inhibition EC50 uM>
0.534

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Hydroiodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-151
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.9664   -4.8108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6809   -4.3983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -4.8108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6809   -3.5733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -3.1608    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -2.3358    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1098   -1.9233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8243   -2.3358    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1098   -1.0983    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4424   -0.6134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6973    0.1712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5223    0.1712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7773   -0.6134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0073    0.8386    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6717    1.5923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8647    1.7638    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7785    2.5843    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.5322    2.9199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7871    3.7045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5941    3.8760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1461    3.2629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8912    2.4783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0842    2.3068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1098   -3.5733    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.6973   -4.2878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5223   -2.8589    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.8243   -3.9858    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 18 23  4  0  0  0  0
  5 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
 24 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-151

>  <JC_XSMILES>
CC(C)CN(CC(=O)N1CCC(C1)NC2=NSC3=CC=CC=C23)S(C)(=O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.984

>  <W2 Pf proliferation inhibition EC50 uM>
3.94

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.68

>  <Powder data?>
Yes

>  <IFI value>
0.208333333

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-201
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    4.7309  -10.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4911   -9.9526    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6876   -9.7655    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1238  -10.3678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3203  -10.1808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0806   -9.3914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2771   -9.2043    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0373   -8.4149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6444   -8.7890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4479   -8.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4046   -7.9996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6251   -7.7296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6410   -6.9048    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4304   -6.6650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9023   -7.3417    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7004   -5.8855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1604   -5.2618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3502   -5.4177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8101   -4.7941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2700   -5.7296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5401   -4.3264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5106   -5.7296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0507   -6.3532    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7806   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5908   -4.7941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8608   -4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6709   -3.8586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2110   -4.4823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9410   -5.2618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1308   -5.4177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 16 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-201

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CSC(=N2)N(CCCN(C)C)C(=O)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
4.05

>  <W2 Pf proliferation inhibition EC50 uM>
3.43

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.69

>  <Powder data?>
Yes

>  <IFI value>
0.092783505

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2635
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
  5 10  4  0  0  0  0
  3 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 11 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2635

>  <JC_XSMILES>
CN1C(=CC2=CC=CC=C12)C(OCC(=O)N3CCN(CC3)CC4=CC=CC=C4)C5=CC=CN=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
2.252

>  <W2 Pf proliferation inhibition EC50 uM>
1.104

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.12

>  <Powder data?>
Yes

>  <IFI value>
0.058252427

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2907
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.7512    1.5884    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9262    0.7634    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.5762    0.7634    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -3.8062    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2991   -2.7666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6860   -3.3186    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1276   -1.9596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3430   -1.7047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1714   -0.8977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6132   -0.6428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7847    0.1642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1716    0.7162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3431    1.5232    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.6130    0.4613    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7845   -0.3457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2907

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(C=C1)C2CNCC2C(=O)NCC3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.392

>  <W2 Pf proliferation inhibition EC50 uM>
0.412

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.2

>  <Powder data?>
Yes

>  <IFI value>
0.014285714

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3935
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 11 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
  8 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3935

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CC=C(OC2CCN(CC2)CC3CCCCC3)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.326

>  <W2 Pf proliferation inhibition EC50 uM>
0.1296

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.79

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4248
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  9 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
  7 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4248

>  <JC_XSMILES>
OC(=O)C1=CC=C2CN(CC3=CC=CN=C3)C(=NC2=C1)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.476

>  <W2 Pf proliferation inhibition EC50 uM>
0.0657

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012195122

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4398
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.6534    1.5387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3862    1.0091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1831    0.4992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -3.7192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633   -4.5039    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 18 28  4  0  0  0  0
 28 29  2  0  0  0  0
 28 30  4  0  0  0  0
 15 30  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  30
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4398

>  <JC_XSMILES>
CC(C)(C)C1=NN(C2=CC=C(Cl)C=C2)C3=C1C=C(CNCC4=CC=CC=C4)C(=O)N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.731

>  <W2 Pf proliferation inhibition EC50 uM>
0.539

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025641026

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4757
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4757

>  <JC_XSMILES>
COC(=O)C1CCN(CC1)C(=O)COC(C2=CC=CC=C2)C3=CC=CN=C3Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00796

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.447

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
Trifluoroacetate

>  <Equiv of salt>
2

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5177
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.8908   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -3.1895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9533   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3658   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1908   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6033   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1908   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6033   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4283   -0.3316    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.8408   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6658   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0783   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9033   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9033   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0783   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6658   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8408   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4283   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 13 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5177

>  <JC_XSMILES>
CCN(CC)CCNC1=CC=NC2=CC3=CC=CC=C3C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02859

>  <W2 Pf proliferation inhibition EC50 uM>
0.03127

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.26

>  <Powder data?>
Yes

>  <IFI value>
0.074468085

>  <Salt>
Phosphate

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2335
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    3.8989    3.0350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8370    3.9911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0300    4.1626    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710    3.7211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161    4.5057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
  2 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2335

>  <JC_XSMILES>
CC1CCC(C(C)C)C(C1)OC(=O)CN2C3=CC=CC=C3[N+](C)=C2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.376

>  <W2 Pf proliferation inhibition EC50 uM>
0.426

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.23

>  <Powder data?>
No

>  <IFI value>
0.131386861

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3265
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 15 21  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 28  4  0  0  0  0
  6 28  4  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3265

>  <JC_XSMILES>
CCCCCC1=CC=C(OCCCC[N+]2=CC=CC(C)=C2)C(CCCCC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.713

>  <W2 Pf proliferation inhibition EC50 uM>
0.336

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.51

>  <Powder data?>
Yes

>  <IFI value>
0.147286822

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3564
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
M  CHG  1   1   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3564

>  <JC_XSMILES>
NC1=CC=C2N=C3C=CC(N)=CC3=[S+]C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0857

>  <W2 Pf proliferation inhibition EC50 uM>
0.1429

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
11.58

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4280
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4280

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C2=[N+](C)C3=CC=CC=C3N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.122

>  <W2 Pf proliferation inhibition EC50 uM>
0.636

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5449
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  1  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
  8 20  4  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5449

>  <JC_XSMILES>
C(C1=CC=CC=C1)C2=CC=[N+](CC3=CC=CC=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1442

>  <W2 Pf proliferation inhibition EC50 uM>
0.0725

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Chloride

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3251
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    6.3569   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 11 21  1  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3251

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(=O)C[N+]2=C(C)C3=CC=C(C)N3CC2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.05

>  <W2 Pf proliferation inhibition EC50 uM>
1.658

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3286
  Mrv1591402191617072D          

 28 29  0  0  0  0            999 V2000
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
  6 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  CHG  1  15   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3286

>  <JC_XSMILES>
CCC(C)(C)C1=CC=C(OCCCC[N+]2=CC=C(C)C=C2)C(=C1)C(C)(C)CC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.532

>  <W2 Pf proliferation inhibition EC50 uM>
0.1933

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3727
  Mrv1591402191617072D          

 28 34  0  0  0  0            999 V2000
    5.2582   -1.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8457   -0.7516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3978   -0.1385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1515   -0.4741    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.0652   -1.2946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2377    0.3464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0447    0.5179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4572    1.2324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2822    1.2324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6947    1.9468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5197    1.9468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9322    1.2324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7572    1.2324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1697    0.5179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9766    0.3464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0629   -0.4741    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   12.8165   -0.1385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.3686   -0.7516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9561   -1.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1491   -1.2946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3092   -0.8097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7572   -0.1966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.9322   -0.1966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5197    0.5179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6947    0.5179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2822   -0.1966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4572   -0.1966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9051   -0.8097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  1  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 16 21  1  0  0  0  0
 21 22  1  0  0  0  0
 14 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 12 24  4  0  0  0  0
 24 25  4  0  0  0  0
  9 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  7 27  4  0  0  0  0
 27 28  1  0  0  0  0
  4 28  1  0  0  0  0
M  CHG  2   4   1  16   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3727

>  <JC_XSMILES>
C1CC[N+]2(C1)CC3=CC4=CC=C5C=C6C[N+]7(CCCC7)CC6=CC5=C4C=C3C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.645

>  <W2 Pf proliferation inhibition EC50 uM>
1.057

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015384615

>  <Salt>
Bromide

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3949
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3949

>  <JC_XSMILES>
ClC1=CC=CC(Cl)=C1C[N+]2=CC=C3C=CC=CC3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.889

>  <W2 Pf proliferation inhibition EC50 uM>
0.867

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4098
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -0.0631    2.8298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1918    2.0452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9988    1.8737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2537    1.0890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7017    0.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1053    0.6475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3602    1.4321    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566   -0.3087    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.7413   -0.5636    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863   -0.0492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906   -0.2328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5485   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1906   -1.7194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3863   -1.9030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7413   -1.3886    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9566   -1.6436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4717   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3533   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7658   -1.6906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5908   -1.6906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0033   -0.9761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5908   -0.2616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7658   -0.2616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4098

>  <JC_XSMILES>
CC1=CC=C(C=C1)[N+]2=C3CCCCCN3C=C2C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.605

>  <W2 Pf proliferation inhibition EC50 uM>
0.515

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
67.83

>  <Powder data?>
Yes

>  <IFI value>
0.064220183

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4264
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  CHG  1  17   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4264

>  <JC_XSMILES>
CC(C(=O)C1=CC=C(C=C1)C2=CC=CC=C2)[N+]3=CC=CC(C)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.61

>  <W2 Pf proliferation inhibition EC50 uM>
0.649

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4391
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752    0.3126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  3  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  2 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  CHG  1   5   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4391

>  <JC_XSMILES>
CN1C(C)=[N+](CC(=O)C2=CC=CC=C2)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1135

>  <W2 Pf proliferation inhibition EC50 uM>
0.547

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4486
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.1926   -3.4757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3802   -3.6190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323   -3.7623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.2448   -5.1695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9626   -5.9447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1501   -6.0880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3802   -5.4560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980   -4.6808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  3  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  4 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  3  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4486

>  <JC_XSMILES>
C#CC[N+]1(CCCCC1)CC#CC2=CC=CC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.973

>  <W2 Pf proliferation inhibition EC50 uM>
0.484

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036363636

>  <Salt>
Bromide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5419
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  CHG  2   7   1  18   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5419

>  <JC_XSMILES>
CC1=CC=CC=[N+]1CCCCCCCCCC[N+]2=CC=CC=C2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1015

>  <W2 Pf proliferation inhibition EC50 uM>
0.0818

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.013888889

>  <Salt>
Bromide

>  <Equiv of salt>
2

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3352
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  3  9  4  0  0  0  0
 10  9  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3352

>  <JC_XSMILES>
CC[N+]1=CC(C)=CC=C1C=CC2=CC=C(C=C2)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1953

>  <W2 Pf proliferation inhibition EC50 uM>
0.2318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.21

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3630
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    2.4820    0.5756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1964    0.1631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9109    0.5756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6254    0.1631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3399    0.5756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0543    0.1631    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.8080    0.4987    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9795    1.3057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3600   -0.1144    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1805   -0.0282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5161    0.7255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3366    0.8118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6721    1.5654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9475   -0.8289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2025   -1.6135    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6504   -2.2266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9054   -3.0112    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.8435   -2.0551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2914   -2.6681    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.5885   -1.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1406   -0.6573    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
  6 21  4  0  0  0  0
 14 21  4  0  0  0  0
M  CHG  1   6   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3630

>  <JC_XSMILES>
CCCCCN1C(C)=[N+](CCCC)C2=CC(Cl)=C(Cl)C=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
1.237

>  <W2 Pf proliferation inhibition EC50 uM>
1.161

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4377
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
  9 18  1  0  0  0  0
M  CHG  1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4377

>  <JC_XSMILES>
CN1C=CC(C=C1)=CC2=[N+](C)C3=CC=CC=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2077

>  <W2 Pf proliferation inhibition EC50 uM>
0.558

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4495
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0954   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
  7 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  4 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  CHG  1  13   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4495

>  <JC_XSMILES>
CCCN1C(=O)C(C(=O)NCC[N+](CC)(CC)CC)=C(O)C2=CC=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.813

>  <W2 Pf proliferation inhibition EC50 uM>
0.48

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4798
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.6538    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 12  4  0  0  0  0
 12 13  4  0  0  0  0
  3 13  1  0  0  0  0
  6 13  4  0  0  0  0
  4 14  2  0  0  0  0
 14 15  1  4  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4798

>  <JC_XSMILES>
CCN1C(SC2=CC=C(OC)C=C12)=CC3=CC=CC=[N+]3C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.331

>  <W2 Pf proliferation inhibition EC50 uM>
0.3041

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4963
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  3  8  1  0  0  0  0
  6  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4963

>  <JC_XSMILES>
CCN1C=CC(C=C1)=CC2=CC=C3C=C(C)C=CC3=[N+]2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1695

>  <W2 Pf proliferation inhibition EC50 uM>
0.1401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>57.96

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
Iodide

>  <Equiv of salt>
1

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1004
  Mrv1591402191617072D          

 15 16  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 14 15  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1004

>  <JC_XSMILES>
CC1=NN=C2SC(SCC=C)=NN2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.624

>  <W2 Pf proliferation inhibition EC50 uM>
1.083

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1012
  Mrv1591402191617072D          

 19 19  0  0  0  0            999 V2000
    0.9059   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3809   -2.9980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2059   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -2.2836    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4434   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8559   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6809   -1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0934   -2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6809   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8559   -2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0309   -4.4270    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
 16 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1012

>  <JC_XSMILES>
CC(C)OC(=O)NC(NC1=CC=CC=C1)C(Cl)(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.082

>  <W2 Pf proliferation inhibition EC50 uM>
>1.076

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1049
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8986    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592    0.6320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8163   -2.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0416   -2.3784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  4  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
  8 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1049

>  <JC_XSMILES>
CC(=NO)C1=CC=C2C(=C1)C(C)(C)CCC2(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
3.51

>  <W2 Pf proliferation inhibition EC50 uM>
3.9

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
37.13

>  <Powder data?>
Yes

>  <IFI value>
0.041666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1054
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
  9 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
  7 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1054

>  <JC_XSMILES>
CC1=CC=C2N=C(C=C(C(=O)NC3=CC=C(Cl)C=C3)C2=C1)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.606

>  <W2 Pf proliferation inhibition EC50 uM>
1.044

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1055
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
   -0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    2.0009    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -0.5465    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -1.3312    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -1.9986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3130   -2.7523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7980   -3.4197    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4926   -2.8385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -1.3312    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -0.5465    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1055

>  <JC_XSMILES>
CC(=O)NC1=CC=CC=C1C2=NN(CC(N)=O)N=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.53

>  <W2 Pf proliferation inhibition EC50 uM>
>10.44

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1063
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    3.3523    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819    5.6434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3889    5.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8014    6.5294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6264    6.5294    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0389    5.8150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6264    5.1005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8014    5.1005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2494    4.4874    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
  5 13  4  0  0  0  0
  2 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1063

>  <JC_XSMILES>
O=C(CSC1=NC2=CC=CC=C2N1)NC3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.037

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1085
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 11 24  4  0  0  0  0
 24 25  4  0  0  0  0
  8 25  4  0  0  0  0
 22 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1085

>  <JC_XSMILES>
CCCCNC(=O)C1=CC=C2CN(CCN3CCOCC3)C(=NC2=C1)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.062

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.42

>  <Powder data?>
No

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1089
  Mrv1591402191617072D          

 20 24  0  0  0  0            999 V2000
    1.5534   -4.2795    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.5533   -3.4545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8179   -3.8282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2673   -3.0379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0028   -3.4116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7384   -3.0379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2889   -3.8282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7384   -2.2905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0028   -1.9168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2673   -2.2905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5533   -2.7071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0028   -1.0918    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3353   -0.6068    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5903    0.1778    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4153    0.1778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9673    0.7909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7743    0.6194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0292   -0.1652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4772   -0.7783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6702   -0.6068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  9 11  1  0  0  0  0
  2  7  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
  6  8  1  0  0  0  0
  2 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1089

>  <JC_XSMILES>
ClC12CC3CC(C1)CC(C3)(C2)N4N=NC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.018

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014705882

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1106
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
   -1.4528    5.6334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6459    5.4618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3909    4.6772    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4161    4.5057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6710    3.7211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7546   -1.2813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3379   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7546   -0.1146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1106

>  <JC_XSMILES>
CCN1CCC(CC1)N2CCC(CC2)N3C4=CC=C(F)C=C4N=C3C5CCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.453

>  <W2 Pf proliferation inhibition EC50 uM>
2.172

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.51

>  <Powder data?>
Yes

>  <IFI value>
0.026548673

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1115
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1115

>  <JC_XSMILES>
OC1=CC=C(Cl)C=C1C(=O)NC2=CC=C(C=C2)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
1.087

>  <W2 Pf proliferation inhibition EC50 uM>
1.006

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.24742268

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-112
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  4  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  1  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-112

>  <JC_XSMILES>
C1=CC=C(N=C1)C2=CC=C(N=C2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2872

>  <W2 Pf proliferation inhibition EC50 uM>
0.1413

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.36

>  <Powder data?>
Yes

>  <IFI value>
0.159090909

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1133
  Mrv1591402191617072D          

 37 39  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -2.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -3.3320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.3320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -2.5474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -2.2925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -1.4855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -1.2306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -1.7826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -1.5277    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -2.5896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -3.1416    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.8445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.9995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6679   -4.6669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4845   -4.4844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8504   -3.5146    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 16 23  4  0  0  0  0
 13 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
  6 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 30 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1133

>  <JC_XSMILES>
CCCCCN(CC(=O)NC1=CC(=NN1C2=CC=C(Cl)C(Cl)=C2)C(C)(C)C)C(=O)C3=CC=CC(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.597

>  <W2 Pf proliferation inhibition EC50 uM>
0.992

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1178
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743    0.7145    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875    1.2330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945    1.4045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070    0.6900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550    0.0769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
  2 12  4  0  0  0  0
  8 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1178

>  <JC_XSMILES>
NC1=NC(N)=C2C=C(C=CC2=N1)S(=O)(=O)N3CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0585

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.93

>  <Powder data?>
No

>  <IFI value>
0.1171875

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1185
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    5.4957    8.1229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    7.2979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    6.8854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 12 24  4  0  0  0  0
  8 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1185

>  <JC_XSMILES>
OC1=CC=C(C=C1)C2=CN=CC(NCC3=CC=C4OCOC4=C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.172

>  <W2 Pf proliferation inhibition EC50 uM>
0.96

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.033333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1186
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    4.7812    1.9354    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8441    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  4  3  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 18 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1186

>  <JC_XSMILES>
S=C(NN=CC1=CC=CC=N1)NC2CC3CC2C4C=CCC34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1232

>  <W2 Pf proliferation inhibition EC50 uM>
0.1088

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>1.135

>  <Powder data?>
No

>  <IFI value>
0.324675325

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1215
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 12 11  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1215

>  <JC_XSMILES>
OC1=CC2=CC=CC=C2C=C1C=NNC(=O)C3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.871

>  <W2 Pf proliferation inhibition EC50 uM>
0.946

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1216
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1216

>  <JC_XSMILES>
CC(CC1=CC=CC=C1)NCCCCCNC(C)CC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2382

>  <W2 Pf proliferation inhibition EC50 uM>
0.503

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.32

>  <Powder data?>
Yes

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1230
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    1.2528   -0.5825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4243   -1.3895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8112   -1.9415    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8974   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7553   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1842   -2.7620    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8987   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8987   -3.9995    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.6132   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6132   -1.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3277   -1.5245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0421   -1.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0421   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3277   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7566   -3.1745    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    9.4711   -2.7620    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    8.7566   -3.9995    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3277   -0.6995    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.0421   -0.2870    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.6132   -0.2870    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1437   -3.0975    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4083   -2.4844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288   -2.5707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5643   -3.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3848   -3.4106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8697   -2.7432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5342   -1.9895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7137   -1.9032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0042   -1.7700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3313   -1.0163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1518   -0.9301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4874   -0.1764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0025    0.4910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1820    0.4048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.3489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
  4 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 26 33  4  0  0  0  0
  3 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  CHG  4  19   1  20  -1  22   1  23  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1230

>  <JC_XSMILES>
CCN1C(SCCCCNC(=O)C2=CC(=CC(=C2)[N+]([O-])=O)[N+]([O-])=O)=NC(C3=CC=CC=C3)=C1C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.724

>  <W2 Pf proliferation inhibition EC50 uM>
0.612

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.52

>  <Powder data?>
No

>  <IFI value>
0.018518519

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1267
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
  6 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1267

>  <JC_XSMILES>
CCCCCN(C(C)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC=C3OCC)C(=O)NC4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.843

>  <W2 Pf proliferation inhibition EC50 uM>
0.917

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-128
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    1.4358   -6.8365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -6.2234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -5.4388    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.7714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -5.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -6.2003    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4856   -6.9540    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6787   -7.1255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0987   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -8.7435    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -8.3310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5277   -7.5060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8132   -7.0935    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6417   -6.2865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4236   -6.0234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7322   -5.4665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -4.1039    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8838   -3.3193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -3.1478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -2.3631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -1.7501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.9216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -4.3589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -3.9464    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -5.5964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -5.1839    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
  4 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 20 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-128

>  <JC_XSMILES>
CC[N+]1=C(\C=C\C=C2/N(C)C3=CC=CC=C3C2(C)C)N(C4=CC=CC=C4)C5=CC(Cl)=CC=C15

>  <PF proliferation inhibition 3D7 EC50 uM>
0.287

>  <W2 Pf proliferation inhibition EC50 uM>
0.53

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.691

>  <Powder data?>
Yes

>  <IFI value>
0.333333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1297
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1297

>  <JC_XSMILES>
CC1=NC2=CC=CC=C2C(=O)N1C3=CC=C(C=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.765

>  <W2 Pf proliferation inhibition EC50 uM>
0.896

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1304
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
  6 11  4  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1304

>  <JC_XSMILES>
OC1=C(C=CC2=CC=CN=C12)C(NC3=CC=CC=N3)C4=CC=NC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.83

>  <W2 Pf proliferation inhibition EC50 uM>
0.892

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1329
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819    0.9475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3889    1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8014    0.4046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2494   -0.2085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6219    0.3184    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    8.1068    0.9858    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.9574   -0.4353    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 13 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 11 27  4  0  0  0  0
 27 28  4  0  0  0  0
  9 28  4  0  0  0  0
M  CHG  2  22   1  23  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1329

>  <JC_XSMILES>
CC1=CC=C(C=C1Br)C2=NC3=CC(NC(=O)C4=CC=C(O4)[N+]([O-])=O)=CC=C3O2

>  <PF proliferation inhibition 3D7 EC50 uM>
6.92

>  <W2 Pf proliferation inhibition EC50 uM>
6.49

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
73.99

>  <Powder data?>
Yes

>  <IFI value>
0.181818182

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1340
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3149   -0.4305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1354   -0.3443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4710   -1.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2582   -0.8513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0262   -1.7081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9684   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3184   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 14 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1340

>  <JC_XSMILES>
CC(NCCN1CCNCC1)C2=CC(=CC3=C2CCC3(C)C)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.598

>  <W2 Pf proliferation inhibition EC50 uM>
0.586

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.72

>  <Powder data?>
Yes

>  <IFI value>
0.066666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1395
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -2.4304   -4.3005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1604   -3.5209    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3502   -3.3650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0802   -2.5855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2700   -2.4296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8101   -1.4941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3502   -2.1177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0802   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8903   -0.5586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1604    0.2209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9705    0.3768    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2405    1.1564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0507    1.3123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3207    2.0918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1308    2.2478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6709    1.6241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4811    1.7800    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7511    2.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4009    0.8446    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9410    0.2209    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6709   -0.5586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5908    0.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5106   -0.2468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3207   -0.0909    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2405   -1.0264    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7806   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5106   -2.4296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9825   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4848   -3.7642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7052   -3.4941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7212   -2.6693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2700   -3.0532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0802   -2.8973    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6203   -3.5209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3502   -4.3005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5401   -4.4564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.8327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8101   -3.9887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 14 23  4  0  0  0  0
 12 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  1  0  0  0  0
  5 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  4  0  0  0  0
  3 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1395

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=C(OC)C(OC)=C2)C(=O)CCC3CCCC3)=C4N=CC=CC4=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.687

>  <W2 Pf proliferation inhibition EC50 uM>
0.333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.99

>  <Powder data?>
No

>  <IFI value>
0.030075188

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1398
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 31 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1398

>  <JC_XSMILES>
COC1=CC=CC=C1CC2=NC3=CC=CC=C3N=C2SCC(=O)NC4=CC=CC(=C4)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.52

>  <W2 Pf proliferation inhibition EC50 uM>
>8.34

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1418
  Mrv1591402191617072D          

 32 34  0  0  1  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4647   -4.0640    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0778   -4.6160    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9063   -5.4230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5193   -5.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3040   -5.7201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4755   -4.9131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8624   -4.3611    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4824   -3.5721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9070   -6.9093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -5.8331    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -5.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  5  3  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  7 20  1  1  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1418

>  <JC_XSMILES>
COC(=O)[C@@H]1C[C@H](CN1C\C(C)=C\C2=CC=CC=C2)NC(=O)C3=CC=C(OC)C=C3OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.432

>  <W2 Pf proliferation inhibition EC50 uM>
0.821

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017391304

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1421
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -1.1962   -6.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4817   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4817   -5.1917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2328   -6.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9473   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6617   -6.4292    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3762   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3762   -5.1917    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0907   -6.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1769   -7.2497    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9839   -7.4212    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3964   -6.7067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8443   -6.0937    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0159   -5.2867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8005   -5.0317    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4028   -4.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6182   -4.9896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0051   -4.4376    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1766   -3.6306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5635   -3.0786    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.9612   -3.3756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5743   -3.9277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3589   -3.6727    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.2169   -6.6205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5524   -5.8668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3729   -5.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8578   -6.4480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6783   -6.3618    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.5223   -7.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7018   -7.2880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 22 23  1  0  0  0  0
 12 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1421

>  <JC_XSMILES>
CC(C)CCNC(=O)C1CSC(N1C(=O)C2=CC=C(Cl)C=C2Cl)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
8.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.032258065

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1431
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -5.7158   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5888   -1.1270    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4138    0.3020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  2  0  0  0  0
 24 26  4  0  0  0  0
 16 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 29  1  0  0  0  0
 10 30  4  0  0  0  0
  5 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1431

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(Cl)C(NC(=O)CSC2=NC3=CC=CC=C3C(=O)N2C4CC4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.719

>  <W2 Pf proliferation inhibition EC50 uM>
8.11

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1436
  Mrv1591402191617072D          

 24 23  0  0  0  0            999 V2000
    3.0409    6.0721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2544    5.2753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6711    4.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8846    3.8950    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6815    3.6815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2648    4.2648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0617    4.0513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3012    3.3116    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    1.7179    3.8950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9210    3.6815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7179    2.7283    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9314    1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3480    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5616    0.5511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9210    2.9418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3376    2.3584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4593    2.5720    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8846    2.7283    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6711    1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2544    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0409    0.5511    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6815    2.9418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2648    2.3584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0513    1.5616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  CHG  1   8   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1436

>  <JC_XSMILES>
CCCN(CCC)[P+](CC)(N(CCC)CCC)N(CCC)CCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2068

>  <W2 Pf proliferation inhibition EC50 uM>
0.2731

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.39

>  <Powder data?>
Yes

>  <IFI value>
0.127272727

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1465
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -1.8267    3.3100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0198    3.1385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648    2.3539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971    1.3977    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168    1.7408    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.2549   -2.1195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971   -2.7326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422   -3.5172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7648   -3.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3168   -3.0756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619   -2.2910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 11 18  4  0  0  0  0
 18 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
M  CHG  1  11   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1465

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=CN(C3=CC=CC=C3)C4=[N+]2CCS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.778

>  <W2 Pf proliferation inhibition EC50 uM>
0.784

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1468
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
    1.4291    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3790    0.3412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6498    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1433   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -2.4749    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -4.1249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
  9 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1468

>  <JC_XSMILES>
COC(=O)C1=CNC=C(C1C2=CC(Br)=CC=C2OC)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.25

>  <W2 Pf proliferation inhibition EC50 uM>
4.52

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>57.75

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1474
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4618   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.1118   -4.9500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 17 20  1  0  0  0  0
  9 21  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1474

>  <JC_XSMILES>
CC1=CC=C2N=CN=C(NC3=CC=CC(=C3)C(F)(F)F)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.947

>  <W2 Pf proliferation inhibition EC50 uM>
2.174

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
27.89

>  <Powder data?>
Yes

>  <IFI value>
0.044117647

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1507
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  5 18  4  0  0  0  0
 13 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1507

>  <JC_XSMILES>
O=C(NNC1=C2C=CC=CC2=NC3=CC=CC=C13)NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.873

>  <W2 Pf proliferation inhibition EC50 uM>
0.756

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1523
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
   -1.2731   -4.1850    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4913   -3.9214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2278   -4.7032    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7549   -3.1396    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.2904   -3.6578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4530   -2.8490    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2348   -2.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3974   -1.7766    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.8540   -3.1307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6357   -2.8671    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2549   -3.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0743   -3.3171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5519   -2.6443    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3733   -2.7215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7171   -3.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2396   -4.1442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4182   -4.0670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8112   -4.6258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9065   -5.4452    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0922   -4.2212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3105   -4.4847    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6913   -3.9395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9096   -4.2031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  9 22  4  0  0  0  0
 22 23  4  0  0  0  0
  5 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1523

>  <JC_XSMILES>
FC(F)(F)C1=CC(Cl)=C2N=C3C4=CC=CC=C4C(=O)C3=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.035

>  <W2 Pf proliferation inhibition EC50 uM>
0.747

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.063636364

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1528
  Mrv1591402191617072D          

 14 14  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1528

>  <JC_XSMILES>
CNC(=O)NNC(=O)C1=CC=CN=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>7.47

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027522936

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1552
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    5.0645   -0.6422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435   -1.1567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813    1.0986    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842    2.4963    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8912    2.6679    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1461    3.4525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9531    3.6240    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5051    3.0109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2502    2.2263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4432    2.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322    3.1094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252    2.9379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1732    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4281    4.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2351    4.5071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871    3.8940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  2  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
  9 15  1  0  0  0  0
  7 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 22 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1552

>  <JC_XSMILES>
CCN1C(=O)C2=C(SC3=C2CCN(C)C3)N=C1SCC(=O)N(C4=CC=CC=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.08

>  <W2 Pf proliferation inhibition EC50 uM>
7.34

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1553
  Mrv1591402191617072D          

 37 39  0  0  0  0            999 V2000
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3427   -4.9455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5357   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1232   -4.4025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6753   -3.7894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5037   -2.9825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2809   -2.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4524   -1.9206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1607   -1.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.5616    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.9453   -1.6235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5584   -1.0714    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.1168   -2.4304    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2002   -5.8707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1354   -6.6244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5535   -5.5351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9539   -6.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4467   -6.0770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -4.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 31 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 34 37  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1553

>  <JC_XSMILES>
CC(C)N(CC(=O)NC1=CC(=NN1C2=CC=C(Cl)C(Cl)=C2)C(C)(C)C)C(=O)C3=CC=C(C=C3)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
6.03

>  <W2 Pf proliferation inhibition EC50 uM>
7.33

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1615
  Mrv1591402191617072D          

 27 32  0  0  1  0            999 V2000
    2.3838   -1.4901    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8989   -0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0739   -0.8227    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8190   -0.0381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4864    0.4468    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.7413    1.2315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5663    1.2315    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.8213    0.4468    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4887   -0.0381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2338   -0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4088   -0.8227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1538   -0.0381    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.0513    1.8989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7157    2.6526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2006    3.3200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0291    4.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7436    4.5395    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3567    3.9875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0211    3.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3567    2.4801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8718    1.8127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5890   -1.4901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9245   -2.2438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4396   -2.9112    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3809   -2.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7164   -2.0713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2315   -1.4039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  6  0  0  0
  5  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12  2  1  0  0  0  0
  5 12  1  0  0  0  0
 12  8  1  6  0  0  0
  7 13  1  1  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
  3 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1615

>  <JC_XSMILES>
O=C1N(C[C@@H]2C[C@H](N3CCC[C@@]123)C4=CC5=NSN=C5C=C4)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.888

>  <W2 Pf proliferation inhibition EC50 uM>
0.641

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.25

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1621
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 16 23  4  0  0  0  0
 11 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 32 33  1  0  0  0  0
  5 34  4  0  0  0  0
 34 35  4  0  0  0  0
  2 35  4  0  0  0  0
 35 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1621

>  <JC_XSMILES>
CC1=CC=C(NC(=O)C2=CC(=CN(C2=O)C3=CC=C(C)C(C)=C3)C(=O)C4=CC(Cl)=CC=C4O)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
8.07

>  <W2 Pf proliferation inhibition EC50 uM>
6.9

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1631
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
  -10.1159   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.7034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8784   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.8784    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6409    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2284    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4034    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9909    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    0.0165    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659   -0.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    0.8415    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -2.7631    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  2  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  2  0  0  0  0
 25 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  1  0  0  0  0
 35 36  1  0  0  0  0
 29 36  1  0  0  0  0
 30 37  4  0  0  0  0
 24 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1631

>  <JC_XSMILES>
CCOC(=O)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)C(=O)NC3=C(C(N)=O)C4=C(CN(CC)CC4)S3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.392

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.36

>  <Powder data?>
Yes

>  <IFI value>
0.012048193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1635
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    0.7144   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0933   -4.0537    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5253   -6.2599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2703   -7.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4453   -7.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1904   -6.2599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1106   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5394   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 12 16  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  5 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  2  0  0  0  0
 29 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1635

>  <JC_XSMILES>
CC(C)CN(C(C(=O)NC(CN1CCCC1)C2=CC=CC=C2)C3=CC=CC=C3)S(=O)(=O)C4=CC=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.321

>  <W2 Pf proliferation inhibition EC50 uM>
0.682

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1659
  Mrv1591402191617072D          

 45 52  0  0  1  0            999 V2000
    5.9875    2.6586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6519    1.9049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8314    1.8187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1368    1.2375    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.4223    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4529    2.0221    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.8500   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3509   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1340    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3509    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1794    1.8869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7925    2.4389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5771    2.1840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7499    1.7895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4644    1.3770    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.5506    2.1975    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.2490    1.6320    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    8.5846    2.3856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4050    2.2994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5766    1.4924    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8621    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.6906    0.2730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3037   -0.2791    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9059    0.0180    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.7344   -0.7889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3475   -1.3410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1321   -1.0860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7452   -1.6381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5737   -2.4450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7891   -2.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1760   -2.1480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2929    0.5701    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4724    0.4838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0599   -0.2307    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  1  0  0  0
  4  5  1  6  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  8  6  1  1  0  0  0
  8  9  1  0  0  0  0
 10  9  1  1  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  1  6  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
  8 24  1  0  0  0  0
  4 25  1  0  0  0  0
 26 25  1  0  0  0  0
 26 27  1  6  0  0  0
 26 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 28 32  1  6  0  0  0
 32 33  1  0  0  0  0
 33 34  2  0  0  0  0
 35 33  1  0  0  0  0
 35 36  1  6  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 37 42  1  0  0  0  0
 35 43  1  0  0  0  0
 26 43  1  0  0  0  0
 43 44  1  0  0  0  0
  4 44  1  0  0  0  0
 44 45  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1659

>  <JC_XSMILES>
CC(C)[C@@]5(NC(=O)[C@@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C)C1)O[C@@]6(O)[C@@H]7CCCN7C(=O)[C@H](CC8CCCCC8)N6C5=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.155

>  <W2 Pf proliferation inhibition EC50 uM>
0.768

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.37

>  <Powder data?>
No

>  <IFI value>
0.095238095

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1668
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -3.6020    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  4  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1668

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=NO)C2CC2C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.735

>  <W2 Pf proliferation inhibition EC50 uM>
0.668

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.013513514

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1673
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.6052   -9.4875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2552   -9.4875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -11.9625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  2  0  0  0  0
 16 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1673

>  <JC_XSMILES>
CCCN(CCC)C(=O)C1=CNC2=CC=C(C=C2C1=O)S(=O)(=O)N(C)C3=CC=C(F)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
6.65

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1686
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.1434   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3184   -5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.9684   -5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
  9 26  4  0  0  0  0
  5 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1686

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(CNC2CCN(CC2)CCC3=CC=CC=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1742

>  <W2 Pf proliferation inhibition EC50 uM>
0.487

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.39

>  <Powder data?>
Yes

>  <IFI value>
0.016129032

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1690
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1690

>  <JC_XSMILES>
CC1=CC=CC(C)=C1NC(=O)N2CCN(CC2)C3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
>6.56

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1757
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3289   -3.8520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9933   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1728   -4.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 11 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  9 29  1  0  0  0  0
 24 29  4  0  0  0  0
  5 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  1  0  0  0  0
 37 39  4  0  0  0  0
 33 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1757

>  <JC_XSMILES>
CCCCN(CC(=O)N1C(C2=CC=C(OC)C=C2)C3=CC=CN3C4=CC=CC=C14)C(=O)NC5=CC=CC(F)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
8.6

>  <W2 Pf proliferation inhibition EC50 uM>
6.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.067307692

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1787
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    6.2388   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7638   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6513   -4.3164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -4.3164    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -5.0309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -5.7454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -6.4599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -7.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -7.8888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -8.6033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -9.3177    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763  -10.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6513   -8.6033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -7.8888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6513   -7.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -6.4599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6513   -5.7454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2388   -5.0309    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -3.6020    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4763   -1.4586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8888   -0.7441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -0.7441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1263   -0.0296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1263   -1.4586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7138   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 13 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  2  0  0  0  0
  9 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1787

>  <JC_XSMILES>
CCN(CC)CCCN(CC1=CC2=CC(OC)=CC=C2NC1=O)C(=S)NC3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.41

>  <W2 Pf proliferation inhibition EC50 uM>
2.021

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
32.97

>  <Powder data?>
Yes

>  <IFI value>
0.054054054

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-179
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
    1.4289    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9731   -4.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4580   -3.3470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2785   -3.4332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6140   -4.1869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1291   -4.8543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3086   -4.7681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3088   -3.6695    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0032   -5.3493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4817   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3022   -5.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 11 29  4  0  0  0  0
  8 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 30 36  4  0  0  0  0
 36 37  1  0  0  0  0
  5 38  4  0  0  0  0
 38 39  4  0  0  0  0
  2 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-179

>  <JC_XSMILES>
FC1=CC=C(CSC2=NN=C(C(CC3=CC=CC=C3)NC(=O)C4CCCCC4)N2C5=CC=C(Cl)C=C5Cl)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.748

>  <W2 Pf proliferation inhibition EC50 uM>
0.35

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.658

>  <Powder data?>
No

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1790
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 13 27  4  0  0  0  0
 11 28  4  0  0  0  0
  6 28  4  0  0  0  0
 28 29  4  0  0  0  0
  3 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1790

>  <JC_XSMILES>
COC1=CC=C2N=C(C)C=C(NC3=CC=C(OC4=CC=C(Cl)C=C4)C(Cl)=C3)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1708

>  <W2 Pf proliferation inhibition EC50 uM>
0.571

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.34

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1834
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.4289    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 11 26  4  0  0  0  0
 20 26  4  0  0  0  0
  6 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1834

>  <JC_XSMILES>
ClC1=CC=CC(NC(=O)CN2C3=CC=CC=C3C(=O)C4=CC=C(Cl)C=C24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.934

>  <W2 Pf proliferation inhibition EC50 uM>
0.589

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.048192771

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1860
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894  -11.5500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605  -12.3750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   12.1460  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 24 31  4  0  0  0  0
  6 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1860

>  <JC_XSMILES>
COC1=CC=C(OCC(O)CNC2CCN(CC2)CC(O)COC3=CC=C(Cl)C(Cl)=C3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.328

>  <W2 Pf proliferation inhibition EC50 uM>
0.524

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.14

>  <Powder data?>
Yes

>  <IFI value>
0.033613445

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1862
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.0470    2.8379    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.3646    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
 16 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 20 23  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
  7 31  4  0  0  0  0
  2 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1862

>  <JC_XSMILES>
CC1=CC=C(O)C(NC(=O)C2=C3N=C(C=C(N3N=C2)C(F)(F)F)C4=CC=C(F)C=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
10.48

>  <W2 Pf proliferation inhibition EC50 uM>
5.72

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1865
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    4.5164    4.2059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039    3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5164    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3414    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7539    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3414    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5164    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1039    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4539    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079   -0.4125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179    2.0361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769    2.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220    3.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 17 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1865

>  <JC_XSMILES>
CCC1CCCCN1S(=O)(=O)C2=CC(Br)=CC3=C2N(CC3)C(=O)CC

>  <PF proliferation inhibition 3D7 EC50 uM>
9.98

>  <W2 Pf proliferation inhibition EC50 uM>
5.7

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1870
  Mrv1591402191617072D          

 48 54  0  0  0  0            999 V2000
   -0.6923   -4.1779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1620   -3.5460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4441   -2.7707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0862   -2.1387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8986   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1808   -3.0572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6505   -3.6892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9592   -2.2820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0493   -3.7934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6368   -3.0789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0493   -2.3645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5243    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9368   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5243   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 14 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  8 29  1  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 30 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 30 43  1  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 43 48  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1870

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2(C)CC(C)(C)N(C(=O)CC3=CC=CC=C3)C4=CC=C(C=C24)C(C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
4.79

>  <W2 Pf proliferation inhibition EC50 uM>
5.68

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1889
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
    2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8498   -1.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -2.5896    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2787   -1.3521    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9932   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7077   -1.3521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7939   -0.5316    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6009   -0.3601    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0134   -1.0745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8338   -1.1608    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    8.1694   -1.9145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9899   -2.0007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4748   -1.3332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2953   -1.4195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6308   -2.1732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1459   -2.8406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3254   -2.7544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4815   -3.5943    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8170   -4.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.7278   -3.9298    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   11.2352   -3.2587    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4613   -1.6876    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.6329   -2.4946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4175   -2.7495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5890   -3.5565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9759   -4.1086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1913   -3.8536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5782   -4.4056    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7936   -4.1507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0198   -3.0466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 19 22  1  0  0  0  0
 10 23  4  0  0  0  0
  7 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 24 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1889

>  <JC_XSMILES>
CCC(=O)NCC1=NN=C(SCC2=CC=CC(=C2)C(F)(F)F)N1C3=CC=CC(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
5.61

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008849558

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1890
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.6021    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  1  0  0  0  0
  2 10  1  0  0  0  0
  4 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  3 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1890

>  <JC_XSMILES>
CC1=C(C(N2N=CN=C2N1)C3=CC=C(O)C=C3)C(=O)NC4=CC=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.561

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1895
  Mrv1591402191617072D          

 18 19  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  2 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1895

>  <JC_XSMILES>
CC1=C[N+](CC=C)=CC=C1\C=C\C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.656

>  <W2 Pf proliferation inhibition EC50 uM>
0.558

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1903
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -4.7651   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2251   -2.0171    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4149   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8748   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5246   -1.0816    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4444   -2.0171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1744   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6358   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9860   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    0.3216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560    1.1012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7961    1.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5261    2.5043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159    2.6603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1758    2.0366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4459    1.2571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9058    0.6334    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0957    0.7893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2560   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7159   -1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0662   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6062   -0.6139    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.3362   -2.0171    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.7946   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9845   -2.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2546   -4.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0647   -3.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3347   -3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1449   -2.9525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
  5 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
  3 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1903

>  <JC_XSMILES>
COC1=CC(NC(C)CCCN(CC2=CC=CC=C2OC)C(=O)C(Cl)Cl)=C3N=CC=CC3=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.497

>  <W2 Pf proliferation inhibition EC50 uM>
0.554

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1927
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    2.8370    3.9911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  4  0  0  0  0
  3 25  4  0  0  0  0
M  CHG  1  14   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1927

>  <JC_XSMILES>
COC1=CC=C(C[N+]2=C3C=CC=CN3C=C2C4=CC=C(Cl)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.693

>  <W2 Pf proliferation inhibition EC50 uM>
0.541

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-193
  Mrv1591402191617072D          

 35 37  0  0  1  0            999 V2000
    3.3048   -1.1701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8425   -0.4868    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.0196   -0.5455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5573    0.1378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7344    0.0791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2721    0.7624    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4112    0.3001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1902    1.4457    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6327    1.5044    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4556    1.5631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8162    2.3052    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.6391    2.3639    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9997    3.1059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5374    3.7892    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8226    3.1646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2849    2.4813    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.1078    2.5400    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9243    1.7393    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2749    1.2305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2092    2.1508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3866    1.0560    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2095    1.1147    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0260    0.3140    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.4883   -0.3693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2031    0.2553    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.7408    0.9386    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3539    2.9885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5310    2.9297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7145    3.7305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2522    4.4138    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4276    4.4414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1991    5.2341    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.8824    5.6964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9100    6.5209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5332    5.1894    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  2  1  1  1  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  6  5  1  0  0  0  0
  6  7  1  6  0  0  0
  6  8  1  0  0  0  0
  9  8  1  1  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 16 15  1  0  0  0  0
 16 17  1  6  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 23 21  1  0  0  0  0
 23 24  1  6  0  0  0
 25 23  1  0  0  0  0
 25  2  1  0  0  0  0
 25 26  1  6  0  0  0
 11 27  1  1  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-193

>  <JC_XSMILES>
C[C@H]1CCC[C@@]2(C)O[C@H]2C[C@H](OC(=O)C[C@H](O)C(C)(C)C(=O)[C@H](C)[C@H]1O)\C(C)=C\C3=CSC(C)=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00409

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.25

>  <Powder data?>
No

>  <IFI value>
0.046875

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1936
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -2.4992    1.4044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7541    0.6198    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5611    0.4483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1131    1.0614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8582    1.8460    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9201    0.8899    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4721    1.5029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2791    1.3314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8311    1.9445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5762    2.7291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7692    2.9007    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2172    2.2876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1282    3.3422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8733    4.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.9352    3.1707    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2021    0.0067    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8152   -0.5453    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5890    0.5587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6501   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9050   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3530   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5460   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1215   -2.3175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7889   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5340   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0860   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8930   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1479   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5959   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2910   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8431   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
  2 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 25 30  4  0  0  0  0
 22 30  4  0  0  0  0
 30 31  4  0  0  0  0
 19 31  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  23
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-1936

>  <JC_XSMILES>
CN(CC(=O)NC1=CC=C(C=C1)C(C)=O)S(=O)(=O)C2=CC=C3NC4=C(CCCC4)C3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
66.88

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1944
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
   -2.2168   -5.2354    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3429   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8580   -1.2680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
  9 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1944

>  <JC_XSMILES>
ClC1=CC=C(CN2C3=C(CCCC3)C(=N)C4=C2CCC4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2223

>  <W2 Pf proliferation inhibition EC50 uM>
0.533

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1952
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0039   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1952

>  <JC_XSMILES>
CC(CCCNCCO)NC1=CC=NC2=CC(Cl)=CC=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02693

>  <W2 Pf proliferation inhibition EC50 uM>
0.736

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.98

>  <Powder data?>
Yes

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1953
  Mrv1591402191617072D          

 46 50  0  0  0  0            999 V2000
    4.8395    8.2204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    7.3954    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539    6.9829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539    6.1579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2684    5.7454    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.2684    4.9204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539    4.5079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    4.9204    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539    3.6829    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539    2.0329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -0.0296    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1250   -0.4421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1250   -1.2671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4105   -1.6796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6961   -1.2671    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6961   -0.4421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4105   -0.0296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9816   -1.6796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2671   -1.2671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5526   -1.6796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5526   -2.5046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1618   -2.9171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8763   -2.5046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8763   -1.6796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1618   -1.2671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2671   -0.4421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5526   -0.0296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5526    0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2671    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9816    0.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9816   -0.0296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1250    1.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1250    2.0329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829    6.1579    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.6974    6.5704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704    6.8724    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954    5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2204    5.4434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6329    4.7289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2204    4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954    4.0145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829    4.7289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 23 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 14 36  4  0  0  0  0
 36 37  4  0  0  0  0
 11 37  4  0  0  0  0
  5 38  1  0  0  0  0
 38 39  2  0  0  0  0
 38 40  2  0  0  0  0
 38 41  1  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 41 46  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1953

>  <JC_XSMILES>
COCCN(CC(=O)NCC1=CC=C(OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C=C1)S(=O)(=O)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1

>  <W2 Pf proliferation inhibition EC50 uM>
0.526

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.014084507

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1967
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 11 29  1  0  0  0  0
 24 29  4  0  0  0  0
 12 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
 36 37  4  0  0  0  0
 30 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1967

>  <JC_XSMILES>
CCN(CC)CCNC(=O)C1C(N(CC2=CC=C(F)C=C2)C(=O)C3=CC=CC=C13)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.782

>  <W2 Pf proliferation inhibition EC50 uM>
2.419

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.43

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-1975
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-1975

>  <JC_XSMILES>
CN(CC1=CC=CC=C1)C2=CC(=NC(=N2)C3=CC=CC=N3)C4=CC=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.531

>  <W2 Pf proliferation inhibition EC50 uM>
0.514

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2008
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.1730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -3.6020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    2.8090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.5235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.5235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    2.8090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    1.3099    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
 11  8  1  4  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 14 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 12 32  1  0  0  0  0
 27 32  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  24
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2008

>  <JC_XSMILES>
CC1=CC=C(C=C1)S(=O)(=O)N=C2C=C(SC3=NC4=CC=CC=C4N3)C(=O)C5=CC=CC=C25

>  <PF proliferation inhibition 3D7 EC50 uM>
0.632

>  <W2 Pf proliferation inhibition EC50 uM>
0.834

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.76

>  <Powder data?>
Yes

>  <IFI value>
0.126582278

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2017
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9606   -3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2961   -2.8193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1166   -2.9055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 12 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2017

>  <JC_XSMILES>
CCCCCCCCCN1C2=C(CCCC2)C(=N)C3=C1CCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1316

>  <W2 Pf proliferation inhibition EC50 uM>
0.1848

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.74

>  <Powder data?>
Yes

>  <IFI value>
0.212598425

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2025
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 19 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2025

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C(OC)=CC=CC2=C1NC3=CC=C(OC)C(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.827

>  <W2 Pf proliferation inhibition EC50 uM>
0.493

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-203
  Mrv1591402191617072D          

 42 46  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    5.3625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0164    5.6645    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414    4.2355    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  5 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
 27 33  4  0  0  0  0
 33 34  4  0  0  0  0
 24 34  4  0  0  0  0
 19 35  4  0  0  0  0
 35 36  2  0  0  0  0
 35 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 17 42  4  0  0  0  0
 37 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-203

>  <JC_XSMILES>
CC1=CC=C(C=C1S(=O)(=O)N2CCCCC2)C3=NN(CC(=O)NC4=CC=C(OC(F)(F)F)C=C4)C(=O)C5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.923

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2047
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -7.4205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -7.5920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -6.8775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -6.2644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 17 26  1  0  0  0  0
  9 27  4  0  0  0  0
 27 28  4  0  0  0  0
  2 28  4  0  0  0  0
  6 28  4  0  0  0  0
  4 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2047

>  <JC_XSMILES>
CC1=CC(=NC2=CC=C(NC(=S)NCCCN3CCC4=CC=CC=C4C3)C=C12)N5CCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2633

>  <W2 Pf proliferation inhibition EC50 uM>
0.924

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
19.09

>  <Powder data?>
Yes

>  <IFI value>
0.117647059

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-205
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4824   -3.5721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-205

>  <JC_XSMILES>
CC1=CC(NC(=O)C2=CC=C(Br)C=C2)=NO1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.911

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2063
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 10 17  4  0  0  0  0
  6 17  4  0  0  0  0
 17 18  4  0  0  0  0
  3 18  4  0  0  0  0
  8 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2063

>  <JC_XSMILES>
COC1=CC=C2N=C(C=C(NCCN(C)C)C2=C1)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1714

>  <W2 Pf proliferation inhibition EC50 uM>
0.478

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035087719

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2065
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
M  CHG  2  17   1  18  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2065

>  <JC_XSMILES>
COC1=CC=C(NC(=O)C2=CC=CC(=C2C)[N+]([O-])=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.55

>  <W2 Pf proliferation inhibition EC50 uM>
4.77

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-207
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -1.4604    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2784   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7534    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7534    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5159    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
  8 20  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  2  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-207

>  <JC_XSMILES>
COC(=O)C1=C(SC2=C1CCN(CC3=CC=CN=C3)C2)S(=O)(=O)NCCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.575

>  <W2 Pf proliferation inhibition EC50 uM>
1.907

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2075
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    8.4669   -1.7116    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1344   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8794   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0544   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7995   -3.0215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.5695   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7490   -4.3874    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9051   -5.2273    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4202   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7557   -6.6484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2708   -7.3158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4503   -7.2296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9654   -7.8970    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3009   -8.6507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1214   -8.7369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4570   -9.4906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9721  -10.1580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1516  -10.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6667  -10.7392    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8462  -10.6530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3613  -11.3205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5408  -11.2342    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2052  -10.4805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3847  -10.3943    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8998  -11.0617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0793  -10.9755    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2354  -11.8154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0423  -11.9869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1286  -12.8074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3749  -13.1430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2034  -13.9500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.8229  -12.5299    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6901   -9.8131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5106   -9.8993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8160   -9.3181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1148   -6.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5997   -5.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 28 33  4  0  0  0  0
 24 34  4  0  0  0  0
 34 35  4  0  0  0  0
 21 35  4  0  0  0  0
 19 36  4  0  0  0  0
 15 36  4  0  0  0  0
 13 37  4  0  0  0  0
 37 38  4  0  0  0  0
 10 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2075

>  <JC_XSMILES>
BrC1=CC=C(O1)C(=O)NC2=CC=C(OC3=CC=CC(OC4=CC=C(NC(=O)C5=CC=C(Br)O5)C=C4)=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
4.42

>  <W2 Pf proliferation inhibition EC50 uM>
4.71

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2076
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -2.3174    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6669   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0794   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6669   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0794    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9044    0.4934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3169    1.2079    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.3169   -0.2211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9044   -0.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3169   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -0.9826    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  1  0  0  0  0
 16 26  4  0  0  0  0
 12 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2076

>  <JC_XSMILES>
CC(C)CC(N)C(=O)N1CCC2=C(C1)SC(CC3=CC=C(F)C=C3Cl)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.471

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.042253521

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2101
  Mrv1591402191617072D          

 50 56  0  0  0  0            999 V2000
    8.7252   -1.1026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0107   -0.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2963   -1.1026    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5818   -0.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5818    0.1349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673   -1.1026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673   -1.9276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529   -2.3401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384   -1.9276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6538   -2.1826    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1688   -1.5151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3438   -1.5151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9313   -2.2296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2669   -2.9833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0739   -3.1548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6538   -3.5353    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7400   -4.3558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0726   -4.8407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1588   -5.6612    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4914   -6.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2623   -5.8106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9297   -6.2955    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3485   -4.9901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3189   -4.5052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9393   -3.1228    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1547   -3.3777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4584   -2.8257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2869   -2.0187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4978   -1.7638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1109   -2.3158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6538   -0.8477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3988   -0.0631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384   -1.1026    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529   -0.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529    0.1349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673    0.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8673    1.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1529    1.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384    1.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7239    1.7849    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7239    2.6099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4384    0.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7239    0.1349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0094    0.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5818   -2.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2963   -1.9276    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0107   -2.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0107   -3.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2963   -3.5776    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5818   -3.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  4  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 13 30  4  0  0  0  0
 25 30  4  0  0  0  0
 11 31  4  0  0  0  0
 31 32  2  0  0  0  0
 31 33  4  0  0  0  0
  9 33  4  0  0  0  0
 33 34  1  0  0  0  0
  6 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 39 42  4  0  0  0  0
 35 42  4  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
  7 45  1  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 45 50  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2101

>  <JC_XSMILES>
CCOC(=O)C1=C(N=c2sc(=CC3=C(C)N(CC4=CC=C(F)C=C4)C5=CC=CC=C35)c(=O)n2C1C6=CC=CC(OC)=C6OC)C7=CC=CC=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
1.128

>  <W2 Pf proliferation inhibition EC50 uM>
4.62

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.045977011

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2110
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2110

>  <JC_XSMILES>
CN(C)CCCNC1=C2C=CC=CC2=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0327

>  <W2 Pf proliferation inhibition EC50 uM>
0.387

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.45

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2115
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 19 28  4  0  0  0  0
 15 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  4  0  0  0  0
 31 32  4  0  0  0  0
  9 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2115

>  <JC_XSMILES>
CCN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)C4=CC(OC)=CC(OC)=C4)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1831

>  <W2 Pf proliferation inhibition EC50 uM>
0.587

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.9

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2122
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 13 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  2  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
  9 33  4  0  0  0  0
 33 34  4  0  0  0  0
  6 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2122

>  <JC_XSMILES>
CCN(CC)C1=CC=C(NC(=O)C2CC3=CC=CC=C3CN2S(=O)(=O)C4=CC=C(F)C=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
7.43

>  <W2 Pf proliferation inhibition EC50 uM>
4.53

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2134
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -3.1902   -7.0706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1902   -6.2456    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4757   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7613   -6.2456    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4757   -5.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1902   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1902   -3.7706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4757   -3.3581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7613   -3.7706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0468   -5.0081    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -3.7706    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0966   -4.5956    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0966   -3.7706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8111   -5.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5648   -4.6725    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1168   -5.2856    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7043   -6.0001    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8973   -5.8286    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9373   -5.1994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2728   -4.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0933   -4.3595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5782   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3987   -4.9407    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7343   -4.1870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2427   -5.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4222   -5.8668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 22 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2134

>  <JC_XSMILES>
COC(=O)C1=CC=CC=C1NC(=O)CN(C)C2=NC(=NO2)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.786

>  <W2 Pf proliferation inhibition EC50 uM>
0.449

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2139
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
    3.1617    9.0422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7937    9.5725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5689    9.2903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2009    9.8206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9761    9.5384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1194    8.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8947    8.4438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0379    7.6313    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8132    7.3492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9564    6.5367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3244    6.0064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9564    5.4761    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5492    6.2886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4059    7.1010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9119    5.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3244    4.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9119    3.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    3.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5349    3.2499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8675    4.4059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6744    4.5775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0869    5.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4874    8.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7122    8.4778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 11 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  4  0  0  0  0
 15 23  4  0  0  0  0
 20 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  4  0  0  0  0
 34 35  4  0  0  0  0
 27 35  4  0  0  0  0
  6 36  4  0  0  0  0
 36 37  4  0  0  0  0
  3 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2139

>  <JC_XSMILES>
CCC1=CC=C(CN2CCC(O)(CC2)C3=CC=C4OC(=CC4=C3)C(=O)NC5=CC=C6OCOC6=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.359

>  <W2 Pf proliferation inhibition EC50 uM>
0.46

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.27

>  <Powder data?>
Yes

>  <IFI value>
0.068965517

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2151
  Mrv1591402191617072D          

 35 39  0  0  1  0            999 V2000
    7.5171   -5.2875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8680   -4.7784    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9880   -3.8450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3425   -3.2192    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.4515   -2.6357    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6858   -2.1229    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.7464   -1.3035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3600   -2.3725    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.0466   -2.1805    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2850   -1.3907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7203   -0.7893    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0882   -1.2023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3267   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1299   -0.2241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6946   -0.8255    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4978   -0.6371    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7363    0.1527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0626   -1.2385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8241   -2.0283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0209   -2.2167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7825   -3.0065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3472   -3.6079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9793   -3.1949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7408   -3.9847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3056   -4.5861    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9376   -4.1731    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3729   -3.5717    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5697   -3.7601    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.4533   -4.5768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1024   -5.0860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0049   -3.1587    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.2313   -3.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0369   -2.4342    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.2119   -2.4397    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6196   -1.7225    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  4  3  1  0  0  0  0
  4  5  1  6  0  0  0
  6  5  1  0  0  0  0
  6  7  1  1  0  0  0
  8  7  1  1  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 12 10  1  4  0  0  0
 12 13  2  0  0  0  0
 14 13  1  4  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 23 24  1  4  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 28 27  1  0  0  0  0
 28  4  1  0  0  0  0
 28 29  1  6  0  0  0
 29 30  1  0  0  0  0
  2 30  1  0  0  0  0
 31 28  1  0  0  0  0
 31  8  1  0  0  0  0
 31 32  1  1  0  0  0
 31 33  1  0  0  0  0
 33  6  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 35  1  1  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2151

>  <JC_XSMILES>
CC1=C[C@H]2O[C@@H]3C[C@H]4OC(=O)C=CC=CC(=O)OCCC(C)=CC(=O)OC[C@@]2(CC1)[C@]4(C)[C@]35CO5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00391

>  <W2 Pf proliferation inhibition EC50 uM>
0.00918

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.2064

>  <Powder data?>
No

>  <IFI value>
0.226415094

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2203
  Mrv1591402191617072D          

 46 52  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8917   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1466   -5.9614    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4792   -6.4463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8117   -5.9614    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4792   -7.2713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1936   -7.6838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1936   -8.5088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4792   -8.9213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7647   -8.5088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7647   -7.6838    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4792   -9.7463    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1936  -10.1588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7647  -10.1588    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3766   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0410   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5260   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3464   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6820   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1971   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 20 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 12 39  4  0  0  0  0
 39 40  4  0  0  0  0
 10 40  4  0  0  0  0
 39 41  1  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 41 46  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  23
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  40
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2203

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)C2=NC(C3=CC=C(C=C3)C4=C(N=C(N4)C5=CC=C(C=C5)N(C)C)C6=CC=CC=C6)=C(N2)C7=CC=CC=C7

>  <PF proliferation inhibition 3D7 EC50 uM>
7.82

>  <W2 Pf proliferation inhibition EC50 uM>
2.907

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
68.37

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2209
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    6.8913    0.0616    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768   -1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623   -1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -1.4308    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083   -2.2155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2603   -2.8285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0673   -2.6570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6194   -3.2701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3644   -4.0547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5574   -4.2263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3025   -5.0109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4955   -5.1824    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9435   -4.5693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1984   -3.7847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0054   -3.6132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783   -0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533   -0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633   -0.0960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7083    0.6887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479   -0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  8 17  4  0  0  0  0
 12 17  4  0  0  0  0
  6 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2209

>  <JC_XSMILES>
BrC1=CC=C2N(CC3=CC=CC4=CC=CC=C34)C(=O)C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
4.23

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2223
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 23 24  1  0  0  0  0
 10 24  4  0  0  0  0
 24 25  4  0  0  0  0
  7 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2223

>  <JC_XSMILES>
C=CCNC(=O)C1=CC=C2CN(CCOC3=CC=CC=C3)C=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.441

>  <W2 Pf proliferation inhibition EC50 uM>
0.419

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024691358

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2252
  Mrv1591402191617072D          

 31 32  0  0  0  0            999 V2000
   -5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -8.2500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -9.4875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.2500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 23 30  4  0  0  0  0
 18 31  4  0  0  0  0
 13 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2252

>  <JC_XSMILES>
CCCCN(C)CCCNC(=O)C1=CC=C(Cl)C(NC(=O)NC2=CC=C(Cl)C(Cl)=C2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2331

>  <W2 Pf proliferation inhibition EC50 uM>
0.822

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.28

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2256
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7679   -2.3346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5884   -2.2483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0733   -2.9158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7378   -3.6695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  5  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 11 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
  9 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2256

>  <JC_XSMILES>
CC1=CC=C(C=C1)N=C2SC(=C/C3=CC=CC=C3)\C(=O)N2C4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.737

>  <W2 Pf proliferation inhibition EC50 uM>
0.404

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012048193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2287
  Mrv1591402191617072D          

 41 46  0  0  0  0            999 V2000
   -3.7923   -1.1767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0638   -1.5638    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3642   -1.1265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3932   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937    0.1353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9651   -0.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9362   -1.0763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2076   -1.4635    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4919   -1.0261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2204   -1.4133    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4629   -0.2017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1725    0.3212    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0841    1.2649    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6349    1.1456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4025    1.4739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8583    0.7254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0550    0.3597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8811    0.4621    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4594   -0.1263    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9973    1.2836    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7337    1.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7800    2.4791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5165    2.8509    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5627    3.6746    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2992    4.0464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9894    3.5945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9432    2.7708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2067    2.3990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2637    1.6800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1776    2.5005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8451    2.9853    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4239    2.8361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3378    3.6566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4158    3.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5019    4.8128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1656    5.2976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9193    4.9619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5868    5.4468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0054    4.1414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7590    3.8058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6357   -1.5137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 12 16  1  0  0  0  0
 14 17  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
 20 29  1  0  0  0  0
 14 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 37 39  1  0  0  0  0
 33 39  1  0  0  0  0
 39 40  1  0  0  0  0
  7 41  4  0  0  0  0
  3 41  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2287

>  <JC_XSMILES>
CSC1=CC=CC(NC(=O)C2C3OC4(C=C3)C2C(=O)N(CCN5CCCCC5)C4C(=O)NC6CCCC(C)C6C)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.1

>  <W2 Pf proliferation inhibition EC50 uM>
1.904

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.13

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-229
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
  9 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 17 25  4  0  0  0  0
 25 26  4  0  0  0  0
  7 26  4  0  0  0  0
 26 27  4  0  0  0  0
  4 27  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-229

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C2N=C(NC3CCCCC3)C(NC4CCCCC4)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
2.487

>  <W2 Pf proliferation inhibition EC50 uM>
2.645

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.68

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2296
  Mrv1591402191617072D          

 16 16  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2296

>  <JC_XSMILES>
ClCC(=O)NCCOC1=CC=C(Cl)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.538

>  <W2 Pf proliferation inhibition EC50 uM>
0.511

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.95

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2314
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -2.2501    8.4777    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    1.8053    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    1.0206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    1.8053    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538    0.3532    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1087   -0.4314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4413   -0.9163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7738   -0.4314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0288    0.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5438    1.0206    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  1  0  0  0  0
 26 27  2  0  0  0  0
  5 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2314

>  <JC_XSMILES>
ClC1=CC=C(CCNC(=O)C2CCCN(C2)C3=NN=C(S3)N4CCCC4=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.89

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.020408163

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2315
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2315

>  <JC_XSMILES>
ClC1=CC=C(NC(=O)OC2=CC=CC=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.014

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
51.9

>  <Powder data?>
Yes

>  <IFI value>
0.048

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2320
  Mrv1591402191617072D          

 14 14  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2320

>  <JC_XSMILES>
CC(=NNC(=S)NN)C1=CC=CC=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.366

>  <W2 Pf proliferation inhibition EC50 uM>
0.386

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2329
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 11 16  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2329

>  <JC_XSMILES>
CC1=C2C=CC=CC2=C(C)C3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.803

>  <W2 Pf proliferation inhibition EC50 uM>
0.827

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
21.61

>  <Powder data?>
Yes

>  <IFI value>
0.037593985

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2339
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    3.2789    7.0125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0150   -2.6088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4630   -1.9957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7179   -1.2111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2339

>  <JC_XSMILES>
FC1=CC=C(C=C1)N2CCN(CC2)C3=NC=NC4=C3C=NN4C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.78

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2348
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6144   -3.1605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2788   -2.4068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4584   -2.4930    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
  6 35  4  0  0  0  0
 35 36  4  0  0  0  0
  3 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2348

>  <JC_XSMILES>
COC1=CC=C(NC(=O)CCCCCN2C(=O)C3=C(C=CS3)N=C2SCC(=O)C4=CC=CC=C4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.119

>  <W2 Pf proliferation inhibition EC50 uM>
3.76

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2367
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -0.7145    2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  9 24  4  0  0  0  0
  5 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2367

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC(=S)N2CCCC2C3=CC=NC=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.327

>  <W2 Pf proliferation inhibition EC50 uM>
0.37

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2375
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5253   -1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2704   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4454   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1904   -1.1651    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  1  0  0  0  0
 22 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2375

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CC(NC(=O)C2=CC=CS2)=CC=C1N3CCC4=CC=CC=C4C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.349

>  <W2 Pf proliferation inhibition EC50 uM>
0.0327

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.893

>  <Powder data?>
No

>  <IFI value>
0.010869565

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2382
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -1.1439   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -3.8913    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9186   -3.8913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9186   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5564   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1561   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -2.5093    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3861   -1.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9381   -1.1116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5691   -2.3518    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -3.8442    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
 24 25  1  0  0  0  0
 14 25  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2382

>  <JC_XSMILES>
CCN1C(\C=CC2=CC=CC=C12)=C\C3=[N+](CC)C4=CC(I)=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.55

>  <W2 Pf proliferation inhibition EC50 uM>
0.364

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2402
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.3501   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1602   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7003   -2.0171    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9703   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5104   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0505   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8606   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4007   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1307   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2109   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7510   -0.6139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4809    0.1657    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0210    0.7893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8311    0.6334    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1012   -0.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9113   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.1814   -1.0816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6413   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8311   -1.5493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.5611   -0.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9113   -2.4848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7214   -2.6407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.9915   -3.4202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4514   -4.0439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6413   -3.8880    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3712   -3.1084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2402

>  <JC_XSMILES>
CCN(CC)CCCC(C)NC1=CC=NC2=CC=C(C=C12)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2638

>  <W2 Pf proliferation inhibition EC50 uM>
0.359

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2403
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    4.8229    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  9 18  4  0  0  0  0
  2 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2403

>  <JC_XSMILES>
CC1=NC2=NC=NN2C(NC3=CC=C(I)C=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.565

>  <W2 Pf proliferation inhibition EC50 uM>
3.59

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2418
  Mrv1591402191617072D          

 28 31  0  0  1  0            999 V2000
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9697    0.0000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    8.6842   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3987    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1131   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1131   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3987   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6842   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  7 17  4  0  0  0  0
 11 17  4  0  0  0  0
  2 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 22 21  1  0  0  0  0
 22 20  1  0  0  0  0
 22 23  1  1  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2418

>  <JC_XSMILES>
CN(CCCNC1=CC=NC2=CC(Cl)=CC=C12)C(=O)C3C[C@H]3C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0761

>  <W2 Pf proliferation inhibition EC50 uM>
0.411

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>11.58

>  <Powder data?>
No

>  <IFI value>
0.08490566

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2450
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2450

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2N(C)C3=CC=CC=C3N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2495

>  <W2 Pf proliferation inhibition EC50 uM>
0.344

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02739726

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2462
  Mrv1591402191617072D          

 40 43  0  0  0  0            999 V2000
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0418   -2.5519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5938   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1813   -3.8795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3744   -3.7080    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 19 23  4  0  0  0  0
 17 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 30 37  4  0  0  0  0
 24 38  4  0  0  0  0
 38 39  4  0  0  0  0
 14 39  4  0  0  0  0
 39 40  4  0  0  0  0
 11 40  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2462

>  <JC_XSMILES>
CC(C)OCCCNC(=O)C1=CC=C2C(=O)N(CC3=CC=CO3)C(SCC(=O)NC4=CC=C(C)C(Cl)=C4)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.938

>  <W2 Pf proliferation inhibition EC50 uM>
0.34

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2486
  Mrv1591402191617072D          

 36 42  0  0  0  0            999 V2000
    2.2809   -6.6084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5664   -6.1960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8520   -6.6085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1375   -6.1960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1374   -5.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8519   -4.9585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8518   -4.1335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5663   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5662   -2.8960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2808   -4.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2808   -4.9584    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5664   -5.3710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9952   -3.7209    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9952   -2.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7096   -2.4833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4241   -2.8958    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4242   -3.7208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7097   -4.1333    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1386   -2.4833    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1385   -1.6583    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8530   -1.2457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5675   -1.6582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2819   -1.2456    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5675   -2.4832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8531   -2.8957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 15 16  1  0  0  0  0
 14 15  1  0  0  0  0
 13 18  1  0  0  0  0
 11 19  1  0  0  0  0
 17 18  1  0  0  0  0
 15 20  1  0  0  0  0
 17 19  1  0  0  0  0
 16 17  1  0  0  0  0
 11 20  1  0  0  0  0
 13 14  1  0  0  0  0
  8 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
  6 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 30 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2486

>  <JC_XSMILES>
CC1=CC=CC2=CC(CNC34CC5CC(CC(C5)C3)C4)=C(N=C12)N6CCC(CC6)N7CCC(O)CC7

>  <PF proliferation inhibition 3D7 EC50 uM>
0.793

>  <W2 Pf proliferation inhibition EC50 uM>
0.1632

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.9

>  <Powder data?>
No

>  <IFI value>
0.029126214

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2488
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  7 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
  6 25  4  0  0  0  0
 18 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2488

>  <JC_XSMILES>
CCOC(=O)C1=C(CNC2=CC=NC=C2)N(C)C3=CC(Br)=C(O)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.315

>  <W2 Pf proliferation inhibition EC50 uM>
0.333

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2493
  Mrv1591402191617072D          

 30 33  0  0  1  0            999 V2000
   -2.5797   -0.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4082   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0213   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6236   -1.8980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652   -3.2570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8974   -4.4120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7179   -4.3257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0535   -3.5721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5685   -2.9046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9041   -2.1510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7246   -2.0647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2095   -2.7322    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8739   -3.4858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  7  5  1  1  0  0  0
  7  8  1  0  0  0  0
  9  8  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
  9 23  1  6  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2493

>  <JC_XSMILES>
CC(C)NC(=O)[C@@H]1C[C@H](CN1CC2=CC=C3C=CC=CC3=C2)NCC4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>10.93

>  <W2 Pf proliferation inhibition EC50 uM>
3.31

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2500
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    8.5003   -1.7771    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.3646    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -0.8853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -0.1006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  5 30  4  0  0  0  0
 30 31  4  0  0  0  0
  2 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2500

>  <JC_XSMILES>
FC1=CC=C(NC(=O)N2CCN(CC2)C3=NN4C(C=C3)=NN=C4C5=CC=CC=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.29

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2556
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
   -1.9512   -2.7058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9511   -3.5308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2366   -3.9432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2366   -4.7682    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5221   -5.1807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1924   -4.7682    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5220   -6.0057    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1924   -6.4182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9069   -6.0056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6214   -6.4181    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3358   -6.0055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0503   -6.4180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0504   -7.2430    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3359   -7.6555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6214   -7.2431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7649   -7.6555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7649   -8.4805    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793   -7.2429    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793   -6.4179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7439   -6.7916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1933   -6.0013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1933   -5.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9288   -4.8802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6644   -5.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6644   -6.0013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9288   -6.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2149   -6.7916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793   -5.6705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2365   -6.4182    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9510   -6.0058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6654   -6.4183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3799   -6.0058    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0944   -6.4184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8089   -6.0059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8089   -5.1809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0945   -4.7684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3800   -5.1808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6655   -4.7683    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9510   -5.1808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 23 24  1  0  0  0  0
 22 23  1  0  0  0  0
 21 26  1  0  0  0  0
 19 27  1  0  0  0  0
 25 26  1  0  0  0  0
 23 28  1  0  0  0  0
 25 27  1  0  0  0  0
 24 25  1  0  0  0  0
 19 28  1  0  0  0  0
 21 22  1  0  0  0  0
  7 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2556

>  <JC_XSMILES>
CCCCC(=O)N(CCN1CCN(CC1)C(=O)NC23CC4CC(CC(C4)C2)C3)C\C=C\C5=CC=CC=C5OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.449

>  <W2 Pf proliferation inhibition EC50 uM>
0.3131

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.027522936

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2560
  Mrv1591402191617072D          

 39 43  0  0  0  0            999 V2000
   -5.1659    0.0165    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.3409    0.0165    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.9284    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.5306   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1806   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.9521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5784   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4034   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8159   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6409   -2.8414    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5784   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 13 28  4  0  0  0  0
 10 28  4  0  0  0  0
  6 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 37 38  4  0  0  0  0
 32 38  4  0  0  0  0
 30 39  4  0  0  0  0
  4 39  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2560

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(NC(=O)C2=NN3C(N=C(C=C3C(F)(F)F)C4=CC=CC=C4)=N2)=CC(OC5=CC=C(F)C=C5)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
3.114

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2565
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.9820    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  9 18  4  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
  7 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2565

>  <JC_XSMILES>
BrC1=CC=C2N=C(C=C(C(=O)NC3=NOC=C3)C2=C1)C4=CC=CN=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.969

>  <W2 Pf proliferation inhibition EC50 uM>
2.512

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>81.04

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2580
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    5.2520   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355    0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  7 19  4  0  0  0  0
 11 19  4  0  0  0  0
  8 20  1  0  0  0  0
  3 20  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2580

>  <JC_XSMILES>
COC1=CC(=O)C2=C(C=CC3=C(OC)C(O)=CC=C23)C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1996

>  <W2 Pf proliferation inhibition EC50 uM>
0.3018

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.122807018

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2617
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9293    3.5549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4143    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9293    2.2201    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
 14 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 12 31  4  0  0  0  0
 31 32  4  0  0  0  0
  8 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2617

>  <JC_XSMILES>
CN1CCN(CC1)C2=CC(C)=C3C=C(NC(=O)\C=C\C4=CC=C5OCOC5=C4)C=CC3=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.2924

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2647
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  2  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2647

>  <JC_XSMILES>
CCN(CC)C1=[S+]C(=CS1)C2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3032

>  <W2 Pf proliferation inhibition EC50 uM>
0.725

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.38

>  <Powder data?>
Yes

>  <IFI value>
0.030769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2650
  Mrv1591402191617072D          

 11 11  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2650

>  <JC_XSMILES>
OC(=O)C1=C(F)C=CC=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.73

>  <W2 Pf proliferation inhibition EC50 uM>
2.847

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2671
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.9354    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    7.0714    2.3479    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.3569    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  6 10  4  0  0  0  0
 10 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2671

>  <JC_XSMILES>
CN1C(=O)C2=C(CCS2)N=C1SCC3=CC=CC(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
3.28

>  <W2 Pf proliferation inhibition EC50 uM>
2.789

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-268
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-268

>  <JC_XSMILES>
CC1=CC(NC2=CC=C(Br)C=C2)=NC3=CC=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.689

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.075757576

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2691
  Mrv1591402191617072D          

 19 22  0  0  0  0            999 V2000
    2.4406    1.7485    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2780    0.9396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971    0.3944    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7166    0.4897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1942    1.1624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0155    1.0852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3594    0.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8818   -0.3374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0605   -0.2602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4535   -0.8190    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5488   -1.6385    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7345   -0.4144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9528   -0.6780    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3336   -0.1327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5519   -0.3963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0673    0.1489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0953    0.9577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8771    1.2213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4962    0.6761    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
  3 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2691

>  <JC_XSMILES>
O=C1N2C3=CC=CC=C3C(=O)C2=NC4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2117

>  <W2 Pf proliferation inhibition EC50 uM>
0.2756

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.02189781

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2703
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 15 22  4  0  0  0  0
 22 23  4  0  0  0  0
 12 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  2  0  0  0  0
M  CHG  4   1  -1   2   1  24   1  25  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2703

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)C(=O)C2=CC=C(N3CCOCC3)C(=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
4.2

>  <W2 Pf proliferation inhibition EC50 uM>
2.725

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2709
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  8 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2709

>  <JC_XSMILES>
NCCC(=O)N1CC(C2=CC=CC=C2)C3=CC=CC=C3C1CN4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.342

>  <W2 Pf proliferation inhibition EC50 uM>
0.2307

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.52

>  <Powder data?>
No

>  <IFI value>
0.042253521

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2729
  Mrv1591402191617072D          

 34 39  0  0  0  0            999 V2000
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2046   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7566   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5017   -2.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3053   -2.7260    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8573   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6024   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5602   -3.5106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3672   -3.6821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6221   -4.4668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4291   -4.6383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9811   -4.0252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7262   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9192   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0082   -4.1237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7988   -3.9522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3508   -4.5653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0959   -5.3499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2889   -5.5214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2631   -4.9083    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
  9 14  4  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 21 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
  7 34  4  0  0  0  0
  3 34  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2729

>  <JC_XSMILES>
COC1=CC=C2C(NC3=C(N=CN=C23)N4CCN(CC4)C(C5=CC=CC=C5)C6=CC=CC=C6)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.339

>  <W2 Pf proliferation inhibition EC50 uM>
0.435

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.29

>  <Powder data?>
Yes

>  <IFI value>
0.087719298

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2731
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
  -10.1526    2.0412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.3321    2.1274    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9966    2.8811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -8.1761    2.9673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8405    3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0201    3.8072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5351    3.1398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8707    2.3861    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.6912    2.2999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7147    3.2260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1626    2.6129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4089    2.9485    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4952    3.7690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7415    4.1045    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1895    3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3645    3.4914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9520    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3645    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1895    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6020    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.4914    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1105    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5230    1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3480    1.3480    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605    0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5855    0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7605    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5855    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3022    3.9405    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 12 20  4  0  0  0  0
 15 20  4  0  0  0  0
 17 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 13 31  4  0  0  0  0
 10 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2731

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2=CN3C(SC4=CC(=CC=C34)C(=O)NCCN(CC)CC)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.766

>  <W2 Pf proliferation inhibition EC50 uM>
1.268

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.51

>  <Powder data?>
Yes

>  <IFI value>
0.103448276

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2732
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
   -5.0013   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -9.4875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447  -10.7250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -10.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  2  0  0  0  0
 29 31  4  0  0  0  0
 21 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2732

>  <JC_XSMILES>
CCCCCCCCCC(=O)N1CCN(CC1)C(CC)C2=NC3=CC=CC=C3C(=O)N2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2827

>  <W2 Pf proliferation inhibition EC50 uM>
0.2667

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046296296

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2736
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    7.1447   -6.6000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.0125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -9.4875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -8.7730    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138  -10.2020    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -10.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -9.4875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 26 35  4  0  0  0  0
 35 36  4  0  0  0  0
 23 36  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2736

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)S(=O)(=O)N2CCN(CC2)CC(=O)NC3=CC=C(OCC4=CC=CC=C4)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.91

>  <W2 Pf proliferation inhibition EC50 uM>
2.654

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2739
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 12 18  4  0  0  0  0
  7 19  4  0  0  0  0
  2 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2739

>  <JC_XSMILES>
CC1=CC(C)=NC(NC(=N)NC2=CC=CC(O)=C2)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.92

>  <W2 Pf proliferation inhibition EC50 uM>
2.652

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010526316

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2769
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -4.8395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0405   -5.4394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5925   -6.0525    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1800   -6.7670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3731   -6.5955    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
  5 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 21 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 18 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2769

>  <JC_XSMILES>
CC1=CC=C(C=C1S(=O)(=O)NCC2CCCO2)C3=NN=C(NCC4=CC=CC=C4)C5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
1.851

>  <W2 Pf proliferation inhibition EC50 uM>
2.57

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.029411765

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-277
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    4.0681   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7826   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7826   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4971   -0.0552    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2116   -0.4677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2116   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9260   -1.7052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6405   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3550   -2.5302    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.0694   -1.2927    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.7839   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4984   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.2128   -1.7052    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.9273   -1.2927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0136   -0.4722    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.8205   -0.3007    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   12.5656    0.4839    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.5742    0.0349    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.2330   -1.0152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.0400   -1.1867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2949   -1.9713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.7429   -2.5844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.9359   -2.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.6810   -1.6283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4971   -1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  2  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 15 25  1  0  0  0  0
 20 25  4  0  0  0  0
  6 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-277

>  <JC_XSMILES>
CC1=CC=CC(OCC(=O)NCCNC2=NS(=O)(=O)C3=CC=CC=C23)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.121

>  <W2 Pf proliferation inhibition EC50 uM>
1.677

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2782
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    5.6091    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -3.0215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2827   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6183   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1333   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3129   -5.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9773   -5.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4622   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0775   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8980   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3829   -5.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -5.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5323   -6.4759    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.1968   -7.2296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6817   -7.8970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3461   -8.6507    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5256   -8.7369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0407   -8.0695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3763   -7.3158    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2269   -5.8947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7420   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
  5 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 14 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
 26 34  4  0  0  0  0
 34 35  4  0  0  0  0
 23 35  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2782

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1O)C2=NC(=C(N2)C3=CC=CC=C3)C4=CC=C(SC5=CC=CC=C5)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.278

>  <W2 Pf proliferation inhibition EC50 uM>
1.636

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
64.32

>  <Powder data?>
Yes

>  <IFI value>
0.046511628

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2800
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    5.2520    1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645    0.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520    0.1401    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    0.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -0.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -0.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    0.1401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    0.1401    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    0.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.8546    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    2.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    2.9980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    4.4270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5185    4.5132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6900    5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0244    5.7327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6375    5.1806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    2.2836    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520    4.4270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4895    3.7125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.2520    2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270    2.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770    1.5691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145    0.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  1  0  0  0  0
 13 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
 11 31  4  0  0  0  0
 31 32  4  0  0  0  0
  7 32  4  0  0  0  0
 32 33  4  0  0  0  0
  4 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2800

>  <JC_XSMILES>
CCOC1=CC=C2NC(=O)C(CN(CCN3CCCC3)C(=S)NC4=CC=C(F)C=C4)=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.824

>  <W2 Pf proliferation inhibition EC50 uM>
2.514

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.033613445

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2816
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
  3 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  2  0  0  0  0
 30 32  4  0  0  0  0
 22 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2816

>  <JC_XSMILES>
CCC(N(CCC1=CC=CC=C1)C(=O)C2=CC=C(F)C=C2)C3=NC4=CC=CC=C4C(=O)N3C5=CC=CC=C5OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.018

>  <W2 Pf proliferation inhibition EC50 uM>
0.1797

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>7.25

>  <Powder data?>
No

>  <IFI value>
0.031914894

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2823
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8871   -5.0906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2227   -4.3369    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3721   -5.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1971   -5.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4520   -6.5426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7846   -7.0275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1171   -6.5426    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  1  0  0  0  0
  2 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 24 28  4  0  0  0  0
 20 29  4  0  0  0  0
 29 30  4  0  0  0  0
 17 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2823

>  <JC_XSMILES>
CC(OC1=CC=C(Cl)C=C1Cl)C2=NC(=NO2)C3=CC=C(NC(=O)C4=CC=CS4)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.429

>  <W2 Pf proliferation inhibition EC50 uM>
0.631

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
25.62

>  <Powder data?>
Yes

>  <IFI value>
0.046153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-283
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 11 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
 23 33  4  0  0  0  0
 33 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-283

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C(NC(=O)COC2=CC=CC=C2)C3=CC(Cl)=C4C=CC=NC4=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
4.66

>  <W2 Pf proliferation inhibition EC50 uM>
3.079

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.51

>  <Powder data?>
Yes

>  <IFI value>
0.125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2831
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -5.0013    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.1460    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8605    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8605    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.1460    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 19 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2831

>  <JC_XSMILES>
OC1=CC=CC=C1NC(=O)C2=CC=C(C=C2)C(=O)N(C3CCCCC3)C4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.47

>  <W2 Pf proliferation inhibition EC50 uM>
>2.449

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2843
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.5229    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
  5 19  4  0  0  0  0
  3 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2843

>  <JC_XSMILES>
CC1=C(SC2=C1C(=O)N(CC3=CC=CC=C3Cl)C=N2)C(=O)NC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
5.4

>  <W2 Pf proliferation inhibition EC50 uM>
2.415

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2845
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0032   -5.3493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8237   -5.4355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4817   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2267   -6.8013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5579   -7.0563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8942   -7.2863    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5616   -6.8013    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3067   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7916   -5.3493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6121   -5.4355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0970   -4.7681    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7615   -4.0144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9410   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4560   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0915   -0.7027    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  6 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 25 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2845

>  <JC_XSMILES>
CSC1=NN=C(CCNC(=O)C2=C(C)ON=C2C3=CC=CC=C3)N1C4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
2.408

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.010416667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2850
  Mrv1591402191617072D          

 32 35  0  0  1  0            999 V2000
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 23 11  1  0  0  0  0
 23 24  1  0  0  0  0
  8 24  1  0  0  0  0
 23 25  1  1  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2850

>  <JC_XSMILES>
CC1=CC=C(C=C1)N2CCN(CCNCC3=CC=C(F)C=C3)[C@H](C2)CC4=CC=C(O)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.443

>  <W2 Pf proliferation inhibition EC50 uM>
0.2398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024691358

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2863
  Mrv1591402191617072D          

 37 42  0  0  0  0            999 V2000
   -2.1071    0.7019    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.3926    1.1144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3926    1.9394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6781    2.3519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0364    1.9394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0363    1.1144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6782    0.7019    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6782   -0.1231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0108   -0.6081    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2657   -1.3927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0907   -1.3926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3456   -0.6080    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -2.0601    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2401   -2.8137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7251   -3.4812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5456   -3.3949    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8811   -2.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3961   -1.9738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5189   -1.6476    0.0000 P   0  3  0  0  0  0  0  0  0  0  0  0
    1.3035   -1.9026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9166   -1.3506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7012   -1.6056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8727   -2.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2596   -2.9645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4750   -2.7096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2639   -2.4322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8159   -3.0454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5610   -3.8300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2460   -4.0015    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7980   -3.3884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5431   -2.6037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7739   -0.8630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2218   -0.2499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4768    0.5347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2838    0.7062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8358    0.0931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5808   -0.6915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 19 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 19 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  CHG  1  19   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2863

>  <JC_XSMILES>
ClC1=CC=CC=C1C2=NC(=C(O2)N3CCOCC3)[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.35

>  <W2 Pf proliferation inhibition EC50 uM>
0.2379

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.09

>  <Powder data?>
Yes

>  <IFI value>
0.259259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2870
  Mrv1591402191617072D          

 32 37  0  0  0  0            999 V2000
    7.4232    7.3365    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107    6.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4232    5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0107    5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857    5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    5.9076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1857    6.6221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7732    4.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1088    3.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9528    4.3924    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 13 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
 22 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  23
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2870

>  <JC_XSMILES>
NC1=CC=C(C=C1)C2=NC3=CC=C(C=C3N2)C4=CC=C5N=C(NC5=C4)C6=CC=C(N)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.579

>  <W2 Pf proliferation inhibition EC50 uM>
0.234

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.272727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2881
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -7.2160   -3.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7310   -2.8201    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9106   -2.9063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4256   -2.2389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6052   -2.3251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2696   -3.0788    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7545   -3.7462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5750   -3.6600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0599   -4.3274    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8804   -4.2412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4491   -3.1650    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8971   -2.5519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2296   -3.7080    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0366   -3.8795    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  4  0  0  0  0
 26 35  4  0  0  0  0
 35 36  4  0  0  0  0
 22 36  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2881

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2=CC(=NN2)C3CCN(CC3)C4=NC(N)=C5C=C(OC)C(OC)=CC5=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2023

>  <W2 Pf proliferation inhibition EC50 uM>
0.379

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
16.36

>  <Powder data?>
Yes

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2909
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
  2 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2909

>  <JC_XSMILES>
CC1=CC=C2N=C3N=C4C(C)=CC=CC4=C(N)C3=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1018

>  <W2 Pf proliferation inhibition EC50 uM>
0.1567

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.94

>  <Powder data?>
Yes

>  <IFI value>
0.089552239

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2929
  Mrv1591402191617072D          

 28 32  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846    1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9195    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5070   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7445    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1570   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2195   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6320   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2195   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945   -2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820   -1.7309    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945    1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9820    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3945    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2195    3.2704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6320    2.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2195    1.8414    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 12 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  4 28  1  0  0  0  0
  1 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2929

>  <JC_XSMILES>
C1COC2(CCN(CC2)C3=CC(=NC(=N3)C4=CC=CC=N4)C5=CC=CC=N5)O1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.42

>  <W2 Pf proliferation inhibition EC50 uM>
0.2228

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2953
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6116   -0.3356    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1636    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9841    0.1913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7511    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9441    0.8205    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  4  0  0  0  0
  8 23  4  0  0  0  0
  2 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  21
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2953

>  <JC_XSMILES>
CN(CC(O)COC1=CC=C(CNCCC2=NC(C)=CN2)C=C1)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.483

>  <W2 Pf proliferation inhibition EC50 uM>
1.19

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.76

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2954
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  3 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
  2 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2954

>  <JC_XSMILES>
CC1=C(CC(=O)C2=CC=CC=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.663

>  <W2 Pf proliferation inhibition EC50 uM>
0.3005

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.84

>  <Powder data?>
Yes

>  <IFI value>
0.074074074

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2956
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    7.6391    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
  7 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2956

>  <JC_XSMILES>
COC1=CC=CC(CN2CCC3=C(C2)SC(=N3)N4CCCCC4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.52

>  <W2 Pf proliferation inhibition EC50 uM>
0.2165

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.097222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2958
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
    2.4922   -7.1230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3023   -6.9671    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8424   -7.5907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3825   -6.0316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6525   -5.2520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4627   -5.0961    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7327   -4.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1926   -3.6929    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5428   -4.1607    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0829   -4.7843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8129   -5.5639    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3530   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1631   -6.0316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0829   -6.9671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8129   -3.3811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6230   -3.2252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8931   -2.4457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7032   -2.2897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9732   -1.5102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4332   -0.8865    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7834   -1.3543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.3235   -1.9779    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1336   -1.8220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0534   -2.7575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2433   -2.9134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9732   -3.6929    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1631   -3.8488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8931   -4.6284    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 10 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 17 28  4  0  0  0  0
 28 29  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  27
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2958

>  <JC_XSMILES>
CN(C)CCCNC(=S)N(CCN(C)C)CC1=CC2=C(C)C=C(C)C=C2NC1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
2.013

>  <W2 Pf proliferation inhibition EC50 uM>
2.154

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2978
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559    0.5230    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309    1.9520    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 12 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 10 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2978

>  <JC_XSMILES>
COC1=CC=CC=C1NC2=CC(=NS(=O)(=O)C3=CC=CC=C3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2245

>  <W2 Pf proliferation inhibition EC50 uM>
0.2884

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
13.59

>  <Powder data?>
Yes

>  <IFI value>
0.214285714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2979
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.9820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2460   -5.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4255   -5.5632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5815   -6.4032    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0966   -7.0706    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4322   -7.8243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9473   -8.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2828   -9.2454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7979   -9.9128    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0226   -9.8266    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3581   -9.0729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1268   -8.4055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 18 17  1  4  0  0  0
 18 19  2  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2979

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C2=NNC(=C2)C(=O)NN=CC3=CC=NC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.13

>  <W2 Pf proliferation inhibition EC50 uM>
2.12

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-298
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
  9 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-298

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2N=C(N)N=C(N)N2C3=CC=C(C)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0738

>  <W2 Pf proliferation inhibition EC50 uM>
>1.638

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.01369863

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2984
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    6.3235    0.2277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -1.0098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -1.4223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -1.0098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -2.2473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5620   -2.7322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3467   -2.4773    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3071   -3.5169    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7920   -4.1843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4821   -3.5169    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9972   -4.1843    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2272   -2.7322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4425   -2.4773    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.6975   -1.6927    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1876   -3.2619    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6579   -2.2224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0448   -2.7744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2602   -2.5195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0887   -1.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7018   -1.1605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4864   -1.4154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5302   -0.3535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7456   -0.0985    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433    0.1986    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9718    1.0055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5849    1.5576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3695    1.3026    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5410    0.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9279   -0.0564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9826    1.8546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8111    2.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4242    3.2137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2088    2.9587    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3803    2.1517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1649    1.8968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7672    1.5997    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9388    0.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
  6 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  2  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 25 30  1  0  0  0  0
 28 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 31 37  4  0  0  0  0
 37 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2984

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(C)C(C)=C1S(=O)(=O)N2CCCC(C2)C(=O)N3CCN(CC3)C4=CC=CC(C)=C4C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.923

>  <W2 Pf proliferation inhibition EC50 uM>
2.115

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2989
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    4.0865   -6.8107    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -6.0963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240   -6.0963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -5.3818    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -4.6673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240   -4.6673    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -3.9529    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -2.5239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615   -2.5239    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -3.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615   -3.9529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -4.6673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -1.8094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0240   -1.8094    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2615   -1.0950    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0240   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7545   -0.7930    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7545    0.0320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1414    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3129    1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0975    1.6459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7106    1.0939    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5391    0.2869    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865   -1.0950    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4990   -0.3805    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0865    0.3340    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240   -0.3805    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7365    0.3340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3240    1.0484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7365    1.7629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5615    1.7629    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9740    1.0484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5615    0.3340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7990    1.0484    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6240    1.0484    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 12 13  1  0  0  0  0
 10 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
 21 26  4  0  0  0  0
 16 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
 35 37  1  0  0  0  0
 37 38  3  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-2989

>  <JC_XSMILES>
CC(C)NC(=O)N1CCN(CC1C)C(=O)C(CC2=CNC3=CC=CC=C23)NC(=O)NC4=CC=CC(=C4)C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0567

>  <W2 Pf proliferation inhibition EC50 uM>
0.2106

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.018348624

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-2997
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.3041   -3.3167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3090   -2.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1160   -2.9362    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5285   -2.2217    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9765   -1.6086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1480   -0.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5349   -0.2496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7064    0.5574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4910    0.8123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6626    1.6193    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1041    0.2603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9326   -0.5467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5457   -1.0987    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  1  0  0  0  0
  5 14  4  0  0  0  0
  2 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 18 24  4  0  0  0  0
 24 25  4  0  0  0  0
 15 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-2997

>  <JC_XSMILES>
CC1=NOC(C2=CC=C(O)C=C2O)=C1C3=CC=C4OCCCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.47

>  <W2 Pf proliferation inhibition EC50 uM>
0.2086

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.035714286

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3006
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -6.2980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -7.7270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3006

>  <JC_XSMILES>
NC1=NC=C(Br)C=C1S(=O)(=O)NCCC(=O)N2CCC(=CC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.384

>  <W2 Pf proliferation inhibition EC50 uM>
1.016

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
48.92

>  <Powder data?>
Yes

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3013
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7825   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9966   -3.8404    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5117   -3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9966   -2.5055    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  17
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3013

>  <JC_XSMILES>
CCOC(=O)C1=C(O)C2=C(OC)C=CC=C2N=C1C3=CC=C4OCOC4=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.215

>  <W2 Pf proliferation inhibition EC50 uM>
0.206

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3043
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2309    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0379    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4504    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8984   -0.3356    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3043

>  <JC_XSMILES>
CCOC1=CC=C2N=C3C=C(NCC4=CC=CO4)C=CC3=C(N)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.846

>  <W2 Pf proliferation inhibition EC50 uM>
0.757

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
37.87

>  <Powder data?>
Yes

>  <IFI value>
0.074626866

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3049
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  2  0  0  0  0
  2  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
  6 21  1  0  0  0  0
 21 22  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3049

>  <JC_XSMILES>
CN(C(C)=O)C1=C(N2CCCC2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.516

>  <W2 Pf proliferation inhibition EC50 uM>
0.2993

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.05

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3053
  Mrv1591402191617072D          

 41 45  0  0  1  0            999 V2000
   -4.2531   -0.2412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2531   -1.0662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5386   -1.4787    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8241   -1.0662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5386   -2.3037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8712   -2.7886    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1261   -3.5732    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9511   -3.5732    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2060   -2.7886    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6412   -4.2406    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.8162   -4.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5612   -5.0253    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.2287   -5.5102    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8961   -5.0253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2287   -6.3352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5142   -6.7477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5142   -7.5727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2287   -7.9852    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9431   -7.5727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9431   -6.7477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2287   -8.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9431   -9.2227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9431  -10.0477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6576  -10.4602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3721  -10.0477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3721   -9.2227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6576   -8.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7766   -5.2802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6051   -6.0872    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1635   -4.7282    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6211   -4.9831    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2342   -4.4311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0627   -3.6241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6758   -3.0721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4604   -3.3270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6319   -4.1340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0188   -4.6860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4165   -4.3889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2012   -4.6439    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.1616   -5.1735    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6715   -3.6043    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
 10  7  1  6  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 12 28  1  1  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 38 40  1  0  0  0  0
 38 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3053

>  <JC_XSMILES>
COC(=O)C1=CN(N=N1)[C@@H]2C[C@H](N(C2)C3CCN(CC3)CC4=CC=CC=C4)C(=O)NCC5=CC=CC(=C5)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.521

>  <W2 Pf proliferation inhibition EC50 uM>
1.983

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.01754386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3071
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    7.7525   -0.5973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -1.4223    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.9910   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7360   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9110   -2.6919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6561   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538    0.6402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393   -0.5973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827   -0.1848    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   14.2689    0.6357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.0759    0.8072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   15.4884    0.0927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.9364   -0.5204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  2  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  1  0  0  0  0
 18 28  4  0  0  0  0
 28 29  4  0  0  0  0
 15 29  4  0  0  0  0
 13 30  4  0  0  0  0
 30 31  4  0  0  0  0
 10 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3071

>  <JC_XSMILES>
O=C(CN1CCCC1)NC2=CC=C(CC3=CC=C(NC(=O)CN4CCCC4)C=C3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3069

>  <W2 Pf proliferation inhibition EC50 uM>
0.367

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.84

>  <Powder data?>
Yes

>  <IFI value>
0.010752688

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-309
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
   -2.1434    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615    3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164    4.5695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414    4.5695    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964    3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 16 20  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
  8 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-309

>  <JC_XSMILES>
CC(C)CNC(=O)C1=CN=C(NCCCN2C=CN=C2)N=C1NCC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.768

>  <W2 Pf proliferation inhibition EC50 uM>
1.612

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-311
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    4.8229    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  4 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-311

>  <JC_XSMILES>
CN(C)C1=NC2=NON=C2N=C1NC3=CC=C(C)C(Cl)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.458

>  <W2 Pf proliferation inhibition EC50 uM>
1.608

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3115
  Mrv1591402191617072D          

 17 19  0  0  0  0            999 V2000
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
 10 15  4  0  0  0  0
  8 16  4  0  0  0  0
  3 16  4  0  0  0  0
 16 17  1  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3115

>  <JC_XSMILES>
CC[N+]1=C(C)C=C2C(SC3=CC=CC=C23)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.048

>  <W2 Pf proliferation inhibition EC50 uM>
1.874

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.092592593

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3121
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7079    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1120   -0.3308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6924   -0.5144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3374    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3374    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6924    1.3394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1120    1.1558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249   -1.0396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0769   -1.6527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8839   -1.4811    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8220   -2.4373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3740   -3.0504    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1191   -3.8350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6711   -4.4481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4162   -5.2327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6092   -5.4042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0572   -4.7911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3121   -4.0065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3543   -6.1889    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.9063   -6.8020    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.5473   -6.3604    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  2  0  0  0  0
  3  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  2  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  2  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 12 18  1  0  0  0  0
 11 19  4  0  0  0  0
  8 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
M  CHG  2  31   1  32  -1
M  STY  1   1 DAT
M  SAL   1  1   5
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3121

>  <JC_XSMILES>
CN1C(=O)NC(=O)C2=C1N=C(N3CCCCCC3)N2CC(O)COC4=CC=C(C=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.865

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3162
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    4.0028    1.1372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5611    0.4404    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7368    0.4745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3542    1.2054    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5299    1.2395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0882    0.5427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2639    0.5768    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1187    1.3077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4708   -0.1882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2951   -0.2223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0291   -0.8850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2048   -0.8509    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0001   -1.6501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5898   -2.2270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7944   -1.8724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4412   -1.3603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5238   -0.5372    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1281   -1.8172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9059   -2.6117    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0816   -2.6458    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9015   -1.5300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0396   -0.7166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5369   -2.0562    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3849   -0.2740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1794   -0.4963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7691    0.0806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5644    0.8798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7699    1.1021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1802    0.5252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6143    0.7475    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2497    1.2737    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4117   -1.6159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9701   -2.3127    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2360   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6186   -2.3809    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4349   -2.5010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5729   -3.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8420   -3.6970    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2522   -3.1201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
 12 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 11 32  1  0  0  0  0
 32 33  2  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 35 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3162

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C(N(C(=O)C2=C(N)C(=NS2)C(N)=O)C3=CC=CC=C3OC)C(=O)NC4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.535

>  <W2 Pf proliferation inhibition EC50 uM>
1.793

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.063063063

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3167
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    5.8461    2.4305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0578    2.1873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4530    2.7485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6647    2.5053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4811    1.7010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7378    1.3430    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9945    1.7010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8109    2.5053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3253    3.1503    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1503    3.1503    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9673    3.8936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1447    3.9553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7867    4.6986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2514    5.3802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0741    5.3185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4321    4.5752    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2548    4.5136    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0226    2.7485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8390    3.5528    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4178    2.1873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6014    1.3830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2226    1.3419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4988    0.5644    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3897    1.1398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0859    1.1398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8742    1.3830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4790    0.8219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  4 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  7 24  1  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3167

>  <JC_XSMILES>
CC1=CC2=C(NC3=C(C(N2)C4=CC=CC=C4F)C(=O)CC(C)(C)C3)C=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.646

>  <W2 Pf proliferation inhibition EC50 uM>
1.787

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025641026

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3172
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.9444   -1.7031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3924   -2.3162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4146   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6695   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4765   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0285   -1.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535   -1.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4056   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2125   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4675   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2744   -2.3162    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8265   -1.7031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1085   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -3.0712    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -3.8962    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7266   -4.3087    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7266   -5.1337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -5.5462    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0121   -5.5462    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7736   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9666   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  4  0  0  0  0
 13 14  4  0  0  0  0
  7 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  2  0  0  0  0
 15 21  1  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
  3 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3172

>  <JC_XSMILES>
COC1=CC=C2C3=CC=C(OC)C=C3C(=NNC(N)=N)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1231

>  <W2 Pf proliferation inhibition EC50 uM>
0.1782

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3202
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1994   -1.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  2  0  0  0  0
  6 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 10 17  4  0  0  0  0
  5 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
  4 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3202

>  <JC_XSMILES>
CN(C)C1=C(N(C(C)=O)C2=CC=C(F)C(F)=C2)C(=O)C3=CC=CC=C3C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01612

>  <W2 Pf proliferation inhibition EC50 uM>
0.0411

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.364

>  <Powder data?>
Yes

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3217
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.7329   -4.1608    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3207   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9082   -2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 25  1  0  0  0  0
 19 26  4  0  0  0  0
 26 27  4  0  0  0  0
  6 27  4  0  0  0  0
 16 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3217

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N(C2=CC=CC=C2)C3=CC=C(OC(=O)C4CC4)C=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.749

>  <W2 Pf proliferation inhibition EC50 uM>
1.721

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3226
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  7 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 16 22  1  0  0  0  0
 19 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
 11 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3226

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)N=C(N=C1C(=O)N2CCN(C(C)C2)C(=O)NC3=CC=C(C)C=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.441

>  <W2 Pf proliferation inhibition EC50 uM>
0.1709

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-323
  Mrv1591402191617072D          

 38 42  0  0  1  0            999 V2000
   10.2578    1.4697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4732    1.2147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3016    0.4078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5170    0.1528    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.3455   -0.6541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5609   -0.9091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9478   -0.3570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1193    0.4499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9039    0.7049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1631   -0.6120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.9082   -1.3966    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0832   -1.3966    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.8283   -0.6120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -0.1271    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5983   -2.0640    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9338   -2.8177    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4489   -3.4852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7845   -4.2388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2995   -4.9063    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6351   -5.6599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4791   -4.8200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1435   -4.0664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6284   -3.3989    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2929   -2.6452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  0  0  0  0
 14 13  1  0  0  0  0
 14 10  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  4  0  0  0  0
 27 28  4  0  0  0  0
 20 28  4  0  0  0  0
 12 29  1  1  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
 37 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-323

>  <JC_XSMILES>
CCCN1CCC(CC1)N2C[C@H](C[C@H]2C(=O)NCCC3=CC=C4OCOC4=C3)NCC5=CC(C)=CC=C5C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.478

>  <W2 Pf proliferation inhibition EC50 uM>
0.661

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
4.2

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-324
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    6.6969    1.5328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8845    1.6762    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3540    1.0444    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5416    1.1878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2596    1.9631    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.0111    0.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2931   -0.2194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7627   -0.8512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9503   -0.7078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6683    0.0675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1987    0.6994    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0747   -0.5054    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1893   -1.3224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3463   -0.1179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5710   -0.3999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0608    0.1305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0826    0.9429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8579    1.2249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4898    0.6945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3068    0.8091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2868    1.6339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0019    1.2534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1056   -0.3628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6360    0.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4484    0.1256    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.9789    0.7575    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    6.7304   -0.6497    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
M  CHG  2  25   1  26  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-324

>  <JC_XSMILES>
COC1=C(Br)C2=C(C=CC3(O2)N(C)C4=CC=CC=C4C3(C)C)C=C1[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.741

>  <W2 Pf proliferation inhibition EC50 uM>
>1.571

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3243
  Mrv1591402191617072D          

 22 22  0  0  0  0            999 V2000
    1.6204   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -3.9039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6204   -4.6184    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -5.3329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421   -5.3329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8546   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4421   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3829   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7954   -3.1895    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.6204   -3.1895    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.3829   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -3.9039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.5079   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
  4 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
M  CHG  2  15   1  16  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3243

>  <JC_XSMILES>
CCCC(C(C)=NNC1=CC=CC=C1[N+]([O-])=O)C(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.268

>  <W2 Pf proliferation inhibition EC50 uM>
1.672

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3255
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -4.2868   -6.6000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 21 31  1  0  0  0  0
 26 31  4  0  0  0  0
  5 32  4  0  0  0  0
 32 33  4  0  0  0  0
  2 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3255

>  <JC_XSMILES>
FC1=CC=C(CCNC2=CC=CC=C2C(=O)OCC(=O)N3CC(=O)NC4=CC=CC=C34)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2187

>  <W2 Pf proliferation inhibition EC50 uM>
0.1651

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3264
  Mrv1591402191617072D          

 40 46  0  0  0  0            999 V2000
   -6.7863   -5.6479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9613   -5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5488   -4.9335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7238   -4.9335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3113   -5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7238   -6.3624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5488   -6.3624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4863   -5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0014   -4.9805    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2168   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0734   -4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -6.4729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7126   -4.9805    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1975   -5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7126   -6.3154    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0225   -5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4350   -4.9335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2600   -4.9335    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6725   -5.6479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.4975   -5.6479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.2600   -6.3624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4350   -6.3624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7878   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5023   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2168   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0014   -6.3154    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
 24 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 31 33  4  0  0  0  0
 33 34  4  0  0  0  0
 28 34  4  0  0  0  0
 17 35  4  0  0  0  0
 35 36  4  0  0  0  0
 14 36  4  0  0  0  0
 12 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 10 39  4  0  0  0  0
 39 40  4  0  0  0  0
  8 40  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  23
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  40
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3264

>  <JC_XSMILES>
NC1=CC=C(C=C1)C2=NC3=CC(OC4=CC=C(OC5=CC=C6NC(=NC6=C5)C7=CC=C(N)C=C7)C=C4)=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2884

>  <W2 Pf proliferation inhibition EC50 uM>
0.2465

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.04

>  <Powder data?>
Yes

>  <IFI value>
0.057971014

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3309
  Mrv1591402191617072D          

 22 25  0  0  0  0            999 V2000
    7.1461   -2.6275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0842   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8912   -1.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  1  6  1  0  0  0  0
  4  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3309

>  <JC_XSMILES>
C1CCN(CC1)CCNC2=NC=NC3=C2NC4=CC=CC=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.704

>  <W2 Pf proliferation inhibition EC50 uM>
0.788

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.9

>  <Powder data?>
Yes

>  <IFI value>
0.038461538

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-331
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    0.1067   -2.5366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -1.7116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0597   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1953   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0203   -5.0437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2752   -4.2590    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-331

>  <JC_XSMILES>
O=C(N1CCN(CC1)C2=CC=CC=N2)C3=CC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.022

>  <W2 Pf proliferation inhibition EC50 uM>
>1.56

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3312
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2494   -1.1874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8014   -1.8005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3889   -2.5150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5819   -2.3434    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
 17 26  4  0  0  0  0
 26 27  4  0  0  0  0
 14 27  4  0  0  0  0
 27 28  4  0  0  0  0
 12 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3312

>  <JC_XSMILES>
CC1=CC=CC=C1OCCSC2=NC3=CC=C(NC(=O)C4=CC=CS4)C=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.497

>  <W2 Pf proliferation inhibition EC50 uM>
1.576

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3337
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    1.5229    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  4  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
  2 11  4  0  0  0  0
 11 12  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3337

>  <JC_XSMILES>
CC1=NC2=CC(=NN2C(O)=C1C)C3=CC=C(I)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
4.2

>  <W2 Pf proliferation inhibition EC50 uM>
1.543

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3340
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3340

>  <JC_XSMILES>
COC1=CC(CNC2=CC=C(C=C2)N3CCCCC3)=CC(Cl)=C1OCC4=CC=C(F)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.039

>  <W2 Pf proliferation inhibition EC50 uM>
1.537

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3343
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.5160    1.2530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9285    0.5385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7535    0.5385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1660   -0.1760    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7535   -0.8904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1660   -1.6049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9910   -1.6049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9910   -0.1760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4035   -0.8904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2285   -0.8904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6410   -1.6049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4660   -1.6049    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2285   -2.3194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4080   -2.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2365   -3.2126    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9509   -3.6251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5640   -3.0731    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.7794   -4.4321    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3314   -5.0452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9589   -4.5183    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6234   -3.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8164   -3.5931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2644   -4.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4574   -4.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2025   -3.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6045   -3.0785    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7545   -2.6370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5615   -2.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 16 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3343

>  <JC_XSMILES>
CCCN(CCC)CCNC(=O)C1=CC2=C(S1)N(C)N=C2C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2533

>  <W2 Pf proliferation inhibition EC50 uM>
0.703

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.82

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3348
  Mrv1591402191617072D          

 42 47  0  0  0  0            999 V2000
   -2.2337    2.8744    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5357    1.7474    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067    2.5724    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4944   -3.5854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -4.8229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2089   -6.4729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4944   -6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4944   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2201   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9345   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6490   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6490   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9345   -3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2201   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 26 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 17 38  4  0  0  0  0
 13 38  4  0  0  0  0
 38 39  1  0  0  0  0
 10 39  1  0  0  0  0
 39 40  2  0  0  0  0
  8 41  4  0  0  0  0
 41 42  4  0  0  0  0
  5 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3348

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(CN2C(=O)C3=CC=CC(N4CCCC(C4)C(=O)N5CCCCC5C6=CC=CN=C6)=C3C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.41

>  <W2 Pf proliferation inhibition EC50 uM>
1.53

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.06

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3351
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -8.8337   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.0087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.7712   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3351

>  <JC_XSMILES>
C=CCCC(=O)N1CCC(CC1)C(=O)NC2=CC=C(C=C2)C3=NC4=CC=CC=C4O3

>  <PF proliferation inhibition 3D7 EC50 uM>
5.42

>  <W2 Pf proliferation inhibition EC50 uM>
1.525

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3361
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
  6 16  4  0  0  0  0
 16 17  4  0  0  0  0
  3 17  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3361

>  <JC_XSMILES>
COC1=CC=C2N=C(NC(N)=N)N=C(C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.712

>  <W2 Pf proliferation inhibition EC50 uM>
0.867

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
57.51

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3389
  Mrv1591402191617072D          

 42 47  0  0  0  0            999 V2000
    0.1067   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1067   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7741   -3.0215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5192   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3058   -3.8062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5607   -3.0215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7907   -4.4736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6112   -4.3874    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9468   -3.6337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4618   -2.9662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7672   -3.5474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1797   -2.8330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9867   -3.0045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0729   -3.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3193   -4.1605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7874   -4.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7874   -5.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5019   -5.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2164   -5.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2164   -4.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5019   -3.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0961   -5.0548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7606   -5.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2455   -6.4759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0660   -6.3897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4015   -5.6360    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9166   -4.9686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5509   -7.0571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2153   -7.8108    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7003   -8.4782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5207   -8.3920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8563   -7.6383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3714   -6.9709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4552   -5.2273    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9401   -5.8947    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3653   -5.3135    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7009   -6.0672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214   -6.1534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8569   -6.9071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3720   -7.5745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5515   -7.4883    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2160   -6.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  8 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
  7 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 37 42  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3389

>  <JC_XSMILES>
CC1=CC=C(O1)C(N(C(=O)C2=CC=C(N2)C3=CC=CC=C3)C4=CC=C(C=C4)C5CCCCC5)C(=O)NC6CCCCC6

>  <PF proliferation inhibition 3D7 EC50 uM>
1.165

>  <W2 Pf proliferation inhibition EC50 uM>
1.472

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3393
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.1295   -5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4836   -4.9765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2683   -5.2315    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8814   -4.6794    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7098   -3.8725    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9252   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3121   -4.1696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -2.8106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -1.4830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -1.6545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -3.1895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    5.3033   -1.7605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3393

>  <JC_XSMILES>
CC1=CC=CC(=C1)N2C=CN=C2SCC(=O)NC3=CC(=CC=C3Cl)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.541

>  <W2 Pf proliferation inhibition EC50 uM>
1.467

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3421
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.7512   -5.1348    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -4.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -3.8973    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -3.0723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.6598    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -3.0723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -3.8973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -4.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946   -3.8973    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091   -4.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -3.8973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235   -3.0723    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -4.3098    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -3.8973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -4.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -5.1348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -5.5473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -5.1348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -5.5473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814   -6.3723    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959   -5.1348    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -5.5473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248   -5.1348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393   -5.5473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393   -6.3723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248   -6.7848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104   -6.3723    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -5.1348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8476   -5.6197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5926   -6.4044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -6.4044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5127   -5.6197    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
  8 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 28 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3421

>  <JC_XSMILES>
ClC1=NC=CC=C1C(OCC(=O)N2CCN(CC2)C(=O)NC3=CC=CC=C3)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.419

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3432
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
    2.1402   -6.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4757   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9908   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0980   -0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4323    0.3627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2890   -4.3257    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8671   -5.1657    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3822   -5.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4383   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
 17 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 11 33  1  0  0  0  0
 27 33  4  0  0  0  0
  7 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3432

>  <JC_XSMILES>
CCOC(=O)C1=C(SC(S1)=C2C(=S)C(C)(C)N(C(=O)C3=CC=CC(F)=C3)C4=CC(C)=CC=C24)C(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.52

>  <W2 Pf proliferation inhibition EC50 uM>
>1.401

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3434
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 11 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
  5 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 29 34  4  0  0  0  0
 34 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3434

>  <JC_XSMILES>
COC1=CC2=C(C=C1OC)C(COC3=CC=C(F)C=C3)N(CC2)C(=O)C4=CC=C(OC(C)C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1546

>  <W2 Pf proliferation inhibition EC50 uM>
1.398

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3443
  Mrv1591402191617072D          

 30 32  0  0  1  0            999 V2000
   -5.2246    3.7462    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5796    3.2319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0940    2.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0653    3.8769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9346    2.7175    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0576    1.9017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8256    1.6003    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4126    1.3873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6446    1.6887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1302    2.3337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8288    1.5658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5355    0.5715    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8539    0.1068    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1394    0.5193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4249    0.1068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7105    0.5193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0040    0.1068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7185    0.5193    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7922   -0.7159    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0243   -1.0173    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3970   -1.2771    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2128   -1.1541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6253   -1.8686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4503   -1.8686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8628   -1.1541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6878   -1.1541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4503   -0.4396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6253   -0.4396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3239    0.3284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8850    0.9331    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  9 11  1  0  0  0  0
  8 12  1  0  0  0  0
 13 12  1  0  0  0  0
 13 14  1  1  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 28 29  1  0  0  0  0
 12 29  1  0  0  0  0
 29 30  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3443

>  <JC_XSMILES>
CC(C)(C)NC(=O)C(C1CC1)N2[C@@H](CCCCN)C(=O)NC3=CC=C(O)C=C3C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.1386

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.008264463

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3473
  Mrv1591402191617072D          

 16 17  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  8 14  4  0  0  0  0
 14 15  4  0  0  0  0
  4 15  4  0  0  0  0
 15 16  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   7
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3473

>  <JC_XSMILES>
CCCC1=C(C)N=C2C=CC(Br)=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.507

>  <W2 Pf proliferation inhibition EC50 uM>
1.337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3517
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  2  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  4 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 13 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  2  0  0  0  0
  7 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3517

>  <JC_XSMILES>
CCCN1C(=N)C(=CC2=C1N=C3N(C=CC=C3C)C2=O)C(=O)NC4CCCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.46

>  <W2 Pf proliferation inhibition EC50 uM>
1.291

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3519
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.4347    4.7430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6183    3.9387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8140    3.7551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4226    4.1222    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8019    3.1343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5902    2.8912    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7738    2.0868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1690    1.5257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3807    1.7689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1971    2.5732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526    0.7214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569    0.5378    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5149   -0.2055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1569   -0.9488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3526   -1.1324    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076   -0.6180    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230   -0.8729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4380   -0.2055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9230    0.4619    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7076    0.2070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6713    1.1828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3699    1.9508    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4871    1.0599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0015    1.7049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8172    1.5819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1187    0.8139    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6043    0.1689    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7885    0.2919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9344    0.6910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7502    0.5680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8115   -0.1248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0574    1.5068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  1  0  0  0  0
 16 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 29 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3519

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(C=C1)C2N(CCCN3C=CC=C23)C(=O)C4=CC=C(C=C4)C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.564

>  <W2 Pf proliferation inhibition EC50 uM>
1.29

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.04587156

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3531
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.0367    0.3509    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -3.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.8465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2032   -3.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -4.6312    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -4.6312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -5.2986    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0333   -5.2124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6977   -4.4587    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5484   -5.8798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2721   -5.7936    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1859   -4.9731    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3584   -6.6140    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0926   -5.7073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5775   -6.3748    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3980   -6.2885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7336   -5.5348    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5541   -5.4486    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2486   -4.8674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4282   -4.9536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.8465    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
 13 28  4  0  0  0  0
  9 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3531

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(C)SC(NC(=O)CS(=O)(=O)C3=CC=C(F)C=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.212

>  <W2 Pf proliferation inhibition EC50 uM>
0.56

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
44.06

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3534
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3534

>  <JC_XSMILES>
OC1=CC=C(Br)C=C1CN2CCN(CC2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
3.17

>  <W2 Pf proliferation inhibition EC50 uM>
0.438

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.58

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-354
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    3.5854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.0681    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  2 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  22
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-354

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)N2CCCCC2)N3CCC4=C(C3)NC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.012

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.67

>  <Powder data?>
No

>  <IFI value>
0.054054054

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3540
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 14 20  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  8 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3540

>  <JC_XSMILES>
CCC(C)NC(=O)C1=CC(NC(=O)C2=CC=CC(Cl)=C2)=CC=C1N3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.61

>  <W2 Pf proliferation inhibition EC50 uM>
0.1941

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
15.37

>  <Powder data?>
No

>  <IFI value>
0.018867925

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3541
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 14 25  4  0  0  0  0
  9 25  4  0  0  0  0
  7 26  4  0  0  0  0
 26 27  4  0  0  0  0
  4 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3541

>  <JC_XSMILES>
CCOC1=CC=C(NC2=CC(C)=NC(NC3=CC=C(OCC)C=C3)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1038

>  <W2 Pf proliferation inhibition EC50 uM>
0.1243

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.85

>  <Powder data?>
Yes

>  <IFI value>
0.046153846

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3543
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  4  0  0  0  0
  7 21  4  0  0  0  0
  5 22  4  0  0  0  0
 22 23  4  0  0  0  0
  2 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3543

>  <JC_XSMILES>
CC1=CC=C(NC2=CC(C)=NC(NCC3=CC=CC=C3)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.112

>  <W2 Pf proliferation inhibition EC50 uM>
0.1319

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
10.47

>  <Powder data?>
Yes

>  <IFI value>
0.058139535

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3570
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
  8 25  4  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3570

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2125

>  <W2 Pf proliferation inhibition EC50 uM>
0.1065

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
8.67

>  <Powder data?>
Yes

>  <IFI value>
0.072992701

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-359
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  4  0  0  0  0
  2 16  4  0  0  0  0
 16 17  1  0  0  0  0
  4 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-359

>  <JC_XSMILES>
CC1=NC(=NC(NCCC2=CC=CC=C2)=C1Cl)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.251

>  <W2 Pf proliferation inhibition EC50 uM>
1.508

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.054054054

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3601
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    6.0770   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6645   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8395   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -1.0164    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645    0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    1.5395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750    2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7125    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1250    3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7125    4.3974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8875    4.3974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750    3.6829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    3.6829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    2.9684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4270   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
  9 32  4  0  0  0  0
  3 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3601

>  <JC_XSMILES>
COC1=CC=C(OC)C(CN2CCC3(CC2)CC3C(=O)NCCC4=CC=CC=C4OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.17

>  <W2 Pf proliferation inhibition EC50 uM>
1.192

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3606
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -9.4875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    9.5901   -9.7895    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   10.4151   -8.3605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 13 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 28 30  1  0  0  0  0
 28 31  1  0  0  0  0
  5 32  1  0  0  0  0
 32 33  1  0  0  0  0
  2 33  1  0  0  0  0
M  CHG  2  16   1  17  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3606

>  <JC_XSMILES>
CC1CCN(CCCNC2=CC=C(C=C2[N+]([O-])=O)C(=O)NC3=CC=C(C=C3)C(F)(F)F)CC1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1994

>  <W2 Pf proliferation inhibition EC50 uM>
0.2777

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.39

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3612
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    3.9849   -5.1243    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -5.5368    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -5.1243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -4.2993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.8868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.0618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.0618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.8868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -2.6493    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9849   -1.8243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -1.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -1.8243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -2.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -3.0618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -1.4118    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -1.8243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -1.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572   -0.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -0.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -0.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9862   -1.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717   -1.8243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -6.3618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -7.0763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.0763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
  2 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3612

>  <JC_XSMILES>
O=C(NC1=CC=CC(=C1)N2CCC(CC2)NCC3CCCCC3)C4CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
3.68

>  <W2 Pf proliferation inhibition EC50 uM>
1.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3632
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    4.0954   -3.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -3.1895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7809   -3.9431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1678   -4.4952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4534   -4.0827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6249   -3.2757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6997   -4.4182    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6135   -5.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2809   -5.7236    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1402   -5.5743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2264   -6.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9801   -6.7303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6476   -6.2454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5613   -5.4249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8076   -5.0894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9204   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1579   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8079   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3954   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6184   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9829   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5704   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7454   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3329   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  4  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
  2 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 19 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  2  0  0  0  0
 27 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3632

>  <JC_XSMILES>
OC(CN1CCC(C1)NC(=O)C2CCCCC2)CN(CC3=CC=CC=C3)S(=O)(=O)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1851

>  <W2 Pf proliferation inhibition EC50 uM>
0.1161

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019417476

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3644
  Mrv1591402191617072D          

 44 49  0  0  0  0            999 V2000
    3.9844    1.6281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6989    1.2156    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6989    0.3906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4133   -0.0219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4133   -0.8469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6989   -1.2594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9844   -0.8469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9844   -0.0219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6989   -2.0844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3663   -2.5693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1114   -3.3540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2864   -3.3540    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0314   -2.5693    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2468   -2.3144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0753   -1.5074    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6337   -2.8664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8491   -2.6115    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2360   -3.1635    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -3.9840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5686   -4.3196    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0165   -3.7065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8040   -3.7927    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2889   -3.1253    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1094   -3.2115    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4449   -3.9652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5943   -2.5441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4193   -2.5441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6742   -1.7594    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0068   -1.2745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3393   -1.7594    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4290   -2.9920    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0935   -2.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7270   -2.1521    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0626   -1.3984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8830   -1.3122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5776   -0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2428   -0.8172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5784   -1.5709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3989   -1.6571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5963   -4.0214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4213   -4.0214    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6762   -4.8060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0088   -5.2909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3414   -4.8060    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
 21 31  4  0  0  0  0
 18 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 32 38  4  0  0  0  0
 38 39  1  0  0  0  0
 11 40  1  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 40 44  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3644

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2CC(=NN2C(=O)CSC3=NN=C(CNC(=O)C4=CC=CS4)N3C5=CC(C)=CC=C5C)C6=CC=CS6

>  <PF proliferation inhibition 3D7 EC50 uM>
>8.55

>  <W2 Pf proliferation inhibition EC50 uM>
1.14

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3668
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -4.7407    5.9806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3282    5.2661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5032    5.2661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0907    5.9806    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0907    4.5517    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2657    4.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8532    5.2661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0282    5.2661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6157    4.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1913    4.3801    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2775    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9920    3.1471    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7065    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4209    3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4209    2.3221    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1354    3.5596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5644    3.5596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2788    3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2788    2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5644    1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8499    2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9933    1.9096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7078    2.3221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9933    1.0846    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4761    3.2241    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0282    3.8372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8532    3.8372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 11 26  4  0  0  0  0
 26 27  4  0  0  0  0
  9 27  4  0  0  0  0
 27 28  4  0  0  0  0
  6 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3668

>  <JC_XSMILES>
CCC(=O)NC1=CC=C2N=C(SCC(=O)NC3=CC=C(C=C3)C(C)=O)SC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.109

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023255814

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-367
  Mrv1591402191617072D          

 31 36  0  0  0  0            999 V2000
   -1.4442   -2.1527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8583   -1.4392    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6833   -1.4410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0974   -0.7275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9224   -0.7293    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6865   -0.0121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8615   -0.0103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4474   -0.7238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6224   -0.7220    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2517   -0.0235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3956    0.7306    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6463   -0.3067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3598    0.1074    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0752   -0.3035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7887    0.1106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5041   -0.3004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5060   -1.1254    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7924   -1.5394    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0770   -1.1285    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3635   -1.5426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3653   -2.3676    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6517   -2.7817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6481   -1.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1360   -1.3884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3892   -2.1735    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4997   -0.9923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7862   -1.4064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0708   -0.9955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0690   -0.1705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7825    0.2436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4979   -0.1673    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  2  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  1  0  0  0  0
 12 23  1  0  0  0  0
 23 24  1  0  0  0  0
  9 24  1  0  0  0  0
 24 25  2  0  0  0  0
 20 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 13 31  1  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-367

>  <JC_XSMILES>
CC1=CC(I)=CC=C1N2C(=O)C3C4C5=CC=CC=C5C(CO)(C3C2=O)C6=CC=CC=C46

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>10.07

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>67.94

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3675
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
    1.9409   -1.8844    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1339   -2.0559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8790   -2.8405    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4310   -3.4536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1761   -4.2383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7281   -4.8514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4732   -5.6360    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0252   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7703   -7.0337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9633   -7.2052    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4113   -6.5921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6662   -5.8075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5819   -1.4428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2251   -1.6144    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7771   -1.0013    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5221   -0.2166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0742    0.3965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8192    1.1811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0123    1.3526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5398    0.7395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2848   -0.0451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8369   -0.6582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6438   -0.4867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2427    2.1372    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.0273    1.8823    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5420    2.3922    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4976    2.9218    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0127    3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4976    4.2567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822    4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9967    4.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7112    4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7112    3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9967    2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2822    3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
  2 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 13 22  4  0  0  0  0
 22 23  2  0  0  0  0
 19 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 27 35  1  0  0  0  0
 30 35  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  15
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3675

>  <JC_XSMILES>
O=C(NCCCN1CCOCC1)C2=CNC3=CC=C(C=C3C2=O)S(=O)(=O)N4CCC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.61

>  <W2 Pf proliferation inhibition EC50 uM>
1.106

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3680
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
  7 24  4  0  0  0  0
 24 25  4  0  0  0  0
  4 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3680

>  <JC_XSMILES>
NC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0662

>  <W2 Pf proliferation inhibition EC50 uM>
0.0687

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.25

>  <Powder data?>
No

>  <IFI value>
0.026143791

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3694
  Mrv1591402191617072D          

 24 29  0  0  0  0            999 V2000
    2.9250    1.9083    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6875    1.1183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8280    0.7618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1853    1.2427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4801    0.8145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4983   -0.0103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2217   -0.4069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8462   -0.0630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7170   -0.2163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9892   -0.9951    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1870    0.4617    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0118    0.4799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4084    1.2033    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2332    1.2216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6614    0.5164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2648   -0.2070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6930   -0.9122    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2964   -1.6356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4716   -1.6538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0434   -0.9487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4400   -0.2252    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4097    0.4225    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1149    0.8506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1331    0.0258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
  2 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 16 21  4  0  0  0  0
  7 22  1  0  0  0  0
  4 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3694

>  <JC_XSMILES>
O=C1C2C3C=CC(C2C(=O)N1C4=CC=CC5=CC=CC=C45)C36CC6

>  <PF proliferation inhibition 3D7 EC50 uM>
6.59

>  <W2 Pf proliferation inhibition EC50 uM>
1.086

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3704
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6499    0.6563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8214    1.4633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2083    2.0153    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3798    2.8223    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4237    1.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2522    0.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0968   -3.8419    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    0.9445   -3.6594    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2793   -2.6896    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  5 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
  4 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3704

>  <JC_XSMILES>
CN1N=C(C(=C1NC(=O)NC2=CC=C(F)C=C2)C3=CC=C(F)C=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2412

>  <W2 Pf proliferation inhibition EC50 uM>
0.2535

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.55

>  <Powder data?>
Yes

>  <IFI value>
0.034188034

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3710
  Mrv1591402191617072D          

 38 41  0  0  0  0            999 V2000
   -0.5837   -7.1282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -5.6992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0663   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0489    0.8152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8227    1.9192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9878    1.9803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4780    3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5175    3.0199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9483    2.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 27 30  1  0  0  0  0
 21 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
 37 38  4  0  0  0  0
 20 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3710

>  <JC_XSMILES>
CCCCC1=CC=C(C=C1)C(=O)OC2=CC=CC=C2C3=C(NC(C)(C)CC(C)(C)C)N4C=CC(C)=CC4=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.616

>  <W2 Pf proliferation inhibition EC50 uM>
0.1069

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3724
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4748   -3.9898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9899   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3255   -5.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8406   -6.0783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0201   -5.9921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4648   -6.6595    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.3155   -5.2384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1694   -4.5710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4131   -0.7221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3715   -0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5430    0.3398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0701    0.8918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1015    1.6988    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.8547    0.6369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0262   -0.1701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4191   -3.9035    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2667   -3.7210    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6016   -2.7512    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
  5 16  4  0  0  0  0
  2 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
  4 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3724

>  <JC_XSMILES>
CN1N=C(C(C(=O)NC2=CC=C(Cl)C=C2)=C1SC3=CC=C(Cl)C=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.749

>  <W2 Pf proliferation inhibition EC50 uM>
0.369

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
34.79

>  <Powder data?>
Yes

>  <IFI value>
0.04109589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3744
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    1.5126    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9606    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054    0.9256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3409   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.0165    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.0165    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.1034    0.7310    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1659   -1.4124    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.5784   -2.1269    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -5.5784   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 14 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
  7 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
  6 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 24 29  1  0  0  0  0
M  CHG  4  17   1  18  -1  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3744

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)C2=CC=C(C=C2[N+]([O-])=O)[N+]([O-])=O)SC3=C1CCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
1.042

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3764
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    6.3569   -0.5396    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    3.5854    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 14 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 21 27  4  0  0  0  0
  8 28  4  0  0  0  0
  4 28  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3764

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(CSC2=NC3=C(SC=C3)C(=O)N2C4=CC=C(Br)C=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.31

>  <W2 Pf proliferation inhibition EC50 uM>
1.017

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3787
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -8.2500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -8.2500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -10.7250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -11.9625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.9625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -14.4375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  2  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3787

>  <JC_XSMILES>
COC1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=S)NC3CCCCC3

>  <PF proliferation inhibition 3D7 EC50 uM>
8.54

>  <W2 Pf proliferation inhibition EC50 uM>
1.001

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3790
  Mrv1591402191617072D          

 88 88  0  0  1  0            999 V2000
   -2.4042    3.1952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6897    2.7827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6898    1.9577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9753    1.5452    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2608    1.9576    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.4536    1.5451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2608    2.7826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9752    3.1952    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4537    3.1951    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.1682    2.7826    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9597    3.0150    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7901    2.0493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5727    1.2534    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2361    1.3552    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.8580    0.6220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3040   -0.0721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0339    0.5828    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0602    1.3945    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6004    2.0179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1385    0.5732    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6473   -0.0896    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8890    0.2304    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.9674   -0.5908    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2953   -1.0693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3737   -1.8906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5449   -0.7266    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5610    0.7090    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6785    1.5256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0710    0.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7643   -0.7054    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8876    0.1778    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    5.3975   -0.4707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0909   -1.2366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6008   -1.8851    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2743   -1.3540    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1942    0.9437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8515    1.6942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9738    0.6738    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1299   -0.1362    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5974    1.2141    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.3770    0.9442    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4413    2.0242    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2430    2.2186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8123    1.6215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4755    3.0102    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    8.2772    3.2047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9062    3.6073    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.4755    4.2044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2773    4.0098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2431    4.9960    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.8125    5.5930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6142    5.3985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1836    5.9955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8466    4.6069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4414    5.1905    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7473    4.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5976    6.0006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3772    6.2704    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9741    6.5409    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    5.1945    6.2711    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.8879    7.0370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3979    7.6855    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0713    7.1544    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.7647    7.9204    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2747    8.5688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9681    9.3347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0913    8.4514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5613    6.5060    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6786    5.6894    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8893    6.9845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9677    7.8058    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1388    6.6419    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.4668    7.1204    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.5452    7.9417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0603    5.8206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6006    5.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2363    5.8599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8583    6.5932    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7902    5.1659    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.1682    4.4326    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4537    4.0201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2607    4.4326    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0338    5.2052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6725    4.6830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4119    5.9385    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1303    7.3510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7043    8.0575    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9099    7.6208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  1  6  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  9  7  1  1  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 14 12  1  0  0  0  0
 14 15  1  1  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 14 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 20 21  2  0  0  0  0
 22 20  1  0  0  0  0
 22 23  1  1  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 22 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  2  0  0  0  0
 31 29  1  0  0  0  0
 31 32  1  1  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 31 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
 38 39  2  0  0  0  0
 40 38  1  0  0  0  0
 40 41  1  6  0  0  0
 40 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  2  0  0  0  0
 45 43  1  0  0  0  0
 45 46  1  1  0  0  0
 45 47  1  0  0  0  0
 47 48  1  0  0  0  0
 48 49  2  0  0  0  0
 50 48  1  0  0  0  0
 50 51  1  1  0  0  0
 51 52  1  0  0  0  0
 52 53  1  0  0  0  0
 52 54  1  0  0  0  0
 50 55  1  0  0  0  0
 55 56  1  0  0  0  0
 55 57  1  0  0  0  0
 57 58  2  0  0  0  0
 59 57  1  0  0  0  0
 59 60  1  0  0  0  0
 60 61  1  0  0  0  0
 61 62  2  0  0  0  0
 63 61  1  0  0  0  0
 63 64  1  1  0  0  0
 64 65  1  0  0  0  0
 65 66  1  0  0  0  0
 65 67  1  0  0  0  0
 63 68  1  0  0  0  0
 68 69  1  0  0  0  0
 68 70  1  0  0  0  0
 70 71  2  0  0  0  0
 72 70  1  0  0  0  0
 72 73  1  6  0  0  0
 73 74  1  0  0  0  0
 72 75  1  0  0  0  0
 75 76  1  0  0  0  0
 75 77  1  0  0  0  0
 77 78  2  0  0  0  0
 79 77  1  0  0  0  0
 79 80  1  0  0  0  0
 80 81  1  0  0  0  0
  9 81  1  0  0  0  0
 81 82  2  0  0  0  0
 79 83  1  1  0  0  0
 83 84  1  0  0  0  0
 83 85  1  0  0  0  0
 59 86  1  1  0  0  0
 86 87  1  0  0  0  0
 86 88  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3790

>  <JC_XSMILES>
CCCC[C@@H](C)C(O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](SC)N(C)C(=O)[C@@H](NC1=O)C(C)C)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0325

>  <W2 Pf proliferation inhibition EC50 uM>
0.0517

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.18

>  <Powder data?>
No

>  <IFI value>
0.048780488

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3813
  Mrv1591402191617072D          

 41 44  0  0  0  0            999 V2000
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  2  0  0  0  0
 10 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  8 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
 31 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
M  CHG  2  22   1  23  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3813

>  <JC_XSMILES>
CCC(C)NC(=O)C1=CC(NC(=O)\C=C\C2=CC=C(C=C2)[N+]([O-])=O)=CC=C1N3CCN(CC3)C4=CC=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.0543

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.55

>  <Powder data?>
No

>  <IFI value>
0.027522936

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3815
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
  8 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3815

>  <JC_XSMILES>
CC(C)(C)C1CCC2=C(C1)C(=O)C3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.852

>  <W2 Pf proliferation inhibition EC50 uM>
0.976

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3825
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -4.4270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -2.9980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0418   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5938   -5.6400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1813   -6.3545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3744   -6.1830    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3825

>  <JC_XSMILES>
CCCCN(CCCC)S(=O)(=O)C1=CC=C(NC(=O)C2=CC=CO2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.425

>  <W2 Pf proliferation inhibition EC50 uM>
0.637

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>65.68

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3832
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    7.1883    1.2701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813    1.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.3140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0223    1.5402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8293    1.7117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 10 20  1  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3832

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=CC3=C(N=N2)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.998

>  <W2 Pf proliferation inhibition EC50 uM>
0.799

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
83.18

>  <Powder data?>
Yes

>  <IFI value>
0.11627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3833
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
    0.8034    3.3309    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.6280    3.3567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0180    4.0837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8426    4.1095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2772    3.4082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8872    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3218    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9318    1.2530    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3664    0.5517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1910    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6256   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4502   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8849   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4949   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6703   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2357   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4111   -0.8765    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8784   -1.5066    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1147   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4134   -1.6293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4392   -2.4539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1662   -2.8439    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7379   -2.8885    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7637   -3.7131    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0625   -4.1477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0019   -4.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7993   -5.1671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2339   -4.4659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7013   -3.8359    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1752   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5452    0.1607    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9765   -0.1753    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0626    2.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 25 29  4  0  0  0  0
 19 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
  9 32  4  0  0  0  0
 17 32  4  0  0  0  0
  6 33  4  0  0  0  0
  2 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3833

>  <JC_XSMILES>
FC1=CC=CC(CSC2=NC3=CC=CC=C3C4=NC(CC(=O)NCC5=CC=CS5)C(=O)N24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.192

>  <W2 Pf proliferation inhibition EC50 uM>
0.96

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.142857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-384
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
  7 20  4  0  0  0  0
  3 20  4  0  0  0  0
 20 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-384

>  <JC_XSMILES>
COC1=CC=CC(C=NNC(=O)C2=CC=CC=C2O)=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
5.38

>  <W2 Pf proliferation inhibition EC50 uM>
0.969

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.64

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3856
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -5.1212   -6.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -5.6992    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
  6 27  4  0  0  0  0
 27 28  4  0  0  0  0
  3 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3856

>  <JC_XSMILES>
COC1=CC=C(OCC(=O)NC2=CC=CC(=C2)C3=NC4=NC=CC=C4O3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.473

>  <W2 Pf proliferation inhibition EC50 uM>
0.935

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.021505376

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-386
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -1.5356    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    1.1759    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1393   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3188   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1661   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9866   -3.7311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -2.9774    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1426   -2.8911    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.8372   -2.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0168   -2.3962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 15 17  2  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-386

>  <JC_XSMILES>
CN(C)C1=CC=C(C=C1)N=C2NC(=O)C(\S2)=C\C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.819

>  <W2 Pf proliferation inhibition EC50 uM>
1.456

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3868
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400   -4.0623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0470   -4.2338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5990   -3.6207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4060   -3.7923    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8961   -2.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
  4 11  4  0  0  0  0
  2 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  1  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3868

>  <JC_XSMILES>
CC(OC1=CC=C(Cl)C(C)=C1)C(=O)N2CCC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.897

>  <W2 Pf proliferation inhibition EC50 uM>
0.926

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3872
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
   -6.9831   -4.9206    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -6.3157   -4.4357    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.5620   -4.7713    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4019   -3.6152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1556   -3.2797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2418   -2.4592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5744   -1.9743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8207   -2.3098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7344   -3.1303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -1.8249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1532   -0.9999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -0.7450    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3686   -2.0799    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
 24 32  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  STY  1   1 DAT
M  SAL   1  1  32
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3872

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C2=CC=C(O2)C(=O)NC3=CC=C(C=C3)C4=NC5=CC=CC=C5N4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.236

>  <W2 Pf proliferation inhibition EC50 uM>
0.924

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.057692308

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-391
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-391

>  <JC_XSMILES>
OCC1=NC2=CC=CC=C2N1CC3=CC=CC=C3F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.643

>  <W2 Pf proliferation inhibition EC50 uM>
1.45

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.015873016

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3910
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -6.3587   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5337   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 17 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3910

>  <JC_XSMILES>
NC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)C3=NC4=CC=CC=C4O3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.935

>  <W2 Pf proliferation inhibition EC50 uM>
0.893

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3928
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    5.3194    0.1425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.7556    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435   -1.1567    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.8366   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.7556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 11 17  1  0  0  0  0
  9 18  4  0  0  0  0
  3 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3928

>  <JC_XSMILES>
CSC1=NC(SC)=C2C(SC3=C2CCN(C)C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.75

>  <W2 Pf proliferation inhibition EC50 uM>
0.881

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3945
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -3.5723   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -3.4576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
  8 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 13 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 12 31  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3945

>  <JC_XSMILES>
COCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(OC)C(OC)=C3OC)C(=O)CCC2

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.97

>  <W2 Pf proliferation inhibition EC50 uM>
0.87

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028985507

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3946
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    2.1434    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 10 20  2  0  0  0  0
 20 21  1  4  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3946

>  <JC_XSMILES>
O=C(NC1=CC=CC=C1)C(NC(=O)C2=CC=CC=C2)=CC3=CC=NC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>2.696

>  <W2 Pf proliferation inhibition EC50 uM>
0.87

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-396
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    3.3759   -3.4030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7628   -2.8510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8490   -2.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5635   -1.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5635   -0.7930    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2780   -2.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9924   -1.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7069   -2.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4214   -1.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1358   -2.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8895   -1.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4415   -2.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0290   -3.0225    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2221   -2.8510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0953   -1.6949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5433   -2.3080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9558   -3.0225    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7363   -2.1365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1843   -2.7496    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4814   -1.3519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3256   -1.1804    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5805   -0.3957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0285    0.2173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7785    0.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0334   -0.7388    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8404   -0.9103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3924   -0.2972    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
  3 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 15 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-396

>  <JC_XSMILES>
CC1=C(C(=O)NCCCN2C=CN=C2)C3=C(O1)C(=O)C4=CC=CC=C4C3=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0904

>  <W2 Pf proliferation inhibition EC50 uM>
0.0391

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.2704

>  <Powder data?>
Yes

>  <IFI value>
0.243243243

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3972
  Mrv1591402191617072D          

 35 39  0  0  0  0            999 V2000
   -3.1511   -3.0076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3441   -2.8361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1726   -3.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5156   -2.0291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5371   -2.6646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2822   -1.8800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4752   -1.7084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -2.3479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851   -3.2777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  2  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 13 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
  8 34  4  0  0  0  0
 34 35  4  0  0  0  0
  5 35  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-3972

>  <JC_XSMILES>
CC(C)(C)C1=CC=C(CN2N=NC3=C(O)N=C(N=C23)C4CCN(CC4)C(=O)C5=CC=CC=C5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2418

>  <W2 Pf proliferation inhibition EC50 uM>
0.852

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.108108108

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3989
  Mrv1591402191617072D          

 37 39  0  0  1  0            999 V2000
    0.4917   -3.1816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -2.7691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9373   -3.1816    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2228   -1.9441    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4917   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -0.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -0.7066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -0.1923    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -0.3758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843    0.2692    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7279   -1.1191    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.5529   -1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9654   -0.4047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7904   -0.4047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2029   -1.1191    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2029    0.3098    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3700   -1.8624    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8843   -2.5075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7001   -2.3845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2145   -3.0295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5695   -3.5439    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8595   -2.5151    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7289   -3.6745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5829   -3.2754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7671   -3.3984    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0973   -3.9204    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7959   -4.6884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3103   -5.3334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0089   -6.1014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1931   -6.2244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6787   -5.5793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9801   -4.8114    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5656   -2.0460    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3821   -2.8503    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9206   -1.5316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2062   -1.9441    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 12 10  1  0  0  0  0
 12 13  1  6  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  2  0  0  0  0
 12 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
 19 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
 18 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  1  0  0  0  0
  8 36  4  0  0  0  0
 36 37  4  0  0  0  0
  5 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3989

>  <JC_XSMILES>
CC(=O)NC1=CC=C2NC(=O)[C@H](CCC(O)=O)N(C(CC(C)(C)C)C(=O)NC3CCCCC3)C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.868

>  <W2 Pf proliferation inhibition EC50 uM>
0.0516

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.18

>  <Powder data?>
No

>  <IFI value>
0.012195122

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4005
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.4474   -5.3983    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8953   -4.7852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503   -4.0006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -3.3875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7913   -3.5590    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5983   -0.4834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7913   -0.3119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5363    0.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0884    1.0859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8334    1.8705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0265    2.0420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8953    0.9143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1503    0.1297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 13 16  4  0  0  0  0
 16 17  4  0  0  0  0
 10 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  6 27  4  0  0  0  0
 18 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4005

>  <JC_XSMILES>
CCOC(=O)C1=C(N)N(C2=CC=C(CC)C=C2)C3=NC4=CC=CC=C4N=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.797

>  <W2 Pf proliferation inhibition EC50 uM>
0.823

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4007
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -0.2601    5.1202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5469    4.9487    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018    4.1641    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088    3.9926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047    2.7664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498    3.5510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2498   -4.0609    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8018   -4.6740    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 12 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 26 27  4  0  0  0  0
 20 27  4  0  0  0  0
M  CHG  1  12   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4007

>  <JC_XSMILES>
COC1=CC=C(C=C1)C(=O)C[N+]2=C3CCCN3C(=C2)C4=CC=C(OC)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.892

>  <W2 Pf proliferation inhibition EC50 uM>
0.822

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.048780488

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4008
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -1.9432   -3.8082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -3.0545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -2.3400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -1.7269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -2.8830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -2.3645    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.9355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  7  9  2  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4008

>  <JC_XSMILES>
CN1C=NC(=C1)S(=O)(=O)NC2=CC=CC=C2C(=O)NCC3CC3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.469

>  <W2 Pf proliferation inhibition EC50 uM>
0.0821

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.033613445

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4017
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    4.3808    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    2.9750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    5.6479    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    6.0604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    4.8229    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  4  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 10 24  4  0  0  0  0
 24 25  1  0  0  0  0
  6 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 32 35  4  0  0  0  0
 26 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4017

>  <JC_XSMILES>
CCOC(=O)C1=C(C)N=c2sc(=CC3=CC(Br)=CC=C3O)c(=O)n2C1C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.095

>  <W2 Pf proliferation inhibition EC50 uM>
0.814

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.024691358

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4028
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -0.2934    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8500    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1355    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4210    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  5  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4028

>  <JC_XSMILES>
CC1=CC=C(C=C1)C=NNC2=NC=NC3=C2N=CN3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.697

>  <W2 Pf proliferation inhibition EC50 uM>
0.804

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4030
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 22  4  0  0  0  0
 15 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4030

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2=CN=CC(=N2)C3=CN=CC(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.701

>  <W2 Pf proliferation inhibition EC50 uM>
0.803

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-404
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-404

>  <JC_XSMILES>
COCOC1=CC=C(C=C1)C2=NC(=CN=C2N)C3=CC=NC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.432

>  <W2 Pf proliferation inhibition EC50 uM>
>1.437

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4050
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -2.1434    8.4161    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.9411    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    7.1786    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.2911    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.4661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819    2.9812    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270    2.1965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020    2.1965    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470    2.9812    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119    1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369    1.5291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6918    0.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0244    0.2595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3570    0.7445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  2  8  4  0  0  0  0
  5  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 19 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4050

>  <JC_XSMILES>
FC1=CC=C(C(Cl)=C1)C(=O)N2CCN(CC2)C3=NC(=NS3)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.351

>  <W2 Pf proliferation inhibition EC50 uM>
0.0789

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4061
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 30 33  4  0  0  0  0
 33 34  1  0  0  0  0
 33 35  4  0  0  0  0
 35 36  4  0  0  0  0
 28 36  4  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
  9 39  4  0  0  0  0
  3 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4061

>  <JC_XSMILES>
COC1=CC=C(OC)C(NC(=O)COC2=CC3=CC=CC=C3C=C2C(=O)NC4=CC(OC)=C(Cl)C=C4OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.15

>  <W2 Pf proliferation inhibition EC50 uM>
0.782

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4071
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9685   -1.1853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7568   -1.4284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0582   -2.1964    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8809   -2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3457   -1.5764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1684   -1.6381    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5263   -2.3814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6331   -0.9564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6457   -2.9109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1105   -3.5925    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8299   -3.0338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2252   -2.4727    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
  8 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 20 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 27 33  1  0  0  0  0
 33 34  2  0  0  0  0
 33 35  1  0  0  0  0
 35 36  1  0  0  0  0
 24 36  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4071

>  <JC_XSMILES>
COC1=CC=C2C=C(CNCCC3=CC=CC(Cl)=C3)C(=NC2=C1)N4CCN(CCN(C)C)C(=O)CC4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.0772

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.097345133

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4089
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    0.2854    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.8085    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  3  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  6 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  4  0  0  0  0
 16 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 28 29  4  0  0  0  0
 23 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4089

>  <JC_XSMILES>
NC1=C(C#N)C(C2=CC=CC=C2)=C3C(N)=C(SC3=N1)C(=O)NC4=CC=C(Br)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
8.21

>  <W2 Pf proliferation inhibition EC50 uM>
0.763

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4095
  Mrv1591402191617072D          

 35 40  0  0  0  0            999 V2000
    3.7083    0.1363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633    0.9210    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4783    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6533    1.5884    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2408    0.8739    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158    0.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033    0.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158   -0.5550    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033   -1.2695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158   -1.9840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033   -2.6984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783   -2.6984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2342   -1.9840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783   -1.2695    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783    0.1595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2342    0.8739    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2342    2.3029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1783    3.0173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033    3.0173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4158    2.3029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0033    1.5884    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9633    2.2558    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    2.4134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1768    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4623    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7479    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2603   -0.4768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0673   -0.3052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6194   -0.9183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3644   -1.7030    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5574   -1.8745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0054   -1.2614    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  4  3  1  4  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  6 22  4  0  0  0  0
 17 22  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
  2 29  4  0  0  0  0
 24 29  4  0  0  0  0
  1 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4095

>  <JC_XSMILES>
C(N1C(N=NC2=C(NC3=CC=CC=C3)C=CC4=CC=CC=C24)=NC5=CC=CC=C15)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
2.734

>  <W2 Pf proliferation inhibition EC50 uM>
0.669

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
88.01

>  <Powder data?>
Yes

>  <IFI value>
0.150793651

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4107
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8653    0.4014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0368    1.2084    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0583    0.5729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6722    0.2299    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4107

>  <JC_XSMILES>
CC1=CC=CC(=C1)C(=O)NCc2n[nH]c(=S)n2C3=CC=CC(=C3)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
2.175

>  <W2 Pf proliferation inhibition EC50 uM>
0.75

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4113
  Mrv1591402191617072D          

 24 24  0  0  0  0            999 V2000
   -7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4113

>  <JC_XSMILES>
CCOC(=O)NN=C(C)C1=CC=C(C=C1)C(C)=NNC(=O)OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
>5.59

>  <W2 Pf proliferation inhibition EC50 uM>
0.747

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.02173913

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-413
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
   -0.1712   -4.9848    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 14 13  1  4  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  3  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
  5 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
  2 29  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  26
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-413

>  <JC_XSMILES>
ClC1=CC=C(COC2=CC=CC=C2C=C(C#N)C3=NC4=CC=CC=C4N3)C(Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.129

>  <W2 Pf proliferation inhibition EC50 uM>
0.717

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
5.05

>  <Powder data?>
Yes

>  <IFI value>
N/A

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4130
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    3.9855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    4.8105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3529    7.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6384    7.6980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    7.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9239    6.4605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 18 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4130

>  <JC_XSMILES>
OC(CN1CCN(CC1)CC2=CC=CC=C2)CN3C4=CC=C(I)C=C4C5=CC(I)=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.651

>  <W2 Pf proliferation inhibition EC50 uM>
0.1476

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.13

>  <Powder data?>
Yes

>  <IFI value>
0.075471698

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-416
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7053   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8848   -4.0144    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0152   -4.5956    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2701   -5.3802    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6027   -5.8651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9353   -5.3802    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6027   -6.6901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2701   -7.1751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0152   -7.9597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902   -7.9597    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9353   -7.1751    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 11 25  4  0  0  0  0
 25 26  4  0  0  0  0
  9 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-416

>  <JC_XSMILES>
CC1=CC=CC=C1CN2C=C(NC(=O)C3=NOC(=C3)C4=CC=CS4)C=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.415

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4167
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
    4.9675    0.9963    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9675    0.1713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6820   -0.2412    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2531   -0.2412    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2531   -1.0662    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9205   -1.5511    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6656   -2.3357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1505   -3.0031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8406   -2.3357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5856   -1.5511    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.3556   -3.0031    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6106   -3.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9431   -4.2727    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.2757   -3.7878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4911   -4.0427    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -3.4907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0934   -3.7456    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5197   -3.1936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3482   -2.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9613   -1.8346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4364   -2.1317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0495   -2.6837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5306   -3.0031    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 16 22  4  0  0  0  0
 14 23  4  0  0  0  0
 11 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4167

>  <JC_XSMILES>
CC(=O)NC1=NC(C)=C(S1)C2=CSC(NC3=CC=C(C)C=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2397

>  <W2 Pf proliferation inhibition EC50 uM>
0.1659

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
23.62

>  <Powder data?>
Yes

>  <IFI value>
0.033333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4172
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
  6 20  4  0  0  0  0
 20 21  4  0  0  0  0
  3 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4172

>  <JC_XSMILES>
COC1=CC=C(CCNC(=S)NC2=CC=CC=C2C)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.095

>  <W2 Pf proliferation inhibition EC50 uM>
0.698

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4185
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6918   -3.9591    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0244   -4.4440    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3570   -3.9591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5723   -4.2140    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -0.7027    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.6919    0.1043    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.1335   -1.2547    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  5  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  1  0  0  0  0
 14 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  2  0  0  0  0
M  CHG  2  30   1  31  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4185

>  <JC_XSMILES>
CC1=CC=C(C=C1)C=NNC(=O)C2=C(N(N=N2)C3=NON=C3N)C4=CC=C(C=C4)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2037

>  <W2 Pf proliferation inhibition EC50 uM>
0.503

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>72.99

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-419
  Mrv1591402191617072D          

 26 27  0  0  0  0            999 V2000
    2.8579   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.4105    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -4.8395    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  5 22  4  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  1  0  0  0  0
 23 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-419

>  <JC_XSMILES>
FC(F)(F)C1=CC(NC(=O)NC2=CC=C(Cl)C(Cl)=C2)=CC(=C1)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.814

>  <W2 Pf proliferation inhibition EC50 uM>
0.927

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.57

>  <Powder data?>
Yes

>  <IFI value>
0.188034188

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4194
  Mrv1591402191617072D          

 42 47  0  0  0  0            999 V2000
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3022   -5.9305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7871   -6.5979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6076   -6.5117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9431   -5.7580    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4582   -5.0906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4515   -7.3516    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6446   -7.5231    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0315   -6.9711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5583   -8.3436    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3120   -8.6792    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8640   -8.0661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6845   -8.1523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 19 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
 11 30  4  0  0  0  0
  8 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
  9 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4194

>  <JC_XSMILES>
CC1=CC=C(C=C1)N2C(=CC(C=NNC(=O)C3=CC(=CC=C3)N4C(C)=CC=C4C)=C2C5=CC=CC=C5)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.867

>  <W2 Pf proliferation inhibition EC50 uM>
0.684

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4201
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  8 18  4  0  0  0  0
 13 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 25 26  4  0  0  0  0
 19 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4201

>  <JC_XSMILES>
CCCCNC(=O)C1=NN(C(=O)C2=CC=CC=C12)C3=CC=C(OC)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
2.254

>  <W2 Pf proliferation inhibition EC50 uM>
0.68

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023529412

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4212
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3339   -2.4026    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -1.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -1.6180    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6687   -2.4026    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
  2 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 14 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4212

>  <JC_XSMILES>
CC(NC(=O)C(=O)N1CCCCC1)C(N2CCOCC2)C3=CC=CS3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.685

>  <W2 Pf proliferation inhibition EC50 uM>
0.675

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.014084507

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4227
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.1712    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    1.4455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    1.4455    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    2.1599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1311    1.4925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9157    1.7474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9157    2.5724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1311    2.8274    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9962   -2.1269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  2  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 14  1  0  0  0  0
  4 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  3  0  0  0  0
 15 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4227

>  <JC_XSMILES>
CC1=CC(C=C(C)N1CC2CCCO2)=C(C#N)C3=NC4=CC=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.411

>  <W2 Pf proliferation inhibition EC50 uM>
0.67

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4234
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    0.2498   -4.0609    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2227    3.6495    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7326    2.0803    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
 10 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  8 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  CHG  1  10   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4234

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=C[N+](CC3=CC=C(Cl)C(Cl)=C3)=C4CCCN24

>  <PF proliferation inhibition 3D7 EC50 uM>
0.446

>  <W2 Pf proliferation inhibition EC50 uM>
0.623

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>93.58

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4235
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    2.0367   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -3.7741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -5.4965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -6.2812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -6.9486    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3130   -7.7023    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7980   -8.3697    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4624   -9.1234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6419   -9.2096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1570   -8.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4926   -7.7885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3064   -9.9633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4859  -10.0495    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7913  -10.6307    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4557  -11.3844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9407  -12.0518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6051  -12.8055    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7846  -12.8918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2997  -12.2243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6353  -11.4706    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4491  -13.6454    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8616  -14.3599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3095  -14.9730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4811  -15.7800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5559  -14.6374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6421  -13.8170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0290  -13.2649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -6.2812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -5.4965    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 28 29  1  0  0  0  0
  6 30  4  0  0  0  0
 30 31  4  0  0  0  0
  4 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4235

>  <JC_XSMILES>
CC(=O)C1=CC(CN2CCC(CC2)C(=O)NC3=CC=C(C=C3)N4N=C(C)C=C4C)=CS1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.969

>  <W2 Pf proliferation inhibition EC50 uM>
0.665

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4238
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 10 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 28 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  2  0  0  0  0
 23 34  4  0  0  0  0
  8 34  4  0  0  0  0
M  CHG  2  31   1  32  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4238

>  <JC_XSMILES>
CN1CCN(CC1)C2=NC(NN=CC3=CC(I)=CC=C3O)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.383

>  <W2 Pf proliferation inhibition EC50 uM>
0.316

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.66

>  <Powder data?>
Yes

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4257
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
 10 22  4  0  0  0  0
 15 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
  3 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4257

>  <JC_XSMILES>
COC1=CC=C(C=NNC2=CC(C)=NC3=CC=C(OC)C=C23)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0331

>  <W2 Pf proliferation inhibition EC50 uM>
0.0435

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
6.69

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-427
  Mrv1591402191617072D          

 41 45  0  0  0  0            999 V2000
    0.5942    2.7954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0422    2.1823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2971    1.3977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2549    0.7846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0619    0.9561    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4849   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -1.3819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5474   -1.3819    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -2.0964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7224   -2.8109    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3099   -3.5253    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4894   -3.6116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3179   -4.4185    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0324   -4.8310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1186   -5.6515    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8723   -5.9871    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9585   -6.8075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7122   -7.1431    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2911   -7.2925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5374   -6.9569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1300   -7.4418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0438   -8.2623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7112   -8.7472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7099   -8.5979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7961   -9.4184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3773   -8.1130    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6455   -4.2790    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4525   -4.4505    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7074   -5.2351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5144   -5.4067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0664   -4.7936    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8115   -4.0090    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0045   -3.8374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.3349    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5692   -1.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 21 28  4  0  0  0  0
 16 29  4  0  0  0  0
 13 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 30 35  1  0  0  0  0
  7 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
  6 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 37 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-427

>  <JC_XSMILES>
CCOC(=O)C1=C(NC(=O)CSC2=NN=C(CNC(=O)C3=CC=C(C)C(C)=C3)N2C4CCCCC4)SC5=C1CCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.087

>  <W2 Pf proliferation inhibition EC50 uM>
>1.399

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.024096386

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4272
  Mrv1591402191617072D          

 50 58  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -6.6724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -8.1715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -8.8860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -8.8860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -8.1715    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -7.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -6.6724    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -9.6005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2250  -10.3541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3881  -10.9062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3881  -11.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1025  -12.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8170  -11.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5315  -12.1437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5315  -12.9687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8170  -13.3812    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2459  -13.3812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2459  -14.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9604  -14.6187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6749  -14.2062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6749  -13.3812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3894  -12.9687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3894  -12.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6749  -11.7312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9604  -12.1437    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9604  -12.9687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8170  -10.9062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1025  -10.4937    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9310   -9.6867    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 15 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 28 37  4  0  0  0  0
 32 37  4  0  0  0  0
 24 38  4  0  0  0  0
 38 39  4  0  0  0  0
 21 39  4  0  0  0  0
 39 40  4  0  0  0  0
 19 40  4  0  0  0  0
  2 41  1  0  0  0  0
 41 42  4  0  0  0  0
 42 43  4  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 41 50  4  0  0  0  0
 45 50  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  40
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4272

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C2=NC3=CC=C(C=C3N2)C4=NC5=CC=C(NC(=O)C6=CC=CC7=CC=CC=C67)C=C5N4)C8=CC=CC9=CC=CC=C89

>  <PF proliferation inhibition 3D7 EC50 uM>
0.742

>  <W2 Pf proliferation inhibition EC50 uM>
0.641

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.059701493

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4275
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    1.3099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    2.0945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8974    2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    1.3099    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
  5 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 12 17  4  0  0  0  0
 10 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 21 24  1  0  0  0  0
  9 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4275

>  <JC_XSMILES>
COC(=O)C1=C(C)NC2=C(C1C3=CC=C(C)O3)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.58

>  <W2 Pf proliferation inhibition EC50 uM>
0.638

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.00862069

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4279
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    0.6710   -5.1170    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190   -4.5039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880   -4.6754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739   -3.7192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781   -3.1062    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768   -2.3215    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -2.7631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -3.5477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  4  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  12
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4279

>  <JC_XSMILES>
CC(C)N1CCC(=CC1)C2=CNC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2062

>  <W2 Pf proliferation inhibition EC50 uM>
0.637

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4287
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -3.6791   10.1277    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501   10.1277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    8.4777    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2337    7.7632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4087    9.1922    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    8.0652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.2402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    4.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    4.2803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4287

>  <JC_XSMILES>
BrC1=CC=C(C=C1)S(=O)(=O)N2CCC(CC2)C(=O)NCC3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.362

>  <W2 Pf proliferation inhibition EC50 uM>
0.629

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4294
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1792   -2.8265    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6937   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2960   -0.1085    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  5  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
  7 25  4  0  0  0  0
  2 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4294

>  <JC_XSMILES>
CC1=CC=C(C)C(NC(=O)C2=C(C)ON=C2C3=C(Cl)C=CC=C3Cl)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2177

>  <W2 Pf proliferation inhibition EC50 uM>
0.443

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>70.74

>  <Powder data?>
Yes

>  <IFI value>
0.045977011

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4300
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
  6 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 14 24  1  0  0  0  0
 24 25  2  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
 13 32  1  0  0  0  0
 32 33  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4300

>  <JC_XSMILES>
CC(=O)N(CC1=CC=C(F)C=C1)C2=C(NCCC3=CC=CC=C3)C(=O)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00593

>  <W2 Pf proliferation inhibition EC50 uM>
0.01817

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
2.913

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4321
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -15.2625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.8500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -14.0250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
  7 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 19 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
M  CHG  2  10   1  11  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4321

>  <JC_XSMILES>
CCOC1=CC=C(C=C1[N+]([O-])=O)C(=O)CN2C=CC(C=C2)=NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0697

>  <W2 Pf proliferation inhibition EC50 uM>
0.1213

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.09

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4330
  Mrv1591402191617072D          

 18 18  0  0  0  0            999 V2000
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
  8 17  4  0  0  0  0
 17 18  4  0  0  0  0
  5 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4330

>  <JC_XSMILES>
CC(=O)NC1=CC=C(NC(=O)C(C)(C)CCl)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1

>  <W2 Pf proliferation inhibition EC50 uM>
0.0621

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.48

>  <Powder data?>
No

>  <IFI value>
0.025316456

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4332
  Mrv1591402191617072D          

 47 53  0  0  0  0            999 V2000
    2.3195   -4.0897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3195   -4.9147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6050   -5.3272    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6050   -6.1522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3195   -6.5647    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8905   -6.5647    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8905   -7.3897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1761   -7.8022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5384   -7.3897    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5384   -6.5647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1761   -6.1522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2529   -7.8022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2529   -8.6272    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9674   -7.3897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6818   -7.8022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3963   -7.3897    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3963   -6.5647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1108   -6.1522    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0031   -5.3343    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5053   -4.6797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8109   -5.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5832   -6.5467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7653   -6.6544    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0855   -5.8922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8477   -6.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.5022   -5.7057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.3945   -4.8878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6323   -4.5721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.5246   -3.7541    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9778   -5.0743    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3233   -4.5721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6818   -6.1522    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6818   -5.3272    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9674   -4.9147    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5549   -5.6292    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3799   -4.2002    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2529   -4.5022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2529   -3.6772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5384   -3.2647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1761   -3.6772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8905   -3.2647    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6050   -3.6772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6050   -4.5022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8905   -4.9147    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.1761   -4.5022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5384   -4.9147    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9674   -6.5647    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  2  0  0  0  0
 28 30  4  0  0  0  0
 24 30  4  0  0  0  0
 30 31  1  0  0  0  0
 20 31  1  0  0  0  0
 17 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  2  0  0  0  0
 34 36  2  0  0  0  0
 34 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  1  0  0  0  0
 44 45  1  0  0  0  0
 40 45  4  0  0  0  0
 45 46  4  0  0  0  0
 37 46  4  0  0  0  0
 32 47  4  0  0  0  0
 14 47  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4332

>  <JC_XSMILES>
CCOC(=O)N1CCN(CC1)C(=O)C2=CC=C(N3CC4CC(C3)C5=CC=CC(=O)N5C4)C(NS(=O)(=O)C6=CC=C7OCCOC7=C6)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
2.47

>  <W2 Pf proliferation inhibition EC50 uM>
0.589

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4334
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    3.6047    3.7869    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.1400    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3173    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8526    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9049    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0625   -1.3914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2461   -2.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6413   -2.7569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1471   -2.5137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3306   -1.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2741   -1.1483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3206    2.3003    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  6 29  4  0  0  0  0
  2 29  4  0  0  0  0
 29 30  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4334

>  <JC_XSMILES>
ClC1=CC=CC(C2NC3=CC=CC=C3NC4=C2C(=O)CC(C4)C5=CC=CC=C5)=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2878

>  <W2 Pf proliferation inhibition EC50 uM>
0.464

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>78.83

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4345
  Mrv1591402191617072D          

 50 57  0  0  0  0            999 V2000
   -2.6944    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944    2.1918    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5510   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944   -1.9332    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6944   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9799   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2654   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -0.6957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -0.2832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    0.5418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    0.7967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320    1.5814    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8620    0.1293    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771   -0.5381    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6320   -1.3228    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6870    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245    0.8438    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3370    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9245   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0995   -0.5852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6870   -1.2997    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.9024   -1.5546    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    4.0995   -2.0141    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    0.9543    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    1.7793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780    3.4293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    3.0168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925    2.1918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6717    0.1293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1533    0.1293    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -1.5207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5925   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8780   -3.1707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -2.7582    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1635   -1.9332    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 11 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 25 26  2  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  2  0  0  0  0
 21 36  1  0  0  0  0
  9 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 40 41  4  0  0  0  0
 41 42  4  0  0  0  0
 37 42  4  0  0  0  0
 36 43  1  0  0  0  0
 19 43  1  0  0  0  0
 43 44  2  0  0  0  0
 19 45  1  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 48 49  4  0  0  0  0
 49 50  4  0  0  0  0
 45 50  4  0  0  0  0
M  CHG  2  33   1  34  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4345

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(C3=CC=C(OC)C=C3)C4(C5C(C(=O)N(C5=O)C6=CC=CC=C6[N+]([O-])=O)C2(C7=CC=CC=C7)C4=O)C8=CC=CC=C8

>  <PF proliferation inhibition 3D7 EC50 uM>
1.188

>  <W2 Pf proliferation inhibition EC50 uM>
0.58

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4353
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -2.8579   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7309   -3.6020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5559   -2.1730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4353

>  <JC_XSMILES>
FC(F)(F)C1=CC=C(C=C1)N2N=NC3=CC=CC=C3C2=N

>  <PF proliferation inhibition 3D7 EC50 uM>
0.392

>  <W2 Pf proliferation inhibition EC50 uM>
0.575

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025316456

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4363
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
  9 24  4  0  0  0  0
 24 25  4  0  0  0  0
  5 25  4  0  0  0  0
 25 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4363

>  <JC_XSMILES>
CC1=CC=C2C(C)=NC(NC3=NC(C)=CC(=N3)C4=CC=CC=C4)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.975

>  <W2 Pf proliferation inhibition EC50 uM>
0.569

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4365
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8007   -1.2330    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6077   -1.4045    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0202   -0.6900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4681   -0.0769    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6397    0.7300    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8112    1.5370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8327    0.9016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4466    0.5585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
  6 11  1  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  4  0  0  0  0
 15 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 26 27  2  0  0  0  0
 12 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 28 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
 33 36  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4365

>  <JC_XSMILES>
CCOC(=O)C1CCN(CC1)C(C2=CC3=CC(OC)=C(OC)C=C3NC2=O)C4=NN=NN4C(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.889

>  <W2 Pf proliferation inhibition EC50 uM>
0.567

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.052083333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4371
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    5.4610    7.9545    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.2815    8.0407    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6171    8.7944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4375    8.8807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9225    8.2132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5869    7.4595    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7664    7.3733    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4309    6.6196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9158    5.9522    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5802    5.1985    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0652    4.5311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8902    4.5311    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1451    3.7465    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4777    3.2615    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8102    3.7465    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.4777    2.4365    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7632    2.0240    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.1921    2.0240    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.1921    1.1990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6046    0.4846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7796    0.4846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 14 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 19 21  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4371

>  <JC_XSMILES>
ClC1=CC=CC=C1CSCC2=CC=C(O2)C(=O)NC3CC3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.503

>  <W2 Pf proliferation inhibition EC50 uM>
0.562

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4376
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971    2.3981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491    1.7850    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0366    1.0705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296    1.2420    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 13 17  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
  4 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4376

>  <JC_XSMILES>
CCOC1=CC=C(CCNC(=O)C2=CC=CS2)C=C1OCC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.89

>  <W2 Pf proliferation inhibition EC50 uM>
0.56

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4383
  Mrv1591402191617072D          

 31 33  0  0  0  0            999 V2000
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -8.2500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -10.7250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -11.5500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -9.4875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -10.7250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6993  -10.0105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8743  -11.4395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -11.1375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -13.2000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -13.6125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302  -11.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 22 28  1  0  0  0  0
 28 29  1  0  0  0  0
  7 30  4  0  0  0  0
 30 31  4  0  0  0  0
  4 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4383

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)C2=CC=C(F)C(=C2)S(=O)(=O)NC3CCCC(C)C3C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.041

>  <W2 Pf proliferation inhibition EC50 uM>
0.1778

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
32.23

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4413
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    0.9130   -0.8764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7200   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0171    0.3498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7621    1.1344    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0790   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7464   -0.1215    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4139   -0.6064    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.4349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7729   -1.0479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5179   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7110   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1589   -1.3910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3339   -1.3910    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7819   -2.0041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9749   -1.8326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0368   -2.7887    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8438   -2.9602    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0987   -3.7449    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5467   -4.3580    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7397   -4.1864    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4848   -3.4018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8017   -5.1426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2496   -5.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5046   -6.5403    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9525   -7.1534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1456   -6.9819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5935   -7.5950    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8906   -6.1972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4426   -5.5841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  3  0  0  0  0
  3  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4413

>  <JC_XSMILES>
CC1=C(C#N)C2=NC3=CC=CC=C3N2C(=C1)N4CCN(CC4)CC5=CC=C(F)C=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.625

>  <W2 Pf proliferation inhibition EC50 uM>
0.53

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011764706

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4434
  Mrv1591402191617072D          

 31 35  0  0  1  0            999 V2000
    1.7174    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7174    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4319    1.4041    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.4319    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1464    2.6416    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2839    2.0916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2839    1.5416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1464    0.9916    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.8608    1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8608    2.2291    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.5753    2.6416    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.5753    3.4666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898    3.8791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    3.4666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898    4.7041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    5.1166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    5.9416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7187    6.3541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4332    5.9416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4332    5.1166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7187    4.7041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    2.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7187    2.2291    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7187    1.4041    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0043    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898   -0.2459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5753    0.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5753    0.9916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2898    1.4041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  3  2  1  1  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  6  0  0  0
  3  8  1  0  0  0  0
  8  9  1  0  0  0  0
 10  9  1  0  0  0  0
 10  5  1  0  0  0  0
 10 11  1  1  0  0  0
 11 12  1  1  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 22 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4434

>  <JC_XSMILES>
C=C[C@H]1CN2CC[C@H]1C[C@@H]2[C@@H](OC(=O)CC3=CC=CC=C3)C4=CC=NC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0494

>  <W2 Pf proliferation inhibition EC50 uM>
0.0517

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4439
  Mrv1591402191617072D          

 17 18  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
  2 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   3
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4439

>  <JC_XSMILES>
CC1=NC2=CC=CC=C2C(O)=C1CC=C(Cl)Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.498

>  <W2 Pf proliferation inhibition EC50 uM>
0.514

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4441
  Mrv1591402191617072D          

 15 15  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  7 15  4  0  0  0  0
  2 15  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4441

>  <JC_XSMILES>
CC1=CC(C)=CC(NC(=S)NCCO)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.86

>  <W2 Pf proliferation inhibition EC50 uM>
0.513

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4475
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
  6 16  4  0  0  0  0
 11 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4475

>  <JC_XSMILES>
CCOC(=O)C1=CC=C2N=C(C=C(O)C2=C1)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.549

>  <W2 Pf proliferation inhibition EC50 uM>
0.493

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.156521739

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-448
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
   -1.7605   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5230   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 Sn  0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9520   -3.6020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1895   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 11 20  4  0  0  0  0
 15 20  4  0  0  0  0
  5 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 22 31  4  0  0  0  0
 26 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-448

>  <JC_XSMILES>
CCCC[Sn](CCCC)(OC1=CC=CC2=CC=CN=C12)OC3=CC=CC4=CC=CN=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.658

>  <W2 Pf proliferation inhibition EC50 uM>
1.351

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.3

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4489
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -2.5569    4.4072    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7499    4.2357    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9214    3.4287    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5784    5.0426    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9429    4.0641    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6880    3.2795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1190    3.1080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1781    1.7103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0768    0.9256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -3.1729    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.8128   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.4628   -2.3479    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1530    0.9475    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9600    1.1191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3725    0.4046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8204   -0.2085    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9851    1.8818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2400    2.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 18 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
 16 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
  9 31  4  0  0  0  0
 31 32  4  0  0  0  0
  6 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4489

>  <JC_XSMILES>
FC(F)(F)OC1=CC=C(NC(=O)C2=C3NC(CC(N3N=C2)C(F)(F)F)C4=CC=CS4)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.492

>  <W2 Pf proliferation inhibition EC50 uM>
0.2414

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>49.96

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4502
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
 13 19  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  14
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4502

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)CSC2=NN=CC(=O)N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.859

>  <W2 Pf proliferation inhibition EC50 uM>
0.473

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4508
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    5.3203    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0347    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0347    3.3129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7492    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4637    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1782    2.0754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.8926    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6071    2.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.6071    1.2504    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3216    2.4879    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.0360    2.0754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.7897    2.4110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0447    3.1956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8516    3.3671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4037    2.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2106    2.9256    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   13.1487    1.9694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.3417    1.7979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.9292    1.0834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1842    0.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.6322   -0.3143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8871   -1.0989    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   10.8252   -0.1428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.5702    0.6419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.1223    1.2550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 12 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 11 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4508

>  <JC_XSMILES>
CC(C)CCNCC(O)CN1C2=CC=C(Cl)C=C2C3=CC(Cl)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1921

>  <W2 Pf proliferation inhibition EC50 uM>
0.0966

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.58

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4523
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  5 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4523

>  <JC_XSMILES>
OC1=CC=C(C=C1CNC2CCN(CC2)CC3=CC=CC=C3)C4=CN=CC=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.385

>  <W2 Pf proliferation inhibition EC50 uM>
0.38

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
82.83

>  <Powder data?>
Yes

>  <IFI value>
0.055555556

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4535
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4369   -3.1745    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6918   -3.9591    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0244   -4.4440    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3570   -3.9591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5723   -4.2140    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3381   -0.6605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5204   -0.7027    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6919    0.1043    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -2.3166    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0058   -3.1236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
 15 16  1  0  0  0  0
  7 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 17 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4535

>  <JC_XSMILES>
CCOC(=O)C1=C(N(N=N1)C2=NON=C2N)C3=CC=C(OC)C(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.513

>  <W2 Pf proliferation inhibition EC50 uM>
0.45

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4540
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0392    3.3769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5912    3.9900    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1787    4.7045    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4337    5.4891    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1184    6.1022    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9253    5.9307    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1803    5.1461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6282    4.5330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  3 11  4  0  0  0  0
  6 11  4  0  0  0  0
  1 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 13 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   5
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4540

>  <JC_XSMILES>
C(CC1=CNC2=CC=CC=C12)NC3=C4C=CC=CC4=NC5=CC=CC=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.086

>  <W2 Pf proliferation inhibition EC50 uM>
0.03158

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
7.08

>  <Powder data?>
Yes

>  <IFI value>
0.058823529

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4545
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
   -2.0514   -4.0458    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6498   -3.3251    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8249   -3.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4233   -2.5919    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4016   -2.5793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8249   -3.2875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6498   -3.2749    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0731   -3.9830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8980   -3.9705    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2996   -3.2498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1245   -3.2373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5478   -3.9454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3521   -3.7616    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4259   -2.9399    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6672   -2.6158    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1463   -4.6660    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3213   -4.6786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9198   -5.3993    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0949   -5.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6715   -4.7037    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.8466   -4.7162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4233   -4.0081    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4016   -4.0207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8032   -4.7413    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6281   -4.7539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 11 15  1  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
  8 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  CHG  1  20   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4545

>  <JC_XSMILES>
COC1=CC=C2C=C3C4=CC5=C(OCO5)C=C4CC[N+]3=CC2=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.218

>  <W2 Pf proliferation inhibition EC50 uM>
0.442

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.018404908

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4550
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3739    2.3234    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  7 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 19 20  4  0  0  0  0
  6 20  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4550

>  <JC_XSMILES>
CCOC(=O)C1=C(N=NN(C)C)C2=CC(C)=CC=C2N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1811

>  <W2 Pf proliferation inhibition EC50 uM>
0.1147

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
26.29

>  <Powder data?>
Yes

>  <IFI value>
0.054545455

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4556
  Mrv1591402191617072D          

 42 45  0  0  0  0            999 V2000
   -2.9114   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1969   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4824   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7680   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0535   -3.4137    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -3.0012    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -2.1762    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -3.4137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -3.0012    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0283   -2.1785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2603   -1.8771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1373   -1.0613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6330   -1.6173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3899   -0.8290    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4488   -1.7403    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.8613   -2.4548    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6771   -2.3318    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1915   -2.9768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8901   -3.7448    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4045   -4.3898    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2203   -4.2668    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7346   -4.9119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5504   -4.7889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8518   -4.0209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6676   -3.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1820   -4.5430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.8806   -5.3109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3950   -5.9560    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.2107   -5.8330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0648   -5.4339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0743   -3.8677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5599   -3.2227    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7716   -3.4659    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6486   -4.2817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -4.2387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -4.6512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0899   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3755   -5.8887    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0535   -5.8887    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7680   -5.4762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6610   -4.6512    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 23 30  4  0  0  0  0
 19 31  4  0  0  0  0
 31 32  4  0  0  0  0
 16 32  4  0  0  0  0
 32 33  1  0  0  0  0
  9 33  1  0  0  0  0
 33 34  2  0  0  0  0
  8 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 39 42  4  0  0  0  0
 35 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4556

>  <JC_XSMILES>
CCCCNC(=O)C(N1C(CO)C(=O)NC2=CC=C(OCCC3=CC=CC(OC)=C3)C=C2C1=O)C4=CC=CC(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.11

>  <W2 Pf proliferation inhibition EC50 uM>
0.0429

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4558
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 12 11  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4558

>  <JC_XSMILES>
COC1=CC=CC=C1C(=O)ON=C(N)CC2=CC=CC3=CC=CC=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.352

>  <W2 Pf proliferation inhibition EC50 uM>
0.2123

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.63

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4577
  Mrv1591402191617072D          

 16 18  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 I   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  2  0  0  0  0
 13 15  4  0  0  0  0
  5 15  4  0  0  0  0
 15 16  4  0  0  0  0
  2 16  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   6
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4577

>  <JC_XSMILES>
IC1=CC=C2NC3=CC=CC=C3C(=O)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.393

>  <W2 Pf proliferation inhibition EC50 uM>
0.418

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4584
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2149   -1.4924    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.6998   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2149   -0.1576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.6687   -4.1974    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8987   -5.6495    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5888   -4.9820    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3339   -4.1974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5492   -3.9425    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 16 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  1  0  0  0  0
 22 34  4  0  0  0  0
 34 35  4  0  0  0  0
  8 35  4  0  0  0  0
 35 36  4  0  0  0  0
  5 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4584

>  <JC_XSMILES>
COC(=O)C1=CC=C2C(=O)N(CC3=CC=C4OCOC4=C3)C(SCC(=O)N5N=C(C)C=C5N)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1438

>  <W2 Pf proliferation inhibition EC50 uM>
0.0412

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4588
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    3.2468    4.5302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6047    3.7869    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1400    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8526    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0299    2.5469    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6719    3.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3173    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9594    3.9102    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1367    3.9719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1094    2.3620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3968    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7548    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8616    1.0603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9049    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8433   -0.8714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5647   -1.6489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 14 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  2  0  0  0  0
 27 28  1  0  0  0  0
 13 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 32 35  1  0  0  0  0
 27 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4588

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C2N(C(=O)C(C)C)C3=CC=CC=C3NC4=C2C(=O)CC(C)(C)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
0.0407

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4593
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 10 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
 24 35  4  0  0  0  0
  8 35  4  0  0  0  0
  6 36  4  0  0  0  0
 36 37  4  0  0  0  0
  3 37  4  0  0  0  0
M  CHG  4  20   1  21  -1  32   1  33  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4593

>  <JC_XSMILES>
COC1=CC=C(NC2=NC(NN=CC3=CC=CC(=C3)[N+]([O-])=O)=NC(NC4=CC=C(C=C4)[N+]([O-])=O)=N2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.406

>  <W2 Pf proliferation inhibition EC50 uM>
0.404

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.052631579

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4594
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -7.8375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4594

>  <JC_XSMILES>
CCCNCC(O)COC1=CC=CC=C1C(=O)CCC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2521

>  <W2 Pf proliferation inhibition EC50 uM>
0.1165

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.86

>  <Powder data?>
Yes

>  <IFI value>
0.005494505

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4603
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
  6 16  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4603

>  <JC_XSMILES>
CCOC1=CC2=C(C=C1OCC)C(NCC2)C3=CC(Cl)=CC=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.404

>  <W2 Pf proliferation inhibition EC50 uM>
0.0964

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
24.19

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4621
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813   -0.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6435    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0025    2.4233    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5546    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3615    2.8649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4515    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2585    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8105    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5556    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7486    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1966    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
  6 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 19 24  1  0  0  0  0
 22 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 20 32  4  0  0  0  0
  8 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4621

>  <JC_XSMILES>
CC(C)CSC1=NC2=C(C(=O)N1C3=CC=CC=C3)C4=C(CN(CC4)CC5=CC=CC=C5)S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.945

>  <W2 Pf proliferation inhibition EC50 uM>
0.392

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.025

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4636
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
  5 13  4  0  0  0  0
 13 14  1  0  0  0  0
  3 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 21 23  4  0  0  0  0
 23 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4636

>  <JC_XSMILES>
CCC(SC1=NC(CC)=CC(=O)N1C)C(=O)NC2=CC=C(F)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.484

>  <W2 Pf proliferation inhibition EC50 uM>
0.383

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4639
  Mrv1591402191617072D          

 29 32  0  0  0  0            999 V2000
    2.8972    3.8750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.0808    3.0707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8691    2.8275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0527    2.0232    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4479    1.4620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6596    1.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4760    2.5095    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315    0.6577    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358    0.4742    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7938   -0.2691    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4358   -1.0124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502   -1.6575    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6315   -1.1960    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865   -0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720   -1.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575   -0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5575    0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8431    0.5559    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2720    0.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9865    0.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9502    1.1192    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6488    1.8871    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7660    0.9962    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2804    1.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0961    1.5183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6751    2.1060    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4130    1.7369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2900    0.9211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4762    0.7860    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
  8 20  1  0  0  0  0
 14 20  4  0  0  0  0
  9 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 25 29  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4639

>  <JC_XSMILES>
FC1=CC=C(C=C1)C2N(CC(=O)NC3=CC=C(F)C=C23)C(=O)CCC4CCCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.666

>  <W2 Pf proliferation inhibition EC50 uM>
0.2299

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
60.34

>  <Powder data?>
Yes

>  <IFI value>
0.026315789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-464
  Mrv1591402191617072D          

 25 28  0  0  0  0            999 V2000
   -1.5564   -2.4623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -3.8913    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9186   -3.8913    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9186   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0936   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -6.0347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5564   -5.3202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1439   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3189   -4.6057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3311   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1561   -3.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -2.5093    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3861   -1.7247    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9381   -1.1116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -2.3518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -2.7643    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8546   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1401   -4.0018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4256   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6410   -3.8442    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  4 13  4  0  0  0  0
  8 13  4  0  0  0  0
  5 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  1  0  0  0  0
 15 25  1  0  0  0  0
M  CHG  1   4   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-464

>  <JC_XSMILES>
CCCN1C(\C=CC2=CC=CC=C12)=C\C3=[N+](CC)C4=CC=CC=C4S3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.82

>  <W2 Pf proliferation inhibition EC50 uM>
1.336

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.230769231

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4644
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    4.4104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  6  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
 10 20  4  0  0  0  0
  2 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4644

>  <JC_XSMILES>
CC1=NC2=NC(C)=NN2C(NC3=CC=C(C)C(C)=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1829

>  <W2 Pf proliferation inhibition EC50 uM>
0.378

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4667
  Mrv1591402191617072D          

 42 47  0  0  0  0            999 V2000
    0.7787    4.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1367    3.9719    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9594    3.9102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4241    4.5919    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3173    3.1669    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1400    3.1053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4980    2.3620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0332    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2105    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8526    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3912    0.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2162    0.9370    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5741    1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1094    2.3620    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.3968    1.7420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7548    2.4853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5775    2.5469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0422    1.8653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6842    1.1220    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8616    1.0603    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7305    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5189    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1237   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9401   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1517   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5470   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8037   -0.8703    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0604   -0.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8768    0.2920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0884    0.5352    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9049    1.3395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4837   -0.0260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6673   -0.8303    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4556   -1.0735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0625   -1.3914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2461   -2.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6413   -2.7569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1471   -2.5137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7518   -3.0749    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5402   -2.8317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3306   -1.7094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2741   -1.1483    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  2  0  0  0  0
 28 29  1  0  0  0  0
 11 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 28 34  1  0  0  0  0
 33 35  1  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 38 41  4  0  0  0  0
 41 42  4  0  0  0  0
 35 42  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4667

>  <JC_XSMILES>
COC(=O)C1=CC=C(C=C1)C2N(C(=O)C3=CC=CC=C3)C4=CC=CC=C4NC5=C2C(=O)CC(C5)C6=CC=C(OC)C=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.427

>  <W2 Pf proliferation inhibition EC50 uM>
0.368

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.036585366

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4671
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5  9  1  0  0  0  0
  3 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 10 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  2 24  1  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4671

>  <JC_XSMILES>
O=C1C(NC2CCCC2)=C(N3CCOCC3)C(=O)C4=CC=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1186

>  <W2 Pf proliferation inhibition EC50 uM>
0.1388

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
37.92

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4697
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -2.6462   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -4.2703    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -4.9848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  7  6  1  4  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  18
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4697

>  <JC_XSMILES>
COC1=CC=C(C=NNC2=NC3=CC=CC=C3N2)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2433

>  <W2 Pf proliferation inhibition EC50 uM>
0.1285

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
36.51

>  <Powder data?>
Yes

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-472
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7674    0.0694    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4854    0.9526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7403    0.1680    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1883   -0.4451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3813   -0.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
  9 14  4  0  0  0  0
  7 15  4  0  0  0  0
  3 15  4  0  0  0  0
  1 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-472

>  <JC_XSMILES>
C(SC1=NN=C2C(NC3=CC=CC=C23)=N1)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.301

>  <W2 Pf proliferation inhibition EC50 uM>
1.316

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.038167939

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4721
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    6.1283   -3.0618    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.4138   -2.6493    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    4.6993   -3.0618    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -1.8243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -1.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -0.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138   -0.1743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -0.5868    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283   -1.4118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -1.8243    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427   -2.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2552   -3.3638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.3638    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    0.6507    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    1.0632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    1.8882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    2.3007    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    1.8882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    1.0632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4138    3.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993    3.5382    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    3.5382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1283    4.3632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    4.7757    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    4.3632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5572    3.5382    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2717    3.1257    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.8427    3.1257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 11 13  1  0  0  0  0
  7 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4721

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1NC2CC2)N3CCN(CC3)C(=O)C4=CC=CC(Cl)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.552

>  <W2 Pf proliferation inhibition EC50 uM>
0.34

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4727
  Mrv1591402191617072D          

 41 44  0  0  0  0            999 V2000
   -0.7144   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4251    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8578   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1433   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0001   -9.9000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5223   -5.7037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  2  0  0  0  0
 17 19  4  0  0  0  0
  9 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 20 26  4  0  0  0  0
  5 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 30 35  4  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 36 38  1  0  0  0  0
 31 39  1  0  0  0  0
 39 40  1  0  0  0  0
 39 41  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4727

>  <JC_XSMILES>
CCCCN(C(CC)C1=NC2=CC=CC=C2C(=O)N1C3=CC=CC(Cl)=C3)C(=O)NC4=C(C=CC=C4C(C)C)C(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.0212

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.29

>  <Powder data?>
No

>  <IFI value>
0.019230769

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4729
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  2  0  0  0  0
  9 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  3  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4729

>  <JC_XSMILES>
COC1=CC=CC=C1C2CC(=O)N3CN(CSC3=C2C#N)CC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.599

>  <W2 Pf proliferation inhibition EC50 uM>
0.337

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-473
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -2.1901   -5.2362    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0186   -4.4292    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6317   -3.8772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4602   -3.0702    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7065   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9920   -3.1471    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2775   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4369   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4369   -3.9721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1514   -2.7346    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8659   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5803   -2.7346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2948   -3.1471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2948   -3.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5803   -4.3846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8659   -3.9721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1514   -4.3846    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.7927   -1.9142    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5997   -1.7426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0122   -2.4571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8372   -2.4571    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2497   -3.1716    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2497   -1.7426    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0747   -1.7426    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8372   -1.0282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2497   -0.3137    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0122   -1.0282    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5997   -0.3137    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  5 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  4 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  2  0  0  0  0
 21 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  2  0  0  0  0
 25 27  4  0  0  0  0
 19 27  4  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-473

>  <JC_XSMILES>
CCCN1C(SCC(=O)NC2=CC=CC=C2Cl)=NC3=C1C(=O)N(C)C(=O)N3C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.316

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4731
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  8 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 13 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 11 23  4  0  0  0  0
 23 24  4  0  0  0  0
  6 24  4  0  0  0  0
 24 25  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4731

>  <JC_XSMILES>
CCOC(=O)C1=CN(CC)C2=CC(N3CCCCC3)=C(F)C=C2C1=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1657

>  <W2 Pf proliferation inhibition EC50 uM>
0.336

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.06557377

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4748
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  1  0  0  0  0
 15 16  2  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 11 22  1  0  0  0  0
 17 22  4  0  0  0  0
 12 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 26 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 29 32  4  0  0  0  0
 23 32  4  0  0  0  0
  7 33  4  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 33 36  4  0  0  0  0
  3 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4748

>  <JC_XSMILES>
COC1=C(Cl)C=C(NC(=O)C2C(N(C)C(=O)C3=CC=CC=C23)C4=CC=C(OC)C(OC)=C4)C(OC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.983

>  <W2 Pf proliferation inhibition EC50 uM>
0.328

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4759
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4759

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C(=O)N2CCN(CC2)CC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.67

>  <W2 Pf proliferation inhibition EC50 uM>
0.322

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4768
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    1.8658   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2528   -0.5825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4243   -1.3895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8112   -1.9415    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8974   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7553   -2.7620    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698   -3.9995    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1842   -2.7620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1842   -1.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8987   -1.5245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8987   -0.6995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6132   -0.2870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3277   -0.6995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3277   -1.5245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6132   -1.9370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1437   -3.0975    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4083   -2.4844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2288   -2.5707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5643   -3.3244    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3848   -3.4106    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8697   -2.7432    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5342   -1.9895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7137   -1.9032    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0042   -1.7700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3313   -1.0163    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1518   -0.9301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4874   -0.1764    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0025    0.4910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1820    0.4048    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.3489    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
  5 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
 21 28  4  0  0  0  0
  4 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4768

>  <JC_XSMILES>
CCCN1C(SCCNC(=O)\C=C\C2=CC=CC=C2)=NC(C3=CC=CC=C3)=C1C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.557

>  <W2 Pf proliferation inhibition EC50 uM>
0.02967

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.38

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4773
  Mrv1591402191617072D          

 18 20  0  0  0  0            999 V2000
    2.0367   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7546   -3.1499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2395   -3.8173    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9040   -4.5710    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -4.6572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5986   -3.9898    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  2  6  4  0  0  0  0
  4  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  1 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4773

>  <JC_XSMILES>
N(C1=NC(=CS1)C2=CC=CC=N2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1141

>  <W2 Pf proliferation inhibition EC50 uM>
0.0585

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
18.63

>  <Powder data?>
Yes

>  <IFI value>
0.180451128

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-481
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    3.6664    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    2.9519    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    4.3808    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    5.8098    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    5.0953    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    5.0953    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  4 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
  2 17  4  0  0  0  0
 14 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 20 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-481

>  <JC_XSMILES>
CC1=NC(N2CCCCC2)=C3C(C)=C(SC3=N1)C(=O)N4CCN(CC4)C5=CC=CC=C5F

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.544

>  <W2 Pf proliferation inhibition EC50 uM>
1.298

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4814
  Mrv1591402191617072D          

 33 38  0  0  0  0            999 V2000
    4.0668    3.1729    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7531   -2.5840    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9326   -2.6703    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5971   -1.9166    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
 10 18  4  0  0  0  0
  2 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 22 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
 24 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 28 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4814

>  <JC_XSMILES>
O=C(N1CCN(CC1)CC2=CC=C3OCOC3=C2)C4=CC=C5N=C(SC5=C4)N6CCCCC6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.407

>  <W2 Pf proliferation inhibition EC50 uM>
0.2984

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.028571429

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4817
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
   -3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    0.4125    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.2704   -0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.4454    0.7145    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 10 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  1  0  0  0  0
 26 28  4  0  0  0  0
 21 28  4  0  0  0  0
 19 29  4  0  0  0  0
 15 29  4  0  0  0  0
 29 30  2  0  0  0  0
 18 31  1  0  0  0  0
 31 32  1  0  0  0  0
 31 33  1  0  0  0  0
 31 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4817

>  <JC_XSMILES>
CCN1CCN(CC1)CC2=C(O)C=CC3=C2OC(=C(OC4=CC(C)=CC(C)=C4)C3=O)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
3.63

>  <W2 Pf proliferation inhibition EC50 uM>
0.2965

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.034883721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4820
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    6.3514   -7.0096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -6.5971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -5.7721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -5.3596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -5.7721    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -4.5346    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -4.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -4.1221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -2.0596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9225   -0.4096    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -0.4096    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935    0.4154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    0.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791    1.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935    2.0654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080    1.6529    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2080    0.8279    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -2.0596    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4935   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -3.2971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -2.8846    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0646   -2.0596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7791   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -1.6471    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -2.0596    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.6370   -0.8221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3514   -0.4096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4377    0.4109    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2446    0.5824    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6571   -0.1320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4641   -0.3036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7190   -1.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1670   -1.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3600   -1.5298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1051   -0.7451    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 17 22  1  0  0  0  0
 13 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 12 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 39 40  4  0  0  0  0
 32 40  4  0  0  0  0
 35 40  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  34
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4820

>  <JC_XSMILES>
CCOC(=O)C1=CC=C(C=C1)N(C(C(=O)NC2CCCCC2)C3=CC=CN=C3)C(=O)CC4=CNC5=CC=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2805

>  <W2 Pf proliferation inhibition EC50 uM>
0.2954

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.037037037

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4834
  Mrv1591402191617072D          

 24 28  0  0  0  0            999 V2000
    0.4262    3.3215    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1587    2.9420    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8536    3.3866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5862    3.0071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6238    2.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9288    1.7383    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1963    2.1178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3563    1.8035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0512    2.2481    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7838    1.8686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4787    2.3132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2112    1.9337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2488    1.1096    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9813    0.7301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0190   -0.0941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3240   -0.5387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5915   -0.1592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539    0.6649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8214    1.0445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1264    0.5998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9919   -0.2141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1762   -0.3377    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8066    0.3999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3939    0.9793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  2  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
  8 24  1  0  0  0  0
 20 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4834

>  <JC_XSMILES>
OC1=CC=C(C=C1)C2NC3=CC=C4C=CC=CC4=C3C5C=CCC25

>  <PF proliferation inhibition 3D7 EC50 uM>
0.812

>  <W2 Pf proliferation inhibition EC50 uM>
0.2923

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4846
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    3.2227    3.6495    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.6707    3.0364    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9256    2.2518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3736    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666    1.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695    0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.0542    0.1576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3237   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8388   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0542   -0.6674    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2695   -0.9224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7846   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0146   -1.7070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5666   -2.3201    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117   -3.1047    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5047   -3.2762    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0473   -2.6631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2076   -1.8785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3117    2.5948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8637    3.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6088    3.9926    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  7 14  4  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
  5 21  4  0  0  0  0
 21 22  4  0  0  0  0
  2 22  4  0  0  0  0
 22 23  1  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4846

>  <JC_XSMILES>
ClC1=CC=C(C[N+]2=C3CCCN3C(=C2)C4=CC=CC=C4)C=C1Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
0.499

>  <W2 Pf proliferation inhibition EC50 uM>
0.1582

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>55.66

>  <Powder data?>
Yes

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-485
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.8946    2.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.1759    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    0.7634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    1.1759    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -0.4741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041   -1.7840    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492   -2.5687    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9341   -3.2361    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242   -2.5687    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693   -1.7840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5846   -1.5291    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4131   -0.7221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3715   -0.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5430    0.3398    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0701    0.8918    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8547    0.6369    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0262   -0.1701    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  2  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-485

>  <JC_XSMILES>
COC1=CC=C(C=C1)\C=C2/SC(=O)NC2=NC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.819

>  <W2 Pf proliferation inhibition EC50 uM>
1.296

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4855
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
   -3.0587   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0919    3.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6018    1.6373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  2  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 12 19  4  0  0  0  0
 10 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  1  0  0  0  0
  9 26  1  0  0  0  0
 26 27  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4855

>  <JC_XSMILES>
COC1=CC=C(C=C1)C2=C(NC3=CC=C(C)C(C)=C3)C4=CC=CC=C4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2967

>  <W2 Pf proliferation inhibition EC50 uM>
0.2813

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4856
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
 21 22  1  0  0  0  0
 15 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 23 29  4  0  0  0  0
 21 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 33 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4856

>  <JC_XSMILES>
COC1=CC=C(C=C1OC)C2CC(=O)C3=C(C2)NC(C)=C(C3C4=CC=CC(C)=C4)C(=O)OC5CCCCC5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.837

>  <W2 Pf proliferation inhibition EC50 uM>
0.2809

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.065217391

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4861
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    4.1801    2.2902    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3235    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6091    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669    0.6402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4669   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -0.5973    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0380   -0.1848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7525   -1.4223    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.4199   -1.9072    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.1650   -2.6919    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.3400   -2.6919    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0850   -1.9072    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.0527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    0.6402    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.1814    1.8777    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8959    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248    3.1152    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.3248    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.6104    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.0393    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.1827    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.4682    1.8777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.7538    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4861

>  <JC_XSMILES>
FC1=CC=C(C=C1)C2=CC(=CC(=C2)N3C=NN=N3)C(=O)NC4CCN(CC4)CC5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1255

>  <W2 Pf proliferation inhibition EC50 uM>
0.1256

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
45.03

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4867
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
  9 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  8 24  1  0  0  0  0
 24 25  2  0  0  0  0
  6 26  4  0  0  0  0
 26 27  4  0  0  0  0
  3 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4867

>  <JC_XSMILES>
COC1=CC=C(NC2=C(N3CCCCC3)C(=O)C4=CC=CC=C4C2=O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0331

>  <W2 Pf proliferation inhibition EC50 uM>
0.035

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
12.64

>  <Powder data?>
Yes

>  <IFI value>
0.186666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4871
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
    4.2135   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    2.9750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6534    3.7596    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
 16 19  4  0  0  0  0
 12 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
  9 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4871

>  <JC_XSMILES>
CC1=CC=CC=C1CC2=C(C)N3N=C(C)C(C#N)=C3N=C2C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2819

>  <W2 Pf proliferation inhibition EC50 uM>
0.2732

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4877
  Mrv1591402191617072D          

 32 36  0  0  0  0            999 V2000
    3.0919    3.2065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5399    2.5934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7948    1.8088    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428    1.1957    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -1.4124    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587    0.0165    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8837    0.0165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2962    0.7310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1167    0.8172    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2882    1.6242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5737    2.0367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9606    1.4847    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809    2.1518    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329    2.7649    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  7 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 19 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
  5 31  4  0  0  0  0
 31 32  4  0  0  0  0
  2 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4877

>  <JC_XSMILES>
CC1=CC=C(CN2C3=CC=CC=C3N=C2N4CCC(CC4)C(=O)NCC5=CC=CS5)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.529

>  <W2 Pf proliferation inhibition EC50 uM>
0.2712

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027027027

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4891
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
   -0.9252   -3.6175    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -2.8106    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057   -2.1975    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1262   -2.2837    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6111   -1.6163    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4316   -1.7025    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7671   -2.4562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5876   -2.5424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0726   -1.8750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7370   -1.1213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9165   -1.0351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5810   -0.2814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932   -1.4830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862   -1.6545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
  3 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
  2 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 24 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  2  0  0  0  0
M  CHG  2  27   1  28  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4891

>  <JC_XSMILES>
CN1C(COC2=CC=CC=C2C)=NN=C1SCC(=O)NC3=CC=C(C=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.059405941

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4895
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -4.8946   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -2.5366    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7982   -4.2590    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0531   -5.0437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8781   -5.0437    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1331   -4.2590    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5682   -5.7111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7477   -5.6249    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2628   -6.2923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5984   -7.0460    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4189   -7.1322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9038   -6.4648    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1135   -7.7134    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4490   -8.4671    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2930   -7.6272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1919   -8.2946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0124   -8.2084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3480   -7.4547    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1685   -7.3685    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6534   -8.0359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3178   -8.7896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8028   -9.4570    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6232   -9.3708    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4973   -8.8758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  8 12  4  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 27 30  4  0  0  0  0
 23 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4895

>  <JC_XSMILES>
CCN(CC)C(=O)C1=CN(N=N1)C2CCN(CC2)C(=O)CCC3=CC=CC(OC)=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00877193

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4901
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
 14 27  1  0  0  0  0
 27 28  2  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4901

>  <JC_XSMILES>
CCOC1=CC=CC(=C1)C2=NC3=CC(=CC=C3CN2CC4CCCCC4)C(=O)NC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
~0.02673

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012345679

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-491
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  6  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  8 13  4  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-491

>  <JC_XSMILES>
OC1=CC=CC(=C1)C2=CN=CC(=N2)C3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
1.297

>  <W2 Pf proliferation inhibition EC50 uM>
1.287

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4920
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0231   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1946   -1.8980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6362   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4208   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0339   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8186   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9901   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7747   -2.2373    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3770   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5485   -1.1332    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.5924   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  2  1  4  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 15 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4920

>  <JC_XSMILES>
CN(C)C=NC1=NN(C)C=C1C(=O)NC2=CC=C(F)C(Cl)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>7.01

>  <W2 Pf proliferation inhibition EC50 uM>
0.264

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008196721

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4928
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -1.6258   -7.8457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8008   -7.8457    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3883   -7.1313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4367   -7.1313    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8492   -6.4168    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4367   -5.7023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8492   -4.9878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4367   -4.2734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8492   -3.5589    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6742   -6.4168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0867   -5.7023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9117   -5.7023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3242   -4.9878    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1492   -4.9878    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5617   -5.7023    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3867   -5.7023    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7992   -4.9878    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3867   -4.2734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5617   -4.2734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3067   -3.4888    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.9742   -3.0038    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0604   -2.1834    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8141   -1.8478    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4815   -2.3327    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2352   -1.9972    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    6.3953   -3.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6416   -3.4888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 24 26  4  0  0  0  0
 26 27  4  0  0  0  0
 18 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4928

>  <JC_XSMILES>
CCCCN(CCCC)CCCNC1=NC=NC2=C1NC3=CC=C(Cl)C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2305

>  <W2 Pf proliferation inhibition EC50 uM>
0.162

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
61.78

>  <Powder data?>
Yes

>  <IFI value>
0.048780488

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4930
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296    2.8830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0366    3.0545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491    2.3400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971    1.7269    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 15 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4930

>  <JC_XSMILES>
CCN(CC)CCNC(=O)C1=CC(=CC(=C1)N2C=NN=N2)C3=CC=C(Cl)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.644

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02609

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4953
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0587   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  8  7  1  4  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4953

>  <JC_XSMILES>
CC1=CC=CC=C1C=NNC2=NC3=CC=CC=C3N2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.605

>  <W2 Pf proliferation inhibition EC50 uM>
0.2491

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4956
  Mrv1591402191617072D          

 30 32  0  0  0  0            999 V2000
   -4.1407   -2.6211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1407   -3.4461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4263   -3.8586    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4263   -4.6836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7118   -5.0961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7118   -5.9211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4263   -6.3336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4263   -7.1586    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1407   -7.5711    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8552   -7.1586    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1407   -8.3961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4263   -8.8086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4263   -9.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1407  -10.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1407  -10.8711    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8552   -9.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8552   -8.8086    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5697  -10.0461    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -5.9822   -9.3317    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1572  -10.7606    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2842  -10.4586    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.2842  -11.2836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5409  -11.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3573  -12.4459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.8717  -13.0909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6967  -13.0909    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.2110  -12.4459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0275  -11.6416    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1407   -5.9211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1407   -5.0961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 16 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  2  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 22 28  1  0  0  0  0
  7 29  4  0  0  0  0
 29 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4956

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)C2=CC=C(F)C(=C2)S(=O)(=O)NC3CCCCCC3)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.352

>  <W2 Pf proliferation inhibition EC50 uM>
0.1352

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
54.76

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4970
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
   -0.6895   -0.9185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1175   -0.7470    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6695   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4765   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7314   -0.4039    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1794    0.2092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4343    0.9938    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8823    1.6069    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1372    2.3915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9442    2.5631    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4963    1.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2413    1.1653    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0285   -1.8016    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8535   -1.8016    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4056   -1.1885    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2125   -1.3601    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4675   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1085   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4410   -3.0712    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.7736   -2.5862    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9666   -2.7578    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7117   -3.5424    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4567   -4.3270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4146   -2.1447    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3924   -2.3162    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 13 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  3  0  0  0  0
 22 25  4  0  0  0  0
  3 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4970

>  <JC_XSMILES>
CCC1=C(NCC2=CC=CC=C2)N3C4=CC=CC=C4N=C3C(C#N)=C1C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.787

>  <W2 Pf proliferation inhibition EC50 uM>
0.2378

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.05

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4975
  Mrv1591402191617072D          

 33 35  0  0  0  0            999 V2000
   -0.4366   -0.0605    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.2779   -0.4730    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9923   -0.0605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -1.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1511   -1.2980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8327   -1.7627    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6211   -1.5196    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9225   -0.7516    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5100   -0.0371    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6942    0.0858    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0894   -0.4753    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9747    0.6445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6168    1.3878    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7974    0.5829    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2622    1.2645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0849    1.2029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5496    1.8845    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.1916    2.6278    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3689    2.6895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9042    2.0078    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0110    3.4328    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6530    4.1761    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7543    3.7907    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2677    3.0748    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7068   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4213   -3.3605    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.2943   -3.6625    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.1193   -2.2335    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
  6 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-4975

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=CC=C1N2CCCN(CC2)C(=S)NC3=CC=CC(=C3)C(F)(F)F)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1491

>  <W2 Pf proliferation inhibition EC50 uM>
0.13

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
55.04

>  <Powder data?>
Yes

>  <IFI value>
0.026315789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4988
  Mrv1591402191617072D          

 25 29  0  0  0  0            999 V2000
   -1.8021   -1.0036    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5166   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2311   -1.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9455   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9455    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2311    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5166    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8021    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0877    0.2339    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3732    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540    0.2037    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4540   -0.6213    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0558   -1.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7702   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7702    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0558    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8495   -0.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1350   -0.5911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1350    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6600    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3745    0.2339    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0890    0.6464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0890    1.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.3745    1.8839    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6600    1.4714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 15 16  1  0  0  0  0
 11 16  1  0  0  0  0
 16 17  1  0  0  0  0
 13 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 17 19  1  0  0  0  0
  5 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4988

>  <JC_XSMILES>
OC1=CC=C(C=C1CNCC2CC3C=CC2C34CC4)C5=CC=CN=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.835

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02328

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.016949153

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-4994
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -2.6462   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8212   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -2.1269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -2.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -3.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087   -2.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.0165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.9521    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  2  8  1  0  0  0  0
  4  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 11 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-4994

>  <JC_XSMILES>
CC1CN(CC(C)O1)C(=O)C2=C(Cl)C3=C(F)C=CC=C3S2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2989

>  <W2 Pf proliferation inhibition EC50 uM>
0.2317

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5010
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    5.4957   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    0.6979    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    3.5854    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.3687    4.2999    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.1937    2.8710    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    5.2354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6391    5.2354    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.3536    4.8229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9246    3.9979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2102    3.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  2  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 11 18  4  0  0  0  0
  6 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 22 26  4  0  0  0  0
 26 27  4  0  0  0  0
 19 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5010

>  <JC_XSMILES>
COC(=O)CC(NS(=O)(=O)C1=CC=C(OC)C=C1)C2=CC=C3OCOC3=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.459

>  <W2 Pf proliferation inhibition EC50 uM>
<0.02336

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10.34

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5014
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
   -0.7145   11.7161    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   10.8911    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    9.2411    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    9.6536    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   10.4786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    8.4161    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    6.7661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    5.9411    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    5.5286    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    5.9411    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.7036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674    4.2187    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125    3.4340    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674    4.2187    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    7.1786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    8.0036    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 15 19  4  0  0  0  0
 11 20  4  0  0  0  0
 20 21  4  0  0  0  0
  8 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5014

>  <JC_XSMILES>
ClC1=CC=C(C=C1)C2=CC=C(NC(=O)C3=CC=CS3)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2851

>  <W2 Pf proliferation inhibition EC50 uM>
0.2247

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.054054054

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5026
  Mrv1591402191617072D          

 37 41  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
  9 20  4  0  0  0  0
 20 21  4  0  0  0  0
  6 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
  4 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 29 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5026

>  <JC_XSMILES>
CCCC1=NC2=CC=C(NC(=O)C3=CC=CC=C3F)C=C2C(=O)N1CC4=CC=C(C=C4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.079

>  <W2 Pf proliferation inhibition EC50 uM>
0.2173

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.072727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-505
  Mrv1591402191617072D          

 24 25  0  0  0  0            999 V2000
    3.0789   -5.5539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664   -4.8395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -4.8395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.5539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -6.2684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.9829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -6.9829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1914   -6.2684    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -5.5539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6664   -3.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.9039   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164   -3.4105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.1414   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539   -2.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3789   -2.6961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7914   -3.4105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.6164   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3789   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  3 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  2  0  0  0  0
 10 13  2  0  0  0  0
  2 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 18 24  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-505

>  <JC_XSMILES>
CC(N(C1=CC=CC=C1)S(C)(=O)=O)C(=O)NN=C2CCN(C)CC2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
1.27

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5062
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  4  0  0  0  0
  9 15  4  0  0  0  0
 15 16  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 17 26  4  0  0  0  0
 26 27  1  0  0  0  0
  6 28  4  0  0  0  0
  2 28  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5062

>  <JC_XSMILES>
CC1=CC=NC(NC(C2=CC=C(Cl)C=C2Cl)C3=CC=C4C=CC=NC4=C3O)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2964

>  <W2 Pf proliferation inhibition EC50 uM>
0.1198

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
60.09

>  <Powder data?>
Yes

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5063
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    4.3974   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599   -1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3349   -1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9224   -1.8414    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9224   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0974   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6849    0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0974    1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6849    1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0974    2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9224    2.4454    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3349    3.1599    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9224    3.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3349    4.5888    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3349    1.7309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9224    1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3349    0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1599    0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3974   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8099   -1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6349   -1.1270    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8724   -1.8414    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0474   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5063

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C=CC(OCC)=CC2=C1NCCCN(CC)CC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1169

>  <W2 Pf proliferation inhibition EC50 uM>
0.1397

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
70.11

>  <Powder data?>
Yes

>  <IFI value>
0.083333333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-508
  Mrv1591402191617072D          

 32 37  0  0  0  0            999 V2000
    5.2351   -3.6821    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4281   -3.5106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1732   -2.7260    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3662   -2.5545    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1113   -1.7698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6633   -1.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4703   -1.3283    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7252   -2.1129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5322   -2.2844    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7871   -3.0690    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    6.5941   -3.2406    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2072   -2.6885    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9217   -3.1010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7063   -2.8461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3194   -3.3981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1478   -4.2051    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3632   -4.4600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7501   -3.9080    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9296   -3.9942    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  4  0  0  0  0
 11 19  4  0  0  0  0
  6 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 20 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 24 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  STY  2   1 DAT   2 DAT
M  SAL   1  1  19
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  SAL   2  1  26
M  SDT   2 MRV_IMPLICIT_H                                        
M  SDD   2     0.0000    0.0000    DR    ALL  0       0  
M  SED   2 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-508

>  <JC_XSMILES>
COC1=CC=C(C=C1CSC2=NC3=CC=CC=C3N2)C4NCCC5=C4NC6=CC=CC=C56

>  <PF proliferation inhibition 3D7 EC50 uM>
1.753

>  <W2 Pf proliferation inhibition EC50 uM>
2.587

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.45

>  <Powder data?>
Yes

>  <IFI value>
0.022222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5094
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846   -0.2549    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2695    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7846    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0396    1.8646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4875    2.4777    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8465    2.0361    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1015    2.8207    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9084    2.9922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1634    3.7769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6113    4.3900    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8044    4.2184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5494    3.4338    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 13 23  4  0  0  0  0
 10 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  2  0  0  0  0
  9 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  2  0  0  0  0
 28 30  1  0  0  0  0
 30 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 36 37  4  0  0  0  0
 31 37  4  0  0  0  0
 37 38  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5094

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2N3N=CC(C(=O)NC4=CC=CC=C4)=C3NC(C)=C2C(=O)NC5=CC=C(C)C=C5C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.59

>  <W2 Pf proliferation inhibition EC50 uM>
0.1899

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5096
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
   -2.2501    4.3527    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6791    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3935    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3935    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6791    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    5.5902    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.0027    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7041    3.0428    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4492    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6242    2.2581    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3693    3.0428    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5096

>  <JC_XSMILES>
BrC1=CC=CC=C1NC(=O)CN2CCN(CC2)C(=O)C3=CC=CO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.358

>  <W2 Pf proliferation inhibition EC50 uM>
0.188

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5106
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556   -0.1271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701   -1.3646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -1.7771    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845   -2.6021    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4520   -3.0870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1970   -3.8716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3720   -3.8716    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1171   -3.0870    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4534    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    0.0940    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.9284    0.0940    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1034    2.9519    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6909    3.6664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8659    2.2374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
  4 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 14 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
  3 20  4  0  0  0  0
 20 21  1  0  0  0  0
 16 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 24 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 28 31  4  0  0  0  0
 22 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5106

>  <JC_XSMILES>
CCC1=C(NCCCN2C=CN=C2)N3N=C(C=C3N=C1C)C4=CC(OC)=CC(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.874

>  <W2 Pf proliferation inhibition EC50 uM>
0.1854

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5116
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  3  0  0  0  0
  6  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
  2 11  4  0  0  0  0
 12 11  1  4  0  0  0
 12 13  2  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5116

>  <JC_XSMILES>
CC1=CC(C)=C(C#N)C(=O)N1N=CC2=CC=C(Cl)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.07

>  <W2 Pf proliferation inhibition EC50 uM>
0.1831

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5134
  Mrv1591402191617072D          

 19 21  0  0  0  0            999 V2000
    1.4358    1.3672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.7541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838   -2.1500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0650   -1.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0162   -0.2164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7681   -0.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4380   -0.0745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3561    0.7464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6041    1.0859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0658    0.6044    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
  3 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5134

>  <JC_XSMILES>
CCN1C2=CC=CC=C2N(C)C1(C)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0465

>  <W2 Pf proliferation inhibition EC50 uM>
0.0493

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
28.79

>  <Powder data?>
Yes

>  <IFI value>
0.06557377

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5146
  Mrv1591402191617072D          

 38 43  0  0  0  0            999 V2000
    6.4938   -3.1948    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8053   -3.6493    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8546   -4.4728    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5925   -4.8418    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2810   -4.3874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0189   -4.7564    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0682   -5.5799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3797   -6.0344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6418   -5.6654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0674   -3.2803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4148   -3.7849    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6133   -3.5893    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2665   -2.8408    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6355   -2.1029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0835   -1.4898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2765   -1.6613    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7245   -1.0482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9175   -1.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3655   -0.6067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4415   -0.7782    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9935   -0.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7386    0.6195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0684    0.7910    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6204    0.1779    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3385   -0.7052    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1454   -0.5337    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6975   -1.1468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4425   -1.9314    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0798   -2.4553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    0.2510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9154    0.9184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4004    1.5858    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    1.7434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    1.3309    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6139    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8995    0.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1850    0.5059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 14 28  4  0  0  0  0
 28 29  1  0  0  0  0
 10 29  1  0  0  0  0
 26 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 30 38  4  0  0  0  0
 33 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5146

>  <JC_XSMILES>
O=C(CC1=CC=CC=C1)N2CCOC3=C(OCCC4=CC=CC=N4)C=C(C=C3C2)C5=CSC6=CC=CC=C56

>  <PF proliferation inhibition 3D7 EC50 uM>
0.257

>  <W2 Pf proliferation inhibition EC50 uM>
0.1654

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.04040404

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5150
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9091   -0.6605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1792   -2.8265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7923   -3.3785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5769   -3.1236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7484   -2.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  9 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5150

>  <JC_XSMILES>
COC1=CC=CC=C1C2CC(=NN2C(=O)C3=CC=CC=C3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.262

>  <W2 Pf proliferation inhibition EC50 uM>
0.1099

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
66.96

>  <Powder data?>
Yes

>  <IFI value>
0.022988506

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5156
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 11 18  4  0  0  0  0
  9 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5156

>  <JC_XSMILES>
COC(=O)C1=CNC=C(C1C2=CC=C(Cl)C(Cl)=C2)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1138

>  <W2 Pf proliferation inhibition EC50 uM>
0.105

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>64.86

>  <Powder data?>
Yes

>  <IFI value>
0.06097561

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5174
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  6  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 18 24  1  0  0  0  0
 16 25  4  0  0  0  0
 11 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5174

>  <JC_XSMILES>
COC1=CC=C(OC)C(=C1)C2=CC=C(O)C(CN3CCCC(C)C3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1313

>  <W2 Pf proliferation inhibition EC50 uM>
0.0945

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
61.03

>  <Powder data?>
Yes

>  <IFI value>
0.017241379

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5181
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
   -1.9562   -0.8856    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042   -1.4986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481   -2.1661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -3.9556    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -3.5431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -2.3056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -4.7806    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2902   -5.1931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3764   -6.0136    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1834   -6.1851    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5959   -5.4707    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0439   -4.8576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  2 10  1  0  0  0  0
  5 10  1  0  0  0  0
  7 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
  3 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 25 26  4  0  0  0  0
 18 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5181

>  <JC_XSMILES>
O=C1N(CC2CN(CCN12)CC3=CSC=C3)CC4=CC5=CC=CC=C5S4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1073

>  <W2 Pf proliferation inhibition EC50 uM>
0.1527

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.013888889

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5199
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8263   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1763   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 11 19  4  0  0  0  0
  7 19  4  0  0  0  0
 19 20  2  0  0  0  0
  9 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 21 26  1  0  0  0  0
  2 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5199

>  <JC_XSMILES>
CC(CNC(=O)C1=CN(C=C(C(=O)NC(C)(C)C)C1=O)C2CCCCC2)C3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1743

>  <W2 Pf proliferation inhibition EC50 uM>
<0.015

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.00990099

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5219
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.8592    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
  8 17  1  0  0  0  0
 17 18  2  0  0  0  0
  9 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5219

>  <JC_XSMILES>
CCN(CC)CCN1C(NC2=CC=CC=C2C1=O)C3=CC=C(Br)C=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2175

>  <W2 Pf proliferation inhibition EC50 uM>
0.0671

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
47.75

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-523
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3507   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1353   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3068   -0.9576    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7484   -2.3166    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5769   -3.1236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7923   -3.3785    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6207   -4.1855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2338   -4.7375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0623   -5.5445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0184   -4.4826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.1900   -3.6756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4324   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9173   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5817   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0667   -5.1768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7613   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2763   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
  9 13  4  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 19 25  4  0  0  0  0
 11 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-523

>  <JC_XSMILES>
COC1=CC=C(C=C1)N2C=C(N=C2SCC(=O)NC3=CC=C(C)C=C3)C4=CC=C(C)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
2.227

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5231
  Mrv1591402191617072D          

 20 22  0  0  0  0            999 V2000
   -2.5855   -0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1730   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -1.3480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9355   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3480   -2.7770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.7770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7770   -2.7770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3645   -0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5395   -0.6336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -1.3480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1105   -0.6336    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 11 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
  6 19  4  0  0  0  0
 19 20  2  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5231

>  <JC_XSMILES>
CCOC(=O)C1=CN=C2C3=C(CCCC3)C=CC2=C1O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.133

>  <W2 Pf proliferation inhibition EC50 uM>
0.1373

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5239
  Mrv1591402191617072D          

 33 37  0  0  1  0            999 V2000
    2.3591   -5.2686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0265   -4.7837    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9403   -3.9632    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6078   -3.4783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5215   -2.6578    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.1890   -2.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9426   -2.5084    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.1027   -1.3524    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    4.7158   -0.8004    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3803   -0.0467    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5598   -0.1329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3882   -0.9399    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6346   -1.2755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9671   -0.7905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2135   -1.1261    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5460   -0.6412    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6323    0.1793    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0352    0.6642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0511    1.4847    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8047    1.8203    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4722    1.3353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3859    0.5149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0534    0.0299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7928    0.6678    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.6178    0.6678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1027    1.3352    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.8873    1.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6018    1.4928    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3162    1.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3162    0.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6018   -0.1572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8873    0.2553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1027    0.0003    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  8  6  1  1  0  0  0
  8  9  1  0  0  0  0
 10  9  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  8 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 22 23  4  0  0  0  0
 14 23  4  0  0  0  0
 10 24  1  6  0  0  0
 24 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 27 32  4  0  0  0  0
 32 33  4  0  0  0  0
 25 33  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  33
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5239

>  <JC_XSMILES>
COCCNC(=O)[C@@H]1C[C@H](CN1CC2=CC=C3C=CC=CC3=C2)SC4=NC5=CC=CC=C5N4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.638

>  <W2 Pf proliferation inhibition EC50 uM>
0.1348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.088235294

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5240
  Mrv1591402191617072D          

 34 39  0  0  0  0            999 V2000
    0.6009   -5.9671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0134   -5.2526    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6009   -4.5382    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0134   -3.8237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6009   -3.1092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0134   -2.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8384   -2.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2509   -3.1092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8384   -3.8237    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2509   -1.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0759   -1.6803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4884   -0.9658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0759   -0.2513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2509   -0.2513    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8384   -0.9658    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0315   -0.7943    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9452    0.0262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2778    0.5111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3640    1.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1177    1.6672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7851    1.1822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6989    0.3618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4884   -2.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0759   -3.1092    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.3134   -2.3948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7984   -3.0622    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5830   -2.8073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2975   -3.2198    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0119   -2.8073    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.7264   -3.2198    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    7.0119   -1.9823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2975   -1.5698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5830   -1.9823    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7984   -1.7273    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 10 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 14 22  4  0  0  0  0
 17 22  4  0  0  0  0
 11 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 33 34  4  0  0  0  0
 25 34  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  16
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5240

>  <JC_XSMILES>
CCOC1=CC=C(C=C1)C2N(CCC3=C2NC4=CC=CC=C34)C(=O)C5=CC6=CC(Br)=CC=C6O5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.3162

>  <W2 Pf proliferation inhibition EC50 uM>
0.1348

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.011627907

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5247
  Mrv1591402191617072D          

 19 20  0  0  0  0            999 V2000
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
  4 19  4  0  0  0  0
M  CHG  1   7   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5247

>  <JC_XSMILES>
CN(C)C1=CC=[N+](CC(=O)C2=CC=C(Cl)C=C2)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1682

>  <W2 Pf proliferation inhibition EC50 uM>
0.132

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5260
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 14 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5260

>  <JC_XSMILES>
CCN1CCCC(C1)NC2=CC=NC3=CC4=CC=CC=C4C=C23

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00824

>  <W2 Pf proliferation inhibition EC50 uM>
0.00481

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
3.75

>  <Powder data?>
Yes

>  <IFI value>
0.117647059

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5262
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
   -6.3235   -3.7741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.3235   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6091   -2.5366    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4656   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1801   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.8946   -3.7741    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -4.1866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -3.7741    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7512   -5.0116    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -5.0116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -5.4241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6078   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -6.6616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0367   -6.2491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3222   -7.4866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6548   -7.9715    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7347   -8.7562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9897   -7.9715    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -2.9491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.4669   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7525   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.0380   -1.7116    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1814   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.9351   -1.6347    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.4871   -1.0216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0746   -0.3071    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2677   -0.4786    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 17 19  1  0  0  0  0
 19 20  2  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 19 23  1  0  0  0  0
  2 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 30 34  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5262

>  <JC_XSMILES>
O=C(NC1=CC=C(C=C1)C(=O)NC2=CC=CC(=C2)C3=NCCN3)C4=CC=C(C=C4)C5=NCCN5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1929

>  <W2 Pf proliferation inhibition EC50 uM>
0.1277

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008695652

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5270
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -5.8085    0.6960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0812    0.3065    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0548   -0.5180    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3803    0.7417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4067    1.5663    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7058    2.0014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9785    1.6120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9521    0.7874    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2248    0.3980    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5239    0.8331    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5503    1.6577    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7535    0.4206    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2622    0.3731    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2791   -0.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0497   -0.8176    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8029   -0.4811    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0976    0.2895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7611    1.0427    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9905    1.3374    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2373    1.0009    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7507    0.2525    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2373    0.2005    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8124   -0.5466    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4979   -1.3093    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3198   -1.4183    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6343   -2.1810    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1311   -2.8347    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6867   -2.7257    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0012   -1.9630    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6530    0.3523    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 13 20  1  0  0  0  0
 19 21  1  0  0  0  0
 15 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  8 30  4  0  0  0  0
  4 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5270

>  <JC_XSMILES>
CC(=O)C1=CC=CC(NC(=O)NC2CC3CCCC(C2)N3CCC4=CC=CC=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01726

>  <W2 Pf proliferation inhibition EC50 uM>
0.01259

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.012658228

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5279
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
  6 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 16 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 25 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 23 30  4  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5279

>  <JC_XSMILES>
CCOC1=CC(=CC=C1O)C2CC(=O)NC3=C2C(=O)CC(C3)C4=CC(OC)=CC=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.431

>  <W2 Pf proliferation inhibition EC50 uM>
0.1231

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5291
  Mrv1591402191617072D          

 36 40  0  0  0  0            999 V2000
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -9.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -9.9320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -9.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914   -8.8925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0783   -9.4445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7064   -9.1896    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8779   -8.3826    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6625   -8.1277    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2756   -8.6797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1041   -9.4867    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0602   -8.4248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6733   -8.9768    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.4579   -8.7219    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6295   -7.9149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0164   -7.3628    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2318   -7.6178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.4141   -7.6599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5856   -6.8530    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -6.0272   -8.2120    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.8118   -7.9570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.4249   -8.5091    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.2095   -8.2541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.3811   -7.4472    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.7680   -6.8951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.9833   -7.1501    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.1657   -7.1922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.8331   -7.6771    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.5006   -7.1922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.2456   -6.4076    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.4206   -6.4076    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -8.9357   -5.7402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2648   -7.8306    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5198   -8.0855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 26 29  1  0  0  0  0
 29 30  2  0  0  0  0
 30 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 29 33  1  0  0  0  0
 33 34  1  0  0  0  0
 10 35  4  0  0  0  0
 35 36  4  0  0  0  0
  7 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5291

>  <JC_XSMILES>
CN1CCN=C1C2=CC=C(NC(=O)C3=CC=C(C=C3)C(=O)NC4=CC=C(C=C4)C5=NCCN5C)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0911

>  <W2 Pf proliferation inhibition EC50 uM>
0.01197

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.025210084

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5307
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 12 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  2  0  0  0  0
 30 32  4  0  0  0  0
 22 32  4  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  1  0  0  0  0
 35 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 33 39  4  0  0  0  0
 39 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5307

>  <JC_XSMILES>
COC1=CC=CC=C1NC(=O)N(CC2=CC=CC=C2)C(C)C3=NC4=CC=CC=C4C(=O)N3C5=CC(C)=CC=C5C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.451

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00688

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>6.06

>  <Powder data?>
No

>  <IFI value>
0.037735849

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5314
  Mrv1591402191617072D          

 33 36  0  0  0  0            999 V2000
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  7 12  1  0  0  0  0
 10 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  3  0  0  0  0
 23 26  4  0  0  0  0
 26 27  4  0  0  0  0
  4 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
 30 33  1  0  0  0  0
 26 33  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5314

>  <JC_XSMILES>
CC(C)C1=NC(N2CCN(CC2)C(=S)NCC3=CC=CC=C3)=C(C#N)C4=C1COC(C)(C)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1831

>  <W2 Pf proliferation inhibition EC50 uM>
0.1121

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5319
  Mrv1591402191617072D          

 23 25  0  0  0  0            999 V2000
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -0.9826    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.8419   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3570   -2.3174    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  4  0  0  0  0
 13 14  4  0  0  0  0
  6 14  4  0  0  0  0
  2 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  2  0  0  0  0
M  CHG  2  21   1  22  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5319

>  <JC_XSMILES>
OC(CNCC1=CC=C2OCOC2=C1)C3=CC=CC(=C3)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
1.015

>  <W2 Pf proliferation inhibition EC50 uM>
0.1107

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.008130081

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5323
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
  9 14  1  0  0  0  0
 12 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 18 22  4  0  0  0  0
 22 23  1  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5323

>  <JC_XSMILES>
COC1=CC=CC=C1N2CCN(CC2)CC3=CC(C(C)C)=C(C)C=C3O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.623

>  <W2 Pf proliferation inhibition EC50 uM>
0.085

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
77.45

>  <Powder data?>
Yes

>  <IFI value>
0.03125

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-534
  Mrv1591402191617072D          

 21 23  0  0  0  0            999 V2000
    3.5724   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 12 21  4  0  0  0  0
  8 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-534

>  <JC_XSMILES>
OC1=CC=C(C=C1)C2=CN=CC(NCC3=CC=CC=C3)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.747

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5350
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -4.3935    9.7152    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -3.6791   10.1277    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -3.6791   10.9527    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501   10.1277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    9.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9646    8.8902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    8.4777    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2337    7.7632    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4087    9.1922    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    8.0652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    8.4777    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    8.0652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    7.2402    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    7.2402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.8277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    7.2402    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    6.0027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    5.5902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    4.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    3.4956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    4.2803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 23 27  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5350

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=S)NCC3CCCO3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1356

>  <W2 Pf proliferation inhibition EC50 uM>
0.1007

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5351
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
    4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1665   -1.4675    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7796   -2.0195    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5642   -1.7646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7358   -0.9576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1773   -2.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6119   -3.1745    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7376   -1.4675    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6377   -5.1768    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  1  0  0  0  0
 16 22  4  0  0  0  0
 22 23  2  0  0  0  0
 22 24  4  0  0  0  0
 24 25  4  0  0  0  0
 15 25  4  0  0  0  0
 25 26  1  0  0  0  0
 24 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 27 33  4  0  0  0  0
 10 34  4  0  0  0  0
  6 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5351

>  <JC_XSMILES>
CCOC(=O)C1=CC=CC(NC(=O)CC2N(CCC(C)C)C(=O)N(C2=O)C3=CC=C(F)C=C3)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2015

>  <W2 Pf proliferation inhibition EC50 uM>
0.1006

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5360
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0964   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8810   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3264   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1468   -4.3257    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6318   -4.9932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4522   -4.9070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9372   -5.5744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6016   -6.3281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7811   -6.4143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2962   -5.7469    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0865   -6.9955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7510   -7.7492    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.9070   -6.9093    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.3919   -7.5767    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2124   -7.4905    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5315   -4.4120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7615   -2.9599    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
  9 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
  6 25  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5360

>  <JC_XSMILES>
CCOC(=O)C1=C(C)C(CNC2=CC=C(C=C2)C(=O)OCC)=C(C)N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2376

>  <W2 Pf proliferation inhibition EC50 uM>
0.0977

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5362
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 10 20  4  0  0  0  0
  5 20  4  0  0  0  0
  4 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5362

>  <JC_XSMILES>
CC1=CC(C2=CC=C(O)C(CN3CCCCC3CO)=C2)=C4C=CC=CC4=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.361

>  <W2 Pf proliferation inhibition EC50 uM>
0.0577

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
59.13

>  <Powder data?>
Yes

>  <IFI value>
0.008474576

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5384
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
    0.0000    0.0000    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -3.6829    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.0329    0.8250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -3.6020    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -2.1730    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 18 20  1  0  0  0  0
 18 21  1  0  0  0  0
  6 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 22 25  1  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5384

>  <JC_XSMILES>
[O-][N+](=O)C1=CC(=CC=C1N2CCN(CC2)C(=O)C(Cl)(Cl)Cl)C(F)(F)F

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2633

>  <W2 Pf proliferation inhibition EC50 uM>
0.0866

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>95.03

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5392
  Mrv1591402191617072D          

 34 36  0  0  0  0            999 V2000
   -1.8786    0.8319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1641    0.4194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4497    0.8319    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2648    0.4194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2648   -0.4056    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9793    0.8319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9793    1.6569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6937    2.0694    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4082    1.6569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4082    0.8319    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227    0.4194    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1227   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4082   -0.8181    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8372   -0.8181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5516   -0.4056    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2661   -0.8181    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.0198   -0.4825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1913    0.3245    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5718   -1.0956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1593   -1.8101    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3523   -1.6386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7392   -2.1906    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9108   -2.9976    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2977   -3.5496    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5130   -3.2947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9000   -3.8467    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.3415   -2.4877    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9546   -1.9356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3923   -1.0094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8772   -1.6768    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7278   -0.2557    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.2429    0.4117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5785    1.1654    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6937    0.4194    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 19 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 10 34  4  0  0  0  0
  6 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5392

>  <JC_XSMILES>
CCOC(=O)C1=CC=CC(NC(=O)CCN2C(C)=C(C=C2C3=CC=C(F)C=C3)C(=O)OCC)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.059

>  <W2 Pf proliferation inhibition EC50 uM>
0.0897

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5398
  Mrv1591402191617072D          

 34 38  0  0  0  0            999 V2000
    1.0035   -7.2870    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.6166   -6.7350    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1686   -7.3481    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.0645   -6.1219    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.2296   -6.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8971   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4491   -5.6400    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0366   -6.3545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3722   -7.1082    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1927   -7.1944    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5282   -7.9481    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0433   -8.6155    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2228   -8.5293    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8873   -7.7756    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  5  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 21 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  1  0  0  0  0
 30 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 24 34  4  0  0  0  0
 28 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5398

>  <JC_XSMILES>
FC(F)(F)C1=C(C=NN1C2=CC=CC=C2)C(=O)N3CCN(CC3)C4=CC=NC5=CC(Cl)=CC=C45

>  <PF proliferation inhibition 3D7 EC50 uM>
0.349

>  <W2 Pf proliferation inhibition EC50 uM>
0.0882

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.064516129

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5418
  Mrv1591402191617072D          

 30 34  0  0  0  0            999 V2000
    3.2789    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2629    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7780   -0.2549    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9934    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2789   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5645    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798    1.0799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5249    1.8646    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2949    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7798   -0.2549    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574    1.1270    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0574   -0.3020    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7676   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051   -1.0164    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176   -0.3020    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0051    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4176    1.1270    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1801    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
  8 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 28 30  4  0  0  0  0
 24 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5418

>  <JC_XSMILES>
CC1=CC=C(C=C1)C2=C3CCCC3=NC4=C2C(N)=C(S4)C(=O)NC5=CC=CC(C)=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
1.008

>  <W2 Pf proliferation inhibition EC50 uM>
0.0827

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.047058824

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5424
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
   -0.4366   -0.0605    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    0.2779   -0.4730    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.9923   -0.0605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -1.2980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9923   -2.5355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -2.9480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -2.5355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4366   -1.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2779   -3.7730    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0212   -4.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2047   -4.9353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6904   -5.5803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1346   -5.5803    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6490   -4.9353    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4654   -4.1310    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4926   -6.3236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3153   -6.3852    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0279   -7.0052    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3858   -7.7485    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0789   -8.4302    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2790   -9.1735    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1017   -9.2351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5665   -8.5535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2085   -7.8102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 10 16  1  0  0  0  0
 14 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5424

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(N=C1)N2CCCN(CC2)C(=S)NC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0915

>  <W2 Pf proliferation inhibition EC50 uM>
0.0801

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.016666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5433
  Mrv1591402191617072D          

 39 42  0  0  1  0            999 V2000
   -1.1087   -2.7186    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3788   -1.9391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8387   -1.3154    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0286   -1.4713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2415   -2.2508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5115   -0.8476    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2414   -0.0681    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5087    0.2754    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.7078    1.0760    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5155    1.2440    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2060    1.7309    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6188    1.7468    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9053    2.5205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7186    2.6592    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2453    2.0243    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0586    2.1630    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3451    2.9367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1583    3.0754    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8183    3.5716    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9589    1.2506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1456    1.1119    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9776    0.3042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6325   -0.1976    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1436   -0.2514    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0049   -1.0646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6398   -1.5914    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4135   -1.3049    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5522   -0.4917    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9173    0.0351    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3216   -1.0035    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8617   -0.3798    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5917   -1.7830    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4018   -1.9389    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6719   -2.7185    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4821   -2.8743    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7522   -3.6539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2121   -4.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4020   -4.1217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1319   -3.3421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  8  7  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  2  0  0  0  0
 15 20  4  0  0  0  0
 20 21  4  0  0  0  0
 12 21  4  0  0  0  0
 21 22  1  0  0  0  0
  7 22  1  0  0  0  0
 22 23  2  0  0  0  0
  8 24  1  1  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  6 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5433

>  <JC_XSMILES>
CCCC(C)C(N1[C@H](C(=O)NC2=CC=C(NC(C)=O)C=C2C1=O)C3=CC=CC=C3)C(=O)NCC4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
<0.00712

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
9.21

>  <Powder data?>
No

>  <IFI value>
0.024390244

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5460
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  4  0  0  0  0
  6 19  4  0  0  0  0
  4 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  2  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
  2 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  20
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5460

>  <JC_XSMILES>
CC1=CC(NC2=CC=C(OCC3=CC=CC=C3)C=C2)=NC4=CC(O)=CC=C14

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0736

>  <W2 Pf proliferation inhibition EC50 uM>
0.01186

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
17.2

>  <Powder data?>
Yes

>  <IFI value>
0.090909091

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5465
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    0.5050    5.6355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3200    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3300    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    2.3355    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3896   -0.8137    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  4  0  0  0  0
 11 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  1  0  0  0  0
 20 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 10 24  4  0  0  0  0
 18 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5465

>  <JC_XSMILES>
CC(C)(C)NCC(O)CN1C2=CC=C(Br)C=C2C3=CC(Br)=CC=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2126

>  <W2 Pf proliferation inhibition EC50 uM>
0.0141

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
20.7

>  <Powder data?>
Yes

>  <IFI value>
0.016260163

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5466
  Mrv1591402191617072D          

 36 41  0  0  0  0            999 V2000
    2.8051    6.4533    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9982    6.2818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4461    6.8949    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7011    7.6795    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1490    8.2926    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4040    9.0772    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2109    9.2487    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7630    8.6356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5080    7.8510    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7432    5.4971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9362    5.3256    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2953    4.8841    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0403    4.0994    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5923    3.4863    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3993    3.6579    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6543    4.4425    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1022    5.0556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4793    4.4425    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.7342    3.6579    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5188    3.4029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1319    3.9550    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9165    3.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0881    2.8930    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4750    2.3410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6903    2.5960    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 12 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 25 29  4  0  0  0  0
 29 30  4  0  0  0  0
 22 30  4  0  0  0  0
 19 31  1  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 31 36  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5466

>  <JC_XSMILES>
NC(CC1=CC=CC=C1)C(=O)N2CCN3C(C2)=NC(=C3NC4=CC=C5OCOC5=C4)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
0.03037

>  <W2 Pf proliferation inhibition EC50 uM>
0.02908

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
42.82

>  <Powder data?>
Yes

>  <IFI value>
0.04109589

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5509
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9732   -7.4070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1527   -7.4932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8171   -6.7395    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7402   -8.2077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1527   -8.9221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7402   -9.6366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9152   -9.6366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5027   -8.9221    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9152   -8.2077    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 12 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 15 18  4  0  0  0  0
 18 19  4  0  0  0  0
 10 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
  8 24  4  0  0  0  0
 20 24  4  0  0  0  0
 22 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5509

>  <JC_XSMILES>
CCOCCCNC1=NC2=CC(OC)=C(OC)C=C2C3=NC(=NN13)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0831

>  <W2 Pf proliferation inhibition EC50 uM>
0.0563

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5520
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    0.8957    3.8948    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0647    3.0873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4499    2.5372    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6188    1.7297    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4026    1.4722    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0175    2.0223    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8013    1.7649    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9703    0.9574    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7541    0.7000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4698    1.1102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0812    0.5562    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7432   -0.1964    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9230   -0.1075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3082   -0.6576    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4772   -1.4651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6461   -2.2727    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5244   -0.4002    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8086   -0.8104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1973   -0.2565    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3765   -0.3401    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1063    0.3289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.2317    1.0815    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0524    1.1651    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5352    0.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3554    0.4073    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.8485    2.8298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  9 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  3  0  0  0  0
 14 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
  8 25  4  0  0  0  0
 17 25  4  0  0  0  0
  6 26  4  0  0  0  0
  2 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5520

>  <JC_XSMILES>
CC1=CC=CC(NC2=C3CCCC3=C(C#N)C4=NC5=CC=CC=C5N24)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0926

>  <W2 Pf proliferation inhibition EC50 uM>
0.0518

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5523
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
   -3.0789   -2.0921    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6664   -2.8066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -2.8066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.5211    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -4.2355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8414   -5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039   -3.5211    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1914   -4.2355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6039   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6336   -4.2355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0461   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8711   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2836   -4.2355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1086   -4.2355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1086   -5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2836   -5.6645    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8711   -6.3789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0461   -6.3789    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2836   -7.0934    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1086   -7.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211   -6.3789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3461   -6.3789    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7586   -7.0934    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3461   -7.8079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5211   -7.8079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5523

>  <JC_XSMILES>
CCCN(CCC)CC(O)COC1=CC=CC=C1C(=O)NC2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.365

>  <W2 Pf proliferation inhibition EC50 uM>
0.0511

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5526
  Mrv1591402191617072D          

 30 33  0  0  0  0            999 V2000
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    3.7125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7537   -0.3356    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3057    0.2775    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8932    0.9920    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0862    0.8205    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 15 17  4  0  0  0  0
 11 17  4  0  0  0  0
  7 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
  5 24  1  0  0  0  0
 24 25  2  0  0  0  0
  6 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 26 30  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5526

>  <JC_XSMILES>
CC(C)CN1C(C(C(=O)NC2=CC=CC(Cl)=C2)C3=CC=CC=C3C1=O)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0885

>  <W2 Pf proliferation inhibition EC50 uM>
0.047

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
93.55

>  <Powder data?>
Yes

>  <IFI value>
0.0625

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5535
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9559   -1.0942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4256   -2.0127    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  6 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 25 27  1  0  0  0  0
 25 28  1  0  0  0  0
 11 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5535

>  <JC_XSMILES>
CCOC(=O)C1=C(CC)NC2=C(C1C3=CC=C(Cl)C=C3Cl)C(=O)CC(C)(C)C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.208

>  <W2 Pf proliferation inhibition EC50 uM>
0.0459

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5538
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    1.5662   -2.8960    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -2.4835    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -2.8960    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.1373   -3.7210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.1336    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5771   -4.9586    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0904   -5.4435    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1645   -6.2281    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9895   -6.2281    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2445   -5.4435    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3205   -6.8955    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1409   -6.8092    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6259   -7.4766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2904   -8.2303    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.4699   -8.3166    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0151   -7.6492    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -1.6585    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1163   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5657   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -0.1208    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -0.4945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0368   -1.2419    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3012   -1.6156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5873   -2.0322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8517   -0.9111    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  6 10  4  0  0  0  0
  8 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
  2 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 21 22  1  0  0  0  0
 20 21  1  0  0  0  0
 19 24  1  0  0  0  0
 17 25  1  0  0  0  0
 23 24  1  0  0  0  0
 21 26  1  0  0  0  0
 23 25  1  0  0  0  0
 22 23  1  0  0  0  0
 17 26  1  0  0  0  0
 19 20  1  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  10
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5538

>  <JC_XSMILES>
O=C(NCCC1=NC(=NN1)C2=CC=NC=C2)C34CC5CC(CC(C5)C3)C4

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.0449

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5555
  Mrv1591402191617072D          

 22 24  0  0  0  0            999 V2000
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
 11 17  1  0  0  0  0
 12 18  4  0  0  0  0
 18 19  2  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  4  0  0  0  0
  6 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5555

>  <JC_XSMILES>
CCCCCC1=CC(O)=C2C3=C(CN(C)CC3)C(=O)OC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0494

>  <W2 Pf proliferation inhibition EC50 uM>
0.0376

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>96.81

>  <Powder data?>
Yes

>  <IFI value>
0.022900763

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5557
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 18 23  1  0  0  0  0
 14 24  4  0  0  0  0
  9 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5557

>  <JC_XSMILES>
COC1=CC=CC(=N1)C2=CC=C(O)C(CNCC3CCCCC3)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0585

>  <W2 Pf proliferation inhibition EC50 uM>
0.01771

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
46.6

>  <Powder data?>
Yes

>  <IFI value>
0.01980198

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5558
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    5.0013   -2.8875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -6.6000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.8908   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5408   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.0750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302  -10.3125    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -10.3125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  7 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  2  0  0  0  0
 10 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
M  CHG  2   1  -1   2   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5558

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=C(C=C1)S(=O)(=O)N2CCN(CC2)C(=S)NCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0796

>  <W2 Pf proliferation inhibition EC50 uM>
0.038

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-556
  Mrv1591402191617072D          

 61 63  0  0  1  0            999 V2000
    8.9160    8.7797    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.3857    8.1477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6678    7.3724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.1982    8.0044    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    9.4256    8.7974    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.0106    7.8611    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   10.5410    8.4931    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.2928    7.0859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7624    6.4539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9500    6.5972    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0446    5.6786    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5142    5.0467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7964    4.2714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2660    3.6395    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    9.5482    2.8642    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   10.3606    2.7209    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.4536    3.7827    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.9233    3.1508    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1108    3.2941    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5805    2.6621    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.8287    4.0693    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0162    4.2126    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.4859    3.5807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3590    4.7013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0769    5.4766    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2644    5.6199    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6072    6.1085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3251    6.8838    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    6.5126    7.0271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8554    7.5157    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.5732    8.2910    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.7357    3.0075    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3088    2.4140    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2054    2.3755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3929    2.5188    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.4875    1.6003    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    9.3000    1.4570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.9572    0.9683    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.4269    1.6003    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6717    0.5558    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6716   -0.2692    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    9.3861   -0.6818    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3860   -1.5068    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   10.1005   -1.9193    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.1005   -2.7443    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   10.8149   -3.1568    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.3860   -3.1568    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    9.3859   -3.9818    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6714   -4.3942    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6714   -5.2192    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9570   -3.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.6715   -2.7442    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.9570   -3.1567    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.6715   -1.9192    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.9571   -0.6817    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.9571   -1.5067    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2427   -0.2692    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    7.2427    0.5558    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.5282   -0.6816    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.5282   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8137   -1.9191    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  4  3  1  0  0  0  0
  4  5  1  1  0  0  0
  4  6  1  0  0  0  0
  6  7  1  6  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  4  0  0  0
 12 13  2  3  0  0  0
 14 13  1  0  0  0  0
 14 15  1  6  0  0  0
 15 16  1  0  0  0  0
 17 14  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 21 24  2  0  0  0  0
 24 25  1  4  0  0  0
 25 26  1  4  0  0  0
 25 27  2  0  0  0  0
 28 27  1  0  0  0  0
 28 29  1  1  0  0  0
 30 28  1  0  0  0  0
 30  3  1  0  0  0  0
 30 31  1  6  0  0  0
 17 32  1  6  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 36 34  1  0  0  0  0
 36 37  1  6  0  0  0
 36 38  1  0  0  0  0
 38 39  1  6  0  0  0
 38 40  1  0  0  0  0
 41 40  1  0  0  0  0
 41 42  1  1  0  0  0
 43 42  1  1  0  0  0
 43 44  1  0  0  0  0
 45 44  1  0  0  0  0
 45 46  1  1  0  0  0
 47 45  1  0  0  0  0
 47 48  1  6  0  0  0
 48 49  1  0  0  0  0
 49 50  1  0  0  0  0
 49 51  2  0  0  0  0
 47 52  1  0  0  0  0
 52 53  1  1  0  0  0
 52 54  1  0  0  0  0
 43 54  1  0  0  0  0
 55 41  1  0  0  0  0
 55 56  1  6  0  0  0
 55 57  1  0  0  0  0
 57 58  1  0  0  0  0
 38 58  1  1  0  0  0
 57 59  1  1  0  0  0
 59 60  2  0  0  0  0
 60 61  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-556

>  <JC_XSMILES>
CCC1[C@@H](O)[C@H](C)CC(C)=CC=C[C@H](OC)[C@H](OC(=O)C(OC)=CC(C)=C[C@@H](C)[C@@H]1O)C(C)C(O)[C@H](C)[C@@]2(O)C[C@@H](O[C@H]3C[C@@H](O)[C@H](OC(N)=O)[C@@H](C)O3)[C@H](C)[C@H](O2)\C=C\C

>  <PF proliferation inhibition 3D7 EC50 uM>
1.179

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.175438596

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5571
  Mrv1591402191617072D          

 32 35  0  0  0  0            999 V2000
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4290   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7144    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5350    1.3237    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    3.5723   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 19 20  1  0  0  0  0
 12 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 11 25  1  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  1  0  0  0  0
 29 31  4  0  0  0  0
 31 32  4  0  0  0  0
 26 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5571

>  <JC_XSMILES>
CC(C)OC(=O)C1=C(C)NC2=C(C1C3=CC=CC=C3F)C(=O)CC(C2)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1093

>  <W2 Pf proliferation inhibition EC50 uM>
0.0351

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022222222

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5582
  Mrv1591402191617072D          

 29 30  0  0  0  0            999 V2000
    5.0013   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -0.8250    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.6993   -1.5395    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.8743   -0.1105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    2.4750    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    7.9697    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.3197    1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  1  0  0  0  0
 12 14  2  0  0  0  0
  4 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  2  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 24 27  1  0  0  0  0
 22 28  4  0  0  0  0
 28 29  4  0  0  0  0
 19 29  4  0  0  0  0
M  CHG  2  12   1  13  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5582

>  <JC_XSMILES>
OC(=O)C(CC1=CC=C(C=C1)[N+]([O-])=O)NS(=O)(=O)C2=CC=C(OC(F)(F)F)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.58

>  <W2 Pf proliferation inhibition EC50 uM>
0.00329

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5587
  Mrv1591402191617072D          

 28 31  0  0  1  0            999 V2000
    0.9051   -4.3827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5151   -3.6557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9497   -2.9545    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5597   -2.2275    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2649   -2.2017    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9943   -1.5262    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6043   -0.7992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0390   -0.0980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8636   -0.1238    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2982    0.5775    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1228    0.5517    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    3.5127   -0.1753    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    4.3140   -0.3719    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3745   -1.1947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6108   -1.5066    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0781   -0.8765    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    2.2535   -0.8508    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8189   -1.5520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5574    1.2530    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1674    1.9800    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6020    2.6812    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4266    2.6554    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8166    1.9284    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6412    1.9027    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0758    2.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3820    1.2272    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7720    0.5002    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.5966    0.4744    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 11 10  1  0  0  0  0
 12 11  1  0  0  0  0
 12 13  1  1  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 16 15  1  1  0  0  0
 12 16  1  0  0  0  0
 16 17  1  0  0  0  0
  9 17  4  0  0  0  0
 17 18  4  0  0  0  0
  6 18  4  0  0  0  0
 11 19  1  1  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 23 26  4  0  0  0  0
 19 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5587

>  <JC_XSMILES>
CCOC(=O)C1=CC=C2N[C@H]([C@H]3CC=C[C@H]3C2=C1)C4=CC=CC(OC)=C4OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.471

>  <W2 Pf proliferation inhibition EC50 uM>
0.0318

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-559
  Mrv1591402191617072D          

 31 35  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9280   -2.6326    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4130   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.9280   -3.9674    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  7  8  1  0  0  0  0
  5  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  2  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 12 16  4  0  0  0  0
 13 17  4  0  0  0  0
 17 18  4  0  0  0  0
  9 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  2  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 21 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-559

>  <JC_XSMILES>
CC1=CC=C(C=C1C)N2C(=O)C3=C(C=CS3)N=C2SCC4=CC(=O)N5C=CC=CC5=N4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.163

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5593
  Mrv1591402191617072D          

 33 37  0  0  0  0            999 V2000
   -0.6193   -2.0998    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6193   -2.9248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0952   -3.3373    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.8097   -2.9248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8097   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5241   -1.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2386   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9531   -1.6873    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6675   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3125   -1.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1169   -1.7690    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4748   -2.5123    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1169   -3.2556    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3125   -3.4391    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6675   -2.9248    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.9531   -3.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9531   -4.1623    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.2386   -2.9248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5241   -3.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -3.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3338   -4.1623    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0482   -2.9248    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7627   -3.3373    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4772   -2.9248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4772   -2.0998    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.7627   -1.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0482   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1916   -1.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9061   -2.0998    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6206   -1.6873    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.6206   -0.8623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.9061   -0.4498    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1916   -0.8623    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
  9 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  2  0  0  0  0
 16 18  4  0  0  0  0
  7 18  4  0  0  0  0
 18 19  4  0  0  0  0
  4 19  4  0  0  0  0
  2 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 22 27  1  0  0  0  0
 25 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 28 33  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5593

>  <JC_XSMILES>
O=C(NC1=CC=C2N=C3CCCCCN3C(=O)C2=C1)C(=O)N4CCN(CC4)C5=CC=CC=C5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1333

>  <W2 Pf proliferation inhibition EC50 uM>
0.03078

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-561
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
    2.1434   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.8375    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
 10  7  1  4  0  0  0
 10 11  2  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  1  0  0  0  0
 19 21  2  0  0  0  0
M  CHG  2  19   1  20  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-561

>  <JC_XSMILES>
OC(=O)C1=CC=C(C=C1)C=NNC2=CC=C(C=C2)[N+]([O-])=O

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.158

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.043165468

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5610
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3149   -5.3445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.1354   -5.4307    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    3.4710   -4.6770    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2780   -4.5055    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9918   -4.8246    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6044   -4.1538    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 12 16  4  0  0  0  0
 16 17  4  0  0  0  0
  9 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 18 22  4  0  0  0  0
 22 23  2  0  0  0  0
 19 24  1  0  0  0  0
  8 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5610

>  <JC_XSMILES>
CCOC(=O)C(=O)N1C2=CC=C(OCC)C=C2C3=C(SSC3=S)C1(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2523

>  <W2 Pf proliferation inhibition EC50 uM>
0.02525

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5614
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 17 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
  5 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 33 35  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5614

>  <JC_XSMILES>
COC1=CC(=CC=C1OC2CCN(CC2)CC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)NC(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0743

>  <W2 Pf proliferation inhibition EC50 uM>
0.02362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.027777778

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5622
  Mrv1591402191617072D          

 37 40  0  0  0  0            999 V2000
   -4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 14 19  4  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 20 22  2  0  0  0  0
 12 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 11 27  1  0  0  0  0
 26 28  1  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 31 34  4  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 34 37  4  0  0  0  0
 28 37  4  0  0  0  0
M  CHG  2  20   1  21  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-5622

>  <JC_XSMILES>
CCCOC(=O)C1=C(C)NC2=C(C1C3=CC=C(C=C3)[N+]([O-])=O)C(=O)CC(C2)C4=CC=C(OC)C(OC)=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.02587

>  <W2 Pf proliferation inhibition EC50 uM>
0.02053

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.023809524

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5630
  Mrv1591402191617072D          

 23 24  0  0  0  0            999 V2000
   -2.1434    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270    0.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020    1.9520    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  5  7  1  0  0  0  0
  5  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 16 17  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5630

>  <JC_XSMILES>
CN(C)CC(C)(C)CNCC1=CC(=CC=C1O)C2=CC=CC=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0661

>  <W2 Pf proliferation inhibition EC50 uM>
0.00653

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
38.04

>  <Powder data?>
Yes

>  <IFI value>
0.017391304

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5631
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  7 12  4  0  0  0  0
 12 13  1  0  0  0  0
  9 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5631

>  <JC_XSMILES>
CC(C)CNCC1=CC(=CC=C1O)C2=CC=C(F)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1035

>  <W2 Pf proliferation inhibition EC50 uM>
0.01

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
58.55

>  <Powder data?>
Yes

>  <IFI value>
0.009803922

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5637
  Mrv1591402191617072D          

 24 27  0  0  0  0            999 V2000
   -2.0473   -0.5791    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328   -0.1666    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    0.6584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0473    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0473    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3328    3.1334    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    3.5459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0962    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8106    1.0709    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5251    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396    3.5459    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    2.9959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3771    2.4459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2396    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9540    3.1334    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6685    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3830    2.3084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.8959    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6183    1.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 19 21  1  0  0  0  0
 21 22  2  0  0  0  0
 10 23  4  0  0  0  0
  6 23  4  0  0  0  0
 23 24  4  0  0  0  0
  3 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5637

>  <JC_XSMILES>
COC1=CC=C2N=CC=C(C(O)C3CN4CCC3C(C4)C=C)C2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00721

>  <W2 Pf proliferation inhibition EC50 uM>
0.01512

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.022900763

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5638
  Mrv1591402191617072D          

 38 42  0  0  0  0            999 V2000
    2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8109   -9.1474    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.5559   -9.9320    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7309   -9.9320    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4760   -9.1474    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6914   -8.8925    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0408  -10.5995    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8613  -10.5132    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3462  -11.1807    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0107  -11.9344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4956  -12.6018    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3161  -12.5156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6516  -11.7619    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.8010  -13.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6215  -13.0968    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1064  -13.7642    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7709  -14.5179    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9504  -14.6041    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4654  -13.9367    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2558  -15.1853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9202  -15.9390    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    8.0763  -15.0991    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    8.5612  -15.7665    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.3817  -15.6803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.8666  -16.3477    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.5310  -17.1014    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7105  -17.1876    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.2256  -16.5202    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0159  -17.7688    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.8409  -17.7688    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.0959  -18.5535    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.8805  -18.8084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4284  -19.0384    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.4284  -19.8634    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.7610  -18.5535    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1902  -12.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7053  -11.3532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  5  6  1  0  0  0  0
  2  6  1  0  0  0  0
  6  7  1  0  0  0  0
  4  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  1  0  0  0  0
 21 22  2  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  2  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  1  0  0  0  0
 34 35  1  0  0  0  0
 34 36  1  0  0  0  0
 30 36  1  0  0  0  0
 11 37  4  0  0  0  0
 37 38  4  0  0  0  0
  8 38  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5638

>  <JC_XSMILES>
CC1NC(=NC1C)C2=CC=C(NC(=O)C3=CC=C(C=C3)C(=O)NC4=CC=C(C=C4)C5=NC(C)C(C)N5)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0576

>  <W2 Pf proliferation inhibition EC50 uM>
0.01478

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.081081081

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5664
  Mrv1591402191617072D          

 13 12  0  0  0  0            999 V2000
    0.8250    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375    0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -0.7145    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500   -1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6500    0.0000    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0625    0.7145    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750    1.4289    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3000    1.4289    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125    2.1434    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7125    0.7145    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  4  0  0  0
  3  4  2  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  8  2  0  0  0  0
  2  9  2  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5664

>  <JC_XSMILES>
CC(C=NNC(N)=S)=NNC(N)=S

>  <PF proliferation inhibition 3D7 EC50 uM>
0.00894

>  <W2 Pf proliferation inhibition EC50 uM>
0.00723

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.217741935

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-5669
  Mrv1591402191617072D          

 24 28  0  0  0  0            999 V2000
    2.7455    0.3751    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9859   -0.4141    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7656   -0.6836    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4201   -0.1813    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2208   -0.3798    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.5649   -1.1296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3886   -1.0832    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8406   -1.7734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4689   -2.5099    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6452   -2.5563    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.1932   -1.8661    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3856   -2.0347    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.7503   -1.5084    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9611   -1.7488    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6116   -2.4961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7896   -2.5671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3172   -1.8907    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6667   -1.1434    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4886   -1.0724    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2514    0.6263    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    0.9646    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5882    1.7848    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3958    1.9534    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8057    1.2374    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
  3 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
  2 19  1  0  0  0  0
 14 19  4  0  0  0  0
  4 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-5669

>  <JC_XSMILES>
OC1=C2C(SC3=CC=CC=C3N=C2C4=CC=CC=C14)C5=CC=CS5

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0428

>  <W2 Pf proliferation inhibition EC50 uM>
<0.002468

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
49.51

>  <Powder data?>
Yes

>  <IFI value>
0.022727273

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
1

>  <Class Total>
1

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-572
  Mrv1591402191617072D          

 42 44  0  0  0  0            999 V2000
    1.5850   -4.1102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4290   -3.3001    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0527   -2.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6495   -3.0301    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4935   -2.2200    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1171   -1.6798    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8967   -1.9499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4991   -2.5136    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.5203   -1.4097    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2999   -1.6798    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.9235   -1.1396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7676   -0.3295    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9880   -0.0595    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3644   -0.5996    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5848   -0.3296    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.4805    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0525    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8321    0.7506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4558   -2.4899    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    4.2660   -2.3339    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.7335   -2.8885    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.6118   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3913   -3.5700    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0150   -3.0299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7945   -3.2999    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9505   -4.1100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3269   -4.6502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5473   -4.3801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2860   -1.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4420   -1.1398    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9097   -2.4901    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8392   -3.3121    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5992   -3.6330    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1394   -3.0094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7132   -2.3030    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0341   -1.5430    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5364   -0.8851    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8528   -1.4410    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3505   -2.0990    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8482   -2.7569    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0085   -1.6013    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6925   -2.5967    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  7  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 10 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  2  0  0  0  0
 19 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
  5 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 31 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  2  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 39 41  1  0  0  0  0
 39 42  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-572

>  <JC_XSMILES>
CC(C)CN(CC(O)CN(CCN1CCOCC1)S(=O)(=O)CC2=CC=CC=C2)C(=O)C3CCCN3C(=O)OC(C)(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.132

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.019607843

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-575
  Mrv1591402191617072D          

 35 38  0  0  0  0            999 V2000
    5.7158    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724    2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  2  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 15 27  4  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 29 34  4  0  0  0  0
 27 35  4  0  0  0  0
 12 35  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-575

>  <JC_XSMILES>
CC1CCCCN1CCCNC2=NC=C(C(=O)NCCC3=CC=CC=C3)C(NC4=CC=CC=C4)=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
1.123

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.028846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-597
  Mrv1591402191617072D          

 26 30  0  0  0  0            999 V2000
    1.3998   -3.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6461   -3.3892    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0213   -3.8742    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0649   -4.6946    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6025   -5.1796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3562   -4.8440    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4424   -4.0235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7750   -3.5386    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8612   -2.7181    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5757   -2.3056    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4042   -1.4986    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837   -1.4124    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712   -0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -0.0305    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -0.2854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -1.3654    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.6218   -0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1369   -0.0305    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387   -1.3654    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2481   -2.1661    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 18 22  1  0  0  0  0
 19 23  4  0  0  0  0
 23 24  4  0  0  0  0
 16 24  4  0  0  0  0
 24 25  4  0  0  0  0
 14 25  4  0  0  0  0
 12 26  4  0  0  0  0
  9 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-597

>  <JC_XSMILES>
COC1=CC=CC=C1C2=NN=C(NC3=NC4=CC5=C(OCO5)C=C4S3)O2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.053

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-598
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    9.2148    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5003    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5003   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.7858    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.0714   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569   -0.5396    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424   -0.1271    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6424    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9279    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2135   -0.1271    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4990    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7845    0.6979    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    0.6979    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.1104    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6411    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3556    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0701    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    2.1904    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6284    1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1435    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3984    0.0709    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1536   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1014   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9083   -1.4984    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1633   -2.2830    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4604   -0.8853    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2054   -0.1006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3569    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 18 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 17 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
 29 30  4  0  0  0  0
 24 30  4  0  0  0  0
  9 31  4  0  0  0  0
  5 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-598

>  <JC_XSMILES>
CC(=O)NC1=CC=CC(NC(=O)CSC2=NN3C(C=C2)=NN=C3C4=CC=C(F)C=C4)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.047

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-602
  Mrv1591402191617072D          

 29 33  0  0  0  0            999 V2000
    2.6435    1.9817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    1.0256    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2575    1.6387    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0645    1.4672    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.6165    2.0803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4235    1.9087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.6784    1.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1264    0.5110    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3194    0.6825    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   -0.3721    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8995    0.0694    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1544   -0.7152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9614   -0.8867    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2163   -1.6713    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0233   -1.8429    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5753   -1.2298    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3204   -0.4451    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5134   -0.2736    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   -0.6855    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
  3 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 15 20  1  0  0  0  0
 18 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 23 28  4  0  0  0  0
 16 29  4  0  0  0  0
 13 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-602

>  <JC_XSMILES>
O=C1N(CC2CCCCC2)C=NC3=C1C4=C(CC(CC4)NCC5=CC=CN=C5)S3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.04

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.017094017

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-63
  Mrv1591402191617072D          

 34 36  0  0  1  0            999 V2000
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -7.0125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.7750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -5.7750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -3.3000    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  1  0  0  0  0
 10 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  1  0  0  0  0
 13 15  4  0  0  0  0
  8 15  4  0  0  0  0
 15 16  4  0  0  0  0
  5 16  4  0  0  0  0
  3 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 17 22  4  0  0  0  0
 20 23  1  0  0  0  0
 23 24  2  0  0  0  0
 23 25  1  0  0  0  0
 26 25  1  6  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  2  0  0  0  0
 26 32  1  0  0  0  0
 32 33  1  0  0  0  0
 32 34  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-63

>  <JC_XSMILES>
CCC(CC1=CN=C2N=C(N)N=C(N)C2=N1)C3=CC=C(C=C3)C(=O)N[C@@H](CCC(O)=O)C(O)=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01484

>  <W2 Pf proliferation inhibition EC50 uM>
0.1081

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.0304

>  <Powder data?>
Yes

>  <IFI value>
0.178861789

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-67
  Mrv1591402191617072D          

 14 15  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  2  0  0  0  0
  7  9  4  0  0  0  0
  9 10  1  0  0  0  0
  9 11  4  0  0  0  0
 11 12  2  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
  6 14  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-67

>  <JC_XSMILES>
CN1N=CN=C2C(=O)N(C)C(=O)N=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
>12.5

>  <W2 Pf proliferation inhibition EC50 uM>
0.481

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.1986

>  <Powder data?>
Yes

>  <IFI value>
0.266666667

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-674
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    5.0013   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   14.2894   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 11 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 22 32  4  0  0  0  0
  8 32  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-674

>  <JC_XSMILES>
CN(C)CCCNC1=NC=C(C(=O)NCC2=CC=CC=C2)C(NCCC3=CC=CC=C3)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.817

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.03

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-690
  Mrv1591402191617072D          

 13 14  0  0  0  0            999 V2000
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
  2 13  4  0  0  0  0
  6 13  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-690

>  <JC_XSMILES>
CC1=CC=CC2=NC(N)=NC(N)=C12

>  <PF proliferation inhibition 3D7 EC50 uM>
0.753

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-693
  Mrv1591402191617072D          

 27 30  0  0  0  0            999 V2000
    0.0000    5.7750    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145    2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3819   -1.7224    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1270   -2.5070    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3020   -2.5070    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0470   -1.7224    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1830   -3.1745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1526   -3.9282    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3323   -4.5956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1528   -4.5094    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4884   -3.7557    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0034   -3.0882    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 11 16  4  0  0  0  0
 14 17  1  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 20 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-693

>  <JC_XSMILES>
BrC1=CC=C(C=C1)C(=O)NC2=CC=C(C=C2)C3=NN=C(O3)C4=CC=CC=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.75

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.046875

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-70
  Mrv1591402191617072D          

 34 41  0  0  1  0            999 V2000
    1.8745   -1.5100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6173   -1.1511    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6779   -0.3283    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    3.4344    0.0841    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5338    1.0055    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    2.7827    1.0941    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0390    1.0801    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    1.2156    1.0288    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9974    0.1846    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.2507   -0.1662    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8843    1.9773    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.0835    2.2889    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3424    1.9265    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3420    2.3872    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2853    3.2102    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4558    3.5726    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1403    3.1120    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9681    3.3506    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4182    4.0584    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1609    4.8423    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8268    5.3292    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4958    4.8464    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2796    5.1037    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2432    4.0610    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054    3.3236    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5326    3.0981    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.2083    3.5714    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9561    3.2229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0281    2.4010    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3524    1.9277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6046    2.2763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7855    1.9083    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.2637    2.6117    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4189    2.6517    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  3  2  1  6  0  0  0
  3  4  1  0  0  0  0
  5  4  1  0  0  0  0
  5  6  1  6  0  0  0
  7  6  1  0  0  0  0
  7  8  1  1  0  0  0
  9  7  1  0  0  0  0
  9  3  1  0  0  0  0
  9 10  1  6  0  0  0
  7 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 12 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  2  0  0  0  0
 22 24  1  0  0  0  0
 19 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
 31 32  4  0  0  0  0
  5 32  1  0  0  0  0
 32 33  4  0  0  0  0
 25 33  4  0  0  0  0
 33 34  4  0  0  0  0
 11 34  4  0  0  0  0
 18 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-70

>  <JC_XSMILES>
CN[C@H]1C[C@@H]2O[C@](C)([C@H]1O)N3C4=CC=CC=C4C5=C6CNC(=O)C6=C7C8=CC=CC=C8N2C7=C35

>  <PF proliferation inhibition 3D7 EC50 uM>
0.0554

>  <W2 Pf proliferation inhibition EC50 uM>
0.0521

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.0323

>  <Powder data?>
Yes

>  <IFI value>
0.462184874

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-716
  Mrv1591402191617072D          

 21 24  0  0  0  0            999 V2000
    3.3523   -0.2854    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812   -2.7604    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523   -2.7604    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -2.6029    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3683   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8532   -1.2680    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378   -1.5229    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.5433   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -2.6499    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1067   -1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9317   -1.9354    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.6942   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1308   -1.2210    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  2  0  0  0  0
  2  3  4  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  3  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  2 14  4  0  0  0  0
 10 14  4  0  0  0  0
 12 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   9
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-716

>  <JC_XSMILES>
OC1=C2CCCCC2=NC3=CC(=NN13)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
6.48

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-721
  Mrv1591402191617072D          

 54 62  0  0  0  0            999 V2000
    0.5050    4.8105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    5.2230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    6.0480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    6.4605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    7.2855    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    7.6980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2095    8.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    8.9355    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050    9.7605    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195   10.1730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195   10.9980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5050   11.4105    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   11.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   12.2355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195   12.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195   13.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   13.8855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484   13.4730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484   12.6480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339   14.7105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   15.1954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595   15.0239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925   15.6370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   16.4216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   16.5932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214   15.9801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464   15.9801    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   16.5932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   16.4216    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604   15.6370    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084   15.0239    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014   15.1954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    8.5230    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    7.6980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    4.8105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    3.9855    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6484    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    2.3355    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    2.7480    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2195    3.5730    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9339    1.5105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6014    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4084    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9604    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7054   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8985   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3464    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5214    0.2410    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9694   -0.3721    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1624   -0.2006    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0925    0.5840    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4595    1.1971    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665    1.0256    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  1  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 20 32  1  0  0  0  0
 27 32  4  0  0  0  0
  8 33  4  0  0  0  0
 33 34  4  0  0  0  0
  5 34  4  0  0  0  0
  2 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  1  0  0  0  0
 40 41  1  0  0  0  0
 36 41  1  0  0  0  0
 39 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 43 48  4  0  0  0  0
 48 49  1  0  0  0  0
 49 50  4  0  0  0  0
 50 51  4  0  0  0  0
 51 52  4  0  0  0  0
 52 53  4  0  0  0  0
 53 54  4  0  0  0  0
 42 54  1  0  0  0  0
 49 54  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-721

>  <JC_XSMILES>
OC(COC1=CC=C(OCC(O)CN2CCN(CC2)C3C4=CC=CC=C4C5=CC=CC=C35)C=C1)CN6CCN(CC6)C7C8=CC=CC=C8C9=CC=CC=C79

>  <PF proliferation inhibition 3D7 EC50 uM>
>6.19

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-741
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
   -2.9646    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2501    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8212    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5356    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    4.7652    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1067    5.5902    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    4.7652    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    4.3527    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    4.7652    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1801    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.8946    2.7027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512    2.2902    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186    1.8053    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387    1.0206    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837    1.8053    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367    3.5277    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222    3.1152    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6078    2.7027    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  2  7  4  0  0  0  0
  5  8  1  0  0  0  0
  8  9  2  0  0  0  0
  8 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  1  0  0  0  0
 14 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  3  0  0  0  0
 16 19  4  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 20 24  4  0  0  0  0
 19 25  4  0  0  0  0
 12 25  4  0  0  0  0
 25 26  1  0  0  0  0
 26 27  3  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-741

>  <JC_XSMILES>
CC1=CC=C(C=C1)C(=O)CSC2=NC(N)=C(C#N)C(C3=CC=CS3)=C2C#N

>  <PF proliferation inhibition 3D7 EC50 uM>
>5

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.071428571

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-76
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
    5.4957    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7812    1.9354    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.4957    3.1729    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0668    2.3479    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3523    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    0.6979    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.1104    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    0.8555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8838    0.0709    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -0.5422    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2428   -0.3707    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -1.3268    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963   -1.5818    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3963   -2.4068    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1809   -2.6617    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4358   -3.4463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6658   -1.9943    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.6538    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1387    2.1904    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    1.9233    1.9354    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6378    2.3479    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1712    1.5229    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    2.2374    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5837    0.8085    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4087    0.8085    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 15 20  4  0  0  0  0
 11 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 10 23  4  0  0  0  0
 23 24  4  0  0  0  0
  7 24  4  0  0  0  0
 21 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-76

>  <JC_XSMILES>
CCN(CC)CC1=CC=C2C(NC(=O)C3=CC=C(C)S3)=C(SC2=N1)C(=O)OC

>  <PF proliferation inhibition 3D7 EC50 uM>
1.226

>  <W2 Pf proliferation inhibition EC50 uM>
1.186

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
1.239

>  <Powder data?>
No

>  <IFI value>
0.00862069

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-768
  Mrv1591402191617072D          

 31 34  0  0  0  0            999 V2000
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.0625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    7.8592   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.5737   -1.6500    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.1460    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749    0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   13.5749   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   12.8605   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   11.4315   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.7171   -4.5375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   10.0026   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2881   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  2 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 16 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 25 30  4  0  0  0  0
 30 31  4  0  0  0  0
 14 31  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-768

>  <JC_XSMILES>
CN(CC1=CC=CC=C1)C(=O)CSC2=NC(NCC3=CC=CC=C3)=C4C=CC=CC4=N2

>  <PF proliferation inhibition 3D7 EC50 uM>
>3.032

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-770
  Mrv1591402191617072D          

 21 22  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  8 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 13 15  2  0  0  0  0
 15 16  1  4  0  0  0
 16 17  1  0  0  0  0
 16 18  2  0  0  0  0
 11 19  4  0  0  0  0
 19 20  4  0  0  0  0
  7 20  4  0  0  0  0
 20 21  4  0  0  0  0
  4 21  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-770

>  <JC_XSMILES>
CCOC1=CC=C2C(C)=NC(NC(N)=NC(C)=O)=NC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
3.021

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.057971014

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-787
  Mrv1591402191617072D          

 29 31  0  0  0  0            999 V2000
    1.3222   -0.0616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.3222   -0.8866    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -0.8866    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -1.2991    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4656   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -2.5366    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0367   -2.1241    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.7512   -3.3616    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4186   -3.8465    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.1637   -4.6312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.6486   -5.2986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3130   -6.0523    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    2.5594   -5.7167    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0667   -6.3878    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.9775   -6.8059    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4624   -7.4734    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2829   -7.3871    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.1269   -8.2271    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.6118   -8.8945    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2762   -9.6482    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.7611  -10.3156    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4557   -9.7344    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9708   -9.0670    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1503   -9.1532    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3064   -8.3133    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3387   -4.6312    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8538   -5.2986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0837   -3.8465    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  7  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  2  0  0  0  0
 13 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  2  0  0  0  0
 17 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 21 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 24 26  1  0  0  0  0
 19 26  1  0  0  0  0
 11 27  4  0  0  0  0
 27 28  1  0  0  0  0
 27 29  4  0  0  0  0
  9 29  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-787

>  <JC_XSMILES>
COC1=CC=CC(=C1)C2=NC(CS(=O)(=O)CC(=O)N3CC(C)CC(C)C3)=C(C)O2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.1355

>  <W2 Pf proliferation inhibition EC50 uM>
>1.25

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-803
  Mrv1591402191617072D          

 25 26  0  0  0  0            999 V2000
   -6.4302   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.0625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -4.5375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
  6 11  4  0  0  0  0
  9 12  1  0  0  0  0
 12 13  2  0  0  0  0
 12 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 22 25  4  0  0  0  0
 18 25  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-803

>  <JC_XSMILES>
CCCCOC1=CC=C(C=C1)C(=O)NCCOC2=CC=CC(OC)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2883

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0.015151515

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-81
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
    2.8579   -0.8250    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0329   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    3.6829   -1.6500    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  1  0  0  0  0
 19 21  4  0  0  0  0
 14 21  4  0  0  0  0
  9 22  4  0  0  0  0
  5 22  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-81

>  <JC_XSMILES>
FC(F)(F)C1=CC=CC(NC(=O)NC2=CC(Cl)=CC(Cl)=C2)=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
0.01378

>  <W2 Pf proliferation inhibition EC50 uM>
>12.5

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
14.92

>  <Powder data?>
Yes

>  <IFI value>
0.172932331

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-815
  Mrv1591402191617072D          

 48 53  0  0  0  0            999 V2000
   -3.5724   -3.7125    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.1250    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
   -5.0013   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7158   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4302   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.8592   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -7.1447   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026   -9.9000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881   -8.6625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.1460   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.1460   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8605   -7.4250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  -13.5749   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -14.2894   -7.4250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -13.5749   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8605   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -12.8605   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -13.5749  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -14.2894   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -14.2894   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -15.0039  -10.3125    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
  -15.0039  -11.1375    0.0000 O   0  5  0  0  0  0  0  0  0  0  0  0
  -15.7184   -9.9000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  -11.4315   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.7171   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -8.5737  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -9.2881  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  -10.0026  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  2  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 13 18  4  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
 23 25  1  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  1  0  0  0  0
 29 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 32 37  4  0  0  0  0
 36 38  1  0  0  0  0
 38 39  1  0  0  0  0
 38 40  2  0  0  0  0
 28 41  4  0  0  0  0
 41 42  4  0  0  0  0
 25 42  4  0  0  0  0
 21 43  1  0  0  0  0
 43 44  4  0  0  0  0
 44 45  4  0  0  0  0
 45 46  4  0  0  0  0
 46 47  4  0  0  0  0
 47 48  4  0  0  0  0
 43 48  4  0  0  0  0
M  CHG  4   1  -1   2   1  38   1  39  -1
M  END
>  <GNF-Pf identifier>
GNF-Pf-815

>  <JC_XSMILES>
[O-][N+](=O)C1=CC=CC(=C1)C(=O)NC2=CC=C(C=C2)C3=CC(=NC(=N3)C4=CC=C(NC(=O)C5=CC=CC(=C5)[N+]([O-])=O)C=C4)C6=CC=CC=C6

>  <PF proliferation inhibition 3D7 EC50 uM>
1.343

>  <W2 Pf proliferation inhibition EC50 uM>
1.238

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-830
  Mrv1591402191617072D          

 32 34  0  0  0  0            999 V2000
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579    0.0000    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  2  0  0  0  0
  6  7  1  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  9 11  2  0  0  0  0
 11 12  1  0  0  0  0
  5 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  1  0  0  0  0
 16 18  4  0  0  0  0
 18 19  4  0  0  0  0
 13 19  4  0  0  0  0
 11 20  1  0  0  0  0
 20 21  2  0  0  0  0
 20 22  1  0  0  0  0
 22 23  1  0  0  0  0
  8 24  1  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 24 29  4  0  0  0  0
 27 30  1  0  0  0  0
 30 31  1  0  0  0  0
 30 32  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-830

>  <JC_XSMILES>
COC(=O)C1=C(C)N(C(C)=C(C1C2=CC=C(Br)C=C2)C(=O)OC)C3=CC=C(C=C3)N(C)C

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.221

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-844
  Mrv1591402191617072D          

 28 30  0  0  0  0            999 V2000
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1447   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.4302   -3.7125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 15 20  4  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 13 23  1  0  0  0  0
 23 24  1  0  0  0  0
 23 25  2  0  0  0  0
 11 26  4  0  0  0  0
 26 27  4  0  0  0  0
  7 27  4  0  0  0  0
 27 28  4  0  0  0  0
  4 28  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1   8
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-844

>  <JC_XSMILES>
CCOC1=CC=C2NC(=O)C(CN(CC3=CC=CC=C3OC)C(C)=O)=CC2=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.739

>  <W2 Pf proliferation inhibition EC50 uM>
>1.21

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.03030303

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-845
  Mrv1591402191617072D          

 28 31  0  0  0  0            999 V2000
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  4  9  4  0  0  0  0
  8 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  6 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  1 22  1  0  0  0  0
 22 23  1  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  1  0  0  0  0
 26 27  1  0  0  0  0
 27 28  1  0  0  0  0
 23 28  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-845

>  <JC_XSMILES>
C(CNC1=CC(=NC(=N1)C2=CC=NC=C2)C3=CC=CN=C3)CN4CCOCC4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.079

>  <W2 Pf proliferation inhibition EC50 uM>
1.21

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-888
  Mrv1591402191617072D          

 23 26  0  0  0  0            999 V2000
    4.0469   -7.1178    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3810   -6.6308    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4698   -5.8106    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8039   -5.3235    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0492   -5.6567    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8928   -4.5033    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.2269   -4.0163    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.3157   -3.1961    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7044   -2.6421    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8836   -2.7258    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4008   -2.0568    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7387   -1.3042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5595   -1.2205    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0423   -1.8895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8625   -1.9783    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4773   -1.4283    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2612   -1.6857    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9769   -1.2754    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.5883   -1.8294    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.2503   -2.5820    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.4301   -2.4932    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8153   -3.0433    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.0315   -2.7859    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  7  6  1  0  0  0  0
  7  8  2  0  0  0  0
  8  9  1  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
  9 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 17 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
  8 23  1  0  0  0  0
 15 23  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-888

>  <JC_XSMILES>
CCOC(=O)NN=C1C2=CC=CC=C2C3=NC4=NON=C4N=C13

>  <PF proliferation inhibition 3D7 EC50 uM>
1.446

>  <W2 Pf proliferation inhibition EC50 uM>
1.182

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-897
  Mrv1591402191617072D          

 26 28  0  0  0  0            999 V2000
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -5.3625    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7550   -5.0269    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3070   -5.6400    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.8945   -6.3545    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0875   -6.1830    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 11 15  4  0  0  0  0
  5 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
  3 18  4  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-897

>  <JC_XSMILES>
COC1=CC(CNCCCN2C=CN=C2)=CC=C1OCC3=CC=CC=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.173

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009345794

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-91
  Mrv1591402191617072D          

 60 63  0  0  0  0            999 V2000
   -5.9482   -4.2796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.2338   -3.8671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5193   -4.2796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8048   -3.8671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0903   -4.2796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3759   -3.8671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6614   -4.2796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9469   -3.8671    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2325   -4.2796    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2325   -5.1046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.5800   -4.9614    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9469   -5.5171    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6614   -5.1046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3759   -5.5171    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0497   -5.8799    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7255   -6.1620    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250   -5.5977    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.3319   -6.6551    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1443   -6.7984    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1984   -7.2871    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0837   -8.0624    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8768   -8.2898    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.5269   -7.7819    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9055   -9.1143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.5039   -9.7903    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3085   -9.6081    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.2765  -10.5833    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4760  -10.7829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8496  -11.1768    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.6501  -10.9772    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.6222  -11.9698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8217  -12.1694    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1953  -12.5633    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9958  -12.3637    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5688  -12.9572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3414  -13.7502    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5409  -13.9498    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.9679  -13.3563    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1674  -13.5559    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9399  -14.3490    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.5943  -12.9625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2062  -13.1620    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7793  -12.5686    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3096  -13.2006    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5519  -11.7755    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.3524  -11.9751    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5798  -12.7682    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3803  -12.9677    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1250  -11.1821    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.9255  -11.3817    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8976  -10.3890    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.0971  -10.1895    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4707   -9.7956    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2712   -9.9952    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8443   -9.4017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6169   -8.6087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8164   -8.4091    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2433   -9.0025    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3776   -8.7463    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.1102   -9.4117    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 10 12  1  0  0  0  0
 12 13  1  0  0  0  0
  7 13  1  0  0  0  0
 13 14  1  0  0  0  0
 10 15  1  0  0  0  0
 15 16  1  0  0  0  0
 15 17  1  0  0  0  0
 15 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 22 23  1  0  0  0  0
 22 24  1  0  0  0  0
 24 25  1  0  0  0  0
 25 26  2  0  0  0  0
 25 27  1  0  0  0  0
 27 28  1  0  0  0  0
 27 29  1  0  0  0  0
 29 30  1  0  0  0  0
 29 31  1  0  0  0  0
 31 32  2  0  0  0  0
 31 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  1  0  0  0  0
 35 36  1  0  0  0  0
 36 37  1  0  0  0  0
 37 38  1  0  0  0  0
 33 38  1  0  0  0  0
 38 39  1  0  0  0  0
 39 40  2  0  0  0  0
 39 41  1  0  0  0  0
 41 42  1  0  0  0  0
 42 43  1  0  0  0  0
 43 44  2  0  0  0  0
 43 45  1  0  0  0  0
 45 46  1  0  0  0  0
 46 47  1  0  0  0  0
 47 48  1  0  0  0  0
 45 49  1  0  0  0  0
 49 50  1  0  0  0  0
 49 51  1  0  0  0  0
 51 52  2  0  0  0  0
 51 53  1  0  0  0  0
 53 54  1  0  0  0  0
 54 55  1  0  0  0  0
 55 56  1  0  0  0  0
 56 57  1  0  0  0  0
 57 58  1  0  0  0  0
 53 58  1  0  0  0  0
 58 59  1  0  0  0  0
 21 59  1  0  0  0  0
 59 60  2  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-91

>  <JC_XSMILES>
CCCCCCC1CCC(O)(OC1C)C(C)(O)C(=O)NC2C(C)OC(=O)C(C)N(O)C(=O)C3CCCNN3C(=O)CNC(=O)C(COC)N(O)C(=O)C4CCCNN4C2=O

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2189

>  <W2 Pf proliferation inhibition EC50 uM>
0.1239

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.197

>  <Powder data?>
No

>  <IFI value>
0.392857143

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-917
  Mrv1591402191617072D          

 27 28  0  0  0  0            999 V2000
    4.1633   -6.2168    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3531   -6.3728    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8131   -5.7491    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.0029   -5.9050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4628   -5.2814    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -4.5018    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5430   -4.3459    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0831   -4.9696    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1928   -3.8782    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3827   -4.0341    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1574   -3.4105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9676   -3.5664    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5077   -2.9427    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3178   -3.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.5878   -3.8782    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6680   -2.6309    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    1.4628   -3.0986    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2730   -2.9427    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.9227   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.1928   -1.6954    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6527   -1.0718    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9227   -0.2923    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.7329   -0.1363    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2730   -0.7600    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0831   -0.6041    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    2.0029   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  3  8  4  0  0  0  0
  6  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  1  0  0  0  0
  9 18  1  0  0  0  0
 18 19  2  0  0  0  0
 18 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 21 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-917

>  <JC_XSMILES>
COC1=CC=C(C=C1)N(CCCNC(=O)CCl)C(=O)NC2=CC=CC(Cl)=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.596

>  <W2 Pf proliferation inhibition EC50 uM>
1.15

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009259259

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-918
  Mrv1591402191617072D          

 22 23  0  0  0  0            999 V2000
   -4.2868   -1.6500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  2  0  0  0  0
  5  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 10 15  4  0  0  0  0
  9 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
 21 22  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-918

>  <JC_XSMILES>
NCCNC(=O)COC(C1=CC=CN=C1)C2=CC=CC=C2Cl

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.15

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.009708738

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-92
  Mrv1591402191617072D          

 34 37  0  0  0  0            999 V2000
    8.0289    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.2039    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7914   -0.1105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.2039   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7914   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.9664   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5539   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7289   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7289   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.4914   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -2.2539    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -1.5395    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -2.2539    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039   -0.8250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2211   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6336   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4586   -0.1105    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8711    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6961    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8711   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6961   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.0164   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6039    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.8414   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789    0.6039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4914   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3164   -0.1105    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7289    0.6039    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0789   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.2539   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  3  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  4  0  0  0  0
  9 10  2  0  0  0  0
  9 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  2  0  0  0  0
 15 17  4  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 21 22  1  0  0  0  0
 20 23  1  0  0  0  0
 23 24  1  0  0  0  0
 17 25  4  0  0  0  0
 25 26  2  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
  8 31  4  0  0  0  0
 31 32  2  0  0  0  0
 30 33  4  0  0  0  0
 11 33  4  0  0  0  0
 33 34  4  0  0  0  0
 14 34  4  0  0  0  0
 27 34  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-92

>  <JC_XSMILES>
CCN(CC)CCN1C(=O)C2=CC=C3C(=O)N(CCN(CC)CC)C(=O)C4=CC=C(C1=O)C2=C34

>  <PF proliferation inhibition 3D7 EC50 uM>
0.2435

>  <W2 Pf proliferation inhibition EC50 uM>
0.1362

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
0.2212

>  <Powder data?>
No

>  <IFI value>
0.151785714

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
1

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-931
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
   -1.2375   -7.4763    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -6.7618    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -6.0474    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -5.3329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.9039    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.1895    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2375   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4750   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8875   -3.1895    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -1.7605    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.7125   -1.7605    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.3000   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750   -1.0461    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625   -0.3316    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4750    0.3829    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375   -0.3316    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    0.3829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.3829    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125    1.0974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    1.8118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8250    1.8118    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    2.5263    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.2375    1.0974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0625    1.0974    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -4.6184    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -5.3329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  2  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 14 16  1  0  0  0  0
 11 17  1  0  0  0  0
 17 18  1  0  0  0  0
 17 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 21 26  4  0  0  0  0
 26 27  4  0  0  0  0
 27 28  2  0  0  0  0
 27 29  4  0  0  0  0
 19 29  4  0  0  0  0
 29 30  1  0  0  0  0
 30 31  4  0  0  0  0
 31 32  4  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  1  0  0  0  0
 34 36  4  0  0  0  0
 30 36  4  0  0  0  0
 36 37  1  0  0  0  0
  7 38  4  0  0  0  0
 38 39  4  0  0  0  0
  4 39  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-931

>  <JC_XSMILES>
CCOC1=CC=C(NC(=O)N(CCC(C)C)C(C)C2=NC3=CC=CC=C3C(=O)N2C4=CC=CC(Cl)=C4C)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.196

>  <W2 Pf proliferation inhibition EC50 uM>
1.141

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.010638298

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-943
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  5  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  3 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
 16 19  1  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 19 24  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-943

>  <JC_XSMILES>
COC1=CC(OC)=CC(=C1)C(=O)N2CCN(CC2)C3=CC=CC=N3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.129

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.076923077

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-955
  Mrv1591402191617072D          

 20 21  0  0  0  0            999 V2000
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -3.3000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.0625    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3020   -1.3480    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1270   -2.7770    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.0625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  2  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
  5 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  2  0  0  0  0
 11 13  2  0  0  0  0
 11 14  1  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-955

>  <JC_XSMILES>
COC(=O)C1CCCCN1S(=O)(=O)C2=CC=C(C)C=C2

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.121

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-96
  Mrv1591402191617072D          

 39 42  0  0  0  0            999 V2000
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.8250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145    1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.4125   -3.7445    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4125   -3.7445    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
   -0.6674   -2.9599    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0652   -3.2570    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8498   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0213   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4082   -1.6431    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6236   -1.8980    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.8059   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.5905   -1.6852    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5510   -1.1555    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.0609   -2.7248    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4521   -2.7050    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6236   -1.8980    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0652   -3.2570    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8498   -3.0021    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0213   -2.1951    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8059   -1.9402    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4190   -2.4922    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2475   -3.2992    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4629   -3.5541    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2913   -4.3611    0.0000 F   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  7 10  4  0  0  0  0
  3 10  4  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
  5 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 15 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 20 25  4  0  0  0  0
 23 26  1  0  0  0  0
 26 27  1  0  0  0  0
 26 28  1  0  0  0  0
 26 29  1  0  0  0  0
 16 30  1  0  0  0  0
 30 31  2  0  0  0  0
 30 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 33 38  4  0  0  0  0
 38 39  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-96

>  <JC_XSMILES>
COC1=CC(=CC(OC)=C1OC)C(=O)N2C(CSC2C3=CC=C(C=C3)C(C)(C)C)C(=O)NC4=CC=CC=C4F

>  <PF proliferation inhibition 3D7 EC50 uM>
1.042

>  <W2 Pf proliferation inhibition EC50 uM>
1.284

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>2.306

>  <Powder data?>
No

>  <IFI value>
0.010526316

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-964
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -7.8375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -7.8375    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -7.4250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -7.8375    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -8.6625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -10.3125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145  -11.1375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.9000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -10.3125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289  -11.5500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -12.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -12.3750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2868  -11.5500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -11.1375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724  -10.3125    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -9.0750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -8.6625    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -6.6000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  4  0  0  0  0
  3  4  4  0  0  0  0
  4  5  1  0  0  0  0
  4  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  2  0  0  0  0
 12 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  2  0  0  0  0
 16 18  1  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 18 23  4  0  0  0  0
 23 24  1  0  0  0  0
 14 25  4  0  0  0  0
 25 26  4  0  0  0  0
 10 26  4  0  0  0  0
  7 27  4  0  0  0  0
  2 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-964

>  <JC_XSMILES>
CC1=CC(C)=NC(SCC2=CC(=O)C(OC(=O)C3=CC=CC=C3Br)=CO2)=N1

>  <PF proliferation inhibition 3D7 EC50 uM>
>11.18

>  <W2 Pf proliferation inhibition EC50 uM>
>11.18

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-972
  Mrv1591402191617072D          

 36 39  0  0  0  0            999 V2000
    3.2095    0.5678    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9240    0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3365    0.8698    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5115   -0.5591    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6384   -0.2572    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529    0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529    0.9803    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.0674   -0.2572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.0674   -1.0822    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.3529   -1.4947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6384   -1.0822    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9240   -1.4947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9240   -2.3197    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.6384   -2.7322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.6384   -3.5572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9240   -3.9697    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.2095   -3.5572    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2095   -2.7322    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7819   -1.4947    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4963   -1.0822    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    6.7819   -2.3197    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.4493   -2.8046    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1944   -3.5892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.3694   -3.5892    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.1144   -2.8046    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.8844   -4.2566    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2200   -5.0103    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7351   -5.6778    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9146   -5.5915    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5790   -4.8378    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0640   -4.1704    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7819    0.1553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.8681    0.9758    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6751    1.1473    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0876    0.4329    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.5355   -0.1802    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  1  0  0  0  0
  2  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  1  0  0  0  0
 14 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 13 18  1  0  0  0  0
  9 19  1  0  0  0  0
 19 20  2  0  0  0  0
 19 21  1  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 21 25  4  0  0  0  0
 24 26  1  0  0  0  0
 26 27  4  0  0  0  0
 27 28  4  0  0  0  0
 28 29  4  0  0  0  0
 29 30  4  0  0  0  0
 30 31  4  0  0  0  0
 26 31  4  0  0  0  0
  8 32  1  0  0  0  0
 32 33  4  0  0  0  0
 33 34  4  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 32 36  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  25
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-972

>  <JC_XSMILES>
CC(C)(C)NC(=O)C(N(CCCN1CCOCC1)C(=O)C2=CC=C(N2)C3=CC=CC=C3)C4=CC=CS4

>  <PF proliferation inhibition 3D7 EC50 uM>
1.227

>  <W2 Pf proliferation inhibition EC50 uM>
1.107

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.032608696

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-976
  Mrv1591402191617072D          

 24 26  0  0  0  0            999 V2000
    1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 Br  0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  1  0  0  0  0
 11 13  4  0  0  0  0
 13 14  4  0  0  0  0
 14 15  4  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  1  0  0  0  0
 17 19  4  0  0  0  0
 19 20  4  0  0  0  0
 14 20  4  0  0  0  0
 20 21  4  0  0  0  0
 10 21  4  0  0  0  0
 21 22  2  0  0  0  0
  8 23  4  0  0  0  0
 23 24  4  0  0  0  0
  5 24  4  0  0  0  0
M  STY  1   1 DAT
M  SAL   1  1  13
M  SDT   1 MRV_IMPLICIT_H                                        
M  SDD   1     0.0000    0.0000    DR    ALL  0       0  
M  SED   1 IMPL_H1
M  END
>  <GNF-Pf identifier>
GNF-Pf-976

>  <JC_XSMILES>
CCCOC1=CC=C(CC2=C(C)N=C3C=CC(Br)=CC3=C2O)C=C1

>  <PF proliferation inhibition 3D7 EC50 uM>
1.034

>  <W2 Pf proliferation inhibition EC50 uM>
1.105

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-978
  Mrv1591402191617072D          

 40 44  0  0  0  0            999 V2000
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4289   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  2  0  0  0  0
  2  4  1  0  0  0  0
  4  5  1  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
  5 10  4  0  0  0  0
  9 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
 13 14  2  0  0  0  0
 13 15  1  0  0  0  0
 15 16  1  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  1  0  0  0  0
 19 20  1  0  0  0  0
 20 21  1  0  0  0  0
 16 21  1  0  0  0  0
 12 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  1  0  0  0  0
 25 27  4  0  0  0  0
 27 28  4  0  0  0  0
 22 28  4  0  0  0  0
 11 29  1  0  0  0  0
 29 30  2  0  0  0  0
 29 31  1  0  0  0  0
 31 32  1  0  0  0  0
 32 33  1  0  0  0  0
 33 34  1  0  0  0  0
 34 35  4  0  0  0  0
 35 36  4  0  0  0  0
 36 37  4  0  0  0  0
 37 38  4  0  0  0  0
 38 39  4  0  0  0  0
 34 39  4  0  0  0  0
 39 40  1  0  0  0  0
 31 40  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-978

>  <JC_XSMILES>
CC(=O)NC1=CC=CC(=C1)N(C(C(=O)NC2CCCCC2)C3=CC=C(O)C=C3)C(=O)C4COC5=CC=CC=C5O4

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.25

>  <W2 Pf proliferation inhibition EC50 uM>
>1.103

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.020833333

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-990
  Mrv1591402191617072D          

 26 29  0  0  0  0            999 V2000
    2.1434   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -1.6500    0.0000 N   0  3  0  0  0  0  0  0  0  0  0  0
    0.7145   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -6.6000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -7.4250    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -6.1875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  4  0  0  0  0
  7  8  4  0  0  0  0
  8  9  4  0  0  0  0
  9 10  4  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
  3 12  4  0  0  0  0
  7 12  4  0  0  0  0
  4 13  1  0  0  0  0
 13 14  2  0  0  0  0
 14 15  1  0  0  0  0
 15 16  2  0  0  0  0
 16 17  1  0  0  0  0
 17 18  1  0  0  0  0
 18 19  2  0  0  0  0
 14 19  1  0  0  0  0
 17 20  1  0  0  0  0
 20 21  4  0  0  0  0
 21 22  4  0  0  0  0
 22 23  4  0  0  0  0
 23 24  1  0  0  0  0
 23 25  4  0  0  0  0
 25 26  4  0  0  0  0
 20 26  4  0  0  0  0
M  CHG  1   3   1
M  END
>  <GNF-Pf identifier>
GNF-Pf-990

>  <JC_XSMILES>
CC[N+]1=C(C=CC2=CC=CC=C12)C=C3C=CN(C=C3)C4=CC=C(Cl)C=C4

>  <PF proliferation inhibition 3D7 EC50 uM>
0.725

>  <W2 Pf proliferation inhibition EC50 uM>
1.094

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0.153846154

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-993
  Mrv1591402191617072D          

 27 29  0  0  0  0            999 V2000
    0.4817   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1962   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9106   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9106   -6.8417    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6251   -5.6042    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.3396   -6.0167    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3396   -6.8417    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.0540   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.7685   -6.0167    0.0000 S   0  0  0  0  0  0  0  0  0  0  0  0
    5.4830   -5.6042    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5692   -4.7837    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.3762   -4.6122    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.7887   -5.3267    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.2367   -5.9398    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.4082   -6.7467    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.1928   -7.0017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.3643   -7.8087    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.7512   -8.3607    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    6.9228   -9.1677    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    5.9666   -8.1057    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7951   -7.2988    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    7.6092   -5.4129    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.0941   -4.7455    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.9146   -4.8317    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    9.2501   -5.5854    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    8.7652   -6.2528    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    7.9447   -6.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  1  0  0  0  0
  3  5  1  0  0  0  0
  5  6  1  0  0  0  0
  6  7  2  0  0  0  0
  6  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  4  0  0  0  0
 11 12  4  0  0  0  0
 12 13  4  0  0  0  0
 13 14  4  0  0  0  0
 10 14  4  0  0  0  0
 14 15  1  0  0  0  0
 15 16  4  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  1  0  0  0  0
 18 20  4  0  0  0  0
 20 21  4  0  0  0  0
 15 21  4  0  0  0  0
 13 22  1  0  0  0  0
 22 23  4  0  0  0  0
 23 24  4  0  0  0  0
 24 25  4  0  0  0  0
 25 26  4  0  0  0  0
 26 27  4  0  0  0  0
 22 27  4  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-993

>  <JC_XSMILES>
CCC(C)NC(=O)CSC1=NN=C(N1C2=CC=C(Cl)C=C2)C3=CC=CN=C3

>  <PF proliferation inhibition 3D7 EC50 uM>
>1.524

>  <W2 Pf proliferation inhibition EC50 uM>
>1.091

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>10

>  <Powder data?>
No

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
0

>  <Class W2>
0

>  <Class Tox>
0

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
GNF-Pf-3035
  Mrv1591402191617072D          

 25 27  0  0  0  0            999 V2000
    4.2868    0.0000    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -0.4125    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -1.2375    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7158   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -2.8875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.0013   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.1250    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.9500    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.8579   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -3.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1434   -6.1875    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -5.3625    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.9500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7145   -3.7125    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.4289   -4.1250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -2.4750    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2868   -1.6500    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -1.2375    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.5724   -0.4125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  3  4  4  0  0  0  0
  4  5  4  0  0  0  0
  5  6  4  0  0  0  0
  6  7  1  0  0  0  0
  7  8  1  0  0  0  0
  8  9  1  0  0  0  0
  9 10  1  0  0  0  0
 10 11  1  0  0  0  0
 11 12  1  0  0  0  0
 12 13  1  0  0  0  0
  8 13  1  0  0  0  0
 11 14  1  0  0  0  0
 14 15  2  0  0  0  0
 14 16  1  0  0  0  0
 16 17  4  0  0  0  0
 17 18  4  0  0  0  0
 18 19  4  0  0  0  0
 19 20  4  0  0  0  0
 20 21  4  0  0  0  0
 16 21  4  0  0  0  0
  6 22  4  0  0  0  0
 22 23  4  0  0  0  0
  3 23  4  0  0  0  0
 23 24  1  0  0  0  0
 24 25  1  0  0  0  0
M  END
>  <GNF-Pf identifier>
GNF-Pf-3035

>  <JC_XSMILES>
COC1=CC=C(CN2CCN(CC2)C(=O)C3=CC=CN=C3)C=C1OC

>  <PF proliferation inhibition 3D7 EC50 uM>
0.349

>  <W2 Pf proliferation inhibition EC50 uM>
2.009

>  <Huh7 cytotox for Pf inhibitiors CC50 uM>
>100

>  <Powder data?>
Yes

>  <IFI value>
0

>  <Salt>
No salt

>  <Equiv of salt>
0

>  <Class 3D7>
1

>  <Class W2>
0

>  <Class Tox>
1

>  <Class Total>
0

>  <StandardizerResult>
Remove Explicit Hydrogens (ID: Remove Explicit Hydrogens)


$$$$
